Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis

Arthritis and Rheumatism

Volumn 56, Issue 8, 2007, Pages 2663-2673

  Xu, Lin ^a   Peng, Haibing ^b   Glasson, Sonya ^c   Lee, Peter L ^a   Hu, Kenpan ^a   Ijiri, Kosei ^b   Olsen, Bjorn R ^a   Goldring, Mary B ^b   Li, Yefu ^a  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALANINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGEN RECEPTOR; COLLAGEN TYPE 2; COLLAGENASE 3; DISCOIDIN; DISCOIDIN DOMAIN RECEPTOR 2; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; POLYCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TYROSINE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FEMUR HEAD; FRACTURE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE OSTEOARTHRITIS; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL MARKERS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME INHIBITORS; FEMUR HEAD; HUMANS; INTEGRIN ALPHA2BETA1; INTERLEUKIN-1; MALE; MATRIX METALLOPROTEINASE 13; MICE; MICE, INBRED STRAINS; OSTEOARTHRITIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN; STIFLE;

EID: 34547783916     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22761     Document Type: Article

References (30)

1. Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: new insights [review]. Part 1. The disease and its risk factors. Ann Intern Med 2000;133:635-46.
2. Scott JC, Lethbridge-Cejku M, Hochberg MC. Epidemiology and economic consequences of osteoarthritis. In: Osteoarthritis: clinical and experimental aspects. Berlin: Springer-Verlag; 1999. p. 20-52.
3. Hamerman D. The biology of osteoarthritis. N Engl J Med 1989;320:1322-30.
4. Fassler R, Schnegelsberg PN, Dausman J, Shinya T, Muragaki Y, McCarthy MT, et al. Mice lacking α1(IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci USA 1994;91:5070-4.
5. Hu K, Xu L, Cao L, Flahiff CM, Brussiau J, Ho K, et al. Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen. Arthritis Rheum 2006;54:2891-900.
6. Li Y, Lacerda DA, Warman ML, Beier DR, Yoshioka H, Ninomiya Y, et al. A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell 1995;80:423-30.
7. Xu L, Flahiff CM, Waldman BA, Wu D, Olsen BR, Setton LA, et al. Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho). Arthritis Rheum 2003;48:2509-18.
8. Xu L, Peng H, Wu D, Hu K, Goldring MB, Olsen BR, et al. Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem 2005;280:548-55.
9. Leitinger B, Steplewski A, Fertala A. The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. J Mol Biol 2004;344:993-1003.
10. Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1997;1:13-23.
11. Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell 1997;1:25-34.
12. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
13. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004;50:2547-58.
14. Chambers MG, Bayliss MT, Mason RM. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthritis Cartilage 1997;5:301-8.
15. Leitinger B. Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2: identification of collagen binding sites in DDR2. J Biol Chem 2003;19:16761-9.
16. Robbins JR, Thomas B, Tan L, Choy B, Arbiser JL, Berenbaum F, et al. Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β. Arthritis Rheum 2000;43:2189-201.
17. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, et al. A novel role for GADD45β as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem 2005;280:38544-55.
18. Forsyth CB, Pulai J, Loeser RF. Fibronectin fragments and blocking antibodies to α2β1 and α5β1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum 2002;46:2368-76.
19. Mengshol JA, Vincenti MP, Brinckerhoff CE. IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocyte cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res 2001;29:4361-72.
20. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
21. Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001;107:35-44.
22. Dijkgraaf LC, de Bont LG, Boering G, Liem RS. The structure, biochemistry, and metabolism of osteoarthritic cartilage: a review of the literature. J Oral Maxillofac Surg 1995;53:1182-92.
23. Mankin HJ, Brandt KD. Biochemistry and metabolism of articular cartilage in osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, editors. Osteoarthritis: diagnosis and medical/surgical management. 2nd ed. Philadelphia: WB Saunders; 1992. p. 109-54.
24. Buckwalter JA, Hunziker EB. Articular cartilage morphology and biology. In: Archer C, Caterson B, Benjamin M, Ralphs J, editors. Biology of the synovial joint. Amsterdam: Harwood Academic; 1999. p. 75-100.
25. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000;103:211-25.
26. Yang K, Kim JH, Kim HJ, Park IS, Kim IY, Yang BS. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. J Biol Chem 2005;280:39058-66.
27. Gotoh N, Tojo A, Hino M, Yazaki Y, Shibuya M. A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. Biochem Biophys Res Commun 1992;186:768-74.
28. Trakul N, Rosner MR. Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res 2005;15:19-23.
29. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000;43:801-11.
30. Verzijl N, DeGroot J, Thorpe SR, Bank RA, Shaw JN, Lyons TJ, et al. Effect of collagen turnover on the accumulation of advanced glycation end products. J Biol Chem 2000;275:39027-31.