Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 5, 1997, Pages 495-502

  Zhao, Qiuyan ^a   Temsamani, Jamal ^a   Zhou, Ren Zhi ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; SPLEEN;

ANIMALIA;

EID: 0030772278     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.495     Document Type: Article

References (6)

1. AGRAWAL, S., Ed. (1996a). Antisense Therapeutics. (The Humana Press, Totowa, NJ).
2. AGRAWAL, S. (1996b). Antisense oligonucleotides: Towards clinical trials. Tibtech 14, 376-387.
3. BAYEVER, E., IVERSON, P.L., BISHOP, M.R., SHARP, G.J., TEWARY, H.K., ARNESON, M.A., PIRRUCCELLO, S.J., RUDDON, R.W., KESSINGER, A., ZONG, G., and ARMITAGE, J.O. (1993). Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodyeplastic syndrome: Initial results of a phase I trial. Antisense Res. Dev. 3, 383-390.
4. BEAUCAGE, S.L. (1993). Oligodeoxyribonucleotide synthesis: Phosphoramidite approach. In: Protocols for Oligonucleotides and Analogs: Synthesis and Properties. S. Agrawal, ed. (Humana Press, Totowa, NJ), pp. 33-62.
5. BIRON, C.A. (1994). Cytokines in the generation of immune responses, and resolution of, virus infection. Crit. Rev. Immunol. 6, 530-538.
6. ZHAO, Q., TEMSAMANI, J., IADAROLA, P.L., JIANG, Z.W., and AGRAWAL, S. (1996b). Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem. Pharmacol. 51, 173-182.