Immunobiology of African trypanosomes: Need of alternative interventions

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Baral, Toya Nath ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; APOLIPOPROTEIN; EFLORNITHINE; INSECTICIDE; MELARSOPROL; NIFURTIMOX; PENTAMIDINE; RIBOSOME RNA; SURAMIN; TUMOR NECROSIS FACTOR; VARIANT SURFACE GLYCOPROTEIN; ANTIGEN; DNA; GLYCOPROTEIN; KINETOPLAST DNA; RNA;

ADAPTIVE IMMUNITY; AFRICAN TRYPANOSOMIASIS; ALTERNATIVE MEDICINE; EUKARYOTE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOBIOLOGY; IMMUNOPATHOLOGY; INFECTION PREVENTION; LIFE CYCLE; MITOCHONDRION; NONHUMAN; PARASITE TRANSMISSION; REVIEW; RNA EDITING; THERAPY RESISTANCE; TRYPANOSOMA; TSETSE FLY; ANIMAL; ARTICLE; CHEMISTRY; CLASSIFICATION; FLAGELLUM; GENETIC VARIABILITY; GENETICS; GEOGRAPHY; IMMUNE SYSTEM; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIGENS; DNA; DNA, KINETOPLAST; FLAGELLA; GENETIC VARIATION; GEOGRAPHY; GLYCOPROTEINS; HUMANS; IMMUNE SYSTEM; RNA; TRYPANOSOMA; TRYPANOSOMIASIS, AFRICAN; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

EID: 77953157365     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/389153     Document Type: Review

References (297)

1. A. Buguet, S. Bisser, T. Josenando, F. Chapotot, and R. Cespuglio, "Sleep structure: a new diagnostic tool for stage determination in sleeping sickness," Acta Tropica, vol. 93, no. 1, pp. 107-117, 2005. (Pubitemid 39611360)
2. P. Cattand, J. Jannin, and P. Lucas, "Sleeping sickness surveillance: an essential step towards elimination," Tr o p i c a l Medicine and International Health, vol. 6, no. 5, pp. 348-361, 2001. (Pubitemid 32510073)
3. WHO, Control and Surveillance of African Trypanosomiasis, Report of WHO Expert Comittee, WHO Technical Report Series, no. 881, World Health Organization, Geneva, Switzerland, 1998.
4. F. A. S. Kuzoe, "Current situation of African trypanosomia-sis, " Acta Tropica, vol. 54, no. 3-4, pp. 153-162, 1993.
5. A. M. Jordan, "Tsetse flies as vectors of trypanosomes," Veterinary Parasitology, vol. 2, no. 1, pp. 143-152, 1976.
6. J. Ford, "The influence of tsetse flies on the distribution of African cattle," in Proceedings of the 1st Federal Scientific Congress, pp. 357-365, Salisbury, Md, USA, 1960.
7. J. J. McKelvey, Man against Tsetse: Struggle for Africa, Cornell University Press, London, UK, 1973.
8. N. Wuyts, N. Chokesajjawatee, and S. Panyim, "A simplified and highly sensitive detection of Trypanosoma evansi by DNA amplification," The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 25, no. 2, pp. 266-271, 1994.
9. P. P. Joshi, V. R. Shegokar, R. M. Powar, et al., "Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report," American Journal of Tropical Medicine and Hygiene, vol. 73, no. 3, pp. 491-495, 2005. (Pubitemid 41324248)
10. WHO, "A new form of human trypanosomiasis in India. Description of the first human case in the world caused by Trypanosoma evansi," Weekly Epidemiological Record, vol. 80, no. 7, pp. 62-63, 2005.
11. C. A. Hoare, "The classification of mammalian trypanosomes," Ergebnisse der Mikrobiologie, Immunitatsf orschung und Experimentellen Therapie, vol. 39, pp. 43-57, 1966.
12. M. Wéry, "Protozoaires Flagellés (Trypanosomatida): parasite du sang et des tissues. Généralités," in Protozoologie M ́edical, pp. 83-89, De Boek, Bruxelles, Belgium, 1995.
13. K. R. Matthews, "Developments in the differentiation of Trypanosoma brucei," Parasitology Today, vol. 15, no. 2, pp. 76-80, 1999. (Pubitemid 129760612)
14. J. David Barry and R. McCulloch, "Antigenic variation in try-panosomes: enhanced phenotypic variation in a eukaryotic parasite," Advances in Parasitology, vol. 49, pp. 2-70, 2001. (Pubitemid 32641452)
15. K. Vickerman, "Developmental cycles and biology of pathogenic trypanosomes," British Medical Bulletin, vol. 41, no. 2, pp. 105-114, 1985. (Pubitemid 15059394)
16. K. Vickerman, "Polymorphism and mitochondrial activity in sleeping sickness trypanosomes," Nature, vol. 208, no. 5012, pp. 762-766, 1965.
17. K. R. Matthews, J. R. Ellis, and A. Paterou, "Molecular regulation of the life cycle of African trypanosomes," Tr e n d s in Parasitology, vol. 20, no. 1, pp. 40-47, 2004. (Pubitemid 38045238)
18. E. Vassella, B. Reuner, B. Yutzy, and M. Boshart, "Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway," Journal of Cell Science, vol. 110, no. 21, pp. 2661-2671, 1997. (Pubitemid 27499424)
19. K. M. Tyler, K. R. Matthews, and K. Gull, "The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers," Proceedings of the Royal Society B, vol. 264, no. 1387, pp. 1481-1490, 1997. (Pubitemid 27480704)
20. L. M. L. McLintock, C. M. R. Turner, and K. Vickerman, "Comparison of the effects of immune killing mechanisms on Trypanosoma brucei parasites of slender and stumpy morphology," Parasite Immunology, vol. 15, no. 8, pp. 475-480, 1993. (Pubitemid 23248600)
21. M. B. Redpath, H. Windle, D. Nolan, E. Pays, H. P. Voorheis, and M. Carrington, "ESAG11, a new VSG expression site-associated gene from Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 111, no. 1, pp. 223-228, 2000.
22. S. Sbicego, E. Vassella, U. Kurath, B. Blum, and I. Roditi, "The use of transgenic Trypanosoma brucei to identify compounds inducing the differentiation of bloodstream forms to procyclic forms," Molecular and Biochemical Parasitology, vol. 104, no. 2, pp. 311-322, 1999. (Pubitemid 29533316)
23. K. Ziegelbauer, B. Stahl, M. Karas, Y.-D. Stierhof, and P. Overath, "Proteolytic release of cell surface proteins during differentiation of Trypanosoma brucei," Biochemistry, vol. 32, no. 14, pp. 3737-3742, 1993. (Pubitemid 23126951)
24. K. Ziegelbauer and P. Overath, "Surface antigen change during differentiation of Trypanosoma brucei," Biochemical Society Transactions, vol. 18, no. 5, pp. 731-733, 1990. (Pubitemid 20359282)
25. A. E. Gruszynski, A. DeMaster, N. M. Hooper, and J. D. Bangs, "Surface coat remodeling during differentiation of Trypanosoma brucei," Journal of Biological Chemistry, vol. 278, no. 27, pp. 24665-24672, 2003. (Pubitemid 37548622)
26. A. E. Gruszynski, F. J. van Deursen, M. C. Albareda, et al., "Regulation of surface coat exchange by differentiating African trypanosomes," Molecular and Biochemical Parasitol-ogy, vol. 147, no. 2, pp. 211-223, 2006.
27. K. R. Matthews, "The developmental cell biology of Tr y -panosoma brucei," Journal of Cell Science, vol. 118, no. 2, pp. 283-290, 2005. (Pubitemid 40277341)
28. J. Sternberg, C. M. R. Turner, J. M. Wells, L. C. Ranford-Cartwright, R. W. F. Le Page, and A. Tait, "Gene exchange in African trypanosomes: frequency and allelic segregation," Molecular and Biochemical Parasitology, vol. 34, no. 3, pp. 269-279, 1989. (Pubitemid 19119812)
29. J. Sternberg, A. Tait, S. Haley, et al., "Gene exchange in African trypanosomes: characterisation of a new hybrid genotype," Molecular and Biochemical Parasitology, vol. 27, no. 2-3, pp. 191-200, 1988. (Pubitemid 18020220)
30. J. Sternberg and A. Tait, "Genetic exchange in African trypanosomes," Trendsin Genetics , vol. 6, no. 10, pp. 317-322, 1990.
31. C. M. R. Turner, N. Aslam, E. Smith, N. Buchanan, and A. Ta i t , " T h e e ffects of genetic exchange on variable antigen expression in Trypanosoma brucei," Parasitology, vol. 103, no. 3, pp. 379-386, 1991.
32. C. M. R. Turner, J. Sternberg, N. Buchanan, E. Smith, G. Hide, and A. Tait, "Evidence that the mechanism of gene exchange in Trypanosoma brucei involves meiosis and syngamy," Parasitology, vol. 101, no. 3, pp. 377-386, 1990.
