Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats

European Journal of Pharmacology

Volumn 640, Issue 1-3, 2010, Pages 129-138

  Wang, Jing ^a   Dong, Ming Qing ^a   Liu, Man Ling ^a   Xu, Dun Quan ^a   Luo, Ying ^a   Zhang, Bo ^a   Liu, Li Li ^a   Xu, Min ^a   Zhao, Peng Tao ^a   Gao, Yu Qi ^b   Li, Zhi Chao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hypoxia; Hypoxic pulmonary hypertension; Pulmonary artery; Rat; Tanshinone IIA

Indexed keywords

4 AMINOPYRIDINE; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; GLIBENCLAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKING AGENT; PROTOPORPHYRIN ZINC; TANSHINONE IIA; TETRYLAMMONIUM; ABIETANE DERIVATIVE; CARBON MONOXIDE; PHENANTHRENE DERIVATIVE; POTASSIUM; PROSTAGLANDIN; TANSHINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; HYPOXIA; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; VASOCONSTRICTION; VASODILATATION; ANIMAL; ANOXIA; COMPLICATION; DRUG EFFECTS; EXTRACELLULAR SPACE; IN VITRO STUDY; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM;

ANIMALS; ANOXIA; CALCIUM; CARBON MONOXIDE; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SPACE; HYPERTENSION, PULMONARY; INTRACELLULAR SPACE; MALE; NITRIC OXIDE; PHENANTHRENES; PHENYLEPHRINE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PROSTAGLANDINS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; DITERPENES, ABIETANE; IN VITRO TECHNIQUES;

EID: 77953812187     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.047     Document Type: Article

References (46)

