Implications of conserved structural motifs in disparate trypanosome surface proteins

Molecular and Biochemical Parasitology

Volumn 81, Issue 2, 1996, Pages 119-126

  Carrington, Mark ^a   Boothroyd, John ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antigenic variation; ISG; tertiary structure conservation; Trypanosoma brucei; VSG

Indexed keywords

CYSTEINE; DISULFIDE; VARIANT SURFACE GLYCOPROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ANTIGENIC VARIATION; CELL SURFACE; HOST PARASITE INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TERTIARY STRUCTURE; REVIEW; TRYPANOSOMA BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0030607411     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02706-5     Document Type: Short Survey

References (27)

1. [1] Cross, G.A.M. (1990) Cellular and genetic aspects of antigenic variation in trypanosomes. Ann. Rev. Immunol. 8, 83-110.
2. [2] Vickerman, K. (1969) On the surface coat and flagellar adhesion in trypanosomes. J. Cell Sci. 5, 163-193.
3. [3] Ziegelbauer, K., Multhaup, G. and Overath, P. (1992) Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei. J. Biol. Chem. 267, 10797-10803.
4. [4] Johnson, J.G. and Cross, G.A.M. (1979) Selective cleavage of variant surface glycoproteins from Trypanosoma brucei. Biochem. J. 178, 689-697.
5. [5] Metcalf, P., Down, J.A., Turner, M.J. and Wiley, D.C. (1988) Crystallization of amino-terminal domains and domain fragments of variant surface glycoproteins from Trypanosoma brucei. J. Biol. Chem. 263, 17030-17033.
6. [6] Ferguson, M.A.J., Romans, S.W., Dwek, R.A. and Rademacher, T.W. (1988) Glycosylphosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science 239, 753-759.
7. [7] Carrington, M., Miller, N., Blum, M., Roditi, I., Wiley, D. and Turner, M. (1991) Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues. J. Mol. Biol. 221, 823-835.
8. [8] Strickler, J.E., Binder, D.A., L'Italien, J.J., Shimamoto, G.T., Wait, S.W., Dalheim, L.J., Novotny, J., Radding, J.A., Konigsberg, W.H., Armstrong, M.Y.K., Richards, F.F. and Lalor, T.M. (1987) Trypanosoma congolense: structure and molecular organisation of the surface glycoproteins of two early bloodstream variants. Biochemistry 26, 796-805.
9. [9] Rausch, S., Shavan, P., Salnikoff, J. and Reinwald, E. (1994) Sequence determination of 3 variable surface glycoproteins from Trypanosoma congolense - conserved sequence and structural motifs. Eur. J. Biochem. 223, 813-821.
10. [10] Blum, M.L., Down, J.A., Gurnett, A.M., Carrington, M., Turner, M.J. and Wiley, D, (1993) A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 362, 603-609.
11. [11] Auffret, C.A. and Turner, M.J. (1981) Variant specific antigens of Trypanosoma brucei exist in solution as glycoprotein dimers. Biochem. J. 193. 647-650.
12. [12] Freymann, D., Down, G., Carrington, M., Roditi, I., Turner, M.J. and Wiley, D.C. (1990) 2.9 Å resolution structure of the N-terminal domain of a variable surface glycoprotein from Trypanosoma brucei. J. Mol. Biol. 216, 141-160.
13. [13] Pays, E., Tebabi, P., Pays, A., Coquelet, H., Revelard, P., Salmon, D. and Steinert, M. (1989) The genes and transcripts of an antigen gene expression site from T. brucei. Cell 57, 835-845.
14. [14] Schell, D., Evers, R., Preis, D., Ziegelbauer, K., Kiefer, H., Lottspeich, F., Cornelissen, A.W.C.A. and Overath, P. (1991) A tranferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein expression site. EMBO J. 10, 1061-1066.
15. [15] Salmon, D., Geuskens, M., Hanocq, F., Hanocq-Quertier, J., Nolan, D., Ruben, L. and Pays, E. (1994) A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei. Cell 78, 75-86.
16. [16] Steverding, D., Stierhof, Y.-D., Chaudhri, M., Ligtenberg, M., Schell, D., Beck-Sickinger, A.G. and Overath, P. (1994) ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding complex. Eur. J. Cell Biol. 64, 78-87.
17. [17] Koenig-Martin, E., Yamage, M. and Roditi, I. (1992) A procyclin-associated gene in Trypanosoma brucei encodes a polypeptide related to ESAG 6 and 7 proteins. Mol. Biochem. Parasitol. 55, 135-145.
18. [18] De Greef, C. and Hamers, R. (1994) The serum resistance associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a VSG-like protein. Mol. Biochem. Parasitol. 68, 277-284.
19. [19] Roditi, I., Schwartz, H., Pearson, T.W., Beecroft, R.P., Liu, M.K., Richardson, J.P., Bühring, H.-J., Pleiss, J., Bülow, R., Williams, R.O. and Overath, P. (1989) Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei. J. Cell Biol. 108, 737-746.
20. [20] Jackson, D.G., Smith, O.K., Luo, C. and Elliott, J.F. (1993) Cloning of a novel surface antigen from the insect stages of Trypanosoma brucei by expression in COS cells J. Biol. Chem. 268, 1894-1900.
21. [21] Bringaud, F. and Baltz, T. (1992) A potential hexose transporter gene expressed predominantly in the bloodstream form of Trypanosma brucei. Mol. Biochem. Parasitol. 52, 145-148.
22. [22] Ziegelbauer, K. and Overath, P. (1993) Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei. Infect. Immun. 61, 4540-4545.
23. [23] Overath, P., Chaudhri, M., Steverding, D. and Ziegelbauer, K. (1994) Invariant surface glycoproteins in bloodstream forms of Trypanosoma brucei. Parasitol. Today, 53-58.
24. [24] Hobbs, M.R. and Boothroyd, J.C. (1990) An expression-site-associated gene family of trypanosomes is expresses in vivo and shows homology to a variant surface glycoprotein gene. Mol. Biochem. Parasitol. 43, 1-16.
25. [25] Allen, G. and Gurnett, L.P. (1983) Locations of the six disulphide bonds in a variant surface glycoprotein (VSG 117) of Trypanosoma brucei. Biochem. J. 209, 481-487.
26. [26] Allen, G., Gurnett, L.P. and Cross, G.A.M. (1982) Complete amino acid sequence of a variant surface glycoprotein (VSG 117) from Trypanosoma brucei. J. Mol. Biol 157, 527-546.
27. [27] Boothroyd, J.C., Paynter, C.A., Coleman, S.L. and Cross, G.A.M. (1982) Complete nucleotide sequence of complementary DNA coding for a variant surface glycoprotein from Trypanosoma brucei. J. Mol. Biol. 157, 547-556.