Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages

Parasite Immunology

Volumn 22, Issue 7, 2000, Pages 361-370

  Namangala, B ^a   Brys, L ^a   Magez, S ^a   De Baetselier, P ^a   Beschin, A ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Antigen presentation; Immunosuppression; Trypanosoma

Indexed keywords

CD4 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; FEMALE; HYBRIDOMA; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

ANIMALS; ANTIGEN PRESENTATION; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0034126492     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2000.00314.x     Document Type: Article

References (35)

1. + macrophages and associated immunosuppression in African trypanosomiasis. Infection and Immunity 32, 188-193
2. Beschin A., Brys L., Magez S., Radwanska M. & De Baetselier P. (1998) Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms. Journal of Leukocyte Biology 63, 429-439
3. Borrowy N.K., Sternberg J.M., Schreiber D., Nonnengaesser C. & Overath P. (1990) Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibits T cell responses in vivo and in vitro. Parasite Immunology 12, 233-246
4. Borst P. & Rudenko G. (1994) Antigenic variation in African trypanosomes. Science 264, 1872-1873
5. Buus S.A., Sette A. & Grey H.M. (1987) The interaction between protein-derived immunogenic peptides and Ia. Immunological Reviews 98, 115-141
6. Darji A., Beschin A., Sileghem M. et al. (1996) In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression. Infection and Immunity 64, 1937-1943
7. Ding L., Linsley P.S., Huang L.-Y., Germain R.N. & Shevach E.M. (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. Journal of Immunology 151, 1224-1234
8. Grosskinsky C.M. & Askonas B.A. (1981) Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis. Infection and Immunity 33, 149-155
9. Howard M. & O'Garra A. (1992) Biological properties of interleukin 10. Immunology Today 13, 198-200
10. Kaufmann J., Dwinger R.H., Halleweek A., Van Dijk B. & Pfister K. (1992) The interaction of Trypanosoma congolense and Haemonchus contortus infections in trypanotolerant N'Dama cattle. Veterinary Parasitology 43, 157-170
11. Kima P.E., Soong L., Chicharro C., Ruddle N.H. & MacMahon-Pratt D. (1996) Leishmania-infecled macrophages sequester endogenously synthesised parasite antigens from presentation to CD4+ T cells. European Journal of Immunology 26, 3163-3169
12. Kissling K., Karbe E. & Fretas E.K. (1982) In vitro phagocytic activity of neutrophils of various cattle breeds with and without Trypanosoma congolense infection. Tropical Medicine and Parasitology 33, 158-160
13. La Flamme A.C., Kahn S.J., Rudensky A.Y. & Van Voorhis W.C. (1997) Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation. European Journal of Immunology 27, 3085-3094
14. Leyva-Cobian F. & Unanue E.R. (1988) Intracellular interference with antigen presentation. Journal of Immunology 141, 1445-1450
15. MacKenzie P.K.I., Boyt W.P., Nesham V.W. & Pirie E. (1978) The aetiology and significance of the phagocytosis of erythrocytes and leukocytes in sheep infected with Trypanosoma congolense (Broden, 1904). Research in Veterinary Science 24, 4-7
16. Magez S., Radwanska M., Beschin A., Sekikawa K. & De Baetselier P. (1999) Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infection and Immunity. 67, 3128-3132
17. Magez S., Stijlemans B., Radwanska M. et al. (1998) The glysosylinositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors. Journal of Immunology 160, 1949-1956
18. Mitchell L.A., Pearson T.W. & Gauldie J. (1986) Interleukin-1 and interleukin-2 production in resistant and susceptible inbred mice infected with Trypanosoma congolense. Immunology 57, 291-296
19. Overath P. & Aebischer T. (1999) Antigen presentation by macrophages harboring intravesicular pathogens. Parasitology Today 15, 325-332
20. Pancholi P., Mizra A., Bhardwaj N. & Steinman R.M. (1993) Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages. Science 260, 984-986
21. Paulnock C.M., Smith C. & Mansfield J.M. (1988) Antigen presenting cell function in African trypanosomiasis. In Antigen Presenting Cells: Diversity, Differentiation and Regulation, eds, L.B. Schook & J.G. Tew, pp. 135-143, Alan R. Liss, Inc, New York
22. Pierre P. & Mellman I. (1998) Exploring the mechanisms of antigen processing by cell fractionation. Current Opinion in Immunology 10, 145-153
23. Plasman N., Guillet J.-G. & Vray B. (1995) Impaired catabolism in Trypanosoma cruzi-infected macrophages: possible involvement of in antigen presentation. Immunology 86, 636-645
24. Prina E., Jouanne C., De Souza Lao S. et al. (1993) Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes. Journal of Immunology 151, 2050-2061
25. Rurangirwa F.R., Tabel H., Losos G., Masiga W.N. & Mwambu P. (1978) Immunosuppressive effect of Trypanosoma congolense and Trypanosoma vivax on the secondary immune response of cattle to Mycoplasma mycoides subsp. mycoides. Research in Veterinary Science 25, 395-397
26. Schleifer K.W. & Mansfield J.M. (1993) Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative response by nitric oxide and prostaglandins. Journal of Immunology 151, 5492-5503
27. Scorza T., Magez S., Brys L. & De Baetselier P. (1999) Hemozoin is a key factor in the induction of malaria-associated immunosuppression. Parasite Immunology 21, 545-554
28. Sileghem M., Darji A., Hammers R., Van De Winkel M. & De Baetselier P. (1989a) Dual role of macrophages in the suppression of interleukin-2 production and interleukin-2 receptor expression in Trypanosome-infectecl mice. European Journal of Immunology 19, 829-835
29. Sileghem M., Darji A., Hammers R. & De Baetselier P. (1989b) Modulation of IL-1 production and IL-1 release during experimental trypanosome infections. Immunology 68, 137-139
30. Sileghem M., Darji A., Remels L., Hamers R. & De Baetselier P. (1989c) Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice. European Journal of Immunology 19, 119-124
31. Sternberg J.M. (1998) Immunobiology of African trypanosomiasis. Chemical Immunology 70, 186-199
32. Stevens D.R. & Moulton J.E. (1978) Ultrastructural and immunoiogical aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages. Infection and Immunity 19, 972-982
33. Swain S.L. (1999) Helper T cell differentiation. Current Opinion in Immunology 11, 180-185
34. Tizard I., Nielsen K.H., Seed J.R. & Hall J.E. (1978) Biologically active products from African trypanosomes. Microbiological Reviews 42, 661-681
35. Watts T.H. & De Benedette M.A. (1999) T cell co-stimulatory molecules other than CD28. Current Opinion in Immunology 11, 286-293