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Volumn 22, Issue 9, 1998, Pages 2125-2132

Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system

Author keywords

Cytochrome P 4501A2; Cytochrome P 4502E1; Cytochrome P 4503A4; Human; Microsomal Ethanol Oxidizing System

Indexed keywords

4 METHYLPYRAZOLE; ACETALDEHYDE; ALCOHOL; ALCOHOL OXIDASE; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; FURAFYLLINE; PHENACETIN O DEETHYLASE; TROLEANDOMYCIN;

EID: 0032407278     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-199812000-00033     Document Type: Article
Times cited : (98)

References (46)
  • 1
    • 0014426950 scopus 로고
    • Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding
    • Lieber CS, DeCarli LM: Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding. Science 162:917-918, 1968
    • (1968) Science , vol.162 , pp. 917-918
    • Lieber, C.S.1    DeCarli, L.M.2
  • 2
    • 0014962167 scopus 로고
    • Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo
    • Lieber CS, DeCarli LM: Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. J Biol Chem 245:2505-2512, 1970
    • (1970) J Biol Chem , vol.245 , pp. 2505-2512
    • Lieber, C.S.1    DeCarli, L.M.2
  • 3
    • 0018121274 scopus 로고
    • Nonuniformity of blood ethanol elimination: Its exaggeration after chronic consumption
    • Salaspuro MP, Lieber CS: Nonuniformity of blood ethanol elimination: Its exaggeration after chronic consumption. Ann Clin Res 10:294-297, 1978
    • (1978) Ann Clin Res , vol.10 , pp. 294-297
    • Salaspuro, M.P.1    Lieber, C.S.2
  • 4
    • 0017664959 scopus 로고
    • Reconstitution of the microsomal ethanol oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption
    • Ohnishi K, Lieber CS: Reconstitution of the microsomal ethanol oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J Biol Chem 252:7124-7131, 1977
    • (1977) J Biol Chem , vol.252 , pp. 7124-7131
    • Ohnishi, K.1    Lieber, C.S.2
  • 5
    • 0020458459 scopus 로고
    • Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits
    • Koop DR, Morgan ET, Tarr GE, Coon MJ: Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem 257:8472-8480, 1982
    • (1982) J Biol Chem , vol.257 , pp. 8472-8480
    • Koop, D.R.1    Morgan, E.T.2    Tarr, G.E.3    Coon, M.J.4
  • 7
    • 0023200612 scopus 로고
    • Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj
    • Wrighton SA, Thomas PE, Ryan DE, Levin W: Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch Biochem Biophys 258:292-297, 1987
    • (1987) Arch Biochem Biophys , vol.258 , pp. 292-297
    • Wrighton, S.A.1    Thomas, P.E.2    Ryan, D.E.3    Levin, W.4
  • 9
    • 0027848703 scopus 로고
    • Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): A specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling
    • Kunitoh S, Tanaka T, Imaoka S, Funae Y, Monna Y: Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): A specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol Alcohol 28:63-68, 1993
    • (1993) Alcohol Alcohol , vol.28 , pp. 63-68
    • Kunitoh, S.1    Tanaka, T.2    Imaoka, S.3    Funae, Y.4    Monna, Y.5
  • 10
    • 0030431698 scopus 로고    scopus 로고
    • Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s
    • Asai H, Imaoka S, Kuroki T, Monna T, Funae Y: Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s. J Pharmacol Exp Ther 277:1004-1009, 1996
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1004-1009
    • Asai, H.1    Imaoka, S.2    Kuroki, T.3    Monna, T.4    Funae, Y.5
  • 11
    • 0026324032 scopus 로고
    • Expression of mammalian cytochrome P-450 using vaccinia virus
    • Gonzalez FJ, Aoyama T, Gelboin HV: Expression of mammalian cytochrome P-450 using vaccinia virus. Methods Enzymol 206:85-92, 1991
    • (1991) Methods Enzymol , vol.206 , pp. 85-92
    • Gonzalez, F.J.1    Aoyama, T.2    Gelboin, H.V.3
  • 12
    • 50449100139 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties
    • Omura T, Sato R: The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem 239:2379-2385, 1964
    • (1964) J Biol Chem , vol.239 , pp. 2379-2385
    • Omura, T.1    Sato, R.2
  • 13
    • 0027139782 scopus 로고
    • Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expresscd, microsomal, and purified CYP1A1 and CYP1A2
    • Tsyrlov IB, Goldfarb IS, Gelboin HV: Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expresscd, microsomal, and purified CYP1A1 and CYP1A2. Arch Biochem Biophys 307:259-266, 1993
