메뉴 건너뛰기




Volumn 29, Issue 2, 2010, Pages 211-233

The balancing act of autoimmunity: Central and peripheral tolerance versus infection control

Author keywords

Arthritis; Autoimmunity; Infection; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DECTIN 1; HLA DR ANTIGEN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 7 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RELB;

EID: 77952520554     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.3109/08830180903434219     Document Type: Review
Times cited : (6)

References (124)
  • 1
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997;84:223-243.
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 2
    • 0036158406 scopus 로고    scopus 로고
    • Brachial endothelial function is impaired in patients with systemic lupus erythematosus
    • Lima D, Sato E, Lima V, et al. Brachial endothelial function is impaired in patients with systemic lupus erythematosus. J Rheumatol 29:292-297, 2002.
    • (2002) J. Rheumatol. , vol.29 , pp. 292-297
    • Lima, D.1    Sato, E.2    Lima, V.3
  • 3
    • 0035676529 scopus 로고    scopus 로고
    • High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors
    • del Rincon I, Williams K, Stern M, et al. High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum 2001;44:2737-2745.
    • (2001) Arthritis Rheum. , vol.44 , pp. 2737-2745
    • Rincon, I.D.1    Williams, K.2    Stern, M.3
  • 4
    • 33645741218 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7
    • Savarese E, Chae OW, Trowitzsch S, et al. U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood 2006;107:3229-3234.
    • (2006) Blood , vol.107 , pp. 3229-3234
    • Savarese, E.1    Chae, O.W.2    Trowitzsch, S.3
  • 5
    • 3142769762 scopus 로고    scopus 로고
    • Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    • van Gaalen FA, van Aken J, Huizinga TW, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 2004;50:2113-2121.
    • (2004) Arthritis Rheum. , vol.50 , pp. 2113-2121
    • Van Gaalen, F.A.1    Van Aken, J.2    Huizinga, T.W.3
  • 6
    • 42249098465 scopus 로고    scopus 로고
    • Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice
    • Hill JA, Bell DA, Brintnell W, et al. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med 2008;205:967-979.
    • (2008) J. Exp. Med. , vol.205 , pp. 967-979
    • Hill, J.A.1    Bell, D.A.2    Brintnell, W.3
  • 7
    • 0025915529 scopus 로고
    • Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells
    • Champion BR, Page KR, Parish N, et al. Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells. J Exp Med 1991;174:363-370.
    • (1991) J. Exp. Med. , vol.174 , pp. 363-370
    • Champion, B.R.1    Page, K.R.2    Parish, N.3
  • 8
    • 33845337973 scopus 로고    scopus 로고
    • Proinsulin: A unique autoantigen triggering autoimmune diabetes
    • You S, Chatenoud L. Proinsulin: A unique autoantigen triggering autoimmune diabetes. J Clin Invest 2006;116:3108-3110.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3108-3110
    • You, S.1    Chatenoud, L.2
  • 9
    • 66249126493 scopus 로고    scopus 로고
    • Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases
    • Gabriel SE, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther 11:229, 2009.
    • (2009) Arthritis Res. Ther. , vol.11 , pp. 229
    • Gabriel, S.E.1    Michaud, K.2
  • 10
    • 38449083553 scopus 로고    scopus 로고
    • The burden of rheumatoid arthritis and access to treatment: Health burden and costs
    • Lundkvist J, Kastang F, Kobelt G. The burden of rheumatoid arthritis and access to treatment: Health burden and costs. Eur J Health Econ 8 Suppl 2: S49-S60, 2008.
    • (2008) Eur. J. Health Econ. , vol.8 , Issue.2 SUPPL.
    • Lundkvist, J.1    Kastang, F.2    Kobelt, G.3
  • 11
    • 0031596028 scopus 로고    scopus 로고
    • Asymptomatic synovitis precedes clinically manifest arthritis
    • Kraan MC, Versendaal H, Jonker M, et al. Asymptomatic synovitis precedes clinically manifest arthritis. Arthritis Rheum 1998;41:1481-1488.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1481-1488
    • Kraan, M.C.1    Versendaal, H.2    Jonker, M.3
  • 12
    • 0036676818 scopus 로고    scopus 로고
    • Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment
    • Kraan MC, Reece RJ, Smeets TJ, et al. Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment. Arthritis Rheum 2002;46:2034-2038.
    • (2002) Arthritis Rheum. , vol.46 , pp. 2034-2038
    • Kraan, M.C.1    Reece, R.J.2    Smeets, T.J.3
  • 13
    • 67650069667 scopus 로고    scopus 로고
    • Disease remission state in patients treated with the combination of tumor necrosis factor blockade and methotrexate or with disease-modifying antirheumatic drugs: A clinical and imaging comparative study
