Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification

Forensic Science International

Volumn 188, Issue 1-3, 2009, Pages 52-56

  Høiseth, Gudrun ^a   Morini, Luca ^b   Polettini, Aldo ^c   Christophersen, Asbjørg ^a   Mørland, Jørg ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

Alcohol; EtG; EtS; Pharmacokinetics

Indexed keywords

ALCOHOL; ETHYL GLUCURONIDE; ETHYL SULPHATE; SULFATE; UNCLASSIFIED DRUG;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ARTICLE; BLOOD; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRINKING; FEMALE; HALF LIFE TIME; HISTORY; HOSPITAL ADMISSION; HUMAN; INGESTION; KIDNEY DISEASE; KINETICS; LIVER DISEASE; MALE; METABOLITE; PRIORITY JOURNAL;

ADULT; ALCOHOLISM; ALKYLATING AGENTS; CHROMATOGRAPHY, LIQUID; FEMALE; FLAME IONIZATION; FORENSIC TOXICOLOGY; GLUCURONATES; HEPATITIS C; HUMANS; KIDNEY DISEASES; MALE; MASS SPECTROMETRY; MIDDLE AGED; NORWAY; SULFURIC ACID ESTERS;

EID: 67349091102     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2009.03.017     Document Type: Article

References (28)

1. Dahl H., Stephanson N., Beck O., and Helander A. Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J. Anal. Toxicol. 26 (2002) 201-204
2. Nishikawa M., Tsuchihashi H., Miki A., Katagi M., Schmitt G., Zimmer H., Keller T., and Aderjan R. Determination of ethyl glucuronide, a minor metabolite of ethanol, in human serum by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B: Biomed. Sci. Appl. 726 (1999) 105-110
3. Politi L., Leone F., Morini L., and Polettini A. Bioanalytical procedures for determination of conjugates or fatty acid esters of ethanol as markers of ethanol consumption: a review. Anal. Biochem. 368 (2007) 1-16
4. Politi L., Morini L., Leone F., and Polettini A. Ethyl glucuronide in hair: is it a reliable marker of chronic high levels of alcohol consumption?. Addiction 101 (2006) 1408-1412
5. Hoiseth G., Bernard J.P., Karinen R., Johnsen L., Helander A., Christophersen A.S., and Morland J. A pharmacokinetic study of ethyl glucuronide in blood and urine: applications to forensic toxicology. Forensic Sci. Int. 172 (2007) 119-124
6. Droenner P., Schmitt G., Aderjan R., and Zimmer H. A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci. Int. 126 (2002) 24-29
7. Halter C.C., Dresen S., Auwaerter V., Wurst F.M., and Weinmann W. Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake. Int. J. Legal Med. 122 (2008) 123-128
8. Schmitt G., Droenner P., Skopp G., and Aderjan R. Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers. J. Forensic Sci. 42 (1997) 1099-1102
9. Kaferstein H., Sticht G., Lenartz D., Sturm V., Sabatowski R., and Rotschild M. Begleitalkohol- und Ethylglucuronidbestimmungen nach einer stundlichen Alkoholbelastnung von 1, 8 g/kg mit Ouzo. Blutalkohol 43 (2006) 73-80
10. Skurtveit S., Christophersen A.S., Grung M., and Morland J. Increased mortality among previously apprehended drunken and drugged drivers. Drug Alcohol Depend. 68 (2002) 143-150
11. Kristoffersen L., Stormyhr L.E., and Smith-Kielland A. Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. Forensic Sci. Int. 161 (2006) 151-157
12. Hoiseth G., Karinen R., Christophersen A.S., Olsen L., Normann P.T., and Morland J. A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol. Forensic Sci. Int. 165 (2007) 41-45
13. Potgieter A. Science, practice and patient needs: the work of the Plinius Maior Society. Alcohol Alcohol. 35 (2000) 16-24
14. Watkins P.B., Kaplowitz N., Slattery J.T., Colonese C.R., Colucci S.V., Stewart P.W., and Harris S.C. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA 296 (2006) 87-93
15. Ceriotti F., Boyd J.C., Klein G., Henny J., Queralto J., Kairisto V., and Panteghini M. Reference intervals for serum creatinine concentrations: assessment of available data for global application. Clin. Chem. 54 (2008) 559-566
16. Klauke R., Schmidt E., and Lorentz K. Recommendations for carrying out standard ECCLS procedures (1988) for the catalytic concentrations of creatine kinase, aspartate aminotransferase, alanine aminotransferase and gamma-glutamyltransferase at 37 degrees C. Standardization Committee of the German Society for Clinical Chemistry, Enzyme Working Group of the German Society for Clinical Chemistry. Eur. J. Clin. Chem. Clin. Biochem. 31 (1993) 901-909
17. Neumann T., Helander A., Dahl H., Holzmann T., Neuner B., Weiss-Gerlach E., Muller C., and Spies C. Value of ethyl glucuronide in plasma as a biomarker for recent alcohol consumption in the emergency room. Alcohol Alcohol. 43 (2008) 431-435
18. Foti R.S., and Fisher M.B. Assessment of UDP-glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGTs. Forensic Sci. Int. 153 (2005) 109-116
19. Vestermark A., and Bostrom H. Studies on ester sulfates. V. On the enzymatic formation of ester sulfates of primary aliphatic alcohols. Exp. Cell Res. 18 (1959) 174-177
20. Manautou J.E., and Carlson G.P. Comparison of pulmonary and hepatic glucuronidation and sulphation of ethanol in rat and rabbit in vitro. Xenobiotica 22 (1992) 1309-1319
21. Kamil I., Smith N., and Williams R.T. A new aspect of ethanol metabolism: isolation of ethyl glucuronide. Biochem. J. 51 (1952) 32-33
22. Hoiseth G., Bernard J.P., Stephanson N., Normann P.T., Christophersen A.S., Morland J., and Helander A. Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment. Alcohol Alcohol. 43 (2008) 187-191
23. Reinke L.A., Moyer M.J., and Notley K.A. Diminished rates of glucuronidation and sulfation in perfused rat liver after chronic ethanol administration. Biochem. Pharmacol. 35 (1986) 439-447
24. Li Y.Q., Prentice D.A., Howard M.L., Mashford M.L., Wilson J.S., and Desmond P.V. Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture. Life Sci. 66 (2000) 575-584
25. Farinati F., Lieber C.S., and Garro A.J. Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue. Alcohol. Clin. Exp. Res. 13 (1989) 357-360
26. Helander A., and Beck O. Ethyl sulfate: a metabolite of ethanol in humans and a potential biomarker of acute alcohol intake. J. Anal. Toxicol. 29 (2005) 270-274
27. Wurst F.M., Dresen S., Allen J.P., Wiesbeck G., Graf M., and Weinmann W. Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption. Addiction 101 (2006) 204-211
28. Kip M.J., Spies C.D., Neumann T., Nachbar Y., Alling C., Aradottir S., Weinmann W., and Wurst F.M. The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting. Alcohol. Clin. Exp. Res. 32 (2008) 1284-1291