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Volumn 263, Issue 1, 2010, Pages 105-113

Synthesis and immunological activities of novel agonists of toll-like receptor 9

Author keywords

Immune stimulatory; Oligodeoxynucleotides; T helper 1 type immune response; Toll like receptor 9

Indexed keywords

ALPHA INTERFERON; IMMUNE MODULATORY OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 77952541603     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.03.005     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 37749044421 scopus 로고    scopus 로고
    • Synthetic agonists of toll-like receptors 7, 8 and 9
    • Agrawal S., Kandimalla E.R. Synthetic agonists of toll-like receptors 7, 8 and 9. Biochem. Soc. Trans. 2007, 35:1461-1467.
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 1461-1467
    • Agrawal, S.1    Kandimalla, E.R.2
  • 4
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman D.M., Yi A.K., Beaucage S.L., Conover J., Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 1996, 93:2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 5
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002, 20:709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 6
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina J.P., Gilkeson G.S., Pisetsky D.S. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 1991, 147:1759-1764.
    • (1991) J. Immunol. , vol.147 , pp. 1759-1764
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 7
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Nat. Cancer Inst. 1984, 72:955-962.
    • (1984) J. Nat. Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6    Furutani, Y.7    Yano, O.8    Kataoka, T.9    Sudo, T.10
  • 8
    • 0030772278 scopus 로고    scopus 로고
    • Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice
    • Zhao Q., Temsamani J., Zhou R.Z., Agrawal S. Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. Antisense Nucleic Acid Drug Dev. 1997, 7:495-502.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 495-502
    • Zhao, Q.1    Temsamani, J.2    Zhou, R.Z.3    Agrawal, S.4
  • 9
    • 23344431704 scopus 로고    scopus 로고
    • A phase I study of HYB2055 in patients (pts) with advanced solid malignancies, J. Clin. Oncol., 2004 ASCO Annual Meeting Proceedings, S (Supplement),
    • J.J. Hwang, S. Park, A. Amin, R.R. Martin, T. Sullivan, T. Burns, S. Agrawal, M.J Waxdal, S. Malik, J.L. Marshall, A phase I study of HYB2055 in patients (pts) with advanced solid malignancies, J. Clin. Oncol., 2004 ASCO Annual Meeting Proceedings, 22, 14S (Supplement), 2004, p. 3111.
    • (2004) , vol.22 , Issue.14 , pp. 3111
    • Hwang, J.J.1    Park, S.2    Amin, A.3    Martin, R.R.4    Sullivan, T.5    Burns, T.6    Agrawal, S.7    Waxdal M.J8    Malik, S.9    Marshall, J.L.10
  • 10
    • 23344439298 scopus 로고    scopus 로고
    • A phase I trial of escalating doses of the TLR9 agonist HYB2055 in patients with advanced solid tumors, J. Clin, Oncol., 2004 ASCO Annual Meeting Proceedings,of II (Supplement),
    • D.J. Moore, J. Hwang, J. McGreivy, S. Park, S. Malik, R.R. Martin, T.M. Sullivan, S. Agrawal, J. Marshall, A phase I trial of escalating doses of the TLR9 agonist HYB2055 in patients with advanced solid tumors, J. Clin, Oncol., 2004 ASCO Annual Meeting Proceedings, 23, 16S part I of II (Supplement), 2005, p. 2503.
    • (2005) , vol.23 , Issue.16 PART 1 , pp. 2503
    • Moore, D.J.1    Hwang, J.2    McGreivy, J.3    Park, S.4    Malik, S.5    Martin, R.R.6    Sullivan, T.M.7    Agrawal, S.8    Marshall, J.9
  • 11
    • 77952545357 scopus 로고    scopus 로고
    • Sullivan A phase 2 multicenter, randomized, open-label study of two dose levels of IMO-2055 in patients with metastatic or recurrent renal cell carcinoma, Presented at the 8th International Kidney Cancer Symposium, September 25-26, Chicago, Il, USA.
    • T. Kuzel, J. Dutcher, S. Ebbinghaus, M. Gordon, S. Grubbs, K. Khan, A. Lipton, D. McDermott, F. Millard, D. Quinn, T. Sullivan, A phase 2 multicenter, randomized, open-label study of two dose levels of IMO-2055 in patients with metastatic or recurrent renal cell carcinoma, Presented at the 8th International Kidney Cancer Symposium, September 25-26, 2009, Chicago, Il, USA.
