Peptide dendrimers: Applications and synthesis

Reviews in Molecular Biotechnology

Volumn 90, Issue 3-4, 2002, Pages 195-229

  Sadler, Kristen ^a   Tam, James P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ligation chemistry; MAP; Multiple antigenic peptide; Peptide dendrimer; Review

Indexed keywords

BIOCOMPATIBLE MATERIALS; BIOTECHNOLOGY; HUMANS; IMMUNOASSAY; MACROMOLECULAR SUBSTANCES; PEPTIDES; POLYMERS; SEROLOGIC TESTS;

EID: 0036177932     PISSN: 13890352     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1389-0352(01)00061-7     Document Type: Article

References (289)

1. Nonepitopic antibody binding sequence: Implications in screening and development of peptide vaccines
2. Synthesis of a diepitope multiple antigen peptide containing sequences from two malaria antigens using Fmoc chemistry
3. Convergent solid-phase peptide synthesis
4. Peptides derived from the unique region of B19 parvovirus minor capsid protein elicit neutralizing antibodies in rabbits
5. Lactose-containing starburst dendrimers: Influence of dendrimer generation and binding-site orientation of receptors (plant/animal lectins and immunoglobulins) on binding properties
6. Antibody against synthetic multiple antigen peptides (MAP) of JC virus capsid protein (VP1) without cross reaction to BK virus: A diagnostic tool for progressive multifocal leukoencephalopathy
7. Lupus humoral autoimmunity induced in a primate model by short peptide immunization
8. Induction of a protection against S. mansoni with a MAP containing epitopes of Sm37-GAPDH and Sm10-DLC. Effect of coadsorbtion with GM-CSF on alum
9. Distribution of IGF-I and -II, IGF binding proteins (IGFBPs) and IGFBP mRNA in ocular fluids and tissues: Potential sites of synthesis of IGFBPs in aqueous and vitreous
10. Epitopic characterization and vaccinal potential of peptides derived from a major antigen of Schistosoma mansoni (Sm28 GST)
11. Immune responses to multiple antigen peptides containing T and B epitopes from Plasmodium falciparum circumsporozoite protein of Brazilian individuals naturally exposed to malaria
12. Antibacterial activity of multiple antigen peptides homologous to a loop region in human lactoferrin
13. Novel version of multiple antigenic peptide allowing incorporation on a cysteine functionalized lysine tree
14. In vitro assembly of coiled bodies in Xenopus egg extract
15. Peptide segment coupling in aqueous medium: Silver ion activation of the thiolcarboxyl group
16. Serological responses to the B subunit of Shiga-like toxin 1 and its peptide fragments indicate that the B subunit is a vaccine candidate to counter action of the toxin
17. Multiple autoepitope presentation for specific detection of antibodies in primary biliary cirrhosis
18. New approaches to vaccination against foot-and-mouth disease
19. Immunization and affinity purification of antibodies using resin-immobilized lysine-branched synthetic peptides
20. A novel lysine-protecting procedure for continuous-flow solid-phase synthesis of branched peptides
21. 2+ release channel
22. Recognition of different domains of the Plasmodium falciparum CS protein by the sera of naturally infected individuals compared with those of sporozoite-immunized volunteers
23. Immunogenicity of multiple antigen peptides containing B and non-repeat T cell epitopes of the circumsporozoite protein of Plasmodium falciparum
24. Autoantibodies directed against ribosomal P proteins: Use of a multiple antigen peptide as the coating agent in ELISA
25. 3, a peptide derived from the HIV-1 gp120 V3 loop
26. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent
27. Enterochromaffin cells of the digestive system: Cellular source of guanylin, a guanylate cyclase-activating peptide
28. Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes
29. Hydraamphiphiles - Novel linear dendritic block-copolymer surfactants
30. Poly(ethylene glycol)-block-poly(L-lysine) dendrimer: Novel linear polymer/dendrimer block copolymer forming a spherical water-soluble polyionic complex with DNA
31. Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: Production of bactericidal antibodies against group B Neisseria meningitidis
32. Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin
33. LasA, alkaline protease and elastase in clinical strains of Pseudomonas aeruginosa: Quantification by immunochemical methods
34. Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence
35. Immunogenicity comparison of a multi-antigenic peptide bearing V3 sequences of the human immunodeficiency virus type 1 with TAB9 protein in mice
36. Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P30 antigen
37. Mimicking a conformational B cell epitope of the heat shock protein PfHsp70-1 antigen of Plasmodium falciparum using a multiple antigenic peptide
38. Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery
39. Immunogenicity of an alum-adsorbed synthetic multiple-antigen peptide based on B- and T-cell epitopes of the Plasmodium falciparum CS protein: Possible vaccine application
40. Human antibodies to immunodominant C5 region of HIV-1 gp120 cross-react with HLA class I on activated cells
41. Macromolecular assemblage in the design of a synthetic AIDS vaccine
42. A rational design of synthetic peptide vaccine with a built-in adjuvant. A modular approach for unambiguity
43. A multiple antigen peptide from the repetitive sequence of the Plasmodium malariae circumsporozoite protein induces a specific antibody response in mice of various H-2 haplotypes
44. Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo
45. Inhibition of peptide binding to DR molecules by a leupeptin-induced invariant chain fragment
46. Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene
47. A new synthetic functionalized antigen carrier
48. Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase
49. Identification of a functionally conserved surface region of rat cytochromes P450IA
50. Immunocytochemical localization of human 5 alpha-reductase 2 with polyclonal antibodies in androgen target and non-target human tissues
51. Iron regulatory factor expressed from recombinant baculovirus: Conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase
52. Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications
53. Determination of B-cell epitopes of nef HIV-I protein: Immunogenicity related to their structure
54. Comprehensive delineation of antigenic and immunogenic properties of peptides derived from the nef HIV-1 regulatory protein
55. Towards protein surface mimetics
56. Induction of autoimmunity by multivalent immunodominant and subdominant T cell determinants of La (SS-B)
57. Oriented immobilization of peptide ligands on solid supports
58. Peptide-based assay for the identification of endothelin-converting enzyme inhibitors
59. Affinity enhancement of complementary peptide recognition
60. Binding of human tumor necrosis factor alpha to multimeric complementary peptides
61. Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries
62. Analysis of the immune response elicited by a multiple antigen peptide (MAP) composed of two distinct protective antigens derived from the parasite Schistosoma mansoni
63. Melanoma cell adhesion and spreading activities of a synthetic 124-residue triple-helical 'mini-collagen'
64. Dynamic actin structures stabilized by profilin
65. Oral uptake and translocation of a polylysine dendrimer with a lipid surface
66. Primary in vitro immunization with multimeric synthetic peptides of HIV-1 envelope glycoproteins: Generation of neutralizing human monoclonal antibodies
67. Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus
68. A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture
69. From random coil to extended nanocylinder: Dendrimer fragments shape polymer chains
70. Construction of protein analogues by site-specific condensation of unprotected fragments
71. A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice
72. Purification and partial amino acid sequence of the actin-fragmin kinase from Physarum polycephalum
73. De-novo design of a novel heterodinuclear 3-helix bundle metalloprotein
74. Lipidic peptides.1. Synthesis, resolution and structural elucidation of lipidic amino-acids and their homo-oligomers and heterooligomers
75. Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis
76. Assessment of synthetic peptides for hepatitis A diagnosis using biosensor technology
77. Use of linear and multiple antigenic peptides in the immunodiagnosis of acute hepatitis A virus infection
78. Collagen mimetics
79. Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch
80. Presentation of T-cell epitopes assembled as multiple-antigen peptides to murine and human T lymphocytes
81. Multiple antigen peptides for specific detection of antibodies to a malaria antigen in human sera
82. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
83. Design and synthesis of a peptide having chymotrypsin-like esterase activity
84. Immune response related to the molecular structure of a peptide from the cholera toxin B subunit
85. GD3 vaccines for melanoma: Superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines
86. Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements
87. Protein-synthesis using s-alkyl thioester of partially protected peptide segments - Synthesis of DNA-binding protein of Bacillus-stearothermophilus
88. Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus
89. Lipophilic multiple antigen peptide system for peptide immunogen and synthetic vaccine
90. Expression of the retinal pigmented epithelial cell-specific pp344 gene during development of the chicken eye and identification of its product