1. Adams J.D., Wall M., Garcia C. Salvia columbariae contains tanshinones. Evid. Based Complement Alternat. Med. 2005, 2:107-110.
2. Archer S., Rich S. Primary pulmonary hypertension: a vascular biology and translational research "Work in progress". Circulation 2000, 102:2781-2791.
3. Barbera J.A., Peinado V.I., Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur. Respir. J. 2003, 21:892-905.
4. Broekaert A., Godfraind T. A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline- and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries. Eur. J. Pharmacol. 1979, 53:281-288.
5. Campbell W.B., Falck J.R., Gauthier K. Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries. Med. Sci. Monit. 2001, 7:578-584.
6. Cao C.M., Xia Q., Zhang X., Xu W.H., Jiang H.D., Chen J.Z. Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes. Life Sci. 2003, 72:2451-2463.
7. Cheng T.O. Cardiovascular effects of danshen. Int. J. Cardiol. 2007, 121:9-22.
8. Chiu T.L., Su C.C. Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential. Int. J. Mol. Med. 2010, 25:231-236.
9. Eckert R.E., Karsten A.J., Utz J., Ziegler M. Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores. Urol. Res. 2000, 28:122-127.
10. Fu J., Huang H., Liu J., Pi R., Chen J., Liu P. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur. J. Pharmacol. 2007, 568:213-221.
11. Huang Y.F., Liu M.L., Dong M.Q., Yang W.C., Zhang B., Luan L.L., Dong H.Y., Xu M., Wang Y.X., Liu L.L., Gao Y.Q., Li Z.C. Effects of sodium tanshinone II A sulphonate on hypoxic pulmonary hypertension in rats in vivo and on Kv2.1 expression in pulmonary artery smooth muscle cells in vitro. J. Ethnopharmacol. 2009, 125:436-443.
12. Hudgins P.M., Weiss G.B. Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium. J. Pharmacol. Exp. Ther. 1968, 159:91-97.
13. Humbert M., Sitbon O., Simonneau G. Treatment of pulmonary arterial hypertension. N. Engl. J. Med. 2004, 351:1425-1436.
14. Jeffery T.K., Morrell N.W. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog. Cardiovasc. Dis. 2002, 45:173-202.
15. Jiang R.W., Lau K.M., Hon P.M., Mak T.C., Woo K.S., Fung K.P. Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza. Curr. Med. Chem. 2005, 12:237-246.
16. Lam F.F., Yeung J.H., Cheung J.H. Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 2005, 46:361-368.
17. Ca channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. Eur. J. Pharmacol. 2006, 546:28-35.
18. Lam F.F., Yeung J.H., Cheung J.H., Or P.M. Pharmacological evidence for calcium channel inhibition by danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 2006, 47:139-145.
19. Lam F.F., Yeung J.H., Kwan Y.W., Chan K.M., Or P.M. Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Eur. J. Pharmacol. 2006, 553:240-245.
20. Lam F.Y., Ng S.C., Cheung J.H., Yeung J.H. Mechanisms of the vasorelaxant effect of danshen (Salvia miltiorrhiza) in rat knee joints. J. Ethnopharmacol. 2006, 104:336-344.
21. Lam F.F., Yeung J.H., Chan K.M., Or P.M. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vascul. Pharmacol. 2007, 46:271-277.
22. Lam F.F., Yeung J.H., Chan K.M., Or P.M. Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. Eur. J. Pharmacol. 2008, 578:253-260.
23. Lam F.F., Yeung J.H., Chan K.M., Or P.M. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J. Ethnopharmacol. 2008, 119:318-321.
24. Lee C.H., Poburko D., Sahota P., Sandhu J., Ruehlmann D.O., van Breemen C. The mechanism of phenylephrine-mediated [Ca(2+)](i) oscillations underlying tonic contraction in the rabbit inferior vena cava. J. Physiol. 2001, 534:641-650.
25. Lee W.Y., Liu K.W., Yeung J.H. Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells. Cancer Lett. 2009, 285:46-57.
26. Lei X.L., Chiou G.C. Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am. J. Chin. Med. 1986, 14:145-152.
27. Leijten P.A., van Breemen C. The effects of caffeine on the noradrenaline-sensitive calcium store in rabbit aorta. J. Physiol. 1984, 357:327-339.
28. Liu C.S., Chen N.H., Zhang J.T. Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae. Phytomedicine 2007, 14:492-497.
29. Mark E.A., Ward J.P. Hypoxic pulmonary vasoconstriction-invited article. Adv. Exp. Med. Biol. 2009, 648:351-360.
30. Moudgil R., Michelakis E.D., Archer S.L. Hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 2005, 98:390-403.
31. Paoletti R., Govoni S. Classification of calcium antagonists: proposal of the WHO Committee. Pharmacol. Res. Commun. 1987, 19:195-208.
32. Sommer N., Dietrich A., Schermuly R.T., Ghofrani H.A., Gudermann T., Schulz R., Seeger W., Grimminger F., Weissmann N. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur. Respir. J. 2008, 32:1639-1651.
33. Soung D.Y., Rhee S.H., Kim J.S., Lee J.Y., Yang H.S., Choi J.S., Yokozawa T., Han Y.N., Chung H.Y. Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza. J. Pharm. Pharmacol. 2003, 55:1427-1432.
34. Sun X., Ma S., Zang Y.M., Lu S.Y., Guo H.T., Bi H., Wang Y.M., Ma H., Ma X.L., Pei J.M. Vasorelaxing effect of U50, 488H in pulmonary artery and underlying mechanism in rats. Life Sci. 2006, 78:2516-2522.
35. Tsai B.M., Wang M., Turrentine M.W., Mahomed Y., Brown J.W., Meldrum D.R. Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies. Ann. Thorac. Surg. 2004, 78:360-368.
36. Wan A.K., Leung S.W., Zhu D.Y., Man R.Y. Vascular effects of different lipophilic components of "danshen", a traditional Chinese medicine, in the isolated porcine coronary artery. J. Nat. Prod. 2008, 71:1825-1828.
37. Wang A.M., Sha S.H., Lesniak W., Schacht J. Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrob. Agents Chemother. 2003, 47:1836-1841.
38. Wanstall J.C. The pulmonary vasodilator properties of potassium channel opening drugs. Gen. Pharmacol. 1996, 27:599-605.
39. Ward J.P., McMurtry I.F. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr. Opin. Pharmacol. 2009, 9:287-296.
40. Wu B., Liu M., Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst. Rev. 2007, 2:CD004295.
41. Wu G.B., Zhou E.X., Qing D.X. Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels. Eur. J. Pharmacol. 2009, 617:102-107.
42. Wu L., Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 2005, 57:585-630.
43. Xu M., Dong M.Q., Cao F.L., Liu M.L., Wang Y.X., Dong H.Y., Huang Y.F., Liu Y., Wang X.B., Zhang B., Zhao P.T., Luo Y., Niu W., Cui Y., Li Z.C. Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity. Eur. J. Pharmacol. 2009, 607:194-200.
44. Zhang F., Kaide J.I., Yang L., Jiang H., Quan S., Kemp R., Gong W., Balazy M., Abraham N.G., Nasjletti A. CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H137-H144.
45. Zhang Z., Gao J., Wang Y., Song T., Zhang J., Wu G., Zhang T., Du G. Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding. Biochem. Pharmacol. 2009, 78:1316-1322.
46. Zhou L., Zuo Z., Chow M.S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol. 2005, 45:1345-1359.