33. L. Jenni, S. Marti, and J. Schweizer, "Hybrid formation between African trypanosomes during cyclical transmission," Nature, vol. 322, no. 6075, pp. 173-175, 1986. (Pubitemid 16005454)
34. J. Schweizer and L. Jenni, "Hybrid formation in the life cycle of Trypanosoma (T) brucei: detection of hybrid trypanosomes in a midgut-derived isolate," Acta Tropica, vol. 48, no. 4, pp. 319-321, 1991.
35. L. E. H. Bingle, J. L. Eastlake, M. Bailey, and W. C. Gibson, "A novel GFP approach for the analysis of genetic exchange in trypanosomes allowing the in situ detection of mating events," Microbiology, vol. 147, no. 12, pp. 3231-3240, 2001. (Pubitemid 33150329)
36. J. Van Den Abbeele, Y. Claes, D. Van Bockstaele, D. Le Ray, and M. Coosemans, "Trypanosoma brucei spp. development in the tsetse fly: characterization of the post-mesocyclic stages in the foregut and proboscis," Parasitology, vol. 118, no. 5, pp. 469-478, 1999. (Pubitemid 29224616)
37. W. Gibson, "Sex and evolution in trypanosomes," International Journal for Parasitology, vol. 31, no. 5-6, pp. 643-647, 2001. (Pubitemid 32382070)
38. W. Gibson and J. Stevens, "Genetic exchange in the try-panosomatidae," Advances in Parasitology, vol. 43, pp. 1-46, 1999.
39. R. Brun, H. Hecker, and Z.-R. Lun, "Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review)," Veterinary Parasitology, vol. 79, no. 2, pp. 95-107, 1998. (Pubitemid 28430269)
40. P. Borst, F. Fase-Fowler, and W. C. Gibson, "Kinetoplast DNA of Trypanosoma evansi," Molecular and Biochemical Parasitolog y, vol. 23, no. 1, pp. 31-38, 1987. (Pubitemid 17034738)
41. C. Clayton, T. Hausler, and J. Blattner, "Protein trafficking in kinetoplastid protozoa," Microbiological Reviews, vol. 59, no. 3, pp. 325-344, 1995.
42. P. Bastin, T. J. Pullen, F. F. Moreira-Leite, and K. Gull, "Inside and outside of the trypanosome flagellum: a multifunctional organelle," Microbes and Infection, vol. 2, no. 15, pp. 1865-1874, 2000. (Pubitemid 32063540)
43. S. L. Hajduk, A. M. Siqueira, and K. Vickerman, "Kinetoplast DNA of Bodo caudatus: a noncatenated structure," Molecular and Cellular Biology, vol. 6, no. 12, pp. 4372-4378, 1986.
44. L. Simpson, "The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication, and evolution," Annual Review of Microbiology, vol. 41, pp. 363-382, 1987.
45. L. Simpson, N. Neckelmann, V. F. de la Cruz, et al., "Comparison of the maxicircle (mitochondrial) genomes of Leishmania tarentolae and Trypanosoma brucei at the level of nucleotide sequence," Journal of Biological Chemistry, vol. 262, no. 13, pp. 6182-6196, 1987.
46. S. A. Motyka, et al., "Overexpression of a cytochrome B5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei," The Journal of Biological Chemistry, vol. 281, pp. 18499-18506, 2006. (Pubitemid 44035509)
47. B. Liu, Y. Liu, S. A. Motyka, E. E. C. Agbo, and P. T. Englund, "Fellowship of the rings: the replication of kinetoplast DNA," Trends in Parasitology, vol. 21, no. 8, pp. 363-369, 2005. (Pubitemid 40968137)
48. N. R. Sturm and L. Simpson, "Kinetoplast DNA minicircles encode guide RNAs for editing of cytochrome oxidase subunit III mRNA," Cell, vol. 61, no. 5, pp. 879-884, 1990.
49. J. C. Mottram, S. D. Bell, R. G. Nelson, and J. D. Barry, "tRNAs of Trypanosoma brucei: unusual gene organization and mitochondrial importation," Journal of Biological Chemistry, vol. 266, no. 27, pp. 18313-18317, 1991. (Pubitemid 21908081)
50. B. F. de Vries, E. Mulder, J. P. J. Brakenhoff, P. Sloof, and R. Benne, "The variable region of the Trypanosoma brucei kinetoplast maxicircle: sequence and transcript analysis of a repetitive and a non-repetitive fragment," Molecular and Biochemical Parasitology, vol. 27, no. 1, pp. 71-82, 1988.
51. K. Hancock and S. L. Jahduk, "The mitochondrial tRNAs of Trypanosoma brucei are nuclear encoded," Journal of Biological Chemistry, vol. 265, no. 31, pp. 19208-19215, 1990.
52. P. Bastin, T. J. Pullen, T. Sherwin, and K. Gull, "Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1," Journal of Cell Science, vol. 112, no. 21, pp. 3769-3777, 1999.
53. R. Broadhead, H. R. Dawe, H. Farr, et al., "Flagellar motility is required for the viability of the bloodstream trypanosome," Nature, vol. 440, no. 7081, pp. 224-227, 2006. (Pubitemid 43372101)
54. L. Kohl, D. Robinson, and P. Bastin, "Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes," EMBO Journal, vol. 22, no. 20, pp. 5336-5346, 2003. (Pubitemid 37279944)
55. L. Kohl and P. Bastin, "The flagellum of trypanosomes," International Review of Cytology, vol. 244, pp. 227-285, 2005. (Pubitemid 41264852)
56. P. Overath and M. Engstler, "Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system," Molecular Microbiology, vol. 53, no. 3, pp. 735-744, 2004. (Pubitemid 39036955)
57. P. Webster and D. G. Russell, "The flagellar pocket of trypanosomatids," Parasitology Today, vol. 9, no. 6, pp. 201-206, 1993. (Pubitemid 23145167)
58. M. C. Field and M. Carrington, "The trypanosome flagellar pocket," Nature Reviews Microbiology, vol. 7, no. 11, pp. 775-786, 2009.
59. K. D. Stuart, A. Schnaufer, N. L. Ernst, and A. K. Panigrahi, "Complex management: RNA editing in trypanosomes," Trends in Biochemical Sciences, vol. 30, no. 2, pp. 97-105, 2005. (Pubitemid 40187302)
60. A. K. Panigrahi, N. L. Ernst, G. J. Domingo, M. Fleck, R. Salavati, and K. D. Stuart, "Compositionally and functionally distinct editosomes in Trypanosoma brucei," RNA, vol. 12, no. 6, pp. 1038-1049, 2006. (Pubitemid 43788122)
61. D. E. Golden and S. L. Hajduk, "The importance of RNA structure in RNA editing and a potential proofreading mechanism for correct guide RNA:pre-mRNA binary complex formation," Journal of Molecular Biology, vol. 359, no. 3, pp. 585-596, 2006. (Pubitemid 43767263)
62. E. F. Michelotti, M. E. Harris, B. Adler, A. F. Torri, and S. L. Hajduk, "Trypanosoma brucei mitochondrial ribosomal RNA synthesis, processing and developmentally regulated expression," Molecular and Biochemical Parasitology, vol. 54, no. 1, pp. 31-41, 1992.
63. B. Wickstead, K. Ersfeld, and K. Gull, "The small chromosomes of Trypanosama brucei involved in antigenic variation are constructed around repetititve palindromes," Genome Research, vol. 14, no. 6, pp. 1014-1024, 2004. (Pubitemid 38811537)
64. F. Bringaud, N. Biteau, S. E. Melville, et al., "A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei," Eukaryotic Cell, vol. 1, no. 1, pp. 137-151, 2002. (Pubitemid 36562357)
65. M. Berriman, E. Ghedin, C. Hertz-Fowler, et al., "The genome of the African trypanosome Trypanosoma brucei," Science, vol. 309, no. 5733, pp. 416-422, 2005. (Pubitemid 40994676)
66. F. R. Opperdoes, "Compartmentation of carbohydrate metabolism in trypanosomes," Annual Review of Microbiology, vol. 41, pp. 127-151, 1987.
67. K. Vickerman, L. Tetley, K. A. K. Hendry, and C. M. R. Turner, "Biology of African trypanosomes in the tsetse fly," Biology of the Cell, vol. 64, no. 2, pp. 109-119, 1988.
68. F. R. Opperdoes, P. Baudhuin, and I. Coppens, "Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei," Journal of Cell Biology, vol. 98, no. 4, pp. 1178-1184, 1984. (Pubitemid 14128900)
69. J. Blattner, S. Helfert, P. Michels, and C. Clayton, "Com- partmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism," Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 20, pp. 11596-11600, 1998. (Pubitemid 28460460)
70. S. Helfert, A. M. Estévez, B. Bakker, P. Michels, and C. Clayton, "Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei," Biochemical Journal, vol. 357, no. 1, pp. 117-125, 2001. (Pubitemid 32642909)
71. P. A. M. Michels, V. Hannaert, and F. Bringaud, "Metabolic aspects of glycosomes in trypanosomatidae-new data and views," Parasitology Today, vol. 16, no. 11, pp. 482-489, 2000.
