Resistance to TNF-induced cytotoxocity correlates with an abnormal cleavage of cytosolic phospholipase A2

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6756-6761

  El Mahdani, N E ^a   Ameyar, M ^a   Cai, Z ^a   Colard, O ^a   Masliah, J ^a   Chouaib, S ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYTOKINE; FLUOROPHOSPHATE; LACTONE DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPID;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNITY; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0034671967     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6756     Document Type: Article

References (46)

1. Apoptosis control by death and decoy receptors
2. Clinical application of TNF α in cancer
3. Resistance to TNF and adriamycin in the human breast cancer MCF7 cell line relationship to MDR1, MnSOD, and TNF gene expression
4. A20 zinc protein inhibits TNF and IL-1 signaling
5. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
6. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein
7. TNF α alters mitochondrial membrane potential in L929 but not in TNFα-resistant L929 12 cells relationship with the expression of stress proteins, annexin 1 and superoxide dismutase activity
8. Resistance of MCF7 to TNF-induced cell death is associated with loss of p53 function
9. Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells
10. Constitutive NF-kB activation, enhanced granulopoeisis, and neonatal lethality in IκBα-deficient mice
11. Control of inducible chemoresistance enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
12. TNFα induces apoptosis in mammary adenocarcinoma cells by an increase in intracellular free calcium concentration and DNA fragmentation
13. TNF induced rapid production of 1,2-diacylglycerol by PC specific PLC
14. Stimulation of different phospholipase A2 isoforms by TNF-α and IL-1β in adult rat ventricular myocytes
15. Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
16. Arachidonic acid-selective cytosolic PLA2 is crucial in the cytotoxic action of TNF
17. Failure to activate cytosolic phospholipase A2 causes TNF resistance in human Leukemic cells
18. Regulatory functions of phospholipases A2
19. The growing PLA2 superfamily of signal transduction enzymes
20. Regulation of arachidonic acid release and cytosolic phospholipase A2 activation
21. Novel human secreted phospholipase A2 with homology to the group III bee venom enzyme
22. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A2s
23. 2+ independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation
24. Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2
25. 2 in regulating arachidonic acid release in macrophages
26. Caspase-mediated inhibition of human cytosolic phospholipases A2 during apoptosis
27. Distinct roles of two intracellular phospholipases A2s in fatty acid release in the cell death pathway
28. Cleavage of human cytosolic phospholipase A2 by caspase-1 (ICE) and caspase-8 (FLICE)
29. Activation of intracellular proteases is an early event in TNF-induced apoptosis
30. Involvement of caspases-dependent activation of cytosolic PLA2 in tumor necrosis factor-induced apoptosis
31. In vivo effect of the combination of TNF and adriamycin against a human breast cell line expressing the MDR-phenotype
32. Differential stimulation of cytosolic phospholipase A2 by bradykinin in human cystic fibrosis cell lines
33. N-terminal and C-terminal plasma membrane anchoring modulate differently agonist-induced activation of cytosolic phospholipase A2
34. The tumor necrosis factor pleitropic cytokine
35. The host tumor immune conflict from immunosuppression to resistance and destruction
36. Apoptosis signaling by death receptors
37. Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c3T3 cells role of phospholipase A2 activation
38. Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by defect in arachidonic acid biosynthesis
39. 2 generation in rat 3Y1 fibroblasts
40. 2 and cyclooxygenase-2
41. Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to TNFα mediated cytotoxicity
42. 2 is necessary for TNFα reduced ceramide generation in L929 cells
43. 2 block TNF-induced activation of transcription factor nuclear factor-κB and expression of ICAM-1
44. Caspases killer proteases
45. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-x(L) has activity independent of cytochrome c release