91. An unusual heparin-binding peptide from the carboxy-terminal hep-2 region of fibronectin
92. Two truncated forms of rat insulin receptor-related receptor
93. Inhibition of angiogenesis, tumour growth and experimental metastasis of human fibrosarcoma cells HT1080 by a multimeric form of the laminin sequence Tyr-Ile-Gly-Ser-Arg (YIGSR)
94. Production and immunogenicity of multiple antigenic peptide (MAP) constructs derived from the S1 glycoprotein of infectious bronchitis virus (IBV)
95. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice
96. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity
97. Activation of nonspecific cytotoxic cells with a multiple antigenic peptide: Specificity and requirements for receptor crosslinkage
98. Incorporation of achiral peptoid-based trimeric sequences into collagen mimetics
99. An effective peptide vaccine to eliminate bovine leukaemia virus (BLV) infected cells in carrier sheep
100. Comparative analysis of genus Vigna seeds using antiserum against a synthesized multiple antigenic peptide
101. Development of a monoclonal antibody to the conserved region of p34cdc2 protein kinase
102. Antagonistic peptides against human anaphylatoxin C5a
103. A structural study of the membrane domain of band 3 by tryptic digestion. Conformational change of band 3 in situ induced by alkali treatment
104. Automated allyl cleavage for continuous-flow synthesis of cyclic and branched peptides
105. Immobilization of ligand-modified polyamidoamine dendrimer for cultivation of hepatoma cells
106. Preparation and some properties of maleimido acids and maleoyl derivatives of peptides
107. Immunogenic and antigenic properties of an HIV-1 gp120-derived multiple chain peptide
108. Synthesis and conformational-analysis of cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid
109. T cell studies in a peptide-induced model of systemic lupus erythematosus
110. Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella
111. Applications of dendrimers in bio-organic chemistry
112. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin
113. Preparation of protein conjugates via intermolecular disulfide bond formation
114. Preparation of protein conjugates via intermolecular hydrazone linkage
115. Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs
116. Radioimmunoassay for circulating human guanylin
117. Efficient transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers
118. Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta
119. The unique N-terminal domain of the large subunit of herpes simplex virus ribonucleotide reductase is preferentially sensitive to proteolysis
120. Immunogenicity of Plasmodium falciparum circumsporozoite protein multiple antigen peptide vaccine formulated with different adjuvants
121. Effects of adjuvants and multiple antigen peptides on humoral and cellular immune responses to gp160 of HIV-1
122. Mapping of two immunodominant antigenic epitopes conserved among the major inner capsid protein, VP7 of five bluetongue viruses
123. A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression
124. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle
125. Peptide segment ligation strategy without use of protecting groups
126. Synthesis of a symmetric peptide dendrimer. Assembly of a cyclic peptide on a small tetraacetate template
127. Orthogonal ligation of unprotected peptide segments through pseudoproline formation for the synthesis of HIV-1 protease analogs
128. Use of orthogonal ligation methods for the synthesis of a hetero peptide dendrimer
129. Molecular context of a viral T cell determinant within a chimeric bacterial protein alters the diversity of its T cell recognition
130. Chemically unambiguous peptide immunogen: Preparation, orientation and antigenicity of purified peptide conjugated to the multiple antigen peptide system
131. Functional and structural comparisons of linear and dendritic arrays of polypeptides
132. Protection of naturally susceptible animals against foot-and-mouth disease with a peptide, synthesized on a lysine matrix
133. A two-motif isoform of the major calcium channel subunit in skeletal muscle
134. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
135. A self-associating hepatitis B surface antigen-derived peptide that is immunogenic in alum
136. Vaccination with multiple antigen peptide as rejection antigen peptide in murine leukemia
137. Immune response to different sequences of the EBNA I molecule in Epstein-Barr virus-related disorders and in autoimmune diseases
138. Analysis of antigenicity and immunogenicity of five different chemically defined constructs of a peptide
139. Advantages of branched peptides in serodiagnosis. Detection of HIV-specific antibodies and the use of glycine spacers to increase sensitivity
