Protein Surface Recognition by Rational Design: Nanomolar Ligands for Potassium Channels

Journal of the American Chemical Society

Volumn 125, Issue 42, 2003, Pages 12668-12669

  Gradl, Stefan N ^a   Felix, John P ^b   Isacoff, Ehud Y ^a   Garcia, Maria L ^b   Trauner, Dirk ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; DENDROTOXIN; POTASSIUM CHANNEL; PROTEIN; RUBIDIUM 86; TETRAPHENYLPORPHYRIN; TETRYLAMMONIUM; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEPROTECTION REACTION; GENETIC TRANSFECTION; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; PH; PROTEIN STRUCTURE; SURFACE PROPERTY; T LYMPHOCYTE ACTIVATION; X RAY CRYSTALLOGRAPHY; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BINDING, COMPETITIVE; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; PORPHYRINS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SURFACE PROPERTIES; XENOPUS;

EID: 0142104260     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036155z     Document Type: Article

References (23)

1. (a) Hille, B. Ion Channels of Excitable Membranes, 3rd ed.; Sinauer: Sunderland, 2001
2. (b) Ashcroft, F. M. Ion Channels and Disease; Academic Press: San Diego, 2000.
3. Ruta, V.; Jiang, Y.; Lee, A.; Chen, J.; MacKinnon, R. Nature 2003, 422, 180.
4. (a) Doyle, D. A.; Cabral, J. M.; Pfuetzner, R. A.; Kuo, A.; Gulbis, J. M.; Cohen, S. L.; Chait, B. T.; MacKinnon, R. Science 1998, 280, 69.
5. (b) Zhou, Y.; Morals-Cabral, J. H.; Kaufman, A.; MacKinnon, R. Nature 2001, 414, 43.
6. Jiang, Y. X.; Lee, A.; Chen, J. Y.; Cadene, M.; Chait, B. T.; MacKinnon, R. Nature 2002, 417, 515.
7. (a) Jiang, Y.; Lee, A.; Chen J.; Ruta, V.; Cadene, M.; Chait, B. T.; MacKinnon, R. Nature 2003, 423, 33.
8. (b) Jiang, Y.; Ruta, V.; Chen J.; Lee, A.; MacKinnon, R. Nature 2003, 423, 42.
9. Peczuh, M. W.; Hamilton, A. D. Chem. Rev. 2000, 100, 2479.
10. Garcia, M. L.; Hanner, M.; Knaus, H.-G.; Slaughter, R. S.; Kaczorowski, G. J. Methods and Tools in Biosciences and Medicine; Birkhäuser: Basel, 2000.
11. Felix, J. P.; Bugianesi, R. M.; Schmalhofer, W. A.; Borris, R.; Goetz, M. A.; Hensens, O. D.; Bao, J.-M.; Kayser, F.; Parsons, W. H.; Rupprecht, K.; Garcia, M. L.; Kaczorowski, G. J.; Slaughter, R. S. Biochemistry 1999, 38, 4922.
12. (a) Garcia, M. L.; Hanner, M.; Kaczorowski, G. J. Toxicon 1998, 36, 1641.
13. (b) Garcia, M. L.; Gao, Y. D.; McManus, O. B.; Kaczorowski, G. J. Toxicon 2001, 39, 739.
14. (a) MacKinnon, R.; Cohen, S. L.; Kuo, A.; Lee, A.; Chait, B. T. Science 1998, 280, 106.
15. (b) Imredy, J. P.; MacKinnon, R. J. Mol. Biol. 2000, 296, 1283.
16. Mammen, M.; Choi, S. K.; Whitesides, G. M. Angew. Chem., Int. Ed. 1998, 37, 2755.
17. Hambright, P. In The Porphyrin Handbook; Kadish, K. M., Guilard, R., Smith, K. M., Eds.; Academic Press: San Diego, 2000; Vol. 3.
18. Jain, R. K.; Hamilton, A. D. Org. Lett. 2000, 2, 1721.
19. Kaczorowski, G. J.; Garcia, M. L. Curr. Opin. Chem. Biol. 1999, 3, 448.
20. Koschak, A.; Bugianesi, R. M.; Mitterdorfer, J.; Kaczorowski, G. J.; Garcia, M. L.; Knaus, H.-G. J. Biol. Chem. 1998, 273, 2639.
21. Gross, A.; Abramson, T.; MacKinnon, R. Neuron 1994, 13, 961.
22. Imredy, J. P.; Chen, C.; MacKinnon, R. Biochemistry 1998, 37, 14867.
23. Coghlan, M. J.; Carroll, W. A.; Gopalakrishnan, M. J. Med. Chem. 2001, 44, 1627.