    • (2009)
    • Kuzel, T.1    Dutcher, J.2    Ebbinghaus, S.3    Gordon, M.4    Grubbs, S.5    Khan, K.6    Lipton, A.7    McDermott, D.8    Millard, F.9    Quinn, D.10
  • 12
    • 77952550403 scopus 로고    scopus 로고
    • Phase 1 study of the toll-like receptor 9 (TLR9) agonist, IMO-2055, combined with erlotinib and bevacizumab in patients with advanced or metastatic non-small cell lung cancer. Presented at the 15th ECCO and 34th ESMO Multidisciplinary Congress, September 20-24, Berl
    • D. Smith, P. Conkling, D. Richards, C. Alemany, T. Boyd, L. Garbo, D. Loesch, D. Wages, A. Bexon, J. Murphy. Phase 1 study of the toll-like receptor 9 (TLR9) agonist, IMO-2055, combined with erlotinib and bevacizumab in patients with advanced or metastatic non-small cell lung cancer. Presented at the 15th ECCO and 34th ESMO Multidisciplinary Congress, September 20-24, 2009, Berlin, Germany.
    • (2009)
    • Smith, D.1    Conkling, P.2    Richards, D.3    Alemany, C.4    Boyd, T.5    Garbo, L.6    Loesch, D.7    Wages, D.8    Bexon, A.9    Murphy, J.10
  • 14
    • 28344457315 scopus 로고    scopus 로고
    • Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a clicensed hepatitis B vaccine in healthy young adults
    • Halperin S.A., Dobson S., McNeil S., Langley J.M., Smith B., McCall-Sani R., Levitt D., VanNest G., Gennevois D., Eiden J.J. Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a clicensed hepatitis B vaccine in healthy young adults. Vaccine 2006, 24:20-26.
    • (2006) Vaccine , vol.24 , pp. 20-26
    • Halperin, S.A.1    Dobson, S.2    McNeil, S.3    Langley, J.M.4    Smith, B.5    McCall-Sani, R.6    Levitt, D.7    VanNest, G.8    Gennevois, D.9    Eiden, J.J.10
  • 21
    • 0030071007 scopus 로고    scopus 로고
    • Effect of different chemically modified oligodeoxynucleotides on immune stimulation
    • Zhao Q., Temsamani J., Iadarola P.L., Jiang Z., Agrawal S. Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem. Pharmacol. 1996, 51:173-182.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 173-182
    • Zhao, Q.1    Temsamani, J.2    Iadarola, P.L.3    Jiang, Z.4    Agrawal, S.5
  • 22
    • 0033590264 scopus 로고    scopus 로고
    • Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity
    • Zhao Q., Yu D., Agrawal S. Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity. Bioorg. Med. Chem. Lett. 1999, 9:3453-3458.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 3453-3458
    • Zhao, Q.1    Yu, D.2    Agrawal, S.3
  • 23
    • 0034657519 scopus 로고    scopus 로고
    • Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside
    • Zhao Q., Yu D., Agrawal S. Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside. Bioorg. Med. Chem. Lett. 2000, 10:1051-1054.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1051-1054
    • Zhao, Q.1    Yu, D.2    Agrawal, S.3
  • 24
    • 0036525602 scopus 로고    scopus 로고
    • Immunostimulatory properties of phosphorothioate CpG DNA containing both 3′,5′- and 2′,5′-internucleotide linkages
    • Yu D., Kandimalla E.R., Zhao Q., Cong Y., Agrawal S. Immunostimulatory properties of phosphorothioate CpG DNA containing both 3′,5′- and 2′,5′-internucleotide linkages. Nucleic Acids Res. 2002, 30:1613-1619.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1613-1619
    • Yu, D.1    Kandimalla, E.R.2    Zhao, Q.3    Cong, Y.4    Agrawal, S.5
  • 25
    • 0035502598 scopus 로고    scopus 로고
    • Antisense and/or immunostimulatory oligonucleotide therapeutics
    • Agrawal S., Kandimalla E.R. Antisense and/or immunostimulatory oligonucleotide therapeutics. Curr. Cancer Drug Targets 2001, 1:197-209.
    • (2001) Curr. Cancer Drug Targets , vol.1 , pp. 197-209
    • Agrawal, S.1    Kandimalla, E.R.2
  • 26
    • 0034806818 scopus 로고    scopus 로고
    • Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages
    • Yu D., Kandimalla E.R., Zhao Q., Cong Y., Agrawal S. Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages. Bioorg. Med. Chem. 2001, 9:2803-2808.