72. B. M. Bakker, F. I. C. Mensonides, B. Teusink, P. Van Hoek, P. A. M. Michels, and H. V. Westerhoff, "Compartmentation protects trypanosomes from the dangerous design of glycol-ysis," Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 5, pp. 2087-2092, 2000. (Pubitemid 30134026)
73. C. Guerra-Giraldez, L. Quijada, and C. E. Clayton, "Com- partmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei," Journal of Cell Science, vol. 115, no. 13, pp. 2651-2658, 2002. (Pubitemid 34846506)
74. C. Colasante, M. Ellis, T. Ruppert, and F. Voncken, "Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei," Proteomics, vol. 6, no. 11, pp. 3275-3293, 2006. (Pubitemid 43886146)
75. F. R. Opperdoes and J.-P. Szikora, "In silico prediction of the glycosomal enzymes of Leishmania major and try-panosomes," Molecular and Biochemical Parasitology, vol. 147, no. 2, pp. 193-206, 2006.
76. M. C. Field, J. H. Lumb, V. O. Adung'a, N. G. Jones, and M. Engstler, "Macromolecular trafficking and immune evasion in African trypanosomes," International Review of Cell and Molecular Biology, vol. 278, pp. 1-67, 2009.
77. M. Engstler, T. Pfohl, S. Herminghaus, et al., "Hydrody-namic flow-mediated protein sorting on the cell surface of trypanosomes," Cell, vol. 131, no. 3, pp. 505-515, 2007. (Pubitemid 350007695)
78. E. Pays, S. Lips, D. Nolan, L. Vanhamme, and D. Pérez-Morga, "The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts," Molecular and Biochemical Parasitology, vol. 114, no. 1, pp. 1-16, 2001. (Pubitemid 32453210)
79. L. Vanhamme, P. Poelvoorde, A. Pays, P. Tebabi, H. Van Xong, and E. Pays, "Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei," Molecular Microbiology, vol. 36, no. 2, pp. 328-340, 2000. (Pubitemid 30229479)
80. E. Pays, L. Vanhamme, and D. Pérez-Morga, "Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries," Current Opinion in Microbiology, vol. 7, no. 4, pp. 369-374, 2004. (Pubitemid 39091121)
81. M. Navarro and K. Gull, "A poll transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei," Nature, vol. 414, no. 6865, pp. 759-763, 2001. (Pubitemid 34000774)
82. E. Pays, "Regulation of antigen gene expression in Tr y -panosoma brucei," Trendsin Parasitology , vol. 21, no. 11, pp. 517-520, 2005. (Pubitemid 41447023)
83. E. Pays, "The variant surface glycoprotein as a tool for adaptation in African trypanosomes," Microbes and Infection, vol. 8, no. 3, pp. 930-937, 2006.
84. P. Borst and S. Ulbert, "Control of VSG gene expression sites," Molecular and Biochemical Parasitology, vol. 114, no. 1, pp. 17-27, 2001. (Pubitemid 32453211)
85. W. Bitter, H. Gerrits, R. Kieft, and P. Borst, "The role of transferrin-receptor variation in the host range of Tr y -panosoma brucei," Nature, vol. 391, no. 6666, pp. 499-502, 1998. (Pubitemid 28086552)
86. E. Pays, M. Guyaux, and D. Aerts, "Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes," Nature, vol. 316, no. 6028, pp. 562-564, 1985. (Pubitemid 16239370)
87. E. Pays, S. Van Assel, M. Laurent, et al., "Gene conversion as a mechanism for antigenic variation in Trypanosomes," Cell, vol. 34, no. 2, pp. 371-381, 1983.
88. G. Rudenko, R. McCulloch, A. Dirks-Mulder, and P. Borst, "Telomere exchange can be an important mechanism of variant surface glycoprotein gene switching in Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 80, no. 1, pp. 65-75, 1996. (Pubitemid 26284387)
89. P. Poelvoorde, L. Vanhamme, J. Van Den Abbeele, W. M. Switzer, and E. Pays, "Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera," Molecular and Biochemical Parasitology, vol. 134, no. 1, pp. 155-157, 2004. (Pubitemid 38121528)
90. E. B. Lugli, M. Pouliot, M. D. P. M. Portela, M. R. Loomis, and J. Raper, "Characterization of primate trypanosome lytic factors," Molecular and Biochemical Parasitology, vol. 138, no. 1, pp. 9-20, 2004. (Pubitemid 39410521)
91. C. De Greef, E. Chimfwembe, J. Kihang'a Wabacha, E. Bajyana Songa, and R. Hamers, "Only the serum-resistant bloodstream forms of Trypanosoma brucei rhodesiense express the serum resistance associated (SRA) protein," Annales de la Societe Belge de Medecine Tropicale, vol. 72, supplement 1, pp. 13-21, 1992.
92. C. De Greef, H. Imberechts, G. Matthyssens, N. Van Meirvenne, and R. Hamers, "A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense," Molecular and Biochemical Parasitology, vol. 36, no. 2, pp. 169-176, 1989. (Pubitemid 19212840)
93. E. Pays, B. Vanhollebeke, L. Vanhamme, F. Paturiaux-Hanocq, D. P. Nolan, and D. Pérez-Morga, "The trypanolytic factor of human serum," Nature Reviews Microbiology, vol. 4, no. 6, pp. 477-486, 2006. (Pubitemid 43771867)
94. H. V. Xong, L. Vanhamme, M. Chamekh, et al., "A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense," Cell, vol. 95, no. 6, pp. 839-846, 1998. (Pubitemid 29014463)
95. N. van Meirvenne, E. Magnus, and P. G. Janssens, "The effect of normal human serum on trypanosomes of distinct antigenic type (ETat 1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense," Annales de la Societe Belge de Medecine Tropicale, vol. 56, no. 1, pp. 55-63, 1976.
96. S. C. Welburn, K. Picozzi, E. M. Fèvre, et al., "Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene," The Lancet, vol. 358, no. 9298, pp. 2017-2019, 2001. (Pubitemid 34084823)
97. C. De Greef and R. Hamers, "The serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein," Molecular and Biochemical Parasitology, vol. 68, no. 2, pp. 277-284, 1994.
98. L. Vanhamme and E. Pays, "The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness," International Journal for Parasitology, vol. 34, no. 8, pp. 887-898, 2004. (Pubitemid 38813250)
99. L. Vanhamme, H. Renauld, L. Lecordier, P. Poelvoorde, J. Van Den Abbeele, and E. Pays, "The Trypanosoma brucei reference strain TREU927/4 contains T. b r u c e i rhodesiense-specific SRA sequences, but displays a distinct phenotype of relative resistance to human serum," Molecular and Biochemical Parasitolog y, vol. 135, no. 1, pp. 39-47, 2004. (Pubitemid 38470073)
100. N. Campillo and M. Carrington, "The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhode-siense," Molecular and Biochemical Parasitology, vol. 127, no. 1, pp. 79-84, 2003. (Pubitemid 36263235)
101. M. L. Blum, J. A. Down, A. M. Gurnett, M. Carrington, M. J. Turner, and D. C. Wiley, "A structural motif in the variant surface glycoproteins of Trypanosoma brucei," Nature, vol. 362, no. 6421, pp. 603-609, 1993. (Pubitemid 23109268)
102. L. Vanhamme, F. Paturiaux-Hanocq, P. Poelvoorde, et al., "Apolipoprotein L-I is the trypanosome lytic factor of human serum," Nature, vol. 422, no. 6927, pp. 83-87, 2003. (Pubitemid 36323300)
103. T. N. Baral, S. Magez, B. Stijlemans, et al., "Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor," Nature Medicine, vol. 12, no. 5, pp. 580-584, 2006.
104. M. Ruvolo, D. Pan, S. Zehr, T. Goldberg, T. R. Disotell, and M. Von Dornum, "Gene trees and hominoid phylogeny," Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 19, pp. 8900-8904, 1994.
105. M. R. Rifkin, "Role of phospholipids in the cytotoxic action of high density lipoprotein on trypanosomes," Journal of Lipid Research, vol. 32, no. 4, pp. 639-647, 1991.
106. S. L. Hajduk, D. R. Moore, J. Vasudevacharya, et al., "Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein," Journal of Biological Chemistry, vol. 264, no. 9, pp. 5210-5217, 1989. (Pubitemid 19092938)
107. K. M. Hager, M. A. Pierce, D. R. Moore, E. M. Tytler, J. D. Esko, and S. L. Hajduk, "Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes," Journal of Cell Biology, vol. 126, no. 1, pp. 155-167, 1994. (Pubitemid 24214936)
108. K. M. Hager and S. L. Hajduk, "Mechanism of resistance of African trypanosomes to cytotoxic human HDL," Nature, vol. 385, no. 6619, pp. 823-826, 1997. (Pubitemid 27106072)
109. H. P. Green, M. D. P. M. Portela, E. N. St. Jean, E. B. Lugli, and J. Raper, "Evidence for a Trypanosoma brucei lipoprotein scavenger receptor," Journal of Biological Chemistry, vol. 278, no. 1, pp. 422-427, 2003. (Pubitemid 36043592)
110. A. B. Smith, J. D. Esko, and S. L. Hajduk, "Killing of trypanosomes by the human haptoglobin-related protein," Science, vol. 268, no. 5208, pp. 284-286, 1995.
