메뉴 건너뛰기




Volumn 306, Issue 2, 2007, Pages 612-623

Genetic ablation of Rac1 in cartilage results in chondrodysplasia

Author keywords

Cartilage; Cre lox; Endochondral ossification; Growth plate; Knockout; Rac1; Skeletal development

Indexed keywords

ACTIN; COLLAGEN TYPE 2; CYCLIN D1; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P57; RAC1 PROTEIN; SONIC HEDGEHOG PROTEIN;

EID: 34249899968     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.03.520     Document Type: Article
Times cited : (86)

References (39)
  • 1
    • 0036400641 scopus 로고    scopus 로고
    • Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion
    • Arthur W.T., Noren N.K., and Burridge K. Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol. Res. 35 (2002) 239-246
    • (2002) Biol. Res. , vol.35 , pp. 239-246
    • Arthur, W.T.1    Noren, N.K.2    Burridge, K.3
  • 2
    • 0141483387 scopus 로고    scopus 로고
    • {beta}1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
    • Aszodi A., Hunziker E.B., Brakebusch C., and Fassler R. {beta}1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 17 (2003) 2465-2479
    • (2003) Genes Dev. , vol.17 , pp. 2465-2479
    • Aszodi, A.1    Hunziker, E.B.2    Brakebusch, C.3    Fassler, R.4
  • 4
    • 10044261918 scopus 로고    scopus 로고
    • Cell-cycle control and the cartilage growth plate
    • Beier F. Cell-cycle control and the cartilage growth plate. J. Cell. Physiol. 202 (2005) 1-8
    • (2005) J. Cell. Physiol. , vol.202 , pp. 1-8
    • Beier, F.1
  • 5
    • 17044396261 scopus 로고    scopus 로고
    • Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes
    • Bengtsson T., Aszodi A., Nicolae C., Hunziker E.B., Lundgren-Akerlund E., and Fassler R. Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J. Cell. Sci. 118 (2005) 929-936
    • (2005) J. Cell. Sci. , vol.118 , pp. 929-936
    • Bengtsson, T.1    Aszodi, A.2    Nicolae, C.3    Hunziker, E.B.4    Lundgren-Akerlund, E.5    Fassler, R.6
  • 10
    • 33645644184 scopus 로고    scopus 로고
    • Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells
    • Gonzalez E., Kou R., and Michel T. Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J. Biol. Chem. 281 (2006) 3210-3216
    • (2006) J. Biol. Chem. , vol.281 , pp. 3210-3216
    • Gonzalez, E.1    Kou, R.2    Michel, T.3
  • 11
    • 0038323946 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates chondrocyte shape and proliferation
    • Grashoff C., Aszodi A., Sakai T., Hunziker E.B., and Fassler R. Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 4 (2003) 432-438
    • (2003) EMBO Rep. , vol.4 , pp. 432-438
    • Grashoff, C.1    Aszodi, A.2    Sakai, T.3    Hunziker, E.B.4    Fassler, R.5
  • 12
    • 27644453166 scopus 로고    scopus 로고
    • Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    • James C.G., Appleton C.T.G., Ulici V., Underhill T.M., and Beier F. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol. Biol. Cell 16 (2005) 5316-5333
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5316-5333
    • James, C.G.1    Appleton, C.T.G.2    Ulici, V.3    Underhill, T.M.4    Beier, F.5
  • 13
    • 17644372415 scopus 로고    scopus 로고
    • External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification
    • Johnson K.A., and Terkeltaub R.A. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. J. Biol. Chem. 280 (2005) 15004-15012
    • (2005) J. Biol. Chem. , vol.280 , pp. 15004-15012
    • Johnson, K.A.1    Terkeltaub, R.A.2
  • 14
    • 0036178447 scopus 로고    scopus 로고
    • Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members
    • Juliano R.L. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 283-323
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 283-323
    • Juliano, R.L.1
  • 17
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G., and Wagner E.F. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2 (2002) 389-406
    • (2002) Dev. Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 18
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 423 (2003) 332-336
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 20
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long F., Zhang X.M., Karp S., Yang Y., and McMahon A.P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128 (2001) 5099-5108
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 22
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., and Johnson R.S. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15 (2001) 2865-2876
    • (2001) Genes Dev. , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 23
    • 33845640215 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells
    • Stanton L.A., and Beier F. Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells. Exp. Cell Res. 313 (2007) 146-155