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 2803-2808
    • Yu, D.1    Kandimalla, E.R.2    Zhao, Q.3    Cong, Y.4    Agrawal, S.5
  • 27
    • 0035801738 scopus 로고    scopus 로고
    • Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases
    • Yu D., Kandimalla E.R., Zhao Q., Cong Y., Agrawal S. Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases. Bioorg. Med. Chem. Lett. 2001, 11:2263-2267.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 2263-2267
    • Yu, D.1    Kandimalla, E.R.2    Zhao, Q.3    Cong, Y.4    Agrawal, S.5
  • 28
    • 0037295379 scopus 로고    scopus 로고
    • Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA
    • Yu D., Kandimalla E.R., Zhao Q., Bhagat L., Cong Y., Agrawal S. Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA. Bioorg. Med. Chem. 2003, 11:459-464.
    • (2003) Bioorg. Med. Chem. , vol.11 , pp. 459-464
    • Yu, D.1    Kandimalla, E.R.2    Zhao, Q.3    Bhagat, L.4    Cong, Y.5    Agrawal, S.6
  • 29
    • 0037179614 scopus 로고    scopus 로고
    • Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences
    • Yu D., Kandimalla E.R., Cong Y., Tang J., Tang J.Y., Zhao Q., Agrawal S. Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences. J. Med. Chem. 2002, 45:4540-4548.
    • (2002) J. Med. Chem. , vol.45 , pp. 4540-4548
    • Yu, D.1    Kandimalla, E.R.2    Cong, Y.3    Tang, J.4    Tang, J.Y.5    Zhao, Q.6    Agrawal, S.7
  • 30
    • 0035098853 scopus 로고    scopus 로고
    • Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships
    • Kandimalla E.R., Yu D., Zhao Q., Agrawal S. Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships. Bioorg. Med. Chem. 2001, 9:807-813.
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 807-813
    • Kandimalla, E.R.1    Yu, D.2    Zhao, Q.3    Agrawal, S.4
  • 32
  • 35
    • 0034606443 scopus 로고    scopus 로고
    • Accessible 5′-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity
    • Yu D., Zhao Q., Kandimalla E.R., Agrawal S. Accessible 5′-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity. Bioorg. Med. Chem. Lett. 2000, 10:2585-2588.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 2585-2588
    • Yu, D.1    Zhao, Q.2    Kandimalla, E.R.3    Agrawal, S.4
  • 36
    • 0036738536 scopus 로고    scopus 로고
    • Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity
    • Kandimalla E.R., Bhagat L., Yu D., Cong Y., Tang J., Agrawal S. Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity. Bioconjug. Chem. 2002, 13:966-974.
    • (2002) Bioconjug. Chem. , vol.13 , pp. 966-974
    • Kandimalla, E.R.1    Bhagat, L.2    Yu, D.3    Cong, Y.4    Tang, J.5    Agrawal, S.6
  • 37
    • 0037109211 scopus 로고    scopus 로고
    • 'Immunomers'-novel 3′,3′-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents
    • Yu D., Kandimalla E.R., Bhagat L., Tang J.Y., Cong Y., Tang J., Agrawal S. 'Immunomers'-novel 3′,3′-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents. Nucleic Acids Res. 2002, 30:4460-4469.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4460-4469
    • Yu, D.1    Kandimalla, E.R.2    Bhagat, L.3    Tang, J.Y.4    Cong, Y.5    Tang, J.6    Agrawal, S.7
  • 38
    • 0036384444 scopus 로고    scopus 로고
    • Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties
    • Yu D., Zhu F.G., Bhagat L., Wang H., Kandimalla E.R., Zhang R., Agrawal S. Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties. Biochem. Biophy. Res. Commun. 2002, 297:83-90.
    • (2002) Biochem. Biophy. Res. Commun. , vol.297 , pp. 83-90
    • Yu, D.1    Zhu, F.G.2    Bhagat, L.3    Wang, H.4    Kandimalla, E.R.5    Zhang, R.6    Agrawal, S.7
  • 40
    • 0037809185 scopus 로고    scopus 로고
    • Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles
    • Kandimalla E.R., Bhagat L., Wang D., Yu D., Zhu F.G., Tang J., Wang H., Huang P., Zhang R., Agrawal S. Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles. Nucleic Acids Res. 2003, 31:2393-2400.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2393-2400
    • Kandimalla, E.R.1    Bhagat, L.2    Wang, D.3    Yu, D.4    Zhu, F.G.5    Tang, J.6    Wang, H.7    Huang, P.8    Zhang, R.9    Agrawal, S.10
  • 41
    • 1242329059 scopus 로고    scopus 로고
    • Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma
    • Agrawal D.K., Edwan J., Kandimalla E.R., Yu D., Bhagat L., Wang D., Agrawal S. Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma. Int. Immunopharmacol. 2004, 4:127-138.
