Variation in ethanol pharmacokinetics and perceived gender and ethnic differences in alcohol elimination

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 4, 2000, Pages 415-416

  Li, Ting Kai ^a   Beard, James D ^b   Orr, William E ^b   Kwo, Paul Y ^a   Ramchandani, Vijay A ^a   Thomasson, Holly R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; CLINICAL ARTICLE; CONFERENCE PAPER; ETHNIC DIFFERENCE; EXCRETION; FEMALE; HUMAN; LIVER SIZE; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0034054936     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02002.x     Document Type: Conference Paper

References (9)

1. Beard JD, Orr WE, Li T-K (1997) Does liver weight play a role in the ethnic and gender differences in ethanol pharmacokinetics (abstract)? Alcohol Clin Exp Res 21:51.
2. Bosron WF, Ehrig T, Li T-K (1993) Genetic factors in alcohol metabolism and alcoholism. Semin Liver Dis 13:126-135.
3. Hawkins RA, Nielsen RC, Veech RL (1974) The increased rate of ethanol removal from blood of clofibrate-treated rats. Biochem J 140:117-120.
4. Kopun M, Propping P (1977) The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects. Eur J Clin Pharmacol 11:337-344.
5. Kwo, PY, Ramchandani VA, O'Connor S, Amann D, Carr LG, Sandrasegara K, Kopecky K, Li, T-K (1998) Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for lean body mass. Gastroenterology 115:1552-1557.
6. Li T-K, Lumeng LL, Thomasson HR (1995) Genetic and gender differences in alcohol consumption and metabolism. In Stress, Gender and Alcohol Seeking Behavior, NIAAA Research Monograph 29 (Hunt WA, Zakhari S eds), pp. 87-100, US Government Printing Office, Washington, DC.
7. Lumeng L, Bosron WF, Li T-K (1979) Quantitative correlation of ethanol elimination rates in vivo with liver alcohol dehydrogenase activities in fed, fasted and food restricted rats. Biochem Pharmacol 28:1547-1551.
8. O'Connor S, Morzorati S, Christian J, Li T-K (1998) Clamping BRAC reduces experimental variance: Application to the study of acute tolerance to alcohol and alcohol elimination rate. Alcohol Clin Exp Res 22:202-210.
9. Thomasson M Beard JD, Li T-K (1995) ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol Clin Exp Res 19: 1494-1499.