111. J. Raper, R. Fung, J. Ghiso, V. Nussenzweig, and S. Tomlinson, "Characterization of a novel trypanosome lytic factor from human serum," Infection and Immunity, vol. 67, no. 4, pp. 1910-1916, 1999. (Pubitemid 29144414)
112. M. D. P. Molina-Portela, E. B. Lugli, E. Recio-Pinto, and J. Raper, "Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes," Molecular and Biochemical Parasitology, vol. 144, no. 2, pp. 218-226, 2005. (Pubitemid 41572228)
113. S. Tomlinson, M. Muranjan, V. Nussenzweig, and J. Raper, "Haptoglobin-related protein and apolipoprotein AI are components of the two trypanolytic factors in human serum," Molecular and Biochemical Parasitology, vol. 86, no. 1, pp. 117-120, 1997. (Pubitemid 27245983)
114. J. Drain, J. R. Bishop, and S. L. Hajduk, "Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes," Journal of Biological Chemistry, vol. 276, no. 32, pp. 30254-30260, 2001.
115. A. B. Smith and S. L. Hajduk, "Identification of haptoglobin as a natural inhibitor of trypanocidal activity in human serum," Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 22, pp. 10262-10266, 1995.
116. D. Pérez-Morga, B. Vanhollebeke, F. Paturiaux-Hanocq, et al., "Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes," Science, vol. 309, no. 5733, pp. 469-472, 2005. (Pubitemid 40994686)
117. A. M. Shiflett, J. R. Bishop, A. Pahwa, and S. L. Hajduk, "Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes," Journal of Biological Chemistry, vol. 280, no. 38, pp. 32578-32585, 2005. (Pubitemid 41368299)
118. M. P. Molina-Portela, M. Samanovic, and J. Raper, "Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model," Journal of Experimental Medicine, vol. 205, no. 8, pp. 1721-1728, 2008.
119. R. Thomson, P. Molina-Portela, H. Mott, M. Carrington, and J. Raper, "Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 46, pp. 19509-19514, 2010.
120. M. Samanovic, M. P. Molina-Portela, A.-D. C. Chessler, B. A. Burleigh, and J. Raper, "Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leish-mania infection," PLoS Pathogens, vol. 5, no. 1, Article ID e1000276, 2009.
121. R. Thomson, M. Samanovic, and J. Raper, "Activity of trypanosome lytic factor: a novel component of innate immunity," Future Microbiology, vol. 4, no. 7, pp. 789-796, 2009.
122. P. N. Duchateau, C. R. Pullinger, R. E. Orellana, et al., "Apolipoprotein L, a new human high density lipopro-tein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L," Journal of Biological Chemistry, vol. 272, no. 41, pp. 25576-25582, 1997. (Pubitemid 27438869)
123. P. N. Duchateau, C. R. Pullinger, M. H. Cho, C. Eng, and J. P. Kane, "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene," Journal of Lipid Research, vol. 42, no. 4, pp. 620-630, 2001. (Pubitemid 32367005)
124. N. M. Page, D. J. Butlin, K. Lomthaisong, and P. J. Lowry, "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution," Genomics, vol. 74, no. 1, pp. 71-78, 2001. (Pubitemid 32500267)
125. J. M. Harrington, S. Howell, and S. L. Hajduk, "Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein," Journal of Biological Chemistry, vol. 284, no. 20, pp. 13505-13512, 2009.
126. I. Roditi and C. Clayton, "An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 103, no. 1, pp. 99-100, 1999. (Pubitemid 29428232)
127. S. Urwyler, E. Vassella, J. Van Den Abbeele, et al., "Expression of procyclin mRNAs during cyclical transmission of Tr y -panosoma brucei," PLoS Pathogens, vol. 1, no. 3, Article ID e22, 2005.
128. K. Vickerman and A. G. Luckins, "Localization of variable antigens in the surface coat of Trypanosoma brucei using ferritin conjugated antibody," Nature, vol. 224, no. 5224, pp. 1125-1126, 1969.
129. G. A. M. Cross, "Identification, purification and properties of clone specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei," Parasitology, vol. 71, no. 3, pp. 393-417, 1975.
130. K. Ziegelbauer and P. Overath, "Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei," Infection and Immunity, vol. 61, no. 11, pp. 4540-4545, 1993. (Pubitemid 23320503)
131. A. Ferrante and A. C. Callison, "Alternative pathway activation of complement by African trypanosomes lacking a glycoprotein coat," Parasite Immunology, vol. 5, no. 5, pp. 491-498, 1983. (Pubitemid 14233390)
132. M. Carrington and J. Boothroyd, "Implications of conserved structural motifs in disparate trypanosome surface proteins," Molecular and Biochemical Parasitology, vol. 81, no. 2, pp. 119-126, 1996. (Pubitemid 26316554)
133. M. Carrington, N. Miller, M. Blum, I. Roditi, D. Wiley, and M. Turner, "Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues," Journal of Molecular Biology, vol. 221, no. 3, pp. 823-835, 1991. (Pubitemid 121003422)
134. A. Mehlert, J. M. Richardson, and M. A. J. Ferguson, "Structure of the glycosylphosphatidylinositol membrane anchor glycan of a class-2 variant surface glycoprotein from Trypanosoma brucei," Journal of Molecular Biology, vol. 277, no. 2, pp. 379-392, 1998. (Pubitemid 28174975)
135. O. C. Hutchinson, W. Smith, N. G. Jones, A. Chattopadhyay, S. C. Welburn, and M. Carrington, "VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain," Molecular and Biochemical Parasitology, vol. 130, no. 2, pp. 127-131, 2003. (Pubitemid 37289130)
136. M. A. J. Ferguson, S. W. Homans, R. A. Dwek, and T. W. Rademacher, "Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane," Science, vol. 239, no. 4841, part 1, pp. 753-759, 1988. (Pubitemid 18070924)
137. M. A. McDowell, D. M. Ransom, and J. D. Bangs, " Glycosylphosphatidylinositol-dependent secretory transport in Trypanosoma brucei," Biochemical Journal, vol. 335, no. 3, pp. 681-689, 1998. (Pubitemid 28515424)
138. D. Freymann, J. Down, M. Carrington, I. Roditi, M. Turner, and D. Wiley, "2.9 Å resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei," Journal of Molecular Biology, vol. 216, no. 1, pp. 141-160, 1990. (Pubitemid 20376180)
139. G. A. Cross, "Structure of the variant glycoproteins and surface coat of Trypanosoma brucei," Philosophical Transactions of the Royal Society B, vol. 307, no. 1131, pp. 3-12, 1984.
140. P. T. Enghund, "The structure and biosynthesis of glycosyl phosphatidylinositol protein anchors," Annual Review of Biochemistry, vol. 62, pp. 121-138, 1993. (Pubitemid 23237867)
141. M. A. Ferguson, S. W. Homans, R. A. Dwek, and T. W. Rademacher, "The glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein," Biochemical Society Transactions, vol. 16, no. 3, pp. 265-268, 1988.
142. V. P. Triggs and J. D. Bangs, "Glycosylphosphatidylinositol- dependent protein trafficking in bloodstream stage Tr y -panosoma brucei," Eukaryotic Cell, vol. 2, no. 1, pp. 76-83, 2003. (Pubitemid 36770377)
143. U. Böhme and G. A. M. Cross, "Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei," Journal of Cell Science, vol. 115, no. 4, pp. 805-816, 2002. (Pubitemid 34196340)
144. W. J. Masterson, T. L. Doering, G. W. Hart, and P. T. Englund, "A novel pathway for glycan assembly: biosynthesis of the glycosyl- phosphatidylinositol anchor of the trypanosome variant surface glycoprotein," Cell, vol. 56, no. 5, pp. 793-800, 1989. (Pubitemid 19082515)
145. M. A. J. Ferguson and A. F. Williams, "Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures," Annual Review of Biochemistry, vol. 57, pp. 285-320, 1988.
146. M. A. J. Ferguson, "The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research," Journal of Cell Science, vol. 112, no. 17, pp. 2799-2809, 1999. (Pubitemid 29430025)
147. K. S. Paul, D. Jiang, Y. S. Morita, and P. T. Englund, "Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery," Trendsin Parasitology , vol. 17, no. 8, pp. 381-387, 2001. (Pubitemid 33042454)
148. M. A. J. Ferguson and G. A. M. Cross, "Myristylation of the membrane form of a Trypanosoma brucei variant surface glycoprotein," The Journal of Biological Chemistry, vol. 259, no. 5, pp. 3011-3015, 1984. (Pubitemid 14162535)
149. T. L. Doering, J. Raper, L. U. Buxbaum, et al., "An analog of myristic acid with selective toxicity for African trypanosomes," Science, vol. 252, no. 5014, pp. 1851-1854, 1991. (Pubitemid 21917110)
150. Y. Hong and T. Kinoshita, "Trypanosome glycosylphos-phatidylinositol biosynthesis," Korean Journal of Parasitology, vol. 47, no. 3, pp. 197-204, 2009.
