The developmental cell biology of Trypanosoma brucei

Journal of Cell Science

Volumn 118, Issue 2, 2005, Pages 283-290

  Matthews, Keith R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cell division; Differentiation; Life cycle; Morphology

Indexed keywords

DNA DIRECTED RNA POLYMERASE; KINETOPLAST DNA; MESSENGER RNA;

ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL MATURATION; CELL MOTILITY; CELL ORGANELLE; CELL STRUCTURE; IMMUNOHISTOCHEMISTRY; LIFE CYCLE; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; RNA PROCESSING; TRYPANOSOMA BRUCEI;

ANIMALS; CELL DIFFERENTIATION; LIFE CYCLE STAGES; MODELS, ANIMAL; TRYPANOSOMA BRUCEI BRUCEI;

EID: 14044264288     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01649     Document Type: Article

References (63)

1. Allen, C. L., Goulding, D. and Field, M. C. (2003). Clathrin-mediated endocyrosis is essential in Trypanosoma brucei. EMBO J. 22, 4991-5002.
2. Amiguet-Vercher, A., Perez-Morga, D., Pays, A., Poelvoorde, P., van Xong, H., Tebabi, P., Vanhamme, L. and Pays, E. (2004). Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream. Mol. Microbiol. 51, 1577-1588.
3. Bastin, P., Sherwin, T. and Gull, K. (1998). Paraflagellar rod is vital for trypanosome motility. Nature 391 548.
4. Bochud-Allemann, N. and Schneider, A. (2002). Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma brucei. J. Biol. Chem 277, 32849-32854.
5. Briggs, L. J., McKean, P. G., Baines, A., Moreira-Leite, R, Davidge, J., Vaughan, S. and Gull, K. (2004). The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J. Cell Sci. 117, 1641-1651.
6. Clayton, C. E. (2002). Life without transcriptional control? From fly to man and back again. EMBO J. 21, 1881-1888.
7. Engstler, M., Thilo, L., Weise, F., Grunfelder, C. G., Schwarz, H., Boshart, M. and Overath, P. (2004). Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei. J. Cell Sci. 117, 1105-1115.
8. Ersfeld, K. and Gull, K. (1997). Partitioning of large and minichromosomes in Trypanosoma brucei. Science 276, 611-614.
9. Ersfeld, K. and Gull, K. (2001). Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei. J. Cell Sci. 114, 141-148.
10. Feagin, J. E. and Stuart, K. (1988). Developmental aspects of uridine addition within mitochondrial transcripts of Trypanosoma brucei. Mol. Cell. Biol. 8, 1259-1265.
11. Ferrante, A. and Allison, A. C. (1983). Alternative pathway activation of complement by African trypanosomes. Parasite Immunol. 5, 491-498.
12. Garcia-Salcedo, J. A., Perez-Morga, D., Gijon, P., Dilbeck, V., Pays, E. and Nolan, D. P. (2004). A differential role for actin during the life cycle of Trypanosoma brucei. EMBO J. 23 780-789.
13. Gibson, W. (2001). Sex and evolution in trypanosomes. Int. J. Parasitol. 31, 643-647.
14. Grunfelder, C. G., Engstler, M., Weise, F., Schwarz, H., Stierhof, Y. D., Boshart, M. and Overath, P. (2002). Accumulation of a GPI-anchored protein at the cell surface requires sorting at multiple intracellular levels. Traffic 3, 547-559.
15. Grunfelder, C. G., Engstler, M., Weise, F., Schwarz, H., Stierhof, Y. D., Morgan, G. W., Field, M. C. and Overath, P. (2003). Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers. Mol. Biol. Cell 14, 2029-2040.
16. Gull, K. (2003). Host-parasite interactions and trypanosome morphogenesis: a flagellar pocketful of goodies. Curr. Opin. Microbiol. 6, 365-370.
17. Gunzl, A., Bruderer, T., Laufer, G., Schimanski, B., Tu, L. C., Chung, H. M., Lee, P. T. and Lee, M. G. (2003). RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei. Eukaryot. Cell 2, 542-551.
