Effects of sodium tanshinone II A sulphonate on hypoxic pulmonary hypertension in rats in vivo and on Kv2.1 expression in pulmonary artery smooth muscle cells in vitro

Journal of Ethnopharmacology

Volumn 125, Issue 3, 2009, Pages 436-443

  Huang, Yu fang ^a,b   Liu, Man ling ^a   Dong, Ming qing ^a   Yang, Wei chuan ^b   Zhang, Bo ^a   Luan, Li li ^a   Dong, Hai ying ^a   Xu, Min ^a   Wang, Yan xia ^a   Liu, Li li ^a   Gao, Yu Qi ^c   Li, Zhi chao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Kv2.1 channel; Pulmonary artery smooth muscle cell (PASMC); Rat; Sodium tanshinone IIA sulphonate

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MESSENGER RNA; OXYGEN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV2.1; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; CELL ASSAY; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HEART RIGHT VENTRICLE; HEART VENTRICLE WALL; HEART WEIGHT; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANOXIA; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION, PULMONARY; MALE; MOLECULAR STRUCTURE; MYOCYTES, SMOOTH MUSCLE; PHENANTHRENES; PULMONARY ARTERY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SHAB POTASSIUM CHANNELS;

RATTUS;

EID: 69949085717     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.07.020     Document Type: Article

References (34)

