Activation of interleukin-1 signaling cascades in normal and osteoarthritis articular cartilage

American Journal of Pathology

Volumn 171, Issue 3, 2007, Pages 938-946

  Fan, Zhiyong ^a   Söder, Stephan ^b   Oehler, Stephan ^c   Fundel, Katrin ^d   Aigner, Thomas ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Orthopedic Hospital   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

ADULT; AGED; ARTICLE; CARTILAGE; CARTILAGE CELL; CATABOLISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIFFUSION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MEDIATOR; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; UPREGULATION;

EID: 34548816723     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.061083     Document Type: Article

References (42)

1. Goldring MB: Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2000, 2:459-465
2. Goldring MB: The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res 1999, 40:1-11
3. Arend WP, Dayer J-M: Inhibition of the production and affects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum 1995, 38:151-160
4. Westacott CI, Sharif M: Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin Arthritis Rheum 1996, 25:254-272
5. Tetlow LC, Adlam DJ, Woolley DE: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001, 44:585-594
6. McCollum R, Martel-Pelletier J, DiBattista J, Pelletier JP: Regulation of interleukin 1 receptor in human articular chondrocytes. J Rheumatol 1991, 18:85-88
7. Ku G, Faust T, Lauffer LL, Livingston DJ, Harding MW: Interleukin-1β converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine 1996, 8:377-386
8. Aigner T, McKenna L, Zien A, Fan Z, Gebhard PM, Zimmer R: Gene expression profiling of serum- and interleukin-1β-stimulated primary human adult articular chondrocytes: a molecular analysis based on chondrocytes isolated from one donor. Cytokine 2005, 31:227-240
9. Murata M, Trahan C, Hirahashi J, Mankin HJ, Towle CA: Intracellular interleukin-1 receptor antagonist in osteoarthritis chondrocytes. Clin Orthop Relat Res 2003, 409:285-295
10. Saha N, Moldovan F, Tardif G, Pelletier JP, Cloutier J-M, Martel-Pelletier J: Interleukin-1β-converting enzyme/capase1 in human osteoarthritic tissues. Arthritis Rheum 1999, 42:1577-1587
11. Lefebvre V, Peeters-Joris C, Vaes G: Modulation by interleukin 1 and tumor necrosis factor α of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes. Biochim Biophys Acta 1990, 1052:366-378
12. Goldring MB, Birkhead JR, Sandell LJ, Kimura T, Krane SM: Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 1988, 82:2026-2037
13. Richardson DW, Dodge GR: Effects of interleukin-1β and tumor necrosis factor-α on expression of matrix-related genes by cultured equine articular chondrocytes. Am J Vet Res 2000, 61:624-630
14. Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T: Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 2002, 46:2648-2657
15. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE: Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000, 43:801-811
16. Geng Y, Valbracht J, Lotz M: Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 1996, 98:2425-2430
17. Lefebvre V, Peeters-Joris C, Vaes G: Production of gelatin-degrading matrix metalloproteinases ("type IV collagenases") and inhibitors by articular chondrocytes during their dedifferentiation by serial subcultures and under stimulation by interleukin-1 and tumor necrosis factor α. Biochim Biophys Acta 1991, 1094:8-18
18. Henrotin YE, DeGroove DD, Labasse AH, Gaspar SE, Zheng S-X, Greenen VG, Reginster J-YL: Effects of exogenous IL-1, TNF-α, IL-6, IL-8 and LIF on cytokine production by human articular chondrocytes. Osteoarthritis Cartilage 1996, 4:163-173
19. Kracht M, Saklatvala J: Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine 2002, 20:91-106
20. Liacini A, Sylvester J, Li WQ, Zafarullah M: Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol 2002, 21:251-262
21. Clancy R, Rediske J, Koehne C, Stoyanovsky D, Amin A, Attur M, Iyama K, Abramson SB: Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence. Osteoarthritis Cartilage 2001, 9:294-299
22. Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. J Bone Joint Surg 1971, 53:523-537
23. Aigner T, Stoss H, Weseloh G, Zeiler G, von der Mark K: Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage. Virchows Arch B Cell Pathol Incl Mol Pathol 1992, 62:337-345
24. Hambach L, Neureiter D, Zeiler G, Kirchner T, Aigner T: Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage. Arthritis Rheum 1998, 41:986-996
25. McKenna LA, Gehrsitz A, Soeder S, Eger W, Kirchner T, Aigner T: Effective isolation of high quality total RNA from human adult articular cartilage. Anal Biochem 2000, 286:80-85
26. Fan Z, Bau B, Yang H, Aigner T: IL-β induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NF-κB signaling pathways. Cytokine 2004, 28:17-24
27. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685
28. Aigner T, Hemmel M, Neureiter D, Gebhard PM, Zeiler G, Kirchner T, McKenna LA: Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritic human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 2001, 44:1304-1312
29. Pelletier JP, McCollum R, Cloutier J-M, Martel-Pelletier J: Synthesis of metalloproteinases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol Suppl 1995, 43:109-114
30. Westacott CI, Whicher JT, Barnes IC, Thompson D, Swan AJ, Dieppe PA: Synovial fluid concentration of five different cytokine in rheumatic diseases. Ann Rheum Dis 1990, 49:676-681
31. Aigner T, Vornehm SI, Zeiler G, Dudhia J, von der Mark K, Bayliss MT: Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. Arthritis Rheum 1997, 40:562-569
32. Häuselmann HJ, Flechtenmacher J, Michal L, Thonar EJMA, Shinmei M, Kuettner KE, Aydelotte MB: The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers. Arthritis Rheum 1996, 39:478-488
33. Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ: Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-α in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 2003, 85A(Suppl 3):59-66
34. Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM: Gene deletion of either interleukin-1β, interleukin-1β-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum 2003, 48:3452-3463
35. Fan Z, Bau B, Yang H, Soeder S, Aigner T: Freshly isolated osteoarthritic chondrocytes are catabolic more active than normal chondrocytes, but less responsive to catabolic stimulation with IL-1β. Arthritis Rheum 2005, 52:136-143
36. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, Geoghegan KF, Hambor JE: Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996, 97:761-768
37. Reboul P, Pelletier JP, Tardif G, Cloutier J-M, Martel-Pelletier J: The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest 1996, 97:2011-2019
38. Roach HI, Yamada N, Cheung KSC, Tilley S, Clarke NMP: Abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes is associated with demethylation of specific CpGs in the promotor. Arthritis Rheum 2005, 52:3110-3124
39. Roach HI, Inglis S, Partridge KA, Clarke NMP, Richard OC: Can changes in the DNA methylation pattern explain the clonally inherited altered phenotypte of osteoarthritic chondrocytes? Proceedings of the 8th International Conference on the Chemistry and Biology of Mineralized Tissues. Edited by W Landis, J Sodek. Toronto, University of Toronto, 2005, pp 192-195
40. Aigner T, Soeder S, Haag J: IL-1β and BMPs: interactive players of cartilage matrix degradation and regeneration. Eur Cell Mater 2006, 12:49-56
41. Glasson SS: In vivo osteoarthritis target validation utilizing genetically-modified mice. Curr Drug Targets 2007, 8:367-376
42. Smith AJ, Keen LJ, Billingham MJ, Perry MJ, Elson CJ, Kirwan JR, Sims JE, Doherty M, Spector TD, Bidwell JL: Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Genes Immun 2004, 5:451-460