Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery

Journal of Cardiovascular Pharmacology

Volumn 47, Issue 1, 2006, Pages 139-145

  Lam, Francis Fu Yuen ^a,b   Yeung, John Hok Keung ^a   Cheung, Jessica Ho Yan ^a   Or, Penelope Mei Yu ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Calcium channel; Danshen; Femoral artery; Potassium channel; Salvia miltiorrhiza; Vasorelaxation

Indexed keywords

4 AMINOPYRIDINE; BARIUM CHLORIDE; CALCIUM CHANNEL; CALCIUM CHLORIDE; GLIBENCLAMIDE; IBERIOTOXIN; NIFEDIPINE; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; SALVIA MILTIORRHIZA EXTRACT; TETRYLAMMONIUM; CALCIUM CHANNEL BLOCKING AGENT; PLANT EXTRACT;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; DOSE RESPONSE; DRUG MECHANISM; FEMORAL ARTERY; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; ANIMAL; DRUG EFFECT; IN VITRO STUDY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHLORIDE; FEMORAL ARTERY; MALE; PLANT EXTRACTS; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TETRAETHYLAMMONIUM COMPOUNDS; VASOCONSTRICTION;

EID: 33646672415     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000197540.12685.ce     Document Type: Article

References (26)

1. Ji XY, Tan BKH, Zhu Z. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin. 2000;21:1089-1094.
2. Chang HM, Cheng KP, Choang TF, et al. Structure elucidation and total synthesis of new tanshinones isolated from Salvia miltiorrhiza Bunge (Danshen). J Org Chem. 1990;55:3537-3543.
3. Kohda H, Takeda O, Tanaka S, et al. Isolation of inhibitors of adenylate cyclase from Dan-shen, the root of Salvia miltiorrhiza. Chem Pharm Bull (Tokyo). 1989;37:1287-1290.
4. Kamata K, Iizuka T, Nagao M, et al. Endothelium-dependent vasodilator effects of the extract from Salviae miltiorrhizae radix. A study on the identification of lithospermic acid B in the extracts. Gen Pharmacol. 1993;24:977-981.
5. Chan K, Chui SH, Wong DYL, et al. Protective effects of Danshensu from aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sci. 2004;75:3157-3171.
6. Fung KP, Zeng LH, Wu J, et al. Demonstration of the myocardial salvage effect of lithospermic acid B isolated from the aqueous extract of Salvia miltiorrhiza. Life Sci. 1993;52:L239-L244.
7. Wu TW, Zeng LH, Fung KP, et al. Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. Biochem Pharmacol. 1993;46:2327-2332.
8. Zhou W, Ruigrok TJ. Protective effect of Danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am J Chin Med. 1990;18:19-24.
9. Kuang P, Tao Y, Tian Y. Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J Trad Chin Med. 1996;16:138-142.
10. Ji XY, Tan BKH, Zhu YC, et al. Comparison of cardioprotective effects using ramipril and Danshen for the treatment of acute myocardial infarction in rats. Life Sci. 2003;72:1413-1426.
11. Cao CM, Xia Q, Zhang X, et al. Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium by anoxia and reoxygenation in rat cardiomyocytes. Life Sci. 2003;72:2251-2263.
12. Chen KJ. Certain progress in the treatment of coronary heart disease with traditional medical plants in China. Am J Chin Med. 1981;9:193-196.
13. Lei XL, Chiou GCY. Studies on cardiovascular actions of Salvia miltiorrhiza. Am J Chin Med. 1986;14:26-32.
14. Li CP, Yung H, Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. Am J Chin Med. 1990;18:157-166.
15. Lam FFY, Yeung JHK, Cheung JHY. Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J Cardiovasc Pharmacol. 2005;46:361-368.
16. Lam FY, Ng SCW, Cheung JHY, et al. Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joint. J Ethnopharmacol. 2005 (in press).
17. Cook NS. Effect of some potassium channel blockers on contractile responses of the rabbit aorta. J Cardiovasc Pharmacol. 1989;13:299-306.
18. Satake N, Shibata M, Shibata S. The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by beta1- and beta2-adrenoceptor activation in rat aortic rings. Br J Pharmacol. 1996;119:505-510.
19. + channels in arterial smooth muscle. Science. 1989;245:177-180.
20. Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 1992;256:532-535.
21. + currents in smooth muscle cells from rat resistance-sized cerebral arteries. Am J Physiol. 1993;265:C1363-C1370.
22. Nagai M, Noguchi M, Iizuk T, et al. Vasodilator effects of des(alphacarboxy-3,4-dihydroxyphenethyl)lithospermic acid (8-epiblechnic acid), a derivative of lithospermic acids in Salviae miltiorrhizae radix. Bio Pharm Bull. 1996;19:228-232.
23. Zhou W, Ruigrok TJ. Protective effect of Danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am J Chin Med. 1990;18:19-24.
24. Patmore L, Whiting RL. Calcium entry blocking properties of tanshinone II-A sulphonate, an active principal of the antianginal extract, Danshen. Br J Pharmacol. 1982;75:149P.
25. Godfraind T. Calcium antagonism and calcium entry blockade. Br J Pharmacol. 1986;89:525-532.
26. 2+ channels in the rat aorta. Chin J Physiol. 1996;39:1-8.