메뉴 건너뛰기




Volumn 27, Issue 4, 1996, Pages 599-605

The pulmonary vasodilator properties of potassium channel opening drugs

Author keywords

Hypoxia; Potassium channel openers; Pulmonary hypertension; Pulmonary vasodilators

Indexed keywords

POTASSIUM CHANNEL STIMULATING AGENT; VASODILATOR AGENT;

EID: 0030176194     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02044-6     Document Type: Review
Times cited : (30)

References (92)
  • 2
    • 0026562018 scopus 로고
    • Clinical pharmacology of potassium channel openers
    • Andersson K.-E. (1992) Clinical pharmacology of potassium channel openers. Pharmacol. Toxicol. 70, 244-254.
    • (1992) Pharmacol. Toxicol. , vol.70 , pp. 244-254
    • Andersson, K.-E.1
  • 5
    • 0027305489 scopus 로고
    • K channel activation by nucleoside diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells
    • Beech D. J., Zhang H., Nakao K. and Bolton T. B. (1993) K channel activation by nucleoside diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells. Br. J. Pharmacol. 110, 573-582.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 573-582
    • Beech, D.J.1    Zhang, H.2    Nakao, K.3    Bolton, T.B.4
  • 6
    • 0020538818 scopus 로고
    • Comparison of the effects of minoxidil and nifedipine on hypoxic pulmonary vasoconstriction in dogs
    • Bishop M. J. and Cheney F. W. (1983) Comparison of the effects of minoxidil and nifedipine on hypoxic pulmonary vasoconstriction in dogs. J. Cardiovasc. Pharmacol. 5, 184-189.
    • (1983) J. Cardiovasc. Pharmacol. , vol.5 , pp. 184-189
    • Bishop, M.J.1    Cheney, F.W.2
  • 8
    • 0023127961 scopus 로고
    • Reversibility of primary pulmonary hypertension during 6 years of treatment with oral diazoxide
    • Chan N. S., McLay J. and Kenmure A. C. F. (1987) Reversibility of primary pulmonary hypertension during 6 years of treatment with oral diazoxide. Br. Heart J. 57, 207-209.
    • (1987) Br. Heart J. , vol.57 , pp. 207-209
    • Chan, N.S.1    McLay, J.2    Kenmure, A.C.F.3
  • 10
    • 4244046885 scopus 로고
    • Differential vasorelaxant effects of BRL 38227 in isolated large and small pulmonary vessels of the rat
    • Chappell L. C., Leach R. M. and Twort C. H. C. (1990) Differential vasorelaxant effects of BRL 38227 in isolated large and small pulmonary vessels of the rat. J. Physiol. 429, 74P.
    • (1990) J. Physiol. , vol.429
    • Chappell, L.C.1    Leach, R.M.2    Twort, C.H.C.3
  • 11
    • 0024238725 scopus 로고
    • Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels
    • Chen G., Suzuki H. and Weston A. H. (1988) Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol. 95, 1165-1174.
    • (1988) Br. J. Pharmacol. , vol.95 , pp. 1165-1174
    • Chen, G.1    Suzuki, H.2    Weston, A.H.3
  • 12
    • 0027301652 scopus 로고
    • + channels mediate vasodilation produced by lemakalim in rabbit pulmonary artery
    • + channels mediate vasodilation produced by lemakalim in rabbit pulmonary artery. Am. J. Physiol. 264, H1907-1915.
    • (1993) Am. J. Physiol. , vol.264
    • Clapp, L.H.1    Davey, R.2    Gurney, A.M.3
  • 13
    • 0026554833 scopus 로고
    • + channels regulate resting potential of pulmonary arterial smooth muscle cells
    • + channels regulate resting potential of pulmonary arterial smooth muscle cells. Am. J. Physiol. 262, H916-H920.
    • (1992) Am. J. Physiol. , vol.262
    • Clapp, L.H.1    Gurney, A.M.2
  • 14
    • 0027359074 scopus 로고
    • Therapeutic potential of potassium channel openers in peripheral vascular disease and asthma
    • Cook N. S. and Chapman I. D. (1993) Therapeutic potential of potassium channel openers in peripheral vascular disease and asthma. Cardiovasc. Drugs Therap. 7, 555-563.