    • (2004) Int. Immunopharmacol. , vol.4 , pp. 127-138
    • Agrawal, D.K.1    Edwan, J.2    Kandimalla, E.R.3    Yu, D.4    Bhagat, L.5    Wang, D.6    Agrawal, S.7
  • 42
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of toll-like receptor 9 activation
    • Krieg A.M. Therapeutic potential of toll-like receptor 9 activation. Nat. Rev. 2006, 5:471-484.
    • (2006) Nat. Rev. , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 43
    • 23944474100 scopus 로고    scopus 로고
    • Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells
    • Abel K., Wang Y., Fritts L., Sanchez E., Chung E., Fitzgerald-Bocarsly P., Krieg A.M., Miller C.J. Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells. Clin. Diagn. Lab. Immunol. 2005, 12:606-621.
    • (2005) Clin. Diagn. Lab. Immunol. , vol.12 , pp. 606-621
    • Abel, K.1    Wang, Y.2    Fritts, L.3    Sanchez, E.4    Chung, E.5    Fitzgerald-Bocarsly, P.6    Krieg, A.M.7    Miller, C.J.8
  • 45
    • 27244443079 scopus 로고    scopus 로고
    • HIV Gag protein conjugated to a toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    • Wille-Reece U., Flynn B.J., Lore K., Koup R.A., Kedl R.M., Mattapallil J.J., Weiss W.R., Roederer M., Seder R.A. HIV Gag protein conjugated to a toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc. Natl. Acad. Sci. USA 2005, 102:15190-15194.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15190-15194
    • Wille-Reece, U.1    Flynn, B.J.2    Lore, K.3    Koup, R.A.4    Kedl, R.M.5    Mattapallil, J.J.6    Weiss, W.R.7    Roederer, M.8    Seder, R.A.9
  • 46
    • 40449127141 scopus 로고    scopus 로고
    • Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques
    • Stewart V.A., McGrath S., Krieg A.M., Larson N.S., Angov E., Smith C.L., Brewer T.G., Heppner D.G. Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques. Clin. Vaccine Immunol. 2008, 15:221-226.
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 221-226
    • Stewart, V.A.1    McGrath, S.2    Krieg, A.M.3    Larson, N.S.4    Angov, E.5    Smith, C.L.6    Brewer, T.G.7    Heppner, D.G.8
  • 49
    • 7444242674 scopus 로고    scopus 로고
    • Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
    • Krieg A.M., Efler S.M., Wittpoth M., Al Adhami M.J., Davis H.L. Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J. Immunother. 2004, 27:460-471.
    • (2004) J. Immunother. , vol.27 , pp. 460-471
    • Krieg, A.M.1    Efler, S.M.2    Wittpoth, M.3    Al Adhami, M.J.4    Davis, H.L.5
  • 50
    • 33644853807 scopus 로고    scopus 로고
    • A whole blood assay to assess peripheral blood dendritic cell function in response to toll-like receptor stimulation
    • Ida J.A., Shrestha N., Desai S., Pahwa S., Hanekom W.A., Haslett P.A. A whole blood assay to assess peripheral blood dendritic cell function in response to toll-like receptor stimulation. J. Immunol. Methods 2006, 310:86-89.
    • (2006) J. Immunol. Methods , vol.310 , pp. 86-89
    • Ida, J.A.1    Shrestha, N.2    Desai, S.3    Pahwa, S.4    Hanekom, W.A.5    Haslett, P.A.6
  • 51
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional Type I interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu Y.J. IPC: Professional Type I interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 2005, 23:275-306.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 53
    • 0036376644 scopus 로고    scopus 로고
    • Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines
    • Gary-Gouy H., Lebon P., Dalloul A.H. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J. Interferon Cytokine Res. 2002, 22:653-659.
    • (2002) J. Interferon Cytokine Res. , vol.22 , pp. 653-659
    • Gary-Gouy, H.1    Lebon, P.2    Dalloul, A.H.3


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