    • Saleem B, Brown AK, Keen H, et al. Disease remission state in patients treated with the combination of tumor necrosis factor blockade and methotrexate or with disease-modifying antirheumatic drugs: A clinical and imaging comparative study. Arthritis Rheum 2009;60:1915-1922.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1915-1922
    • Saleem, B.1    Brown, A.K.2    Keen, H.3
  • 14
    • 0030834144 scopus 로고    scopus 로고
    • Thymic dendritic cells
    • Ardavin C. Thymic dendritic cells. Immunol Today 1997;18:350-361.
    • (1997) Immunol. Today , vol.18 , pp. 350-361
    • Ardavin, C.1
  • 15
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987;49:273-280.
    • (1987) Cell. , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 16
    • 58149376454 scopus 로고    scopus 로고
    • Dendritic cells in the thymus contribute to T-regulatory cell induction
    • Proietto AI, van Dommelen S, Zhou P, et al. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A 2008;105:19869-19874.
    • (2008) Proc. Natl. Acad. Sci. U S A , vol.105 , pp. 19869-19874
    • Proietto, A.I.1    Van Dommelen, S.2    Zhou, P.3
  • 17
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski J, Gabler J, Brors B, et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 2005;202:33-45.
    • (2005) J. Exp. Med. , vol.202 , pp. 33-45
    • Derbinski, J.1    Gabler, J.2    Brors, B.3
  • 18
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002;298:1395-1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3
  • 20
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease. APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • Aaltonen J, Björses P, Perheentupa J. et al. An autoimmune disease. APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997;17:399-403.
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
    • Aaltonen, J.1    Björses, P.2    Perheentupa, J.3
  • 22
    • 63449108301 scopus 로고    scopus 로고
    • Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    • Ohnmacht C, Pullner A, King SB, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009;206:549-559.
    • (2009) J. Exp. Med. , vol.206 , pp. 549-559
    • Ohnmacht, C.1    Pullner, A.2    King, S.B.3
  • 23
    • 33748866909 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
    • Bonasio R, Scimone ML, Schaerli P, et al. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 2006;7:1092-1100.
    • (2006) Nat. Immunol. , vol.7 , pp. 1092-1100
    • Bonasio, R.1    Scimone, M.L.2    Schaerli, P.3
  • 24
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • Li J, Park J, Foss D, Goldschneider I. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med 2009;206:607-622.
    • (2009) J. Exp. Med. , vol.206 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 25
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 2004;200:1039-1049.
    • (2004) J. Exp. Med. , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 26
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 2007;204:2521-2528.
    • (2007) J. Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 27
    • 20444485767 scopus 로고    scopus 로고
    • Cellular and genetic mechanisms of self tolerance and autoimmunity
    • Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005;435:590-597.
    • (2005) Nature , vol.435 , pp. 590-597
    • Goodnow, C.C.1    Sprent, J.2    De St, F.G.B.3    Vinuesa, C.G.4
  • 28
    • 33846938773 scopus 로고    scopus 로고
    • Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells
    • Steptoe RJ, Ritchie JM, Wilson NS, et al. Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. J Immunol 2007;178:2094-2103.
    • (2007) J. Immunol. , vol.178 , pp. 2094-2103
    • Steptoe, R.J.1    Ritchie, J.M.2    Wilson, N.S.3
  • 29
    • 21244468609 scopus 로고    scopus 로고
    • CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
    • Belz GT, Shortman K, Bevan MJ, Heath WR. CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo. J Immunol 2005;175:196-200.
    • (2005) J. Immunol. , vol.175 , pp. 196-200
    • Belz, G.T.1    Shortman, K.2    Bevan, M.J.3    Heath, W.R.4
  • 30
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med 2004;10:801-805.
    • (2004) Nat. Med. , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 31
    • 0035920510 scopus 로고    scopus 로고
    • Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4 (+) 25 (+) immunoregulatory T cells
    • Bensinger SJ, Bandeira A, Jordan MS, et al. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4 (+) 25 (+) immunoregulatory T cells. J Exp Med 194:427-438., 2001.