1. Cao E.H., Liu X.Q., Wang J.J., and Xu N.F. Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells. Free Radical Biology and Medicine 20 (1996) 801-806
2. Chu X., Tang X., Guo L., Bao H., Zhang S., Zhang J., and Zhu D. Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery. Prostaglandins and Other Lipid Mediators 88 (2009) 42-50
3. Feng J., and Zheng Z. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism. Chinese Journal of Integrative Medicine 14 (2008) 197-201
4. Jiang Z., Liu H.X., Kai J.S., Zhang R.Y., and Liu A.H. Effects of hypoxia and danshen extract on ET-1 and NO secretion in pulmonary arterial endothelial cells. Chinese Journal of Integrative Medicine 36 (1997) 778-779
5. Jin U.H., Suh S.J., Chang H.W., Son J.K., Lee S.H., Son K.H., Chang Y.C., and Kim C.H. Tanshinone IIA from Salvia miltiorrhiza Bunge inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. Journal of Cell Biochemistry 104 (2008) 15-26
6. Kim D.D., Sanchez F.A., Duran R.G., Kanetaka T., and Duran W.N. Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension. American Journal of Physiology and Heart Circulation Physiology 292 (2007) H2131-2137
7. Kim J.Y., Kim K.M., Nan J.X., Zhao Y.Z., Park P.H., Lee S.J., and Sohn D.H. Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells. Pharmacology and Toxicology 92 (2003) 195-200
8. Kim S.K., Jung K.H., and Lee B.C. Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy. Biological and Pharmaceutical Bulletin 32 (2009) 220-224
9. Lee A.R., Wu W.L., Chang W.L., Lin H.C., and King M.L. Isolation and bioactivity of new tanshinones. Journal of Natural Products 50 (1987) 157-160
10. Nelson M.T., and Quayle J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. American Journal of Physiology 268 (1995) C799-822
11. Niu X.L., Ichimori K., Yang X., Hirota Y., Hoshiai K., Li M., and Nakazawa H. Tanshinone II-A inhibits low density lipoprotein oxidation in vitro. Free Radical and Research 33 (2000) 305-312
12. Nizamutdinova I.T., Lee G.W., Son K.H., Jeon S.J., Kang S.S., Kim Y.S., Lee J.H., Seo H.G., Chang K.C., and Kim H.J. Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. International Journal of Oncology 33 (2008) 485-491
13. Platoshyn O., Golovina V.A., Bailey C.L., Limsuwan A., Krick S., Juhaszova M., Seiden J.E., Rubin L.J., and Yuan J.X. Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation. American Journal of Physiology and Cell Physiology 279 (2000) C1540-1549
14. Platoshyn O., Yu Y., Golovina V.A., McDaniel S.S., Krick S., Li L., Wang J.Y., Rubin L.J., and Yuan J.X. Chronic hypoxia decreases K(V) channel expression and function in pulmonary artery myocytes. American Journal of Physiology and Lung Cell and Molecular Physiology 280 (2001) L801-812
15. Rubin L.J. Pathology and pathophysiology of primary pulmonary hypertension. American Journal of Cardiology 75 (1995) 51A-54A
16. Skalli O., Ropraz P., Trzeciak A., Benzonana G., Gillessen D., and Gabbiani G. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. Journal of Cell Biology 103 (1986) 2787-2796
17. Su C.C., Chen G.W., Kang J.C., and Chan M.H. Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells. Planta Medica 74 (2008) 1357-1362
18. Su C.C., and Lin Y.H. Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo. International Journal of Molecular Medicine 22 (2008) 847-851
19. Sun D.D., Wang H.C., Wang X.B., Luo Y., Jin Z.X., Li Z.C., Li G.R., and Dong M.Q. Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels. European Journal of Pharmacology 590 (2008) 317-321
20. Takahashi K., Ouyang X., Komatsu K., Nakamura N., Hattori M., Baba A., and Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemistry and Pharmacology 64 (2002) 745-749
21. Wang H., Gao X., and Zhang B. Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells. Journal of Ethnopharmacology 99 (2005) 93-98
22. Wang H., Han H., Zhang L., Shi H., Schram G., Nattel S., and Wang Z. Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart. Molecular and Pharmacology 59 (2001) 1029-1036
23. Wango E.O., Heap R.B., and Wooding F.B. Progesterone and 5 beta-pregnanediol production by isolated fetal placental binucleate cells from sheep and goats. Journal of Endocrinology 129 (1991) 283-289
24. Wu T.W., Zeng L.H., Fung K.P., Wu J., Pang H., Grey A.A., Weisel R.D., and Wang J.Y. Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. Biochemistry and Pharmacology 46 (1993) 2327-2332
25. Xu Y., Feng D., Wang Y., Lin S., and Xu L. Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways. Journal of Clinical Immunology 28 (2008) 512-519
26. Yang L., Zou X., Liang Q., Chen H., Feng J., Yan L., Wang Z., Zhou D., Li S., Yao S., and Zheng Z. Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway. Experimental and Molecular Medicine 39 (2007) 65-73
27. Yang Y., Cai F., Li P.Y., Li M.L., Chen J., Chen G.L., Liu Z.F., and Zeng X.R. Activation of high conductance Ca(2+)-activated K(+) channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells. European Journal of Pharmacology 598 (2008) 9-15
28. Yin Y., Huang L., Liu Y., Huang S., Zhuang J., Chen X., Zhang L., Wu H., Shao F., and Zhao Z. Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model. Clinical and Investigative Medicine 31 (2008) E248-257
29. Yoon Y., Kim Y.O., Jeon W.K., Park H.J., and Sung H.J. Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line. Journal of Ethnopharmacology 68 (1999) 121-127
30. Yu X.Q., Xue C.C., Zhou Z.W., Li C.G., and Zhou S.F. Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro. Phytotherapy Research 22 (2008) 846-850
31. Yuan X.J., Tod M.L., Rubin L.J., and Blaustein M.P. Hypoxic and metabolic regulation of voltage-gated K + channels in rat pulmonary artery smooth muscle cells. Experimental Physiology 80 (1995) 803-813
32. Zhigang H., Weir E.K., Daniel P.N., and Andrea O. Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes. American Journal of Respiratory Cell and Molecular Biology 31 (2004) 337
33. Zhou G., Jiang W., Zhao Y., Ma G., Xin W., Yin J., and Zhao B. Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochemical Pharmacology 65 (2003) 51-57
34. Zhou L., Zuo Z., and Chow M.S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. Journal of Clinical Pharmacology 45 (2005) 1345-1359