Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA

Infection and Immunity

Volumn 74, Issue 8, 2006, Pages 4530-4537

  Harris, Tajie H ^a   Cooney, Nicole M ^a   Mansfield, John M ^b   Paulnock, Donna M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYCLOOXYGENASE 2; CYTOSINE; DEOXYRIBONUCLEASE I; DNA; GUANINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; LIGAND; MESSENGER RNA; NITRIC OXIDE; PROTEIN P40;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CYTOKINE PRODUCTION; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; IMMUNOSTIMULATION; INFECTION RESISTANCE; INNATE IMMUNITY; MACROPHAGE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; BONE MARROW CELLS; CELL LINE; CYTOKINES; DNA, PROTOZOAN; GENE EXPRESSION; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, CONGENIC; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 33746645926     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01938-05     Document Type: Article

References (52)

1. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
2. Baetselier, P. D., B. Namangala, W. Noel, L. Brys, E. Pays, and A. Beschin. 2001. Alternative versus classical macrophage activation during experimental African trypanosomosis. Int. J. Parasitol. 31:575-587.
3. Brown, W. C., D. M. Estes, S. E. Chantler, K. A. Kegerreis, and C. E. Suarez. 1998. DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells. Infect. Immun. 66:5423-5432.
4. Cardon, L. R., C. Burge, D. A. Clayton, and S. Karlin. 1994. Pervasive CpG suppression in animal mitochondrial genomes. Proc. Natl. Acad. Sci. USA 91:3799-3803.
5. Coller, S. P., J. M. Mansfield, and D. M. Paulnock. 2003. Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. J. Immunol. 171:1466-1472.
6. Dempsey, W. L., and J. M. Mansfield. 1983. Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity. J. Immunol. 130:405-411.
7. Diffley, P., and A. N. Jayawardena. 1982. Surface coat variant antigen of Trypanosoma brucei brucei: its clearance from blood and concentration in organs of normal, infected, and immune mice. Infect. Immun. 35:173-178.
8. Drennan, M. B., B. Stijlemans, J. Van den Abbeele, V. J. Quesniaux, M. Barkhuizen, F. Brombacher, P. De Baetselier, B. Ryffel, and S. Magez. 2005. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J. Immunol. 175:2501-2509.
9. Dubois, M. E., K. P. Demick, and J. M. Mansfield. 2005. Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system. Infect. Immun. 73:2690-2697.
10. El-Sayed, N. M., P. Hegde, J. Quackenbush, S. E. Melville, and J. E. Donelson. 2000. The African trypanosome genome. Int. J. Parasitol. 30:329-345.
11. Gommers-Ampt, J., J. Lutgerink, and P. Borst. 1991. A novel DNA nucleotide in Trypanosoma brucei only present in the mammalian phase of the life-cycle. Nucleic Acids Res. 19:1745-1751.
12. Gordon, S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3:23-35.
13. Grosskinsky, C. M., and B. A. Askonas. 1981. Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis. Infect. Immun. 33:149-155.
14. Grosskinsky, C. M., R. A. Ezekowitz, G. Berton, S. Gordon, and B. A. Askonas. 1983. Macrophage activation in murine African trypanosomiasis. Infect. Immun. 39:1080-1086.
15. Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:6230-6240.
16. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
17. Hertz, C. J., H. Filutowicz, and J. M. Mansfield. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J. Immunol. 161:6775-6783.
18. Hertz, C. J., and J. M. Mansfield. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell. Immunol. 192:24-32.
19. Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165:618-622.
20. Huang, L. Y., K. J. Ishii, S. Akira, J. Aliberti, and B. Golding. 2005. Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J. Immunol. 175:3964-3970.
21. Institute for Genomic Research. 23 July 2004, last date modified. The TIGR Index Databases. The Institute for Genomic Research. [Online.] ftp://ftp. tigr.org/pub/data/tgi/Trypanosoma_brucei/.
22. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5:987-995.
23. Janeway, C. A., Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu. Rev. Immunol. 20:197-216.
24. Khabar, K. S. 2005. The AU-rich transcriptome: more than interferons and cytokines, and its role in disease. J. Interferon Cytokine Res. 25:1-10.
25. Krieg, A. M. 2002 CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709-760.
