Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2

Nature Immunology

Volumn 4, Issue 4, 2003, Pages 387-393

  Cauwels, Anje ^a   Janssen, Ben ^b   Waeytens, Anouk ^c   Cuvelier, Claude ^c   Brouckaert, Peter ^a  

^a GHENT UNIVERSITY   (Belgium)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE; PHOSPHOLIPASE A2; PROTEINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDBACK SYSTEM; FEMALE; IN VIVO STUDY; KIDNEY FAILURE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS; SHOCK;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIGENS, HUMAN PLATELET; APOPTOSIS; CASPASES; CATHEPSINS; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; FEMALE; LIVER; MICE; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; OXIDATIVE STRESS; PHOSPHOLIPASES A; REACTIVE OXYGEN SPECIES; SHOCK; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037386245     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni914     Document Type: Article

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