    • (1993) Arch Biochem Biophys , vol.307 , pp. 259-266
    • Tsyrlov, I.B.1    Goldfarb, I.S.2    Gelboin, H.V.3
  • 14
    • 0026349867 scopus 로고
    • Isolation of P450 enzymes from human liver
    • Raucy JL, Lasker JM: Isolation of P450 enzymes from human liver. Methods Enzymol 206:577-587, 1991
    • (1991) Methods Enzymol , vol.206 , pp. 577-587
    • Raucy, J.L.1    Lasker, J.M.2
  • 15
    • 0028858960 scopus 로고
    • Cytochrome P-450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
    • Newton DJ, Wang RW, Lu AYH: Cytochrome P-450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metab Dispos 23:154-158, 1995
    • (1995) Drug Metab Dispos , vol.23 , pp. 154-158
    • Newton, D.J.1    Wang, R.W.2    Lu, A.Y.H.3
  • 16
    • 0028268359 scopus 로고
    • Isoenzyme- and species-specific susceptibility of cDNA-expressed CYP1A P450s to different flavonoids
    • Tsyrlov IB, Mikhailenko VM, Gelboin HV: Isoenzyme- and species-specific susceptibility of cDNA-expressed CYP1A P450s to different flavonoids. Biochim Biophys Acta 1205:325-335, 1994
    • (1994) Biochim Biophys Acta , vol.1205 , pp. 325-335
    • Tsyrlov, I.B.1    Mikhailenko, V.M.2    Gelboin, H.V.3
  • 18
    • 0027380074 scopus 로고
    • Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
    • Kunze KL, Trager WF: Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol 6:649-656, 1993
    • (1993) Chem Res Toxicol , vol.6 , pp. 649-656
    • Kunze, K.L.1    Trager, W.F.2
  • 19
    • 0024541342 scopus 로고
    • NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver
    • NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci USA 86:462-465, 1989
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 462-465
    • Shimada, T.1    Guengerich, F.P.2
  • 20
    • 0020465448 scopus 로고
    • Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols
    • Morgan ET, Koop DR, Coon MJ: Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols. J Biol Chem 257:13951-13957, 1982
    • (1982) J Biol Chem , vol.257 , pp. 13951-13957
    • Morgan, E.T.1    Koop, D.R.2    Coon, M.J.3
  • 21
    • 0027163578 scopus 로고
    • Determination of p-nitrophenol hydroxylase activity of rat liver microsomes by high-pressure liquid chromatography
    • Duescher RJ, Elfarra AA: Determination of p-nitrophenol hydroxylase activity of rat liver microsomes by high-pressure liquid chromatography. Anal Biochem 212:311-314, 1993
    • (1993) Anal Biochem , vol.212 , pp. 311-314
    • Duescher, R.J.1    Elfarra, A.A.2
  • 22
    • 0028106482 scopus 로고
    • Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
    • Burke MD, Thompson S, Weaver RJ, Wolf CR, Mayer RT: Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 48:923-936, 1994
    • (1994) Biochem Pharmacol , vol.48 , pp. 923-936
    • Burke, M.D.1    Thompson, S.2    Weaver, R.J.3    Wolf, C.R.4    Mayer, R.T.5
  • 23
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H: Catalase in vitro. Methods Enzymol 105:121-126, 1984
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 24
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 25
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 28
    • 0027185531 scopus 로고
    • Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates
    • Dai Y, Rashba-Step J, Cederbaum AI: Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry 32: 6928-6937, 1993
    • (1993) Biochemistry , vol.32 , pp. 6928-6937
    • Dai, Y.1    Rashba-Step, J.2    Cederbaum, A.I.3
  • 29
    • 0029067415 scopus 로고
    • Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes
    • Jayyosi Z, Knoble D, Mue M, Erick J, Thomas PE, Kelley M: Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. J Pharmacol Exp Ther 273:1156-1161, 1995
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1156-1161
    • Jayyosi, Z.1    Knoble, D.2    Mue, M.3    Erick, J.4    Thomas, P.E.5    Kelley, M.6
  • 30
    • 0022851547 scopus 로고
    • Hepatic microsomal ethanol-oxidizing system (MEOS): Metabolic aspects and clinical implications
    • Teschke R, Gellert J: Hepatic microsomal ethanol-oxidizing system (MEOS): metabolic aspects and clinical implications. Alcohol Clin Exp Res 10:20S-32S, 1986
    • (1986) Alcohol Clin Exp Res , vol.10
    • Teschke, R.1    Gellert, J.2
  • 31
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423, 1994
