Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 2 I, 1997, Pages 375-381

  Elrod, Kyle C ^b   Moore, William R ^a   Abraham, William M ^b   Tanaka, Richard D ^b  

^a Arris Pharmaceutical Corporation   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LACTOFERRIN;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CONTROLLED STUDY; ENZYME INHIBITION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHEEP;

EID: 0030744683     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.2.9607012     Document Type: Article

References (57)

1. Schwartz, L. B., A. A. Irani, K. Roller, M. C. Castells, and N. M. Schechter. 1987. Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J. Immunol. 138:2611-2615.
2. Schwartz, L. B., and T. R. Bradford. 1986. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J. Biol. Chem. 261:7372-7379.
3. Alter, S. C., J. A. Kramps, A. Janoff, and L. B. Schwartz. 1990. Interactions of mast cell tryptase with biological protease inhibitors. Arch. Biochem. Biophys. 276:26-31.
4. Elrod, K. C., W. R. Moore, W. M. Abraham, and R. D. Tanaka. 1995. Protamine and Heparinase 1 are Potent Tryptase Inhibitors In Vitro and Protamine is Efficacious in the Sheep Model of Asthma. In Asthma 95. Theory to Treatment. (Joint conference sponsored by AAAAI and ATS, Abstr.) Chicago, IL. July 1995.
5. Schwartz, L. B., R. A. Lewis, and K. F. Austen. 1981. Tryptase from human pulmonary mast cells. Purification and characterization. J. Biol. Chem. 256:11939-11943.
6. Smith, T. J., W. W. Houghland, and D. A. Johnson. 1984. Human lung tryptase: purification and characterization. J. Biol. Chem. 259:11046-11051.
7. Alter, S. C., P. Yates, H. S. Margolius, and L. B Schwartz. 1987. Tryptase and kinin generation: tryptase from human mast cells does not activate human urinary prokallikrein. Int. Arch. Allergy Appl. Immunol. 83:321-324.
8. Schechter, N. M., G. Y. Eng, and D. R. McCaslin. 1993. Human skin tryptase: kinetic characterization of its spontaneous inactivation. Biochemistry 32:2617-2625.
9. Gruber, B. L., L. B. Schwartz, N. S. Ramamurthy, A. M. Irani, and M. J. Marchese. 1988. Activation of latent rheumatoid synovial collagenase by human cell tryptase. J. Immunol. 140:3936-3942.
10. Lohi, J., I. Harvima, and J. Keski-Oja. 1992. Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin. J. Cell Biochem. 50:337-349.
11. Schwartz, L. B., T. R. Bradford, B. H. Littman, and B. U. Wintroub. 1985. The fibrinogenolytic activity of purified tryptase from human lung mast cells. J. Immunol. 135:2762-2767.
12. Caughey, G. H., F. Leidig, N. F. Viro, and J. A. Nadel. 1988. Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J. Pharmacol. Exp. Ther. 244:133-137.
13. Proud, D., E. S. Siekierski, and G. S. Bailey. 1988. Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity. Biochem. Pharmacol. 37:1473-1480.
14. Walls, A. F., A. R. Bennett, J. Sueiras-Diaz, and H. Olsson. 1992. The kininogenase activity of human mast cell tryptase. Biochem. Soc. Trans. 20:260S.
15. Ruoss, S. J., T. Hartmann, and G. H. Caughey. 1991. Mast cell tryptase is a mitogen for fibroblasts. J. Clin. Invest. 88:493-499.
16. Cairns, J. A., and A. F. Walls. 1996. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J. Immunol. 158:275-283.
17. Schwartz, L. B., J. W. Yunginger, J. Miller, R. Bokhari, and D. Dull. 1989. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J. Clin. Invest. 83: 1551-1555.