18. Hammarton, T. C., Clark, J., Douglas, F., Boshart, M. and Mottram. J. C. (2003). Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin. J. Biol. Chem. 278, 22877-22886.
19. Hammarton, T. C., Engstler, M. and Mottram, J. C. (2004). The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology. J. Biol. Chem 279, 24757-24764.
20. He, C. Y., Ho, H. H., Malsam, J., Chalouni, C., West, C. M., Ullu, E., Toomre, D. and Warren, G. (2004). Golgi duplication in Trypanosoma brucei. J. Cell Biol. 165, 313-321.
21. Hendriks, E. F., Robinson, D. R., Hinkins, M. and Matthews, K. R. (2001). A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form. EMBO J. 20, 6700-6711.
22. Hertz-Fowler, C., Ersfeld, K. and Gull, K. (2001). CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-retated proteins in Trypanosoma brucei. Mol. Biochem. Parasitol. 116, 25-34.
23. Hung, C. H., Qiao, X., Lee, P. T. and Lee, M. G. (2004). Clathrin-dependent targeting of receptors to the flagellar pocket of procyclic-form Trypanosoma brucei. Eukaryot. Cell 3, 1004-1014.
24. Hutchings, N. R., Donelson, J. E. and Hill, K. L. (2002). Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes. J. Cell Biol. 156, 867-877.
25. Kilmartin, J. V., Wright, B. and Milstein, C. (1982). Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line. J. Cell Biol. 93, 576-582.
26. Klingbeil, M. M. and Englund, P. T. (2004). Closing the gaps in kinetoplast DNA network replication. Proc. Natl. Acad. Sci. USA 101, 4333-4334.
27. Klingbeil, M. M., Motyka, S. A. and Englund, P. T. (2002). Multiple mitochondrial DNA polymerases in Trypanosoma brucei. Mol. Cell 10, 175-186.
28. Kohl, L., Sherwin, T. and Gull, K. (1999). Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle. J. Eukaryot. Microbiol. 46, 105-109.
29. Kohl, L., Robinson, D. and Bastin, P. (2003). Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. EMBO J. 22, 5336-5346.
30. Leal, S., Acosta-Serrano, A., Morris, J. and Cross, G. A. (2004). Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A. J. Biol. Chem 279, 28979-28988.
31. Li, Z. and Wang, C. C. (2003). A PHO80-like cyclin and a B-type cyclin control the cell cycle of the procyclic form of Trypanosoma brucei. J. Biol. Chem 278, 20652-20658.
32. Madison-Antenucci, S., Grams, J. and Hajduk, S. L. (2002). Editing machines: the complexities of trypanosome RNA editing. Cell 108, 435-438.
33. Mair, G., Shi, H. F., Li, H. J., Djikeng, A., Aviles, H. O., Bishop, J. R., Falcone, F. H., Gavrilescu, C., Montgomery, J. L., Santori, M. I. et al. (2000). A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA. RNA 6, 163-169.
34. Matthews, K. R. (1999). Developments in differentiation of T. brucei. Parasitol. Today 15, 76-80.
35. Matthews, K. R., Sherwin, T. and Gull, K. (1995). Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated. J. Cell Sci. 108, 2231-2239.
36. Matthews, K. R., Ellis, J. R. and Paterou, A. (2004). Molecular regulation of the life cycle of African trypanosomes. Trends Parasitol. 20, 40-47.
37. McCulloch, R. (2004). Antigenic variation in African trypanosomes: monitoring progress. Trends Parasitol. 20, 117-121.
38. Moreira-Leite, F. F., Sherwin, T., Kohl, L. and Gull, K. (2001). A trypanosome structure involved in transmitting cytoplasmic information during cell division. Science 294, 610-612.
39. Morgan, G. W., Goulding, D. and Field, M. C. (2004). The single dynamin-like protein of Trypanosoma brucei regulates mitochondrial division and is not required for endocytosis. J. Biol. Chem. 279, 10692-10701.
40. Morris, J. C., Wang, Z., Drew, M. E. and Englund, P. T. (2002). Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. EMBO J. 21, 4429-4438.
