Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats

Life Sciences

Volumn 78, Issue 21, 2006, Pages 2516-2522

  Sun, Xin ^a   Ma, Sai ^a   Zang, Yi Min ^a   Lu, Shun Yan ^a   Guo, Hai Tao ^a   Bi, Hui ^a   Wang, Yue Min ^a   Ma, Heng ^a   Ma, Xin Liang ^a   Pei, Jian Ming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Opioid receptor; Endothelium; KV channel; Nitric oxide (NO); Pulmonary artery; U50,488H

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ATROPINE; CALCIUM ACTIVATED POTASSIUM CHANNEL; DYNORPHIN[1-13]; GLIBENCLAMIDE; INDOMETACIN; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORBINALTORPHIMINE; POTASSIUM CHANNEL BLOCKING AGENT; PROPRANOLOL; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; LUNG ARTERY; MALE; NONHUMAN; RAT; RAT STRAIN; VASODILATATION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIHYPERTENSIVE AGENTS; ATROPINE; DYNORPHINS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; INDOMETHACIN; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDE FRAGMENTS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROPRANOLOL; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA;

EID: 33646002931     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.10.042     Document Type: Article

References (19)

1. v2.1, in hypoxic pulmonary and control of resting membrane potential in rat pulmonary vasoconstriction artery myocytes. The Journal of Clinical Investigation 101 11 (1998) 2319-2330
2. Armstead W.M. Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs. The American Journal of Physiology 268 1 Pt 2 (1995) H226-H232
3. + channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases. Cardiovascular Research 60 2 (2003) 326-336
4. Chen M., Pei J.M., Li L.X., Wang Y.M., Fan Q., and Huang D.M. The relaxation effect and underlying mechanism of U50,488H on abdominal aortic artery. Journal of the Fourth Military Medical University 22 1 (2001) 29-32
5. 2+ in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H. British Journal of Pharmacology 140 4 (2003) 750-758
6. + channels mediate vasodilation produced by lemakalim in rabbit pulmonary artery. The American Journal of Physiology 264 6 Pt 2 (1993) H1907-H1915
7. Devine J.O., and Armstead W.M. The role of nitric oxide in opioid-induced pial artery vasodilation. Brain Research 675 1-2 (1995) 257-263
8. Hong Z., Weir E.K., Nelson D.P., and Olschewski A. Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes. American Journal of Respiratory Cell and Molecular Biology 31 3 (2004) 337-343
9. + current in pulmonary arterial smooth muscle cells. Pflugers Archiv: European Journal of Physiology 426 3-4 (1994) 189-198
10. Mauban J.R., Remillard C.V., and Yuan J.X. Hypoxic pulmonary vasoconstriction: role of ion channels. Journal of Applied Physiology 98 1 (2005) 415-420
11. ATP channel in the rats. Acta Phyisologica Sinica 55 1 (2003) 91-95
12. Schultz J.E., Hsu A.K., and Gross G.J. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circulation Research 78 6 (1996) 1100-1104
13. + channels. The American Journal of Physiology 269 3 Pt 2 (1995) H997-H1002
14. 3H]-U69593 binding sites in the rat heart by receptor binding assays. Journal of Molecular and Cellular Cardiology 23 11 (1999) 1297-1302
15. Wang Y.X., Legzdins P., Poon J.S., and Pang C.C. Vasodilator effects of organotransition-metal nitrosyl complexes, novel nitric oxide donors. Journal of Cardiovascular Pharmacology 35 1 (2000) 73-77
16. Wanstall J.C. The pulmonary vasodilator properties of potassium channel opening drugs. General Pharmacology 27 4 (1996) 599-605
17. Wong T.M., and Shan J. Modulation of sympathetic actions on the heart by opioid receptor stimulation. Journal of Biomedical Science 8 4 (2001) 299-306
18. Younes A., Pepe S., Barron B.A., Spurgeon H.A., Lakatta E.G., and Caffrey J.L. Cardiac synthesis, processing, and coronary release of enkephalin-related peptides. American Journal of Physiology. Heart and Circulatory Physiology 279 4 (2000) H1989-H1998
19. Zhang Y., Irwin M.G., Wong T.M., Chen M., and Cao C.M. Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology 102 2 (2005) 371-378