151. M. Carrington, N. Carnall, M. S. Crow, et al., "The properties and function of the glycosylphosphatidylinositol-phospholipase C in Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 91, no. 1, pp. 153-164, 1998. (Pubitemid 28242511)
152. D. J. Grab, P. Webster, S. Ito, et al., "Subcellular localization of a variable surface glycoprotein phosphatidylinositol-specific phospholipase-C in African trypanosomes," Journal of Cell Biology, vol. 105, no. 2, pp. 737-746, 1987. (Pubitemid 18043836)
153. K. Mensa-Wilmot, D. Hereld, and P. T. Englund, "Genomic organization, chromosomal localization, and developmen-tally regulated expression of the glycosyl-phosphatidyl-inositol-specific phospholipase C of Trypanosoma brucei," Molecular and Cellular Biology, vol. 10, no. 2, pp. 720-726, 1990.
154. M. Carrington, R. Bulow, H. Reinke, et al., "Sequence and expression of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 33, no. 3, pp. 289-296, 1989. (Pubitemid 19060266)
155. M. L. C. De Almeida, M. Geuskens, and E. Pays, "Cell lysis induces redistribution of the GPI-anchored variant surface glycoprotein on both faces of the plasma membrane of Trypanosoma brucei," Journal of Cell Science, vol. 112, no. part 23, pp. 4461-4473, 1999. (Pubitemid 30122037)
156. M. A. J. Ferguson, K. Haldar, and G. A. M. Cross, "Tr y -panosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus," The Journal of Biological Chemistry, vol. 260, no. 8, pp. 4963-4968, 1985. (Pubitemid 15038691)
157. M. A. J. Ferguson, M. G. Low, and G. A. M. Cross, "Glycosyl-sn-1,2- dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein," The Journal of Biological Chemistry, vol. 260, no. 27, pp. 14547-14555, 1985. (Pubitemid 16210977)
158. M. L. Cardoso de Almeida and M. J. Turner, "The membrane form of variant surface glycoproteins of Trypanosoma brucei," Nature, vol. 302, no. 5906, pp. 349-352, 1983. (Pubitemid 13154530)
159. A. A. Holder and G. A. M. Cross, "Glycopeptides from variant surface glycoproteins of Trypanosoma brucei. C-terminal location of antigenically cross-reacting carbohydrate moieties," Molecular and Biochemical Parasitology, vol. 2, no. 3-4, pp. 135-150, 1981.
160. S. E. Zamze, M. A.J. Ferguson, R. Collins, R. A. Dwek, and T. W. Rademacher, "Characterization of the cross-reacting determinant (CRD) of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein," European Journal of Biochemistry, vol. 176, no. 3, pp. 527-534, 1988.
161. R. Bulow, C. Nonnengasser, and P. Overath, "Release of the variant surface glycoprotein during differentiation of bloodstream to procyclic forms of Trypanosoma brucei," Molecular and Biochemical Parasitology, vol. 32, no. 1, pp. 85-92, 1989.
162. S. Rolin, J. Hanocq-Quertier, F. Paturiaux-Hanocq, et al., "Simultaneous but independent activation of adenylate cyclase and glycosylphosphatidylinositol-phospholipase C under stress conditions in Trypanosoma brucei," The Journal of Biological Chemistry, vol. 271, no. 18, pp. 10844-10852, 1996. (Pubitemid 26145822)
163. M. Carrington, D. Walters, and H. Webb, "The biology of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei," Cell Biology International Reports, vol. 15, no. 11, pp. 1101-1114, 1991.
164. H. Webb, N. Carnall, L. Vanhamme, et al., "The GPI-phospholipase C of Trypanosoma brucei is non essential but influences parasitemia in mice," Journal of Cell Biology, vol. 139, no. 1, pp. 103-114, 1997. (Pubitemid 27444084)
165. P. Overath, M. Chaudhri, D. Steverding, and K. Ziegelbauer, "Invariant surface proteins in bloodstream forms of Tr y -panosoma brucei," Parasitology Today, vol. 10, no. 2, pp. 53-58, 1994. (Pubitemid 24052917)
166. K. Ziegelbauer and P. Overath, "Identification of invariant surface glycoproteins in the bloodstream stage of Tr y -panosoma brucei," The Journal of Biological Chemistry, vol. 267, no. 15, pp. 10791-10796, 1992.
167. D. G. Jackson, H. J. Windle, and H. P. Voorheis, "The identification, purification, and characterization of two invariant surface glycoproteins located beneath the surface coat barrier of bloodstream forms of Trypanosoma brucei," The Journal of Biological Chemistry, vol. 268, no. 11, pp. 8085-8095, 1993. (Pubitemid 23120391)
168. D. P. Nolan, D. G. Jackson, H. J. Windle, et al., "Characterization of a novel, stage-specific, invariant surface protein in Trypanosoma brucei containing an internal, serine-rich, repetitive motif," The Journal of Biological Chemistry, vol. 272, no. 46, pp. 29212-29221, 1997. (Pubitemid 27498213)
169. D. Schell, N. K. Borowy, and P. Overath, "Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei," Parasitology Research, vol. 77, no. 7, pp. 558-560, 1991.
170. D. Steverding, Y. D. Stierhof, H. Fuchs, R. Tauber, and P. Overath, "Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei," Journal of Cell Biology, vol. 131, no. 5, pp. 1173-1182, 1995.
171. D. Steverding, "Bloodstream forms of Trypanosoma brucei require only small amounts of iron for growth," Parasitology Research, vol. 84, no. 1, pp. 59-62, 1998. (Pubitemid 28097627)
172. D. Steverding, "The significance of transferrin receptor variation in Trypanosoma brucei," Trends in Parasitology, vol. 19, no. 3, pp. 125-127, 2003. (Pubitemid 36338076)
173. H. A. Huebers and C. A. Finch, "The physiology of transfer-rin and transferrin receptors," Physiological Reviews, vol. 67, no. 2, pp. 520-582, 1987.
174. D. Salmon, J. Hanocq-Quertier, F. Paturiaux-Hanocq, et al., "Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein," EMBO Journal, vol. 16, no. 24, pp. 7272-7278, 1997. (Pubitemid 28010487)
175. D. Steverding, "The transferrin receptor of Trypanosoma brucei," Parasitology International, vol. 48, no. 3, pp. 191-198, 2000.
176. I. Coppens, Ph. Bastin, F. R. Opperdoes, P. Baudhuin, and P. J. Courtoy, "Trypanosoma brucei brucei: antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host," Experimental Parasitology, vol. 74, no. 1, pp. 77-86, 1992.
177. I. Coppens, P. Bastin, P. J. Courtoy, P. Baudhuin, and F. R. Opperdoes, "A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei," Biochemical and Biophysical Research Communications, vol. 178, no. 1, pp. 185-191, 1991.
178. E. Tetaud, M. P. Barrett, F. Bringaud, and T. Baltz, "Kineto-plastid glucose transporters," Biochemical Journal, vol. 325, no. 3, pp. 569-580, 1997.
179. M. A. Sanchez, S. Drutman, M. Van Ampting, K. Matthews, and S. M. Landfear, "A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle," Molecular and Biochemical Parasitology, vol. 136, no. 2, pp. 265-272, 2004. (Pubitemid 38757995)
180. P. Vincendeau and B. Bouteille, "Immunology and immunopathology of African trypanosomiasis," Anais da Academia Brasileira de Ciencias, vol. 78, no. 4, pp. 645-665, 2006. (Pubitemid 44905149)
181. B. Stijlemans, M. Guilliams, G. Raes, A. Beschin, S. Magez, and P. De Baetselier, "African trypanosomosis: from immune escape and immunopathology to immune intervention," Veterinary Parasitology, vol. 148, no. 1, pp. 3-13, 2007. (Pubitemid 47016765)
182. C. A. Janeway Jr. and R. Medzhitov, "Innate immune recognition," Annual Review of Immunology, vol. 20, pp. 197-216, 2002. (Pubitemid 34293424)
183. K. Takeda, T. Kaisho, and S. Akira, "Toll-like receptors," Annual Review of Immunology, vol. 21, pp. 335-376, 2003. (Pubitemid 37174535)
184. L. K.M. Shoda, K. A. Kegerreis, C. E. Suarez, et al., "DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. b r u c e i is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide," Infection and Immunity, vol. 69, no. 4, pp. 2162-2171, 2001. (Pubitemid 32239682)
185. T. H. Harris, N. M. Cooney, J. M. Mansfield, and D. M. Paulnock, "Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA," Infection and Immunity, vol. 74, no. 8, pp. 4530-4537, 2006. (Pubitemid 44157239)
186. M. B. Drennan, B. Stijlemans, J. Van Den Abbeele, et al., "The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent," Journal of Immunology, vol. 175, no. 4, pp. 2501-2509, 2005. (Pubitemid 41113861)
187. I. C. Almeida, M. M. Camargo, D. O. Procópio, et al., "Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents," EMBO Journal, vol. 19, no. 7, pp. 1476-1485, 2000. (Pubitemid 30182155)
188. S. P. Coller, J. M. Mansfield, and D. M. Paulnock, "Gly- cosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-γ-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis," Journal of Immunology, vol. 171, no. 3, pp. 1466-1472, 2003. (Pubitemid 36900081)
189. S. D. Tachado and L. Schofield, "Glycosylphosphatidylinos-itol toxin of Trypanosoma brucei regulates IL-1α and TNF-α expression in macrophages by protein tyrosine kinase mediated signal transduction," Biochemical and Biophysical Research Communications, vol. 205, no. 2, pp. 984-991, 1994.
