The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells

Journal of Clinical Investigation

Volumn 98, Issue 9, 1996, Pages 2066-2075

  Rufo, Paul A ^a,c   Jiang, Lianwei ^b,c   Moe, Signa J ^a   Brugnara, Carlo ^a,c   Alper, Seth L ^b,c,d   Lencer, Wayne I ^a,c,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Ca++; Cl secretion; clotrimazole; K+ channels; T84 cell

Indexed keywords

ANTIFUNGAL AGENT; BARIUM CHLORIDE; CALCIUM ION; CARBACHOL; CHARYBDOTOXIN; CHLORIDE CHANNEL; CHLORIDE ION; CLOTRIMAZOLE; ECONAZOLE; IMIDAZOLE DERIVATIVE; IODINE 125; KETOCONAZOLE; METRONIDAZOLE; MICONAZOLE; POTASSIUM CHANNEL; RUBIDIUM 86; VASOACTIVE INTESTINAL POLYPEPTIDE; CALCIUM; CHLORIDE; CYCLIC AMP; POTASSIUM;

ARTICLE; CALCIUM CELL LEVEL; CELL LINE; CHLORIDE TRANSPORT; COLON MUCOSA; CONTROLLED STUDY; DOSE RESPONSE; EPITHELIUM CELL; FLUORESCENCE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MONOLAYER CULTURE; PRIORITY JOURNAL; SHORT CIRCUIT CURRENT; SIGNAL TRANSDUCTION; TRANSPORT KINETICS; CELL CULTURE; CELL POLARITY; COLON; DRUG EFFECT; ELECTROLYTE BALANCE; EPITHELIUM; INTESTINE MUCOSA; METABOLISM; PHYSIOLOGY; SECRETION; TRANSPORT AT THE CELLULAR LEVEL;

ANTIFUNGAL AGENTS; BIOLOGICAL TRANSPORT; CALCIUM; CELL POLARITY; CELLS, CULTURED; CHLORIDE CHANNELS; CHLORIDES; CLOTRIMAZOLE; COLON; CYCLIC AMP; EPITHELIUM; HUMANS; INTESTINAL MUCOSA; POTASSIUM; POTASSIUM CHANNELS; SIGNAL TRANSDUCTION; WATER-ELECTROLYTE BALANCE;

EID: 0029658673     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119012     Document Type: Article

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