    • (1993) Cardiovasc. Drugs Therap. , vol.7 , pp. 555-563
    • Cook, N.S.1    Chapman, I.D.2
  • 15
    • 0021187646 scopus 로고
    • + channels in pancreatic β cells
    • + channels in pancreatic β cells. Nature 311, 271-273.
    • (1984) Nature , vol.311 , pp. 271-273
    • Cook, D.L.1    Hales, C.N.2
  • 18
    • 0025340654 scopus 로고
    • Primary pulmonary hypertension: Diagnosis, medical and surgical treatment
    • Dinh-Xuan A. T., Higenbottam T. W., Scott J. P. and Wallwork J. (1990) Primary pulmonary hypertension: diagnosis, medical and surgical treatment. Respir. Med. 84, 189-197.
    • (1990) Respir. Med. , vol.84 , pp. 189-197
    • Dinh-Xuan, A.T.1    Higenbottam, T.W.2    Scott, J.P.3    Wallwork, J.4
  • 22
    • 0027409532 scopus 로고
    • The pharmacology of ATP-sensitive potassium channels
    • Edwards G. and Weston A. H. (1993) The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol. 33, 597-637.
    • (1993) Annu. Rev. Pharmacol. Toxicol. , vol.33 , pp. 597-637
    • Edwards, G.1    Weston, A.H.2
  • 23
    • 0024397055 scopus 로고
    • Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery
    • Eltze M. (1989) Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery. Europ. J. Pharmacol. 165, 231-239.
    • (1989) Europ. J. Pharmacol. , vol.165 , pp. 231-239
    • Eltze, M.1
  • 26
    • 0027161385 scopus 로고
    • Blockade by glibenclamide of the flow-evoked endothelial release of ATP that contributes to vasodilatation in the pulmonary vascular bed of the rat
    • Hassessian H., Bodin P. and Burnstock G. (1993) Blockade by glibenclamide of the flow-evoked endothelial release of ATP that contributes to vasodilatation in the pulmonary vascular bed of the rat. Br. J. Pharmacol. 109, 466-472.
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 466-472
    • Hassessian, H.1    Bodin, P.2    Burnstock, G.3
  • 28
    • 0023761002 scopus 로고
    • Pinacidil actions on ion channels in vascular smooth muscle
    • Hermsmeyer R. K. (1988) Pinacidil actions on ion channels in vascular smooth muscle. J. Cardiovasc. Pharmacol. 12 (Suppl. 2): S17-S22.
    • (1988) J. Cardiovasc. Pharmacol. , vol.12 , Issue.SUPPL. 2
    • Hermsmeyer, R.K.1
  • 29
    • 0023470788 scopus 로고
    • The place of prostacyclin in the clinical management of primary pulmonary hypertension
    • Higenbottam T. W. (1987) The place of prostacyclin in the clinical management of primary pulmonary hypertension. Am. Rev. Resp. Dis. 136, 782-785.
    • (1987) Am. Rev. Resp. Dis. , vol.136 , pp. 782-785
    • Higenbottam, T.W.1
  • 30
    • 0021367046 scopus 로고
    • Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin)
    • Higenbottam T. W., Wheeldon D., Wells F. C. and Wallwork J. (1984) Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet i, 1046-1047.
    • (1984) Lancet , vol.1 , pp. 1046-1047
    • Higenbottam, T.W.1    Wheeldon, D.2    Wells, F.C.3    Wallwork, J.4
  • 31
    • 0019307450 scopus 로고
    • Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension
    • Honey M., Cotter L., Davies N. and Denison D. (1980) Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension. Thorax 35, 269-276.
    • (1980) Thorax , vol.35 , pp. 269-276
    • Honey, M.1    Cotter, L.2    Davies, N.3    Denison, D.4
  • 32
    • 0025743821 scopus 로고
    • Influence of lemakalim on the pulmonary vascular bed of the cat
    • Hood J. S., McMahon T. J. and Kadowitz P. J. (1991a) Influence of lemakalim on the pulmonary vascular bed of the cat. Europ. J. Pharmacol. 202, 101-104.
    • (1991) Europ. J. Pharmacol. , vol.202 , pp. 101-104
    • Hood, J.S.1    McMahon, T.J.2    Kadowitz, P.J.3
  • 34
    • 0025814921 scopus 로고
    • Mechanisms of vasodilatation induced by potassium-channel activators
    • Kajioka S., Nakashima M., Kitamura K. and Kuriyama H. (1991) Mechanisms of vasodilatation induced by potassium-channel activators. Clin. Sci. 81, 129-139.
