Effects of imidazole antimycotics on the liver microsomal cytochrome P450 isoforms in rats: Comparison of in vitro and ex vivo studies

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 2, 2000, Pages 121-126

  Suzuki, S ^a   Kurata, N ^b   Nishimura, Y ^b   Yasuhara, H ^b   Satoh, T ^a  

^a Biomedical Research Institute   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Drug induction; Drug inhibition; Drug drug interaction; Imidazole antimycotics

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2E; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; DIAZEPAM; DRUG METABOLIZING ENZYME; IMIDAZOLE DERIVATIVE; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; ANTIFUNGAL AGENTS; CLOTRIMAZOLE; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; ENZYME INDUCTION; HUMANS; KETOCONAZOLE; MALE; MICONAZOLE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033694996     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190078     Document Type: Article

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