Chondrogenic potential of human synovial mesenchymal stem cells in alginate

Osteoarthritis and Cartilage

Volumn 15, Issue 10, 2007, Pages 1178-1189

  Kurth, T ^a   Hedbom, E ^a   Shintani, N ^a   Sugimoto, M ^a   Chen, F H ^b   Haspl, M ^c   Martinovic, S ^c   Hunziker, E B ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

BMP 2; BMP 7; Chondrogenesis; Synovial cells; TGF 1

Indexed keywords

AGGRECAN; ALGINIC ACID; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; DEXAMETHASONE; INSULIN; MESSENGER RNA; OSTEOGENIC PROTEIN 1; PROTEOGLYCAN; SELENIUM; SOMATOMEDIN C; TOLONIUM CHLORIDE; TRANSCRIPTION FACTOR SOX9; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DENSITY; CELL DIFFERENTIATION; CELL TRANSFORMATION; CHONDROGENESIS; CONTROLLED STUDY; CULTURE MEDIUM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE OSTEOARTHRITIS; MESENCHYMAL STEM CELL; MONOLAYER CULTURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SYNOVIOCYTE; SYNOVIUM;

AGED; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CHONDROCYTES; CHONDROGENESIS; HUMANS; MESENCHYMAL STEM CELLS; MIDDLE AGED; POLYMERASE CHAIN REACTION; STATISTICS AS TOPIC; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 34548599652     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.03.015     Document Type: Article

References (44)