140. Role of the carboxy terminus of herpes simplex virus type 1 DNA polymerase in its interaction with UL42
141. Linear and multiple antigen peptides containing defined T and B epitopes of the Plasmodium yoelii circumsporozoite protein: Antibody-mediated protection and boosting by sporozoite infection
142. Immunization with a peptide of Sm B/B′ results in limited epitope spreading but not autoimmune disease
143. Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47
144. Generation of anti-peptide and anti-protein sera. Effect of peptide presentation on immunogenicity
145. Rapid attachment of a helper T cell epitope to branched peptides by fragment condensation to give enhanced immunogenicity
146. Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig
147. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
148. Antibodies to DNA, chromatin core particles and histones in mice with graft-versus-host disease and their involvement in glomerular injury
149. Malaria vaccine: Immunization of mice with a synthetic T cell helper epitope alone leads to protective immunity
150. Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala
151. Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: Cellular and subcellular distribution in the rat forebrain
152. Characterization of a new oriental-mustard (Brassica juncea) allergen, Bra j IE: Detection of an allergenic epitope
153. Diversity in the processing events at the N-terminus of type-V collagen
154. Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
155. Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte
156. Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: Integrin alpha IIb beta 3 (platelet GPIIb-IIIa)
157. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein
158. Synthesis and properties of first-generation to 3rd-generation dendrimers with doubly and triply branched chiral building-blocks
159. Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons
160. Expression of the Bunyamwera virus M genome segment and intracellular localization of NSm
161. Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed 'cementoin'
162. Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide
163. Design of a complete synthetic peptide-based AIDS vaccine with a built-in adjuvant
164. A chemically defined synthetic vaccine model for HIV-1
165. Oral administration of an antigenic synthetic lipopeptide (MAP-P3C) evokes salivary antibodies and systemic humoral and cellular responses
166. T cell responses to pre-erythrocytic stages of malaria: Role in protection and vaccine development against pre-erythrocytic stages
167. Plasmodium falciparum polyoximes: Highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein
168. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types
169. A potential peptide vaccine against two different strains of influenza virus isolated at intervals of about 10 years
170. Polytryptophane terminated dendritic macromolecules
171. Nuclear transport of influenza virus polymerase PA protein
172. Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis
173. Antipeptide antibody responses following intranasal immunization: Effectiveness of mucosal adjuvants
174. Protection against measles virus-induced encephalitis by anti-mimotope antibodies: The role of antibody affinity
175. SCID mouse spleen does not support scrapie agent replication
176. Synthesis of disulfide-bridged heterotrimeric collagen peptides. Conformational properties and digestion by matrix metalloproteinese
177. Cyclization of totally unprotected peptides in aqueous-solution by oxime formation
178. Assembly of cyclic peptide dendrimers from unprotected linear building blocks in aqueous solution
179. Evaluation of the effect of Sm28GST-derived peptides in murine hepatosplenic schistosomiasis: Interest of the lipopeptidic form of the C-terminal peptide
180. Purification and properties of the herpes simplex virus type 1 UL8 protein
181. Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts
182. The COOH terminus of synaptotagmin mediates interaction with the neurexins
183. Lack of H-2 restriction of the Plasmodium falciparum (NANP) sequence as multiple antigen peptide
184. Enhancement of the immunogenicity of a synthetic peptide bearing a VP3 epitope of hepatitis A virus
185. A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain
186. Interaction of cationic partial dendrimers with charged and neutral liposomes
187. Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition
188. Use of the 3-nitro-2-pyridine sulfenyl protecting group to introduce N epsilon-branching at lysine during solid-phase peptide synthesis. I. Application to the synthesis of a peptide template containing two addressable sites
189. Synthesis of peptide dendrimer
190. Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha
