Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels

Vascular Pharmacology

Volumn 46, Issue 4, 2007, Pages 271-277

  Lam, Francis Fu Yuen ^a   Yeung, John Hok Keung ^a   Chan, Kam Ming ^a   Mei Yu Or, Penelope ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Calcium channel; Coronary artery; Danshen; Danshensu; Potassium channel; Salvia miltiorrhiza

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; CALCIUM; CALCIUM CHANNEL; CALCIUM CHLORIDE; POTASSIUM CHLORIDE; SALVIA MILTIORRHIZA EXTRACT; SEROTONIN; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CORONARY ARTERY; DOSE RESPONSE; DRUG MECHANISM; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; LACTATES; MALE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM; VASODILATION; VASODILATOR AGENTS;

EID: 33846268462     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2006.10.011     Document Type: Article

References (30)

1. Cao C.M., Xia Q., Zhang X., Xu W.H., Jiang H.D., and Chen J.Z. Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes. Life Sci. 72 22 (2003) 2451-2463
2. Chan K., Chui S.H., Wong D.Y.L., Ha W.Y., Chan C.L., and Wong R.N.S. Protective effects of Danshensu from aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sci. 75 26 (2004) 3157-3171
3. Chang H.M., Cheng K.P., Choang T.F., Chow H.F., Chui K.Y., Hon P.M., Lau-Tan F.W., Yang Y., and Zhong Z.P. Structure elucidation and total synthesis of new tanshinones isolated from Salvia miltiorrhiza Bunge (Danshen). J. Org. Chem. 55 (1990) 3537-3543
4. Chen K.J. Certain progress in the treatment of coronary heart disease with traditional medicinal plants in China. Am. J. Chin. Med. 9 3 (1981) 193-196
5. Cheng Z.H., Lou Y.P., Dai H.J., and Xue F. Studies on effects of "danshensu" on experimental microcirculatory disturbances and plasma lactic acid concentrations. Shanghai Yike Daxue Xuebao 14 (1987) 25-29
6. Dong Z.T., and Jiang W.D. Effect of danshensu on isolated swine coronary artery perfusion preparation. Yao Hsueh Hsueh Pao 17 3 (1982) 226-228
7. Fung K.P., Zeng L.H., Wu J., Wong H.N., Lee C.M., Hon P.M., Chang H.M., and Wu T.W. Demonstration of the myocardial salvage effect of lithospermic acid B isolated from the aqueous extract of Salvia miltiorrhiza. Life Sci. 52 22 (1993) PL239-PL244
8. Godfraind T., Miller R., and Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 38 4 (1986) 321-416
9. Huang Y., and Ho I.H. Separate activation of intracellular Ca2+ release, voltage-dependent and receptor-operated Ca2+ channels in the rat aorta. Chin. J. Physiol. 39 1 (1996) 1-8
10. Ji X.Y., Tan B.K., and Zhu Y.Z. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol. Sin. 21 12 (2000) 1089-1094
11. Ji X., Tan B.K., Zhu Y.C., Linz W., and Zhu Y.Z. Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats. Life Sci. 73 11 (2003) 1413-1426
12. Kamata K., Iizuka T., Nagai M., and Kasuya Y. Endothelium-dependent vasodilator effects of the extract from Salviae miltiorrhizae radix. A study on the identification of lithospermic acid B in the extracts. Gen. Pharmacol. 24 4 (1993) 977-981
13. Kohda H., Takeda O., Tanaka S., Yamasaki K., Yamashita A., Kurokawa T., and Ishibashi S. Isolation of inhibitors of adenylate cyclase from Dan-shen, the root of Salvia miltiorrhiza. Chem. Pharm. Bull. 37 5 (1989) 1287-1290
14. Kuang P., Tao Y., and Tian Y. Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J. Trad. Chin. Med. 16 2 (1996) 138-142
15. Lam F.F.Y., Yeung J.H.K., and Cheung J.H.Y. Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 46 3 (2005) 361-368
16. Lam F.F.Y., Yeung J.H.K., and Cheung J.H.Y. Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 47 1 (2006) 139-145
17. Lei X.L., and Chiou G.C. Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am. J. Chin. Med. 14 3-4 (1986) 145-152
18. Lei X.L., and Chiou G.C. Studies on cardiovascular actions of Salvia miltiorrhiza. Am. J. Chin. Med. 14 1-2 (1986) 26-32
19. Li C.Z., Yang S.C., Zhao F.D., Yang Y.Q., Yang C.X., and Zhang D.C. Anticoagulant studies of Danshen. Zhongxiyi Jiehe Zazhi 3 (1983) 297-299
20. Li C.P., Yung K.H., and Chiu K.W. Hypotensive action of Salvia miltiorrhiza cell culture extract. Am. J. Chin. Med. 18 3-4 (1990) 157-166
21. Liu G.T., Zhang T.M., Wang B.E., and Wang Y.W. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem. Pharmacol. 43 2 (1992) 147-152
22. Liu X.Q., Luo X.T., and Ouyang X.A. Research advance of Fufang Danshen dosage forms. Shizhen Guoyi Guoyao 12 (2001) 474-475
23. Nagai M., Noguchi M., Iizuka T., Otani K., and Kamata K. Vasodilator effects of des(alpha-carboxy-3,4-dihydroxyphenethyl)lithospermic acid (8-epiblechnic acid), a derivative of lithospermic acids in Salviae miltiorrhizae radix. Biol. Pharm. Bull. 19 2 (1996) 228-232
24. Patmore L., and Whiting R.L. Calcium entry blocking properties of tanshinone II-A sulphonate, an active principle of the antianginal extract, Danshen. Br. J. Pharmacol. 75 (1982) 149P
25. Su X.H., Liang D.Q., and Wang X.M. The effect of danshensu (DS-182) of the injury of oxygen free radicals in myocardial mitochondria from rat myocardium. Zhongguo Bingli Shengli Zazhi 8 (1992) 122-124
26. Tang L.H., Wang X.M., and Liang D.Q. The protection of DS-182 during reperfusion of total ischemia heart. Zhongguo Bingli Shengli Zazhi 5 (1989) 65-69
27. Wang W., Hu G.H., and Wang Y.P. Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes. Life Sci. 78 26 (2006) 2989-2997
28. Wu T.W., Zeng L.H., Fung K.P., Wu J., Pang H., Grey A.A., Weisel R.D., and Wang J.Y. Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. Biochem. Pharmacol. 46 12 (1993) 2327-2332
29. Zhao B.L., Jiang W., Zhao Y., Hou J.W., and Xin W.J. Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Biochem. Mol. Biol. Int. 38 6 (1996) 1171-1182
30. Zhou W., and Ruigrok T.J. Protective effect of danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am. J. Chin. Med. 18 1-2 (1990) 19-24