    • (1991) Clin. Sci. , vol.81 , pp. 129-139
    • Kajioka, S.1    Nakashima, M.2    Kitamura, K.3    Kuriyama, H.4
  • 35
    • 85030202238 scopus 로고
    • + channel-mediated vasorelaxation is upregulated in sheep pulmonary arteries during pulmonary hypertension to compensate for impaired NO production
    • Abstract
    • + channel-mediated vasorelaxation is upregulated in sheep pulmonary arteries during pulmonary hypertension to compensate for impaired NO production. Can. J. Physiol. Pharmacol. 72, P 1.7.30 (Abstract).
    • (1994) Can. J. Physiol. Pharmacol. , vol.72
    • Kemp, B.K.1    Smolich, J.J.2    Ritchie, B.C.3    Cocks, T.M.4
  • 37
    • 0025753163 scopus 로고
    • Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization
    • Kukovetz W. R., Holzmann S., Braida C. and Poch G. (1991) Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization. J. Cardiovasc. Pharmacol. 17, 627-633.
    • (1991) J. Cardiovasc. Pharmacol. , vol.17 , pp. 627-633
    • Kukovetz, W.R.1    Holzmann, S.2    Braida, C.3    Poch, G.4
  • 38
    • 0026661113 scopus 로고
    • Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers
    • Lawson K., Barras M., Zazzi-Sudriez E., Martin D. J., Armstrong J. M. and Hicks P. E. (1992) Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers. Br. J. Pharmacol. 107, 58-65.
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 58-65
    • Lawson, K.1    Barras, M.2    Zazzi-Sudriez, E.3    Martin, D.J.4    Armstrong, J.M.5    Hicks, P.E.6
  • 39
    • 0026073757 scopus 로고
    • Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation
    • Lippton H. L., Cohen G. A., McMurtry I. F. and Hyman A. L. (1991) Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation. J. Appl. Physiol. 70, 947-952.
    • (1991) J. Appl. Physiol. , vol.70 , pp. 947-952
    • Lippton, H.L.1    Cohen, G.A.2    McMurtry, I.F.3    Hyman, A.L.4
  • 41
    • 0026518170 scopus 로고
    • Potassium channel activator drugs: Mechanisms of action, pharmacological properties and therapeutic potential
    • Longman S. D. and Hamilton T. C. (1992) Potassium channel activator drugs: mechanisms of action, pharmacological properties and therapeutic potential. Med. Res. Rev. 12, 73-148.
    • (1992) Med. Res. Rev. , vol.12 , pp. 73-148
    • Longman, S.D.1    Hamilton, T.C.2
  • 42
    • 0025036217 scopus 로고
    • Pulmonary and systemic haemodynamic effects of cromakalim in conditions of normoxia and hypoxia in dogs
    • Martin D. J., Gelotte M., Armstrong J. M. and Hicks P. E. (1990) Pulmonary and systemic haemodynamic effects of cromakalim in conditions of normoxia and hypoxia in dogs. J. Auton. Pharmacol. 10, 261-272.
    • (1990) J. Auton. Pharmacol. , vol.10 , pp. 261-272
    • Martin, D.J.1    Gelotte, M.2    Armstrong, J.M.3    Hicks, P.E.4
  • 43
    • 0022635848 scopus 로고
    • Drug treatment of primary pulmonary hypertension
    • McLeod A. A. and Jewitt D. E. (1986) Drug treatment of primary pulmonary hypertension. Drugs 31, 177-184.
    • (1986) Drugs , vol.31 , pp. 177-184
    • McLeod, A.A.1    Jewitt, D.E.2
  • 45
    • 0024330439 scopus 로고
    • A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery
    • Mellemkjaer S., Nielsen-Kudsk J. E., Nielsen C. B. and Siggaard C. (1989) A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery. Europ. J. Pharmacol. 167, 275-280.
    • (1989) Europ. J. Pharmacol. , vol.167 , pp. 275-280
    • Mellemkjaer, S.1    Nielsen-Kudsk, J.E.2    Nielsen, C.B.3    Siggaard, C.4
  • 46
    • 0022258211 scopus 로고
    • Pulmonary hypertension
    • Michael J. R. and Summer W. R. (1985) Pulmonary hypertension. Lung 163, 65-82.