191. T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase
192. Immunogenicity of a peptide from a major neutralising determinant of the feline immunodeficiency virus surface glycoprotein
193. Multiple T helper cell epitopes of the circumsporozoite protein of Plasmodium berghei
194. Facile synthesis of homogeneous artificial proteins
195. Triple helix-coil transition of covalently bridged collagen-like peptides
196. Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells
197. Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virus-encoded nuclear antigen EBNA I
198. Mapping of epitopes on the SmD molecule: The use of multiple antigen peptides to measure autoantibodies in systemic lupus erythematosus
199. Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions
200. Synthesis of large peptides in solution
201. Photoinduced hydrogen evolution with peptide dendrimer-multi-Zn(II)-porphyrin, viologen, and hydrogenase
202. Multipeptide-metalloporphyrin assembly on a dendrimer template and photoinduced electron transfer based on the dendrimer structure
203. Helichrome-synthesis and enzymatic-activity of a designed hemeprotein
204. Molecular cloning of a tyrosine kinase gene from the marine sponge Geodia cydonium: A new member belonging to the receptor tyrosine kinase class II family
205. Templates that induce alpha-helical, beta-sheet, and loop conformations
206. Comparison of linear and branched peptide forms (MAPs) in the induction of T helper responses to point-mutated ras immunogens
207. Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules
208. Protein-protein interaction of the Ro-ribonucleoprotein particle using multiple antigenic peptides
209. DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers
210. Unprotected peptides as building-blocks for the synthesis of peptide dendrimers with oxime, hydrazone, and thiazolidine linkages
211. Loligomers: Design of de novo peptide-based intracellular vehicles
212. Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
213. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
214. The use of multiple antigenic peptide (MAP) in the immunodiagnosis of human immunodeficiency virus infection
215. Myotrophin in human cardiomyopathic heart
216. Alternative splicing of the mouse amelogenin primary RNA transcript
217. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): Use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3
218. Characterization of a herpes simplex virus type 1 deletion variant (1703) which under-produces Vmw63 during immediate early conditions of infection
219. Terminal groups in starburst dendrimers: Activation and reactions with proteins
220. Structural and functional properties of region II-plus of the malaria circumsporozoite protein
221. Antigenicity and immunogenicity of a synthetic peptide derived from a glucan-binding domain of mutans streptococcal glucosyltransferase
222. Immunological characteristics of a synthetic peptide associated with a catalytic domain of mutans streptococcal glucosyltransferase
223. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
224. Unprotected peptides as building blocks for branched peptides and peptide dendrimers
225. Self-assembly of cyclic peptides on a dendrimer: Multiple cyclic antigen peptides
226. Production of an antibody to arterial fatty acid-binding protein (FABP) using a synthetic peptide as the antigen
227. Brain ECTO-Mg-ATPase is not the neural cell adhesion molecule
228. +-ATPase from red beet storage tissue
229. Identification and characterization of a Dictyostelium discoideum ribosomal protein gene
230. Synthetic peptide vaccine design-synthesis and properties of a high-density multiple antigenic peptide system
231. Recent advances in multiple antigen peptides
232. Synthesis of peptides and peptidomimetics, Houben-Weyl methods of organic chemistry
233. Vaccine engineering-enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of t-cell and b-cell epitopes
234. Coupling difficulty associated with interchain clustering and phase-transition in solid-phase peptide-synthesis
235. A biomimetic strategy in the synthesis and fragmentation of cyclic protein
236. Methionine ligation strategy in the biomimetic synthesis of parathyroid hormones
237. Multiple antigen peptide. A novel approach to increase detection sensitivity of synthetic peptides in solid-phase immunoassays
238. Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria
239. Peptide synthesis using unprotected peptides through orthogonal coupling methods
240. Thia zip reaction for synthesis of large cyclic peptides: Mechanisms and applications
241. Orthogonal ligation strategies for peptide and protein
242. Methods and strategies of peptide ligation
243. Influence of different tripeptides on the stability of the collagen triple helix. II. An experimental approach with appropriate variations of a trimer model oligotripeptide