41. Navarro, M. and Gull, K. (2001). A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 414, 759-763.
42. Ogbadoyi, E. O., Robinson, D. R. and Gull, K. (2003). A high-order transmembrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol. Biol. Cell 14, 1769-1779.
43. Overath, P. and Engstler, M. (2004). Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system. Mol. Microbiol. 53, 735-744.
44. Parsons, M. (2004). Glycosomes: parasites and the divergence of peroxisomal purpose. Mol. Microbiol. 53, 717-724.
45. Pays, E., Vanhamme, L. and Perez-Morga, D. (2004). Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries. Curr. Opin. Microbiol. 7, 369-374.
46. Ploubidou, A., Robinson, D. R., Docherty, R. C., Ogbadoyi, E. O. and Gull, K. (1999). Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis. J. Cell Sci. 112, 4641-4650.
47. Robinson, D. R., Sherwin, T., Ploubidou, A., Byard, E. H. and Gull, K. (1995). Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle. J. Cell Biol. 128, 1163-1172.
48. Roditi, I. and Liniger, M. (2002). Dressed for success: the surface coats of insect-borne protozoan parasites. Trends Microbiol. 10, 128-134.
49. Rupp, G. and Porter, M. E. (2003). A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product. J. Cell Biol. 162, 47-57.
50. Schnaufer, A., Panigrahi, A. K., Panicucci, B., Igo, R. P., Jr, Wirtz, E., Salavati, R. and Stuart, K. (2001). An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science 291, 2159-2162.
51. Sherwin, T. and Gull, K. (1989a). The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 323, 573-588.
52. Sherwin, T. and Gull, K.(1989b). Visualization of detyrosination along single microtubules reveals novel mechanisms of assembly during cytoskeletal duphcation in trypanosomes. Cell 57 211-221.
53. Sinha, K. M., Hines, J. C., Downey, N. and Ray, D. S. (2004). Mitochondrial DNA ligase in Crithidia fasciculata. Proc. Natl. Acad. Sci. USA 101, 4361-4366.
54. Timms, M. W., van Deursen, F. J., Hendriks, E. F. and Matthews, K. R. (2002). Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point. Mol. Biol. Cell 13, 3747-3759.
55. van Weelden, S. W., Fast, B., Vogt, A., van der Meer, P., Saas, J., van Hellemond, J. J., Tielens, A. G. and Boshart, M. (2003). Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation. J. Biol. Chem. 278, 12854-12863.
56. Vassella, E., Reuner, B., Yutzy, B. and Boshart, M. (1997). Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J. Cell Sci. 110, 2661-2671.
57. Vassella, E., den Abbeele, J. V., Butikofer, P., Renggli, C. K., Furger, A., Brun, R. and Roditi, I. (2000). A major surface glycoprotein of Trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Genes Dev. 14, 615-626.
58. Vassella, E., Probst, M., Schneider, A., Studer, E., Renggli, C. K. and Roditi, I. (2004). Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes. Mol. Biol. Cell 16, 16.
59. Vaughan, S. and Gull, K. (2003). The trypanosome flagellum. J. Cell Sci. 116, 757-759.
60. Vedrenne, C., Giroud, C., Robinson, D. R., Besteiro, S., Bosc, C., Bringaud, F. and Baltz, T. (2002). Two related subpellicular cytoskeleton-associated proteins in Trypanosoma brucei stabilize microtubules. Mol. Biol. Cell 13, 1058-1070.
61. Wang, Z. and Englund, P. T. (2001). RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA. EMBO J. 20, 4674-4683.
62. Wickstead, B., Ersfeld, K. and Gull, K. (2003). The mitotic stability of the minichromosomes of Trypanosoma brucei. Mol. Biochem. Parasitol. 132, 97-100.
63. Wickstead, B., Ersfeld, K. and Gull, K. (2004). The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes. Genome Res. 14, 1014-1024.