    • (1985) Lung , vol.163 , pp. 65-82
    • Michael, J.R.1    Summer, W.R.2
  • 48
    • 0025359587 scopus 로고
    • Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats
    • Miyata N., Tsuchida K. and Otomo S. (1990) Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats. Europ. J. Pharmacol. 182, 209-210.
    • (1990) Europ. J. Pharmacol. , vol.182 , pp. 209-210
    • Miyata, N.1    Tsuchida, K.2    Otomo, S.3
  • 50
    • 0025833429 scopus 로고
    • Effects of pinacidil and other cyanoguanidine derivatives on guinea-pig isolated trachea, aorta and pulmonary artery
    • Nielsen-Kudsk J. E. and Bang L. (1991) Effects of pinacidil and other cyanoguanidine derivatives on guinea-pig isolated trachea, aorta and pulmonary artery. Europ. J. Pharmacol. 201, 97-102.
    • (1991) Europ. J. Pharmacol. , vol.201 , pp. 97-102
    • Nielsen-Kudsk, J.E.1    Bang, L.2
  • 51
    • 0026482651 scopus 로고
    • Potassium channel modulation in rat portal vein by ATP depletion: A comparison with the effects of levcromakalim (BRL 38227)
    • Noack T. E. D., Wards G., Deitmer P. and Weston A. H. (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br. J. Pharmacol. 107, 945-955.
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 945-955
    • Noack, T.E.D.1    Wards, G.2    Deitmer, P.3    Weston, A.H.4
  • 53
    • 0025262282 scopus 로고
    • Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: Differences between tracheal and pulmonary artery preparations
    • O'Donnell S. R., Wanstall J. C. and Zeng X.-P. (1990) Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations. J. Pharmacol. Exp. Therap. 252, 1318-1323.
    • (1990) J. Pharmacol. Exp. Therap. , vol.252 , pp. 1318-1323
    • O'Donnell, S.R.1    Wanstall, J.C.2    Zeng, X.-P.3
  • 54
    • 0027527064 scopus 로고
    • NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension
    • Oka M., Morris K. G. and McMurtry I. F. (1993) NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J. Appl. Physiol. 75, 1075-1080.
    • (1993) J. Appl. Physiol. , vol.75 , pp. 1075-1080
    • Oka, M.1    Morris, K.G.2    McMurtry, I.F.3
  • 55
    • 0026447220 scopus 로고
    • ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung
    • ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung. Am. J. Physiol. 263, H1532-H1536.
    • (1992) Am. J. Physiol. , vol.263
    • Pinheiro, J.M.B.1    Malik, A.B.2
  • 56
    • 0026560976 scopus 로고
    • Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
    • Post J. M., Hume J. R., Archer S. L. and Weir E. K. (1992) Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J. Physiol. 262, C882-C890.
    • (1992) Am J. Physiol. , vol.262
    • Post, J.M.1    Hume, J.R.2    Archer, S.L.3    Weir, E.K.4
  • 57
    • 0027240615 scopus 로고
    • + channels?
    • + channels? TIPS. 14, 332-337.
    • (1993) TIPS , vol.14 , pp. 332-337
    • Quast, U.1
  • 59
    • 0022506203 scopus 로고
    • The case for treatment of selected patients with primary pulmonary hypertension
    • Reeves J. T., Groves B. M. and Turkevich D. (1986) The case for treatment of selected patients with primary pulmonary hypertension. Am. Rev. Resp. Dis. 134, 342-346.
    • (1986) Am. Rev. Resp. Dis. , vol.134 , pp. 342-346
    • Reeves, J.T.1    Groves, B.M.2    Turkevich, D.3
  • 60
    • 0018340698 scopus 로고
    • The pulmonary circulation: Remodelling in growth and disease
    • Reid L. M. (1979) The pulmonary circulation: remodelling in growth and disease. Am. Rev. Resp. Dis. 119, 531-546.
    • (1979) Am. Rev. Resp. Dis. , vol.119 , pp. 531-546
    • Reid, L.M.1
  • 61
    • 0027753961 scopus 로고
    • An overview of the cellular changes in pulmonary hypertension
    • Reid L. M. (1993) An overview of the cellular changes in pulmonary hypertension. Europ. Resp. Rev. 3 (Review 16), 564-568.
    • (1993) Europ. Resp. Rev. , vol.3 , Issue.REVIEW 16 , pp. 564-568
    • Reid, L.M.1
  • 62
    • 0023238042 scopus 로고
    • High-dose calcium channel-blocking therapy for primary pulmonary hypertension: Evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy
    • Rich S. and Brundage B. H. (1987) High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation 76, 135-141.