    • (2007) Exp. Cell Res. , vol.313 , pp. 146-155
    • Stanton, L.A.1    Beier, F.2
  • 24
    • 0242334002 scopus 로고    scopus 로고
    • MAP kinases in chondrocyte differentiation
    • Stanton L.A., Underhill T.M., and Beier F. MAP kinases in chondrocyte differentiation. Dev. Biol. 263 (2003) 165-175
    • (2003) Dev. Biol. , vol.263 , pp. 165-175
    • Stanton, L.A.1    Underhill, T.M.2    Beier, F.3
  • 25
    • 1542314840 scopus 로고    scopus 로고
    • p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation
    • Stanton L.A., Sabari S., Sampaio A.V., Underhill T.M., and Beier F. p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. Biochem. J. 378 (2004) 53-62
    • (2004) Biochem. J. , vol.378 , pp. 53-62
    • Stanton, L.A.1    Sabari, S.2    Sampaio, A.V.3    Underhill, T.M.4    Beier, F.5
  • 27
    • 9444238519 scopus 로고    scopus 로고
    • Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass
    • Sun C.X., Downey G.P., Zhu F., Koh A.L.Y., Thang H., and Glogauer M. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104 (2004) 3758-3765
    • (2004) Blood , vol.104 , pp. 3758-3765
    • Sun, C.X.1    Downey, G.P.2    Zhu, F.3    Koh, A.L.Y.4    Thang, H.5    Glogauer, M.6
  • 28
    • 0034308228 scopus 로고    scopus 로고
    • Rho family GTPases: more than simple switches
    • Symons M., and Settleman J. Rho family GTPases: more than simple switches. Trends Cell Biol. 10 (2000) 415-419
    • (2000) Trends Cell Biol. , vol.10 , pp. 415-419
    • Symons, M.1    Settleman, J.2
  • 30
    • 0038148536 scopus 로고    scopus 로고
    • Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
    • Terpstra L., Prud'homme J., Arabian A., Takeda S., Karsenty G., Dedhar S., and St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J. Cell Biol. 162 (2003) 139-148
    • (2003) J. Cell Biol. , vol.162 , pp. 139-148
    • Terpstra, L.1    Prud'homme, J.2    Arabian, A.3    Takeda, S.4    Karsenty, G.5    Dedhar, S.6    St-Arnaud, R.7
  • 31
  • 32
    • 19044390915 scopus 로고    scopus 로고
    • Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
    • Wang G., and Beier F. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J. Bone Miner. Res. 20 (2005) 1022-1031
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 1022-1031
    • Wang, G.1    Beier, F.2
  • 33
    • 1842581698 scopus 로고    scopus 로고
    • RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation
    • Wang G., Woods A., Sabari S., Pagnotta L., Stanton L.A., and Beier F. RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J. Biol. Chem. 279 (2004) 13205-13214
    • (2004) J. Biol. Chem. , vol.279 , pp. 13205-13214
    • Wang, G.1    Woods, A.2    Sabari, S.3    Pagnotta, L.4    Stanton, L.A.5    Beier, F.6
  • 34
    • 33744956176 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner
    • Woods A., and Beier F. RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner. J. Biol. Chem. 281 (2006) 13134-13140
    • (2006) J. Biol. Chem. , vol.281 , pp. 13134-13140
    • Woods, A.1    Beier, F.2
  • 35
    • 15744375543 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis
    • Woods A., Wang G., and Beier F. RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. J. Biol. Chem. 280 (2005) 11626-11634
    • (2005) J. Biol. Chem. , vol.280 , pp. 11626-11634
    • Woods, A.1    Wang, G.2    Beier, F.3
  • 36
    • 0038688357 scopus 로고    scopus 로고
    • The genetic basis for skeletal diseases
    • Zelzer E., and Olsen B.R. The genetic basis for skeletal diseases. Nature 423 (2003) 343-348
    • (2003) Nature , vol.423 , pp. 343-348
    • Zelzer, E.1    Olsen, B.R.2
  • 37
    • 31044432518 scopus 로고    scopus 로고
    • Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation
    • Zhang R., Murakami S., Coustry F., Wang Y., and de Crombrugghe B. Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. PNAS 103 (2006) 365-370
    • (2006) PNAS , vol.103 , pp. 365-370
    • Zhang, R.1    Murakami, S.2    Coustry, F.3    Wang, Y.4    de Crombrugghe, B.5
  • 38
    • 0242282967 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
    • Zhen X., Wei L., Wu Q., Zhang Y., and Chen Q. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone. J. Biol. Chem. 275 (2000) 15
    • (2000) J. Biol. Chem. , vol.275 , pp. 15
    • Zhen, X.1    Wei, L.2    Wu, Q.3    Zhang, Y.4    Chen, Q.5
  • 39
    • 0035895905 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
    • Zhen X., Wei L., Wu Q., Zhang Y., and Chen Q. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone. J. Biol. Chem. 276 (2001) 4879-4885
    • (2001) J. Biol. Chem. , vol.276 , pp. 4879-4885
    • Zhen, X.1    Wei, L.2    Wu, Q.3    Zhang, Y.4    Chen, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.