Reversible and noncompetitive inhibition of β-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library

Angewandte Chemie - International Edition

Volumn 49, Issue 24, 2010, Pages 4113-4116

  Wich, Peter R ^a   Schmuck, Carsten ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Combinatorial chemistry; Enzymes; Inhibitors; Peptides; Supramolecular chemistry

Indexed keywords

ACTIVE SITE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; INHIBITORS; NANOMOLAR AFFINITY; OLIGOPEPTIDES; PEPTIDE LIGAND; PROTEIN SURFACE; SERINE PROTEASE;

AMINO ACIDS; BIOASSAY; BIOCHIPS; CATALYSTS; ENZYMES; LIGANDS; MACROMOLECULES; PEPTIDES; PHOSPHATASES;

SUPRAMOLECULAR CHEMISTRY;

LIGAND; PEPTIDE; SERINE PROTEINASE INHIBITOR; TRYPTASE;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; METABOLISM; PROTEIN BINDING; SURFACE PROPERTY;

CATALYTIC DOMAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; LIGANDS; PEPTIDES; PROTEIN BINDING; SERINE PROTEINASE INHIBITORS; SURFACE PROPERTIES; TRYPTASES;

EID: 77953105398     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200907221     Document Type: Article

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