26. Krieg, A. M., A. K. Yi, S. Maison, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995 CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549.
27. Levine, R. F., and J. M. Mansfield. 1984. Genetics of resistance to the African trypanosomes. III. Variant-specific antibody responses of H-2-compatible resistant and susceptible mice. J. Immunol. 133:1564-1569.
28. Lund, J., A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki. 2003. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198:513-520.
29. Magez, S., M. Radwanska, A. Beschin, K. Sekikawa, and P. De Baetselier. 1999. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infect. Immun. 67:3128-3132.
30. Mansfield, J. M. 1995. Immunobiology of trypanosomiasis: a revisionist view, p. 477-496. In J. C. Boothroyd (ed.), Molecular approaches to parasitology. Wiley-Liss, Inc., New York, N.Y.
31. Mansfield, J. M., C. J. Hertz, A. Thompson, K. P. Demick, L. R. Schopf, J. Sypeck, and D. M. Paulnock. Submitted for publication.
32. Montoya, M., G. Schiavoni, F. Mattel, I. Gresser, F. Belardelli, P. Borrow, and D. F. Tough. 2002. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99:3263-3271.
33. Namangala, B., W. Noel, P. De Baetselier, L. Brys, and A. Beschin. 2001. Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis. J. Infect. Dis. 183:1794-1800.
34. Paulnock, D. M., and S. P. Coller. 2001. Analysis of macrophage activation in African trypanosomiasis. J. Leukoc. Biol. 69:685-690.
35. Pullen, J. K., E. Eustis-Turf, M. J. Myers, and L. B. Schock. 1989. Regulation of MHC gene expression during the differentiation of bone marrow-derived macrophages. Cell. Immunol. 121:398-413.
36. Reinitz, D. M., and J. M. Mansfield. 1990. T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice. Infect. Immun. 58:2337-2342.
37. Roberts, T. L., J. A. Dunn, T. D. Terry, M. P. Jennings, D. A. Hume, M. J. Sweet, and K. J. Stacey. 2005. Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. J. Immunol. 175:3569-3576.
38. Ropert, C., and R. T. Gazzinelli. 2000. Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa. Curr. Opin. Microbiol. 3:395-403.
39. Schleifer, K. W., H. Filutowicz, L. R. Schopf, and J. M. Mansfield. 1993. Characterization of T helper cell responses to the trypanosome variant surface glycoprotein. J. Immunol. 150:2910-2919.
40. Schleifer, K. W., and J. M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
41. Sester, D. P., S. Naik, S. J. Beasley, D. A. Hume, and K. J. Stacey. 2000. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J. Immunol. 165:4165-4173.
42. Shoda, L. K., K. A. Kegerreis, C. E. Suarez, I. Roditi, R. S. Corral, G. M. Bertot, J. Norimine, and W. C. Brown. 2001. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect. Immun. 69:2162-2171.
43. Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116-2122.
44. Stacey, K. J., G. R. Young, F. Clark, D. P. Sester, T. L. Roberts, S. Naik, M. J. Sweet, and D. A. Hume. 2003. The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. J. Immunol. 170:3614-3620.
45. Sternberg, J. M., J. Rodgers, B. Bradley, L. Maclean, M. Murray, and P. G. Kennedy. 2005. Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. J. Neuroimmunol. 167:81-89.
46. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133-146.
47. Tsumita, T., and M. Iwanaga. 1963. Fate of injected deoxyribonucleic acid in mice. Nature 198:1088-1089.
48. Webb, H., N. Carnall, L. Vanhamme, S. Rolin, J. Van Den Abbeele, S. Welburn, E. Pays, and M. Carrington. 1997. The GPI-phospholipase C of Trypanosoma brucei is nonessential but influences parasitemia in mice. J. Cell Biol. 139:103-114.
49. Yamada, H., I. Gursel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman. 2002. Effect of suppressive DNA on CpG-induced immune activation. J. Immunol. 169:5590-5594.
50. Yeo, S. J., J. G. Yoon, and A. K. Yi. 2003. Myeloid differentiation factor 88-dependent posttranscriptional regulation of cyclooxygenase-2 expression by CpG DNA: tumor necrosis factor-alpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling. J. Biol. Chem. 278:40590-40600.
51. Yi, A. K., J. H. Chace, J. S. Cowdery, and A. M. Krieg. 1996. IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156:558-564.
52. Yi, A. K., and A. M. Krieg. 1998. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J. Immunol. 161:4493-4497.