244. Branched polypeptides as antigens for influenza virus hemagglutinin and T-cell receptor subunits
245. Novel cationic lipidic peptide dendrimer vectors - In vitro gene delivery
246. Sak57, an acidic keratin initially present in the spermatid manchette before becoming a component of paraaxonemal structures of the developing tail
247. Structural probing of human lutropin using antibodies raised against synthetic peptides constructed by classical and multiple antigen peptide system approaches
248. Concept and design of a new class of sequential oligopeptide carriers (SOC) for covalent attachment of multiple antigenic peptides
249. Protein engineering: Design and synthesis of a protein
250. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination
251. Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): Further enhancement by pre-injection of IFA alone
252. Infertility induced in rats by immunization with synthetic peptide segments of a sperm protein
253. Immunization with synthetic peptide segments of a sperm protein impair fertility in rats
254. Immunolocalization of vaccinia virus structural proteins during virion formation
255. Protein conjugates of defined structure: Synthesis and use of a new carrier molecule
256. The majority of neutralizing Abs in HIV-1-infected patients recognize linear V3 loop sequences. Studies using HIV-1MN multiple antigenic peptides
257. A multimeric synthetic peptide combinatorial library
258. Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen
259. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine
260. Lymphocytes and promonocytes attach to the synthetic [Tyr5,12,Lys7]-polyphemusin II peptide
261. A gentle method for linking Tris to amino acids and peptides
262. T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I-restricted malaria peptides
263. A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus
264. A topological analysis of goldfish kainate receptors predicts three transmembrane segments
265. Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult
266. Increased potency of an erythropoietin peptide mimetic through covalent dimerization
267. Immunodetermination of peptide factors. I. Synthesis of N-alpha-maleoyl-peptide derivatives
268. Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells
269. Multibranched V3 peptides inhibit human immunodeficiency virus infection in human lymphocytes and macrophages
270. Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of human immunodeficiency virus type 1 (HIV-1) gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-negative mucosal epithelial cell line
271. Studies on peptides. 103. Chemical synthesis of a crystalline protein with the full enzymatic-activity of ribonuclease-a
272. New segment synthesis of alpha-inhibin-92 by the acyl disulfide method
273. Epitopic mapping of linear and conformation-dependent antigenic determinants on GP5 of five US bluetongue viruses
274. Development of a polyclonal antibody with defined specificity against synthetic peptides from the N-myc oncoprotein using multiple antigen peptide and hemocyanin conjugation methods
275. Antibody against branched epitope as an affinity ligand to separate the parent protein
276. Conjugation of glucose oxidase from Aspergillus niger and rabbit antibodies using N-hydroxysuccinimide ester of N-(4-carboxycyclohexylmethyl)-maleimide
277. Practical synthesis of starburst PAMAM-thiosialodendrimers for probing multivalent carbohydrate-lectin binding properties
278. Protective anti-sporozoite antibodies induced by a chemically defined synthetic vaccine
279. Characterization of a polyclonal anti-peptide antibody to the angiotensin II type-1 (AT1) receptor
280. Angiotensin AT1 receptor blockade by specific antibody prevented two-kidney, one-clip renal hypertension in the rat
281. Totally synthetic lipid-containing polyoxime peptide constructs are potent immunogens
282. Thiazolidine formation as a general and site-specific conjugation method for synthetic peptides and proteins
283. Orthogonal coupling of unprotected peptide segments through histidyl amino terminus
284. Synthesis and application of unprotected cyclic peptides as building blocks for peptide dendrimers
285. Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules
286. Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis
287. Serotonin transporter antibodies: Production, characterization, and localization in the brain
288. Active immunization with complementary peptide PBM 9-1: Preliminary evidence that it modulates experimental allergic encephalomyelitis in PL/J mice and Lewis rats
289. Diversity in the regulatory B-subunits of protein phosphatase 2A: Identification of a novel isoform highly expressed in brain