    • (1987) Circulation , vol.76 , pp. 135-141
    • Rich, S.1    Brundage, B.H.2
  • 63
    • 0026632785 scopus 로고
    • The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
    • Rich S., Kaufmann E. and Levy P. S. (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N. Engl. J. Med. 327, 76-81.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 76-81
    • Rich, S.1    Kaufmann, E.2    Levy, P.S.3
  • 65
    • 0025299550 scopus 로고
    • Potassium channel modulators: Scientific applications and therapeutic promise
    • Robertson D. W. and Steinberg M. I. (1990) Potassium channel modulators: scientific applications and therapeutic promise. J. Med. Chem. 33, 1533-1541.
    • (1990) J. Med. Chem. , vol.33 , pp. 1533-1541
    • Robertson, D.W.1    Steinberg, M.I.2
  • 66
    • 0027313482 scopus 로고
    • Chronic hypoxia results in depolarisation of the resting membrane potential of isolated small pulmonary arteries of the rat
    • Robertson T. P., Priest R., Leach R. M. and Ward T. P. (1993) Chronic hypoxia results in depolarisation of the resting membrane potential of isolated small pulmonary arteries of the rat. J. Physiol. Lond. 467, 54P.
    • (1993) J. Physiol. Lond. , vol.467
    • Robertson, T.P.1    Priest, R.2    Leach, R.M.3    Ward, T.P.4
  • 67
    • 0026692686 scopus 로고
    • + channel-mediated relaxation
    • + channel-mediated relaxation. Am. J. Physiol. 263, L88-L94.
    • (1992) Am. J. Physiol. , vol.263
    • Rodman, D.M.1
  • 68
    • 0021325034 scopus 로고
    • Pulmonary hypertensive diseases
    • Rounds S. and Hill N. S. (1984) Pulmonary hypertensive diseases. Chest 85, 397-405.
    • (1984) Chest , vol.85 , pp. 397-405
    • Rounds, S.1    Hill, N.S.2
  • 69
    • 0027482518 scopus 로고
    • Inhalational agents for pulmonary hypertension
    • Royston D. (1993) Inhalational agents for pulmonary hypertension. Lancet 342, 941-942.
    • (1993) Lancet , vol.342 , pp. 941-942
    • Royston, D.1
  • 70
    • 0027462413 scopus 로고
    • Effect of cromakalim on KCl-noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery
    • Savineau J.-P. and Marthan R. (1993) Effect of cromakalim on KCl-noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery. Pulm. Pharmacol. 6, 41-48.
    • (1993) Pulm. Pharmacol. , vol.6 , pp. 41-48
    • Savineau, J.-P.1    Marthan, R.2
  • 73
    • 0020135694 scopus 로고
    • Membrane properties of smooth muscle cells in pulmonary hypertensive rats
    • Suzuki H. and Twarog B. M. (1982) Membrane properties of smooth muscle cells in pulmonary hypertensive rats. Am. J. Physiol. 242, H907-H915.
    • (1982) Am. J. Physiol. , vol.242
    • Suzuki, H.1    Twarog, B.M.2
  • 75
    • 0017864197 scopus 로고
    • Diazoxide in treatment of primary pulmonary hypertension
    • Wang S. W. S., Pohl J. E. F., Rowlands D. J. and Wade E. G. (1978) Diazoxide in treatment of primary pulmonary hypertension. Br. Heart J. 40, 572-574.
    • (1978) Br. Heart J. , vol.40 , pp. 572-574
    • Wang, S.W.S.1    Pohl, J.E.F.2    Rowlands, D.J.3    Wade, E.G.4
  • 76
    • 0028020185 scopus 로고
    • In vitro hypoxia attenuates vasorelaxation by potassium channel opening drugs and nitroprusside in isolated pulmonary arteries from rats
    • Wanstall J. C. (1994) In vitro hypoxia attenuates vasorelaxation by potassium channel opening drugs and nitroprusside in isolated pulmonary arteries from rats. J. Pharmacol. Exp. Therap. 271, 845-851.
    • (1994) J. Pharmacol. Exp. Therap. , vol.271 , pp. 845-851
    • Wanstall, J.C.1
  • 77
    • 0028916209 scopus 로고
    • Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor
    • Wanstall J. C. (1995) Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor. Physiol. Res. 44, 1-6.