190. M. Shi, G. Wei, W. Pan, and H. Tabel, "Trypanosoma congolense infections: antibody-mediated phagocytosis by Kupffer cells," Journal of Leukocyte Biology, vol. 76, no. 2, pp. 399-405, 2004. (Pubitemid 39006954)
191. N. A. Mabbott, I. A. Sutherland, and J. M. Sternberg, "Tr y -panosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions," Parasitolog y Research, vol. 80, no. 8, pp. 687-690, 1994. (Pubitemid 24343569)
192. J. M. Sternberg and N. A. Mabbott, "Nitric oxide-mediated suppression of T cell responses during Trypanosoma brucei infection: soluble trypanosome products and interferon-γ are synergistic inducers of nitric oxide synthase," European Journal of Immunology, vol. 26, no. 3, pp. 539-543, 1996. (Pubitemid 26091380)
193. R. S. Kaushik, J. E. Uzonna, Y. Zhang, J. R. Gordon, and H. Tabel, "Innate resistance to experimental African trypanoso-miasis: differences in cytokine (TNF-α, IL-6, IL-10 and IL-12) production by bone marrow-derived macrophages from resistant and susceptible mice," Cytokine, vol. 12, no. 7, pp. 1024-1034, 2000. (Pubitemid 30479485)
194. S. Magez, M. Geuskens, A. Beschin, et al., "Specific uptake of tumor necrosis factor-α is involved in growth control of Trypanosoma brucei," Journal of Cell Biology, vol. 137, no. 3, pp. 715-727, 1997. (Pubitemid 27200672)
195. B. Namangala, P. de Baetselier, and A. Beschin, "Both type-I and type-II responses contribute to murine trypanotoler-ance," Journal of Veterinary Medical Science, vol. 71, no. 3, pp. 313-318, 2009.
196. C. J. Hertz, H. Filutowicz, and J. M. Mansfield, "Resistance to the African trypanosomes is IFN-γ dependent," Journal of Immunology, vol. 161, no. 12, pp. 6775-6783, 1998. (Pubitemid 28562221)
197. J. E. Uzonna, R. S. Kaushik, J. R. Gordon, and H. Tabel, "Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance," Parasite Immunology, vol. 21, no. 2, pp. 57-71, 1999. (Pubitemid 29086306)
198. N. Inoue, M. Inoue, K. Kuriki, et al., "Interleukin 4 is a crucial cytokine in controlling Trypanosoma brucei gambiense infection in mice," Veterinary Parasitology, vol. 86, no. 3, pp. 173-184, 1999. (Pubitemid 29425802)
199. B. Mertens, K. Taylor, C. Muriuki, and M. Rocchi, "Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite Trypanosoma congolense: protective role for interleukin-4?" Journal of Interferon and Cytokine Research, vol. 19, no. 1, pp. 59-65, 1999. (Pubitemid 29070233)
200. S. Magez, M. Radwanska, M. Drennan, et al., "Interferon-γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 infections," Journal of Infectious Diseases, vol. 193, no. 11, pp. 1575-1583, 2006. (Pubitemid 43841392)
201. T. N. Baral, P. De Baetselier, F. Brombacher, and S. Magez, "Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response," Journal of Infectious Diseases, vol. 195, no. 10, pp. 1513-1520, 2007. (Pubitemid 46717470)
202. M. Forlenza, M. Nakao, I. Wibowo, et al., "Nitric oxide hinders antibody clearance from the surface of Tr y p a n o p l a s m a borreli and increases susceptibility to complement-mediated lysis," Molecular Immunology, vol. 46, no. 16, pp. 3188-3197, 2009.
203. S. Magez, R. Lucas, A. Darji, E. Bajyana Songa, R. Hamers, and P. De Baetselier, "Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei," Parasite Immunology, vol. 15, no. 11, pp. 635-641, 1993. (Pubitemid 23359171)
204. S. Magez, M. Radwanska, A. Beschin, K. Sekikawa, and P. De Baetselier, "Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections," Infection and Immunity, vol. 67, no. 6, pp. 3128-3132, 1999. (Pubitemid 29244739)
205. B. Namangala, P. De Baetselier, L. Brijs, et al., "Attenuation of Trypanosoma brucei is associated with reduced immunosup-pression and concomitant production of Th2 lymphokines," Journal of Infectious Diseases, vol. 181, no. 3, pp. 1110-1120, 2000. (Pubitemid 30194499)
206. J. M. Sternberg, J. Rodgers, B. Bradley, L. MacLean, M. Murray, and P. G. E. Kennedy, "Meningoencephalitic African trypanosomiasis: brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology," Journal of Neuroimmunology, vol. 167, no. 1-2, pp. 81-89, 2005. (Pubitemid 41242290)
207. P. G. E. Kennedy, "Cytokines in central nervous system trypanosomiasis: cause, effect or both?" Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 103, no. 3, pp. 213-214, 2009.
208. P. Baetselier, B. Namangala, W. Noël, L. Brys, E. Pays, and A. Beschin, "Alternative versus classical macrophage activation during experimental African trypanosomosis," International Journal for Parasitology, vol. 31, no. 5-6, pp. 575-587, 2001. (Pubitemid 32382058)
209. K. M. Hudson, C. Byner, J. Freeman, and R. J. Terry, " Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis," Nature, vol. 264, no. 5583, pp. 256-258, 1976.
210. A. G. Luckins and D. Mehlitz, "Evaluation of an indirect fluorescent antibody test, enzyme-linked immunosorbent assay and quantification of immunoglobulins in the diagnosis of bovine trypanosomiasis," Tropical Animal Health and Production, vol. 10, no. 3, pp. 149-159, 1978. (Pubitemid 8403095)
211. A. G. Luckins and D. Mehlitz, "Observations on serum immunoglobulin levels in cattle infected with Trypanosoma brucei, T. vivax and T. congolense ," Annals of Tropical Medicine and Parasitology, vol. 70, no. 4, pp. 479-480, 1976.
212. + B lymphocytes are the main source of antibodies reactive with non-parasite antigens in Trypanosoma congolense-infected cattle," Immunology, vol. 92, no. 2, pp. 226-233, 1997. (Pubitemid 27428451)
213. D. J. L. Williams, K. Taylor, J. Newson, B. Gichuki, and J. Naessens, "The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance," Parasite Immunology, vol. 18, no. 4, pp. 209-218, 1996. (Pubitemid 26124707)
214. T. Kobayakawa, J. Louis, S. Izui, and P. H. Lambert, "Autoimmune response to DNA, red blood cells, and thymocyte antigens in association with polyclonal antibody synthesis during experimental African trypanosomiasis," Journal of Immunology, vol. 122, no. 1, pp. 296-301, 1979. (Pubitemid 9082448)
215. K. W. Schleifer, H. Filutowicz, L. R. Schopf, and J. M. Mansfield, "Characterization of T helper cell responses to the trypanosome variant surface glycoprotein," Journal of Immunology, vol. 150, no. 7, pp. 2910-2919, 1993. (Pubitemid 23127540)
216. W. I. Morrison and M. Murray, "The role of humoral immune responses in determining susceptibility of A/J and C57BL/6 mice to infection with Trypanosoma congolense," Parasite Immunology, vol. 7, no. 1, pp. 63-79, 1985. (Pubitemid 15146872)
217. K. A. Taylor, V. Lutje, D. Kennedy, et al., "Trypanosoma congolense: B-Lymphocyte responses differ between try-panotolerant and trypanosusceptible cattle," Experimental Parasitology, vol. 83, no. 1, pp. 106-116, 1996. (Pubitemid 26233120)
218. W. I. Morrison, S. J. Black, and J. Paris, "Protective immunity and specificity of antibody responses elicited in cattle by irradiated Trypanosoma brucei," Parasite Immunology, vol. 4, no. 6, pp. 395-407, 1982. (Pubitemid 13182262)
219. R. E. Duxbury, E. H. Sadun, B. T. Wellde, J. S. Anderson, and I. E. Muriithi, "Immunization of cattle with x-irradiated African trypanosomes," Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 66, no. 2, pp. 349-350, 1972.
220. D. M. Mosser and J. F. Roberts, "Trypanosoma brucei: recognition in vitro of two developmental forms by murine macrophages," Experimental Parasitology, vol. 54, no. 3, pp. 310-316, 1982. (Pubitemid 13149789)
221. W. Pan, O. Ogunremi, G. Wei, M. Shi, and H. Tabel, "CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor α and nitric oxide," Microbes and Infection, vol. 8, no. 5, pp. 1209-1218, 2006. (Pubitemid 43831686)
222. D. M. Reinitz and J. M. Mansfield, "T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice," Infection and Immunity, vol. 58, no. 7, pp. 2337-2342, 1990. (Pubitemid 20212316)
223. L. Schofield, M. J. McConville, D. Hansen, et al., "CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells," Science, vol. 283, no. 5399, pp. 225-229, 1999.