18. Sedgwick, J. B., W. J. Calhoun, G. J. Gliech, H. Kita, J. S. Abrams, L. B. Schwartz, B. Volovitz, M. Ben-Yaakov, and W. W. Busse. 1991. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge: characterization of eosinophil and mast cell mediators. Am. Rev. Respir. Dis. 144:1274-1281.
19. Brinkham, G. L. 1968. The mast cell in normal human bronchus and lung. J. Ultrastruct. Res. 231:15-23.
20. Fox, B., T. B. Bull, and A. Guz. 1968. Mast cells in the human alveolar wall: an electronmicrograph study. J. Clin. Pathol. 34:1333-1342.
21. Wenzel, S. E., A. A. Fowler, and L. B. Schwartz. 1988. Activation of pulmonary mast cells by bronchoalveolar allergen challenge: in vivo release of histamine and tryptase in atopic subjects with and without asthma. Am. Rev. Respir. Dis. 137:1002-1008.
22. Broide, D. H., G. J. Gliech, A. J. Cuomo, D. A. Coburn, E. C. Federman, L. B. Schwartz, and S. I. Wasserman. 1988. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J. Allergy Clin. Imunol. 88:637-648.
23. Jarjour, N. N., W. J. Calhoun, L. B. Schwartz, and W. W. Busse. 1991. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction. Am. Rev. Respir. Dis. 144:83-87.
24. Tomioka, M., S. Ida, Y. Shindoh, R. Ishihara, and T. Takishima. 1984. Mast cells in the bronchoalveolar lumen of patients with bronchial asthma. Am. Rev. Respir. Dis. 129:1000-1005.
25. Flint, K. C., K. B. Leung, B. N. Hudspith, J. Brostaff, F. L. Pearce, and N. M. Johnson. 1985. Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. B.M.J. 291:923-926.
26. Salomonsson, P., R. Gronneberg, H. Gilljam, O. Andersson, B. Billing, I. Enander, U. Alkner, and C. G. Persson. 1985. Bronchial exudation of bulk plasma at allergen challenge in allergic asthma. Am. Rev. Respir. Dis. 146:1535-1542.
27. Molinari, J. F., M. Scuri, W. R. Moore, J. Clark, R. Tanaka, and W. M. Abraham. 1996. Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am. J. Respir. Crit. Care Med. 154:649-653.
28. Clark, J. M., W. M. Abraham, C. E. Fishman, R. Forteza, A. Ahmed, A. Cortes, R. L. Warne, W. R. Moore, and R. D. Tanaka. 1995. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am. J. Respir. Crit. Care Med. 152:2076-2083
29. Molinari, J. F., W. R. Moore, J. Clark, R. D. Tanaka, J. H. Butterfield and W. M. Abraham. 1996. Role of tryptase in immediate cutaneous responses in allergic sheep. J. Appl. Physiol. 79:1966-1970.
30. Tanaka, R. D., J. M. Clark, R. L. Warne, W. M. Abraham, and W. R. Moore. 1995. Mast cell tryptase: a new target for therapeutic intervention in asthma. Int. Arch. Allergy Immunol. 107:408-409.
31. Walls, A. F., S. He, L. M. Teran, M. G. Buckley, K. S. Jung, S. T. Holgate, J. K. Shute, and J. A. Cairns. 1995. Granulocyte recruitment by human mast cell tryptase. Int. Arch. Allergy Immunol. 107:372-373.
32. Jeffery, P. K. 1987. The origins of secretions in the lower respiratory tract. Eur. J. Respir. Dis. Suppl. 153:34-42.
33. Mann, D. M., E. Romm, and M. Migliornini. 1994. Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin. J. Biol. Chem. 269:23661-23667.
34. Smith, T. J., M. W. Houghland, and D. A. Johnson. 1984. Human lung tryptase: purification and characterization. J. Biol. Chem. 259:11046-11051.
35. Braganza, V. J., and W. H. Simmons. 1991. Tryptase from rat skin: purification and properties. Biochemistry 30:4997-5007.
36. Butterfield, J. H., D. Weiler, G. Dewald, and G. J. Gleich. 1988. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 12:345-355.
37. Butterfield, J. H., D. Weiler, L. W. Hunt, S. R. Wynn, and P. C. Roche. 1990. Purification of tryptase from a human mast cell line. J. Leuk. Biol. 47:409-419.
