메뉴 건너뛰기




Volumn 13, Issue 8, 2008, Pages 839-850

PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ESTROGEN RECEPTOR; HYBRID PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RUNX2;

EID: 48649110928     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01209.x     Document Type: Article
Times cited : (101)

References (48)
  • 1
    • 1542344522 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 and oncogenic signalling
    • Bardos, J.I. & Ashcroft, M. (2004) Hypoxia-inducible factor-1 and oncogenic signalling. Bioessays 26, 262-269.
    • (2004) Bioessays , vol.26 , pp. 262-269
    • Bardos, J.I.1    Ashcroft, M.2
  • 2
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil, D.P., Yang, Z.Z. & Hemmings, B.A. (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233-242.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 3
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L.C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 4
    • 0034881402 scopus 로고    scopus 로고
    • Multipotent mesenchymal stem cells from adult human synovial membrane
    • De Bari, C., Dell'Accio, F., Tylzanowski, P. & Luyten, F.P. (2001) Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 44, 1928-1942.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1928-1942
    • De Bari, C.1    Dell'Accio, F.2    Tylzanowski, P.3    Luyten, F.P.4
  • 6
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    • Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C., Koida, M., Ogita, K. & Komori, T. (2004a) Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J. Cell Biol. 166, 85-95.
    • (2004) J. Cell Biol. , vol.166 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5    Koida, M.6    Ogita, K.7    Komori, T.8
  • 7
    • 16544371756 scopus 로고    scopus 로고
    • Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2
    • Fujita, T., Fukuyama, R., Enomoto, H. & Komori, T. (2004b) Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J. Cell. Biochem. 93, 374-383.
    • (2004) J. Cell. Biochem. , vol.93 , pp. 374-383
    • Fujita, T.1    Fukuyama, R.2    Enomoto, H.3    Komori, T.4
  • 8
    • 0038633621 scopus 로고    scopus 로고
    • Tissue-specific gene expression in chondrocytes grown on three-dimensional hyaluronic acid scaffolds
    • Girotto, D., Urbani, S., Brun, P., Renier, D., Barbucci, R. & Abatangelo, G. (2003) Tissue-specific gene expression in chondrocytes grown on three-dimensional hyaluronic acid scaffolds. Biomaterials 24, 3265-3275.
    • (2003) Biomaterials , vol.24 , pp. 3265-3275
    • Girotto, D.1    Urbani, S.2    Brun, P.3    Renier, D.4    Barbucci, R.5    Abatangelo, G.6
  • 11
    • 0034869977 scopus 로고    scopus 로고
    • Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5
    • Hidaka, K., Kanematsu, T., Takeuchi, H., Nakata, M., Kikkawa, U. & Hirata, M. (2001) Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5. Int. J. Biochem. Cell Biol. 33, 1094-1103.
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , pp. 1094-1103
    • Hidaka, K.1    Kanematsu, T.2    Takeuchi, H.3    Nakata, M.4    Kikkawa, U.5    Hirata, M.6
  • 13
    • 33750050271 scopus 로고    scopus 로고
    • Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification
    • Hirao, M., Tamai, N., Tsumaki, N., Yoshikawa, H. & Myoui, A. (2006) Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification. J. Biol. Chem. 281, 31079-31092.
    • (2006) J. Biol. Chem. , vol.281 , pp. 31079-31092
    • Hirao, M.1    Tamai, N.2    Tsumaki, N.3    Yoshikawa, H.4    Myoui, A.5
  • 14
    • 0029930722 scopus 로고    scopus 로고
    • Repair of partial-thickness defects in articular cartilage: Cell recruitment from the synovial membrane
    • Hunziker, E.B. & Rosenberg, L.C. (1996) Repair of partial-thickness defects in articular cartilage: Cell recruitment from the synovial membrane. J. Bone Joint Surg. Am. 78, 721-733.
    • (1996) J. Bone Joint Surg. Am. , vol.78 , pp. 721-733
    • Hunziker, E.B.1    Rosenberg, L.C.2
  • 15
    • 14844318507 scopus 로고    scopus 로고
    • The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1
    • Ikeda, R., Yoshida, K., Tsukahara, S., Sakamoto, Y., Tanaka, H., Furukawa, K. & Inoue, I. (2005) The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1. J. Biol. Chem. 280, 8523-8530.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8523-8530
    • Ikeda, R.1    Yoshida, K.2    Tsukahara, S.3    Sakamoto, Y.4    Tanaka, H.5    Furukawa, K.6    Inoue, I.7
  • 19
    • 0242655673 scopus 로고    scopus 로고
    • Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
    • Jimenez, M.J., Balbin, M., Lopez, J.M., Alvarez, J., Komori, T. & Lopez-Otin, C. (1999) Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell. Biol. 19, 4431-4442.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4431-4442
    • Jimenez, M.J.1    Balbin, M.2    Lopez, J.M.3    Alvarez, J.4    Komori, T.5    Lopez-Otin, C.6
  • 20
    • 0031817577 scopus 로고    scopus 로고
    • In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    • Johnstone, B., Hering, T.M., Caplan, A.I., Goldberg, V.M. & Yoo, J.U. (1998) In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238, 265-272.
    • (1998) Exp. Cell Res. , vol.238 , pp. 265-272
    • Johnstone, B.1    Hering, T.M.2    Caplan, A.I.3    Goldberg, V.M.4    Yoo, J.U.5
  • 21
    • 0029145059 scopus 로고
    • In vivo model of cartilage degradation-effects of a matrix metalloproteinase inhibitor
    • Karran, E.H., Young, T.J., Markwell, R.E. & Harper, G.P. (1995) In vivo model of cartilage degradation-effects of a matrix metalloproteinase inhibitor. Ann. Rheum. Dis. 54, 662-669.