224. J. A. Macaskill, P. H. Holmes, D. D. Whitelaw, et al., "Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. II. Mechanisms in immune animals," Immunology, vol. 40, no. 4, pp. 629-635, 1980. (Pubitemid 10035026)
225. W. L. Dempsey and J. M. Mansfield, "Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity," Journal of Immunology, vol. 130, no. 1, pp. 405-411, 1983. (Pubitemid 13172689)
226. R. F. Levine and J. M. Mansfield, "Genetics of resistance to the African trypanosomes: III. Variant-specific antibody responses of H-2-compatible resistant and susceptible mice," Journal of Immunology, vol. 133, no. 3, pp. 1564-1569, 1984. (Pubitemid 14058339)
227. S. J. Black, C. N. Sendashonga, and P. Webster, "Regulation of parasite-specific antibody responses in resistant (C57BL/6) and susceptible (C3H/He) mice infected with Trypanosoma (trypanozoon) brucei brucei," Parasite Immunology, vol. 8, no. 5, pp. 425-442, 1986. (Pubitemid 16016445)
228. S. M. Mahan, L. Hendershot, and S. J. Black, "Control of trypanodestructive antibody responses and parasitemia in mice infected with Trypanosoma (Duttonella) vivax," Infection and Immunity, vol. 54, no. 1, pp. 213-221, 1986. (Pubitemid 16021236)
229. P. H. Lambert, M. Berney, and G. Kazyumba, "Immune complexes in serum and in cerebrospinal fluid in African try-panosomiasis. Correlation with polyclonal B cell activation and with intracerebral immunoglobulin synthesis," Journal of Clinical Investigation, vol. 67, no. 1, pp. 77-85, 1981. (Pubitemid 11163159)
230. B. A. Askonas, A. C. Corsini, C. E. Clayton, and B. M. Ogilvie, "Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations during trypanosomia-sis," Immunology, vol. 36, no. 2, pp. 313-321, 1979. (Pubitemid 9253835)
231. J. A. Ellis, J. R. Scott, and N. D. Machugh, "Peripheral blood leucocytes subpopulation dynamics during Trypanosoma congolense infection in Boran and N'Dama cattle: an analysis using monoclonal antibodies and flow cytometry," Parasite Immunology, vol. 9, no. 3, pp. 363-378, 1987. (Pubitemid 17074202)
232. K. M. Hudson and R. J. Terry, "Immunodepression and the course of infection of a chronic Trypanosoma brucei infection in mice," Parasite Immunology, vol. 1, no. 4, pp. 317-326, 1979. (Pubitemid 10100712)
233. S. Magez, A. Schwegmann, R. Atkinson, et al., "The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice," PLoS Pathogens, vol. 4, no. 8, Article ID e1000122, 2008.
234. K. A. Taylor, "Immune responses of cattle to African try-panosomes: protective or pathogenic?" International Journal for Parasitology, vol. 28, no. 2, pp. 219-240, 1998. (Pubitemid 28097656)
235. A. Darji, R. Lucas, S. Magez, et al., "Mechanisms underlying trypanosome-elicited immunosuppression," Annales de la Societe Belge de Medecine Tropicale, vol. 72, supplement 1, pp. 27-38, 1992.
236. J. N. Flynn and M. Sileghem, "The role of the macrophage in induction of immunosuppression in Trypanosoma con-golense-infected cattle," vol. 74, no. 2, pp. 310-316, 1991.
237. M. Sileghem, A. Darji, and P. De Baetselier, "In vitro simulation of immunosuppresion caused by Trypanosoma brucei," Immunology, vol. 73, no. 2, pp. 246-248, 1991.
238. H. Tabel, G. Wei, and M. Shi, "T cells and immunopathogen-esis of experimental African trypanosomiasis," Immunologi-cal Reviews, vol. 225, no. 1, pp. 128-139, 2008.
239. N. K. Borowy, J. M. Sternberg, D. Schreiber, C. Nonnengasser, and P. Overath, "Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro," Parasite Immunology, vol. 12, no. 3, pp. 233-246, 1990. (Pubitemid 20184706)
240. M. Sileghem, A. Darji, R. Hamers, M. Van de Winkel, and P. De Baetselier, "Dual role of macrophages in the suppression of interleukin 2 production and interleukin 2 receptor expression in trypanosome-infected mice," European Journal of Immunology, vol. 19, no. 5, pp. 829-835, 1989. (Pubitemid 19165441)
241. K. W. Schleifer and J. M. Mansfield, "Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins," Journal of Immunology, vol. 151, no. 10, pp. 5492-5503, 1993. (Pubitemid 23332359)
242. A. Beschin, L. Brys, S. Magez, M. Radwanska, and P. De Baetselier, "Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms," Journal of Leukocyte Biology, vol. 63, no. 4, pp. 429-439, 1998. (Pubitemid 28163182)
243. N. A. Mabbott, P. S. Coulson, L. E. Smythies, R. A. Wilson, and J. M. Sternberg, "African trypanosome infections in mice that lack the interferon-γ receptor gene: nitric oxide-dependent and -independent suppression of T-cell proliferative responses and the development of anaemia," Immunology, vol. 94, no. 4, pp. 476-480, 1998. (Pubitemid 28352785)
244. A. Darji, A. Beschin, M. Sileghem, H. Heremans, L. Brys, and P. De Baetselier, "In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression," Infection and Immunity, vol. 64, no. 6, pp. 1937-1943, 1996. (Pubitemid 26165649)
245. B. Namangala, L. Brys, S. Magez, P. De Baetselier, and A. Beschin, "Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages," Parasite Immunology, vol. 22, no. 7, pp. 361-370, 2000. (Pubitemid 30417360)
246. A. Darji, M. Sileghem, H. Heremans, L. Brys, and P. De Baetselier, "Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon," Infection and Immunity, vol. 61, no. 7, pp. 3098-3102, 1993. (Pubitemid 23182317)
247. G. Raes, P. De Baetselier, W. Noël, A. Beschin, F. Brombacher, and H. G. Gholamreza, "Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages," Journal of Leukocyte Biology, vol. 71, no. 4, pp. 597-602, 2002.
248. B. Namangala, P. De Baetselier, W. Noël, L. Brys, and A. Beschin, "Alternative versus classical macrophage activation during experimental African trypanosomosis," Journal of Leukocyte Biology, vol. 69, no. 3, pp. 387-396, 2001. (Pubitemid 32221442)
249. L. Ding, P. S. Linsley, L. Y. Huang, R. N. Germain, and E. M. Shevach, "IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression," Journal of Immunology, vol. 151, no. 3, pp. 1224-1234, 1993. (Pubitemid 23219258)
250. M. Guilliams, G. Oldenhove, W. Noel, et al., "African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation," Journal of Immunology, vol. 179, no. 5, pp. 2748-2757, 2007.
251. M. Guilliams, T. Bosschaerts, M. Hérin, et al., "Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis," Journal of Infectious Diseases, vol. 198, no. 5, pp. 781-791, 2008.
252. B. Stijlemans, T. N. Baral, M. Guilliams, et al., "A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis- associated immunopathology," Journal of Immunology, vol. 179, no. 6, pp. 4003-4014, 2007.
253. G. D. M. D'Ieteren, E. Authié, N. Wissocq, and M. Murray, "Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis," OIE Revue Scientifique et Technique, vol. 17, no. 1, pp. 154-175, 1998. (Pubitemid 128366520)
254. J. Naessens, "Bovine trypanotolerance: a natural ability to prevent severe anaemia and haemophagocytic syndrome?" International Journal for Parasitology, vol. 36, no. 5, pp. 521-528, 2006. (Pubitemid 43674511)
255. B. Stijlemans, A. Vankrunkelsven, L. Brys, S. Magez, and P. De Baetselier, "Role of iron homeostasis in trypanosomiasis-associated anemia," Immunobiology, vol. 213, no. 9-10, pp. 823-835, 2008.
256. O. O. Akinbamijo, J. J. Bennison, J. Jaitner, and L. Dempfle, "Haematological changes in N'Dama and Gobra Zebu bulls during Trypanosoma congolense infection maintained under a controlled feeding regimen," Acta Tropica, vol. 69, no. 3, pp. 181-192, 1998. (Pubitemid 28243241)
257. K. A. Taylor and B. Mertens, "Immune Response of Cattle Infected with African trypanosomes," Memorias do Instituto Oswaldo Cruz, vol. 94, no. 2, pp. 239-244, 1999. (Pubitemid 129619988)
258. S. Magez, B. Stijlemans, M. Radwanska, E. Pays, M. A. J. Ferguson, and P. De Baetselier, "The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glyco-sylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors," Journal of Immunology, vol. 160, no. 4, pp. 1949-1956, 1998. (Pubitemid 28106485)
259. S. Magez, C. Truyens, M. Merimi, et al., "P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis," Journal of Infectious Diseases, vol. 189, no. 3, pp. 527-539, 2004. (Pubitemid 38210590)
260. M. C. Okomo-Assoumou, S. Daulouede, J.-L. Lemesre, A. N'Zila-Mouanda, and P. Vincendeau, "Correlation of high serum levels of tumor necrosis factor-α with disease severity in human African trypanosomiasis," American Journal of Tropical Medicine and Hygiene, vol. 53, no. 5, pp. 539-543, 1995.
