Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-β1-producing chondrocytes

Tissue Engineering

Volumn 11, Issue 9-10, 2005, Pages 1516-1526

  Song, Sun U ^a   Cha, Young Deog ^a   Han, Jeoung Uk ^a   Oh, In Suk ^a   Choi, Kyoung Baek ^b   Yi, Youngsuk ^b   Hyun, Jong Pil ^b   Lee, Hyeon Youl ^b   Chi, Guang Fan ^b   Lim, Chae Lyul ^b   Ganjei, J Kelly ^c   Noh, Moon Jong ^c   Kim, Seong Jin ^d   Lee, Dug Keun ^c   Lee, Kwan Hee ^a,b,c  

^a Inha University School of Medicine   (South Korea)

^b Tissue Gene Asia   (South Korea)

^c TissueGene   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOTECHNOLOGY; CELLS; GROWTH KINETICS; IMPLANTS (SURGICAL); TISSUE CULTURE;

CARTILAGE FORMATION; CHONDROCYTES; GROWTH FACTOR; RABBITS;

CARTILAGE;

HYALIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; FEMUR CONDYLE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; KNEE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RABBIT; TISSUE REGENERATION; TISSUE REPAIR;

ANIMALS; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; COLLAGEN TYPE II; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMUR; GENETIC VECTORS; HISTOLOGICAL TECHNIQUES; HUMANS; HYALINE CARTILAGE; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; MICE; MICE, NUDE; PLASMIDS; RABBITS; RECOMBINANT PROTEINS; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS;

EID: 27744503399     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2005.11.1516     Document Type: Article

References (24)

1. Buckwalter, J.A., Einhorn, T.A., and Simon, S.R. Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System, 2nd ed. Rosemont, IL: American Academy of Orthopaedic Surgeons. 2000, pp. 472-487.
2. Bentley, G., and Greer, R.B. Homotransplantations of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits. Nature 230, 385, 1971.
3. Brittberg, M., Lindahl, A., and Nilsson, A. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 331, 889, 1994.
4. Brittberg, M. Autologous chondrocyte transplantation. Clin. Orthop. 367(Suppl.), 147, 1999.
5. Buckwalter, J.A., and Mankin, H.J. Articular cartilage: Tissue design and chondrocyte-matrix interactions. Instr. Course Lect. 47, 477, 1998.
6. Chen, F.S., Frenkel, S.R., and DiCesare, P.E. Chondrocyte transplantation and experimental treatment options for articular cartilage defects. Am. J. Orthop. 26, 396, 1997.
7. Chesterman, P.J., and Smith, A.U. Homotransplantation of articular cartilage and isolated chondrocytes: An experimental study in rabbits. J. Bone Joint Surg. 50A, 184, 1968.
8. Gillogly, S.D., Voight, M., and Blackburn, T. Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J. Orthop. Sports Phys. Ther. 28, 241, 1998.
9. Grande, D.A., Singh, I.J., 61nd Pugh, J. Healing of experimentally produced lesions in articular cartilage following chondrocyte transplantation. Anat. Rec. 218, 142, 1987.
10. Hunziker, E.B., and Rosenberg, L.C. Repair of partial-thickness defects in articular cartilage: Cell recruitment from the synovial membrane. J. Bone Joint Surg. 78A, 721, 1996.
11. Johnston, B., and Yoo, J.U. Autologous mesenchymal progenitor cells articular cartilage repair. Clin. Orthop. 367(Suppl.), 156, 1999.
12. Kimura, T., Yasui, N., Ohsawa, S., and Ono, K. Chondrocytes embedded in collagen gels maintain cartilage phenotype during long-term cultures. Clin. Orthop. 186, 231, 1984.
13. 1- producing fibroblasts. Hum. Gene Ther. 12, 1805, 2001.
14. Mankin, H.J. The reaction of articular cartilage to injury and osteoarthritis. N. Engl. J. Med. 291, 1285, 1974.
15. Wakitani, S., Goto, T., Young, R.G., Mansour, J.M., Goldberg, V.M., and Caplan, A.I. Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. Tissue Eng. 4, 429, 1998.
16. O'Driscoll, S.W., Keeley, F.W., and Salter, R.B. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. J. Bone Joint Surg. 70A, 595, 1988.
17. Yang, X., Chen, L., Xu, X., Li, C., Huang, C., and Deng, C.X. TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J. Cell Biol. 153, 35, 2001.
18. 1: Comparison of two proliferation markers, PCNA and BrdU. J. Biomed. Mater. Res. 65B, 150, 2003.
19. Morales, T.I., and Roberts, A.B. Transforming growth factor β regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem. 263, 12828, 1988.
20. Redini, F., Daireaux, M., Mauviel, A., Galera, P., Loyau, G., and Pujol, J.P. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-β (TGF-β). Biochim. Biophys. Acta 1093, 196, 1991.
21. 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. Endocrinology 132, 1603, 1993.
22. 1 stimulates type II collagen expression in cultured poriosteum-derived cells. J. Bone Miner. Res. 7, 115, 1992
23. O'Driscoll, S.W., Recklies, A.D., and Poole, A.R. Chondrogenesis in periosteal explants: An organ culture model for in vitro study. J. Bone Joint Surg. Am. 76, 1042, 1994.
24. Goldberg, A.J., Lee, D., Bader D.L., and Bentley, G. Autologous chondrocyte implantation. Culture in a TGF-β containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes pellet culture. J. Bone Joint Surg. Br. 87, 128, 2005.