1. Hunziker E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10 (2002) 432-463
2. Redman S.N., Oldfield S.F., and Archer C.W. Current strategies for articular cartilage repair. Eur Cell Mater 9 (2005) 23-32 (discussion 23-32)
3. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
4. De Bari C., Dell'Accio F., Tylzanowski P., and Luyten F.P. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 44 (2001) 1928-1942
5. De Bari C., Dell'Accio F., Vandenabeele F., Vermeesch J.R., Raymackers J.M., and Luyten F.P. Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. J Cell Biol 160 (2003) 909-918
6. Sakaguchi Y., Sekiya I., Yagishita K., and Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 52 (2005) 2521-2529
7. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13 (2002) 4279-4295
8. Majumdar M.K., Wang E., and Morris E.A. BMP-2 and BMP-9 promote chondrogenic differentiation of human multipotential mesenchymal cells and overcome the inhibitory effect of IL-1. J Cell Physiol 189 (2001) 275-284
9. Sekiya I., Colter D.C., and Prockop D.J. BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284 (2001) 411-418
10. Schmitt B., Ringe J., Haupl T., Notter M., Manz R., Burmester G.R., et al. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation 71 (2003) 567-577
11. Ma H.L., Hung S.C., Lin S.Y., Chen Y.L., and Lo W.H. Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. J Biomed Mater Res A 64 (2003) 273-281
12. Yang I.H., Kim S.H., Kim Y.H., Sun H.J., Kim S.J., and Lee J.W. Comparison of phenotypic characterization between "alginate bead" and "pellet" culture systems as chondrogenic differentiation models for human mesenchymal stem cells. Yonsei Med J 45 (2004) 891-900
13. O'Connell J.X. Pathology of the synovium. Am J Clin Pathol 114 (2000) 773-784
14. Hunziker E.B., and Rosenberg L.C. Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane. J Bone Joint Surg Am 78 (1996) 721-733
15. Hunziker E.B. Growth-factor-induced healing of partial-thickness defects in adult articular cartilage. Osteoarthritis Cartilage 9 (2001) 22-32
16. Shirasawa S., Sekiya I., Sakaguchi Y., Yagishita K., Ichinose S., and Muneta T. In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: optimal condition and comparison with bone marrow-derived cells. J Cell Biochem 97 (2006) 84-97
17. Hunziker E.B., Driesang I.M., and Morris E.A. Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily. Clin Orthop (2001) S171-S181
18. Park Y., Sugimoto M., Watrin A., Chiquet M., and Hunziker E.B. BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel. Osteoarthritis Cartilage 13 (2005) 527-536
19. Wong M., Siegrist M., and Goodwin K. Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone 33 (2003) 685-693
20. Stahlberg A., Hakansson J., Xian X., Semb H., and Kubista M. Properties of the reverse transcription reaction in mRNA quantification. Clin Chem 50 (2004) 509-515
21. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
22. Pfaffl M.W., Horgan G.W., and Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30 (2002) e36
23. Ostergaard M., Ejbjerg B., Stoltenberg M., Gideon P., Volck B., Skov K., et al. Quantitative magnetic resonance imaging as marker of synovial membrane regeneration and recurrence of synovitis after arthroscopic knee joint synovectomy: a one year follow up study. Ann Rheum Dis 60 (2001) 233-236
24. Vandenabeele F., De Bari C., Moreels M., Lambrichts I., Dell'Accio F., Lippens P.L., et al. Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane. Arch Histol Cytol 66 (2003) 145-153
25. Schulze-Tanzil G., de Souza P., Villegas Castrejon H., John T., Merker H.J., Scheid A., et al. Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tissue Res 308 (2002) 371-379
26. Worster A.A., Brower-Toland B.D., Fortier L.A., Bent S.J., Williams J., and Nixon A.J. Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix. J Orthop Res 19 (2001) 738-749
27. Fickert S., Fiedler J., and Brenner R.E. Identification, quantification and isolation of mesenchymal progenitor cells from osteoarthritic synovium by fluorescence automated cell sorting. Osteoarthritis Cartilage 11 (2003) 790-800
28. Fortier L.A., Nixon A.J., Mohammed H.O., and Lust G. Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor beta-1. Am J Vet Res 58 (1997) 66-70
29. Fitzsimmons J.S., Sanyal A., Gonzalez C., Fukumoto T., Clemens V.R., O'Driscoll S.W., et al. Serum-free media for periosteal chondrogenesis in vitro. J Orthop Res 22 (2004) 716-725
30. Yaeger P.C., Masi T.L., de Ortiz J.L., Binette F., Tubo R., and McPherson J.M. Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes. Exp Cell Res 237 (1997) 318-325
31. Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
32. Wan M., and Cao X. BMP signaling in skeletal development. Biochem Biophys Res Commun 328 (2005) 651-657
33. Nishimura K., Solchaga L.A., Caplan A.I., Yoo J.U., Goldberg V.M., and Johnstone B. Chondroprogenitor cells of synovial tissue. Arthritis Rheum 42 (1999) 2631-2637
34. Bosnakovski D., Mizuno M., Kim G., Ishiguro T., Okumura M., Iwanaga T., et al. Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells in pellet cultural system. Exp Hematol 32 (2004) 502-509
35. Hanada K., Solchaga L.A., Caplan A.I., Hering T.M., Goldberg V.M., Yoo J.U., et al. BMP-2 induction and TGF-beta 1 modulation of rat periosteal cell chondrogenesis. J Cell Biochem 81 (2001) 284-294
36. Zehentner B.K., Dony C., and Burtscher H. The transcription factor Sox9 is involved in BMP-2 signaling. J Bone Miner Res 14 (1999) 1734-1741
37. Steinert A., Weber M., Dimmler A., Julius C., Schutze N., Noth U., et al. Chondrogenic differentiation of mesenchymal progenitor cells encapsulated in ultrahigh-viscosity alginate. J Orthop Res 21 (2003) 1090-1097
38. Derfoul A., Perkins G.L., Hall D.J., and Tuan R.S. Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes. Stem Cells (2006)
39. Chen C.W., Tsai Y.H., Deng W.P., Shih S.N., Fang C.L., Burch J.G., et al. Type I and II collagen regulation of chondrogenic differentiation by mesenchymal progenitor cells. J Orthop Res 23 (2005) 446-453
40. Sekiya I., Koopman P., Tsuji K., Mertin S., Harley V., Yamada Y., et al. Dexamethasone enhances SOX9 expression in chondrocytes. J Endocrinol 169 (2001) 573-579
41. Tanaka H., Murphy C.L., Murphy C., Kimura M., Kawai S., and Polak J.M. Chondrogenic differentiation of murine embryonic stem cells: effects of culture conditions and dexamethasone. J Cell Biochem 93 (2004) 454-462
42. Diefenderfer D.L., Osyczka A.M., Garino J.P., and Leboy P.S. Regulation of BMP-induced transcription in cultured human bone marrow stromal cells. J Bone Joint Surg Am 85-A Suppl 3 (2003) 19-28
43. Rickard D.J., Sullivan T.A., Shenker B.J., Leboy P.S., and Kazhdan I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161 (1994) 218-228
44. Pelttari K., Winter A., Steck E., Goetzke K., Hennig T., Ochs B.G., et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54 (2006) 3254-3266