    • (1995) Physiol. Res. , vol.44 , pp. 1-6
    • Wanstall, J.C.1
  • 78
    • 0028673085 scopus 로고
    • Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens
    • Wanstall J. C., Kay C. S. and O'Donnell S. R. (1994) Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. Pulm. Pharmacol. 7, 401-408.
    • (1994) Pulm. Pharmacol. , vol.7 , pp. 401-408
    • Wanstall, J.C.1    Kay, C.S.2    O'Donnell, S.R.3
  • 79
    • 0012019139 scopus 로고
    • In vitro hypoxia and levcromakalim relax rat pulmonary artery by a common mechanism
    • Wanstall J. C. and O'Brien E. (1995) In vitro hypoxia and levcromakalim relax rat pulmonary artery by a common mechanism. Pharmacol. Res. 31 (Suppl.), 310.
    • (1995) Pharmacol. Res. , vol.31 , Issue.SUPPL. , pp. 310
    • Wanstall, J.C.1    O'Brien, E.2
  • 80
    • 0026580581 scopus 로고
    • Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats
    • Wanstall J. C. and O'Donnell S. R. (1992) Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats. Br. J. Pharmacol. 105, 152-158.
    • (1992) Br. J. Pharmacol. , vol.105 , pp. 152-158
    • Wanstall, J.C.1    O'Donnell, S.R.2
  • 81
    • 0017028177 scopus 로고
    • Minoxidil reduces pulmonary vascular resistance in dogs and cattle
    • Weir E. K., Chidsey C. A., Weil J. V. and Grover R. F. (1976) Minoxidil reduces pulmonary vascular resistance in dogs and cattle. J. Lab. Clin. Med. 88, 885-893.
    • (1976) J. Lab. Clin. Med. , vol.88 , pp. 885-893
    • Weir, E.K.1    Chidsey, C.A.2    Weil, J.V.3    Grover, R.F.4
  • 84
    • 0026599138 scopus 로고
    • Recent progress in potassium channel opener pharmacology
    • Weston A. H. and Edwards G. (1992) Recent progress in potassium channel opener pharmacology. Biochem. Pharmacol. 43, 47-54.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 47-54
    • Weston, A.H.1    Edwards, G.2
  • 85
    • 0012019010 scopus 로고
    • Calcium channel blockers in the treatment of hypoxic pulmonary hypertension
    • Widimsky J. (1990) Calcium channel blockers in the treatment of hypoxic pulmonary hypertension. Prog. Respir. Res. 26, 110-118.
    • (1990) Prog. Respir. Res. , vol.26 , pp. 110-118
    • Widimsky, J.1
  • 86
    • 0025766676 scopus 로고
    • + channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs
    • + channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs. J. Clin. Invest. 88, 500-504.
    • (1991) J. Clin. Invest. , vol.88 , pp. 500-504
    • Wiener, C.M.1    Dunn, A.2    Sylvester, J.T.3
  • 89
    • 0025072626 scopus 로고
    • Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicroandil
    • Yanagisawa T., Teshigawara T. and Taira N. (1990) Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicroandil. Br. J. Pharmacol. 101, 157-165.
    • (1990) Br. J. Pharmacol. , vol.101 , pp. 157-165
    • Yanagisawa, T.1    Teshigawara, T.2    Taira, N.3
  • 90
    • 0027532142 scopus 로고
    • Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes
    • Yuan X.-J., Goldman W. F., Tod M. L., Rubin L. J. and Blaustein M. P. (1993) Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264, L116-L123.
    • (1993) Am. J. Physiol. , vol.264
    • Yuan, X.-J.1    Goldman, W.F.2    Tod, M.L.3    Rubin, L.J.4    Blaustein, M.P.5
  • 91
    • 0028926379 scopus 로고
    • Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery
    • Zhang H. and Bolton T. B. (1995) Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery. Br. J. Pharmacol. 114, 662-672.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 662-672
    • Zhang, H.1    Bolton, T.B.2
  • 92
    • 0028104219 scopus 로고
    • 2a-induced contractions in isolated rat pulmonary artery
    • 2a-induced contractions in isolated rat pulmonary artery. J. Pharmacol. Exp. Therap. 271, 326-333.
    • (1994) J. Pharmacol. Exp. Therap. , vol.271 , pp. 326-333
    • Zhang, F.1    Morice, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.