    • (1995) Ann. Rheum. Dis. , vol.54 , pp. 662-669
    • Karran, E.H.1    Young, T.J.2    Markwell, R.E.3    Harper, G.P.4
  • 23
    • 0033014044 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation by Cbfa1
    • Kim, I.S., Otto, F., Zabel, B. & Mundlos, S. (1999) Regulation of chondrocyte differentiation by Cbfa1. Mech. Dev. 80, 159-170.
    • (1999) Mech. Dev. , vol.80 , pp. 159-170
    • Kim, I.S.1    Otto, F.2    Zabel, B.3    Mundlos, S.4
  • 28
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H.M. (2003) Developmental regulation of the growth plate. Nature 423, 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 29
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T.D., Hancock, D.C., Danielian, P.S., Parker, M.G. & Evan, G.I. (1995) A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23, 1686-1690.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 31
    • 0141592429 scopus 로고    scopus 로고
    • Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1
    • Oh, C.D. & Chun, J.S. (2003) Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J. Biol. Chem. 278, 36563-36571.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36563-36571
    • Oh, C.D.1    Chun, J.S.2
  • 33
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
    • Paling, N.R., Wheadon, H., Bone, H.K. & Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem. 279, 48063-48070.
    • (2004) J. Biol. Chem. , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3    Welham, M.J.4
  • 35
    • 33646364795 scopus 로고    scopus 로고
    • Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes
    • Priore, R., Dailey, L. & Basilico, C. (2006) Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes. J. Cell. Physiol. 207, 800-808.
    • (2006) J. Cell. Physiol. , vol.207 , pp. 800-808
    • Priore, R.1    Dailey, L.2    Basilico, C.3
  • 36
    • 34250623251 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-β in human chondrocytes
    • Qureshi, H.Y., Ahmad, R., Sylvester, J. & Zafarullah, M. (2007) Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-β in human chondrocytes. Cell. Signal. 19, 1643-1651.
    • (2007) Cell. Signal. , vol.19 , pp. 1643-1651
    • Qureshi, H.Y.1    Ahmad, R.2    Sylvester, J.3    Zafarullah, M.4
  • 37
    • 23644456193 scopus 로고    scopus 로고
    • Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source
    • Sakaguchi, Y., Sekiya, I., Yagishita, K. & Muneta, T. (2005) Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. 52, 2521-2529.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2521-2529
    • Sakaguchi, Y.1    Sekiya, I.2    Yagishita, K.3    Muneta, T.4
  • 39
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
    • Schipani, E., Ryan, H.E., Didrickson, S., Kobayashi, T., Knight, M. & Johnson, R.S. (2001) Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev. 15, 2865-2876.
    • (2001) Genes Dev. , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 40
    • 0033577851 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor β (TGF-β) on endochondral bone formation
    • Serra, R., Karaplis, A. & Sohn, P. (1999) Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor β (TGF-β) on endochondral bone formation. J. Cell Biol. 145, 783-794.
    • (1999) J. Cell Biol. , vol.145 , pp. 783-794
    • Serra, R.1    Karaplis, A.2    Sohn, P.3
  • 41
    • 23644450412 scopus 로고    scopus 로고
    • IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
    • Starkman, B.G., Cravero, J.D., Delcarlo, M. & Loeser, R.F. (2005) IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem. J. 389, 723-729.
    • (2005) Biochem. J. , vol.389 , pp. 723-729
    • Starkman, B.G.1    Cravero, J.D.2    Delcarlo, M.3    Loeser, R.F.4
  • 42
    • 34248594901 scopus 로고    scopus 로고
    • The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway
    • Tateishi, K., Higuchi, C., Ando, W., Nakata, K., Hashimoto, J., Hart, D.A., Yoshikawa, H. & Nakamura, N. (2007) The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway. Osteoar. Cartil. 15, 709-718.
    • (2007) Osteoar. Cartil. , vol.15 , pp. 709-718
    • Tateishi, K.1    Higuchi, C.2    Ando, W.3    Nakata, K.4    Hashimoto, J.5    Hart, D.A.6    Yoshikawa, H.7    Nakamura, N.8
  • 44
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M. & Tabin, C.J. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 45
    • 33646549601 scopus 로고    scopus 로고
    • Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
    • Watanabe, S., Umehara, H., Murayama, K., Okabe, M., Kimura, T. & Nakano, T. (2006) Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 25, 2697-2707.
    • (2006) Oncogene , vol.25 , pp. 2697-2707
    • Watanabe, S.1    Umehara, H.2    Murayama, K.3    Okabe, M.4    Kimura, T.5    Nakano, T.6
  • 46
    • 0043210428 scopus 로고    scopus 로고
    • Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
    • Wiznerowicz, M. & Trono, D. (2003) Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference. J. Virol. 77, 8957-8961.
    • (2003) J. Virol. , vol.77 , pp. 8957-8961
    • Wiznerowicz, M.1    Trono, D.2
  • 47
    • 0042887424 scopus 로고    scopus 로고
    • Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo
    • Zheng, Q., Zhou, G., Morello, R., Chen, Y., Garcia-Rojas, X. & Lee, B. (2003) Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J. Cell Biol. 162, 833-842.
    • (2003) J. Cell Biol. , vol.162 , pp. 833-842
    • Zheng, Q.1    Zhou, G.2    Morello, R.3    Chen, Y.4    Garcia-Rojas, X.5    Lee, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.