38. Cha, S. 1975. Tight-binding inhibitors-I: kinetic behavior. Biochem. Pharmacol. 24:2177-2185.
39. Abraham, W. M., J. C. Delahunt, L. Yerger, and B. Marchette. 1983. Characterization of a late phase pulmonary response following antigen challenge in allergic sheep. Am. Rev. Respir. Dis. 128:839-844.
40. Sommerhoff, C. P., C. Sollner, R. Mentele, G. P. Piechottka, E. A. Auerswald, and H. Fritz. 1994. A Kazal-type inhibitor of human mast cell tryptase: isolation from the medicinal leech Hirudo medicinalis, characterization and sequence analysis. Biol. Chem. Happe Seyler 375: 685-694.
41. Boswell, D. R., and I. C. Bathurst. 1985. Molecular physiology and pathology of alpha 1-antitrypsin. Biochem. Edu. 13:98-104.
42. Salvesen, G. S., J. J. Catanese, L. F. Kress, and J. Travis. 1985. Primary structure of the reactive site of human C1-inhibitor. J. Biol. Chem. 260:2432-2436.
43. Weeb, M. C. L., M. U. Ehrengruber, I. Clark-Lewis, M. Baggiolini, and A. Rot. 1990. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc. Nat. Acad. Sci. U.S.A. 90:7158-7162.
44. Taylor, S., and J. Folkman. 1982. Protamine is an inhibitor of angiogenesis. Nature 297:307-312.
45. Ahmed, T., W. M. Abraham, and J. D'Brot. 1992. Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am. Rev. Respir. Dis. 145:566-570.
46. D'Brot, J., W. M. Abraham, and T. Ahmed. 1991. Effect of heparin on immunologic and non-immunologic bronchoconstrictor responses in allergic sheep with and without late responses (abstract). Am. Rev. Respir. Dis. 143:A540.
47. Tyrrel, D. J., S. Kilfeather, and C. P. Page. 1995. Therapeutic uses of heparin beyond its traditional role as an anticoagulant. Trends Pharmacol. Sci. 16:198-204.
48. Frieri, M., and D. D. Metcalfe. 1982. Analysis of the effect of mast cell granules on lymphocyte blastogenisis in the absence or presence of mitogens: identification of heparin as a granule-associated suppressor factor. J. Immunol. 131:1942-1947.
49. Ghosh, T. K., P. S. Eis, J. M. Mullaney, C. L. Ebert, and D. L. Gill. 1988. Competitive reversible, and potent antagonism of inositol 1,4,5-triphosphate-activated calcium release by heparin. J. Biol. Chem. 263: 11075-11079.
50. Ahmed, T., J. M. D. Garrigo, and I. B. S. Danta. 1993. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N. Engl. J. Med. 329:90-95.
51. Thompson, A. B., T. Bohling, F. Payvandi, and S. I. Rennard. 1990. Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis. J. Lab. Clin. Med. 115:148-158.
52. Henson, P., and L. C. Borish. 1995. Neutrophil mediators in asthma. In W. W. Busse and S. T. Holgate, editors. Asthma and Rhinitis. Blackwell, Oxford. 367-382.
53. Nagy, L., T. H. Lee, and A. B. Kay. 1982. Neutrophil chemotactic activity in antigen-induced late asthmatic reactions. N. Engl. J. Med. 306: 497-501.
54. Metzger, W. J., H. B. Richerson, K. Worden, H. Monich, and G. W. Hunninghake. 1986. Bronchoalveolar lavage of allergic asthmatic patients following allergen bronchoprovocation. Chest 89:477-483.
55. Lam, S., J. Le Riche, D. Philips, and M. Chan-Yeung. 1987. Cellular and protein changes in bronchial lavage fluid after late asthmatic reaction in patients with red cedar asthma. J. Allergy Clin. Immunol. 80:44-50.
56. Fabbri, L. M., P. Boschetto, E. Zocca, G. Milani, F. Pivirotto, M. Plebani, A. Burlina, B. Licata, and C. E. Mappa. 1987. Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am. Rev. Respir. Dis. 136:379-383.
57. Kallenbach, J., R. Baynes, B. Fine, D. Dajee, and W. Bezwoda. 1992. Persistent neutrophil activation in mild asthma. J. Allergy Clin. Immunol. 90:272-274.