261. V. Lejon, J. Lardon, G. Kenis, et al., "Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambi-ense sleeping sickness patients before and after treatment," Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 96, no. 3, pp. 329-333, 2002. (Pubitemid 34785077)
262. L. MacLean, M. Odiit, and J. M. Sternberg, "Nitric oxide and cytokine synthesis in human African trypanosomiasis," Journal of Infectious Diseases, vol. 184, no. 8, pp. 1086-1090, 2001. (Pubitemid 32955130)
263. C. A. Hunter, J. W. Gow, P. G. E. Kennedy, F. W. Jennings, and M. Murray, "Immunopathology of experimental African sleeping sickness: detection of cytokine mRNA in the brains of Trypanosoma brucei brucei-infected mice," Infection and Immunity, vol. 59, no. 12, pp. 4636-4640, 1991.
264. C. A. Hunter and P. G. E. Kennedy, "Immunopathology in central nervous system human African trypanosomiasis," Journal of Neuroimmunology, vol. 36, no. 2-3, pp. 91-95, 1992.
265. M. Sileghem, J. N. Flynn, L. Logan-Henfrey, and J. Ellis, "Tumour necrosis factor production by monocytes from cattle infected with Trypanosoma (Duttonella) vivax and Trypanosoma (Nannomonas) congolense: possible association with severity of anaemia associated with the disease," Parasite Immunology, vol. 16, no. 1, pp. 51-54, 1994. (Pubitemid 24176420)
266. P. P. Simarro, J. Jannin, and P. Cattand, "Eliminating human African trypanosomiasis: where do we stand and what comes next?" PLoS Medicine, vol. 5, no. 2, article e55, 2008.
267. J. Bouyer, F. Stachurski, A. S. Gouro, and R. Lancelot, "Control of bovine trypanosomosis by restricted application of insecticides to cattle using footbaths," Veterinary Parasitology, vol. 161, no. 3-4, pp. 187-193, 2009.
268. M. O. Omolo, A. Hassanali, S. Mpiana, et al., "Prospects for developing odour baits to control Glossina fuscipes spp., the major vector of human African trypanosomiasis," PLoS Neglected Tropical Diseases, vol. 3, no. 5, article e435, 2009.
269. A. F. Read, P. A. Lynch, and M. B. Thomas, "How to make evolution-proof insecticides for malaria control," PLoS Biology, vol. 7, no. 4, article e1000058, 2009.
270. P. G. E. Kennedy, "Human African trypanosomiasis of the CNS: current issues and challenges," Journal of Clinical Investigation, vol. 113, no. 4, pp. 496-504, 2004. (Pubitemid 38542496)
271. A. H. Fairlamb, "Chemotherapy of human African try-panosomiasis: current and future prospects," Tr e n d s i n Parasitology, vol. 19, no. 11, pp. 488-494, 2003. (Pubitemid 37329657)
272. D. Legros, G. Ollivier, M. Gastellu-Etchegorry, et al., "Treatment of human African trypanosomiasis-present situation and needs for research and development," Lancet Infectious Diseases, vol. 2, no. 7, pp. 437-440, 2002. (Pubitemid 34693262)
273. C. Burri and R. Brun, "Eflornithine for the treatment of human African trypanosomiasis," Parasitology Research, vol. 90, supplement 1, pp. S49-S52, 2003. (Pubitemid 36831292)
274. C. Burri, S. Nkunku, A. Merolle, T. Smith, J. Blum, and R. Brun, "Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial," The Lancet, vol. 355, no. 9213, pp. 1419-1425, 2000. (Pubitemid 30215965)
275. J. Pepin and F. Milord, "The treatment of human African trypanosomiasis," Advances in Parasitology, vol. 33, pp. 1-47, 1994. (Pubitemid 23357084)
276. C. Schmid, M. Richer, C. M. M. Bilenge, et al., "Effectiveness of a 10-day melarsoprol schedule for the treatment of latestage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II)," Journal of Infectious Diseases, vol. 191, no. 11, pp. 1922-1931, 2005. (Pubitemid 40705401)
277. C. Schmid, S. Nkunku, A. Merolle, P. Vounatsou, and C. Burri, "Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness," The Lancet, vol. 364, no. 9436, pp. 789-790, 2004. (Pubitemid 39165100)
278. F. W. Jennings, J. Rodgers, B. Bradley, G. Gettinby, P. G. E. Kennedy, and M. Murray, "Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen," Parasitology International, vol. 51, no. 4, pp. 381-388, 2002. (Pubitemid 35287509)
279. M. Eisler, J. Brandt, B. Bauer, et al., "Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle," Veterinary Parasitology, vol. 97, no. 3, pp. 171-182, 2001. (Pubitemid 32522825)
280. S. Geerts, P. H. Holmes, O. Diall, and M. C. Eisler, "African bovine trypanosomiasis: the problem of drug resistance," Trends in Parasitology, vol. 17, no. 1, pp. 25-28, 2001.
281. V. Delespaux, D. Geysen, P. A. O. Majiwa, and S. Geerts, "Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense," International Journal for Parasitology, vol. 35, no. 2, pp. 235-243, 2005. (Pubitemid 40248718)
282. A. S. Peregrine, "Chemotherapy and delivery systems: haemoparasites," Veterinary Parasitology, vol. 54, no. 1-3, pp. 223-248, 1994. (Pubitemid 24294206)
283. P. Van den Bossche, M. Doran, and R. J. Connor, "An analysis of trypanocidal drug use in the Eastern Province of Zambia," Acta Tropica, vol. 75, no. 2, pp. 247-258, 2000. (Pubitemid 30120036)
284. C. J. Bacchi, "Resistance to clinical drugs in African try-panosomes," Parasitology Today, vol. 9, no. 5, pp. 190-193, 1993. (Pubitemid 23126434)
285. P. Mäser, A. Lüscher, and R. Kaminsky, "Drug transport and drug resistance in African trypanosomes," Drug Resistance Updates, vol. 6, no. 5, pp. 281-290, 2003. (Pubitemid 37493784)
286. N. S. Carter, B. J. Berger, and A. H. Fairlamb, "Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and-resistant Trypanosoma brucei brucei," The Journal of Biological Chemistry, vol. 270, no. 47, pp. 28153-28157, 1995.
287. A. H. Fairlamb, N. S. Carter, M. Cunningham, and K. Smith, "Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism," Molecular and Biochemical Parasitology, vol. 53, no. 1-2, pp. 213-222, 1992.
288. H. Pospichal, R. Brun, R. Kaminsky, and L. Jenni, "Induction of resistance to melarsenoxide cysteamine (Mel Cy) in Trypanosoma brucei brucei," Acta Tropica, vol. 58, no. 3-4, pp. 187-197, 1994.
289. E. Matovu, M. L. Stewart, F. Geiser, et al., "Mechanisms of arsenical and diamidine uptake and resistance in Tr y -panosoma brucei," Eukaryotic Cell, vol. 2, no. 5, pp. 1003-1008, 2003. (Pubitemid 37298713)
290. V. P. Alibu, C. Richter, F. Voncken, et al., "The role of Trypanosoma brucei MRPA in melarsoprol susceptibility," Molecular and Biochemical Parasitology, vol. 146, no. 1, pp. 38-44, 2006. (Pubitemid 43132801)
291. S. K. Shahi, R. L. Krauth-Siegel, and C. E. Clayton, "Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei," Molecular Microbiology, vol. 43, no. 5, pp. 1129-1138, 2002. (Pubitemid 34304532)
292. W. H. Witola, A. Tsuda, N. Inoue, K. Ohashi, and M. Onuma, "Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40," Parasitology, vol. 131, no. 5, pp. 635-646, 2005. (Pubitemid 41577937)
293. B. Stijlemans, K. Conrath, V. Cortez-Retamozo, et al., "Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies: African trypanosomes as paradigm," The Journal of Biological Chemistry, vol. 279, no. 2, pp. 1256-1261, 2004. (Pubitemid 38082649)
294. E. Authié, A. Boulangé, D. Muteti, G. Lalmanach, F. Gauthier, and A. J. Musoke, "Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targetting the disease rather than the parasite," International Journal for Parasitol-ogy, vol. 31, no. 13, pp. 1429-1433, 2001. (Pubitemid 32946997)
295. G. W. Lubega, D. K. Byarugaba, and R. K. Prichard, "Immunization with a tubulin-rich preparation from Tr y -panosoma brucei confers broad protection against African trypanosomosis," Experimental Parasitology, vol. 102, no. 1, pp. 9-22, 2002. (Pubitemid 36279579)
296. S.-Q. Li, M.-C. Fung, S. A. Reid, N. Inoue, and Z.-R. Lun, "Immunization with recombinant beta-tubulin from Trypanosoma evansi induced protection against T. e v a n s i , T. equiperdum and T. b. b r u c e i infection in mice," Parasite Immunology, vol. 29, no. 4, pp. 191-199, 2007. (Pubitemid 46434885)
297. N. Antoine-Moussiaux, P. Büscher, and D. Desmecht, "Hostparasite interactions in trypanosomiasis: on the way to an antidisease strategy," Infection and Immunity, vol. 77, no. 4, pp. 1276-1284, 2009.