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 33
    • 0024378451 scopus 로고
    • The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver
    • Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS: The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 10:437-446, 1989
    • (1989) Hepatology , vol.10 , pp. 437-446
    • Tsutsumi, M.1    Lasker, J.M.2    Shimizu, M.3    Rosman, A.S.4    Lieber, C.S.5
  • 34
    • 0024832058 scopus 로고
    • Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake
    • Perrot N, Nalpas B, Yang CS, Beaune PH: Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake. Eur J Clin Invest 19:549-555, 1989
    • (1989) Eur J Clin Invest , vol.19 , pp. 549-555
    • Perrot, N.1    Nalpas, B.2    Yang, C.S.3    Beaune, P.H.4
  • 35
    • 0023687412 scopus 로고
    • A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking
    • Sesardic D, Boobis AR, Edwards RJ, Davies DS: A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. Br J Clin Pharmacol 26:363-372, 1988
    • (1988) Br J Clin Pharmacol , vol.26 , pp. 363-372
    • Sesardic, D.1    Boobis, A.R.2    Edwards, R.J.3    Davies, D.S.4
  • 37
    • 0024556650 scopus 로고
    • Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients
    • Watkins PB, Murray SA, Winkelman LG, Heuman DM. Wrighton SA, Guzelian PS: Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest 83:688-697, 1989
    • (1989) J Clin Invest , vol.83 , pp. 688-697
    • Watkins, P.B.1    Murray, S.A.2    Winkelman, L.G.3    Heuman, D.M.4    Wrighton, S.A.5    Guzelian, P.S.6
  • 39
    • 0027170758 scopus 로고
    • Comparison of levels of cytochromes P-450, CYP1A2, CYP2E1, and their related monooxygenase activities in human surgical liver samples
    • Lucas D, Berthou F, Dréano Y, Lozac'h P, Volant A, Ménez J-F: Comparison of levels of cytochromes P-450, CYP1A2, CYP2E1, and their related monooxygenase activities in human surgical liver samples. Alcohol Clin Exp Res 17:900-905, 1993
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 900-905
    • Lucas, D.1    Berthou, F.2    Dréano, Y.3    Lozac'h, P.4    Volant, A.5    Ménez, J.-F.6
  • 40
    • 0030935567 scopus 로고    scopus 로고
    • Cytochrome P-4502E1: Its physiological and pathological role
    • Lieber CS: Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev 77:517-544, 1997
    • (1997) Physiol Rev , vol.77 , pp. 517-544
    • Lieber, C.S.1
  • 42
    • 0017669093 scopus 로고
    • Early perivenular sclerosis in alcoholic fatty liver: An index of progressive liver injury
    • Van Waes L, Lieber CS: Early perivenular sclerosis in alcoholic fatty liver: An index of progressive liver injury. Gastroenterology 73:646-650, 1977
    • (1977) Gastroenterology , vol.73 , pp. 646-650
    • Van Waes, L.1    Lieber, C.S.2
  • 43
    • 0018907018 scopus 로고
    • Histogenesis of alcoholic fibrosis and cirrhosis in the baboon
    • Popper H, Lieber CS: Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 98:695-716, 1980
    • (1980) Am J Pathol , vol.98 , pp. 695-716
    • Popper, H.1    Lieber, C.S.2
  • 44
    • 0025951584 scopus 로고
    • Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age
    • Ratanasavanh D, Beaune P, Morel F, Flinois J-P, Guengerich FP, Guillouzo A: Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age. Hepatology 13:1142-1151, 1991
    • (1991) Hepatology , vol.13 , pp. 1142-1151
    • Ratanasavanh, D.1    Beaune, P.2    Morel, F.3    Flinois, J.-P.4    Guengerich, F.P.5    Guillouzo, A.6
  • 45
    • 0024314124 scopus 로고
    • Human cDNA-expressed cytochrome P-450 1A2: Mutagen activation and substrate specificity
    • Aoyama T, Gonzalez FJ, Gelboin HV: Human cDNA-expressed cytochrome P-450 1A2: Mutagen activation and substrate specificity. Mol Carcinog 2:192-198;1989
    • (1989) Mol Carcinog , vol.2 , pp. 192-198
    • Aoyama, T.1    Gonzalez, F.J.2    Gelboin, H.V.3
  • 46
    • 0024365294 scopus 로고
    • Human liver microsomal cytochrome P-450 enzymes involved in the hioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002
    • Shimada T, Iwasaki M, Martin MV, Guengerich FP: Human liver microsomal cytochrome P-450 enzymes involved in the hioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res 49:3218-3228, 1989
    • (1989) Cancer Res , vol.49 , pp. 3218-3228
    • Shimada, T.1    Iwasaki, M.2    Martin, M.V.3    Guengerich, F.P.4


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