    • (2001) J. Exp. Med. , vol.194 , pp. 427-438
    • Bensinger, S.J.1    Bandeira, A.2    Jordan, M.S.3
  • 32
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan MS, Boesteanu A, Reed AJ, et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-306.
    • (2001) Nat. Immunol. , vol.2 , pp. 301-306
    • Jordan, M.S.1    Boesteanu, A.2    Reed, A.J.3
  • 33
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner K, D'Cruz LM, Vollmann EH, et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 2007;8:351-358.
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3
  • 34
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007;204:1757-1764.
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 35
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D, Park Y, Kim G, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007;317:256-260.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 36
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007;204:1775-1785.
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3
  • 37
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle R. J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-1774.
    • (2007) J. Exp. Med. , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 38
    • 34547431144 scopus 로고    scopus 로고
    • Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB
    • Martin E, Capini C, Duggan E, et al. Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB. Arthritis Rheum 2007;56:2255-2266.
    • (2007) Arthritis Rheum. , vol.56 , pp. 2255-2266
    • Martin, E.1    Capini, C.2    Duggan, E.3
  • 39
    • 65449183747 scopus 로고    scopus 로고
    • Antigen-specific suppression of inflammatory arthritis using liposomes
    • Capini C, Jaturanpinyo M, Chang HI, et al. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol 2009;182:3556-3565.
    • (2009) J. Immunol. , vol.182 , pp. 3556-3565
    • Capini, C.1    Jaturanpinyo, M.2    Chang, H.I.3
  • 40
    • 34247626840 scopus 로고    scopus 로고
    • Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference
    • Li M, Zhang X, Zheng X, et al. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol 2007;178:5480-5487.
    • (2007) J. Immunol. , vol.178 , pp. 5480-5487
    • Li, M.1    Zhang, X.2    Zheng, X.3
  • 41
    • 0028952482 scopus 로고
    • Expression of relB is required for the development of thymic medulla and dendritic cells
    • Burkly L, Hession C, Ogata L, et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373:531-536, 1995.
    • (1995) Nature , vol.373 , pp. 531-536
    • Burkly, L.1    Hession, C.2    Ogata, L.3
  • 42
    • 25144432460 scopus 로고    scopus 로고
    • Modifier loci condition autoimmunity provoked by Aire deficiency
    • Jiang W, Anderson MS, Bronson R, et al. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 2005;202:805-815.
    • (2005) J. Exp. Med. , vol.202 , pp. 805-815
    • Jiang, W.1    Anderson, M.S.2    Bronson, R.3
  • 43
    • 10344231974 scopus 로고    scopus 로고
    • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    • Liston A, Lesage S, Gray DH, et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 2004;21:817-830.
    • (2004) Immunity , vol.21 , pp. 817-830
    • Liston, A.1    Lesage, S.2    Gray, D.H.3
  • 44
    • 20244373339 scopus 로고    scopus 로고
    • A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    • Yoshitomi H, Sakaguchi N, Kobayashi K, et al. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 2005;201:949-960.
    • (2005) J. Exp. Med. , vol.201 , pp. 949-960
    • Yoshitomi, H.1    Sakaguchi, N.2    Kobayashi, K.3
  • 45
    • 20244385126 scopus 로고    scopus 로고
    • New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility
    • du Montcel ST, Michou L, Petit-Teixeira E, et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005;52:1063-1068.
    • (2005) Arthritis Rheum. , vol.52 , pp. 1063-1068
    • Du Montcel, S.T.1    Michou, L.2    Petit-Teixeira, E.3
  • 46
    • 0023500817 scopus 로고
    • The shared epitope hypothesis: An approach to understanding the molecular genetics of suseptibility to rheumatoid arthritis
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: An approach to understanding the molecular genetics of suseptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-1213.
    • (1987) Arthritis Rheum. , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 47
    • 0029877828 scopus 로고    scopus 로고
    • Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins
    • Silman AJ, Newman J, MacGregor AJ. Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum 1996;39:732-735.
    • (1996) Arthritis Rheum. , vol.39 , pp. 732-735
    • Silman, A.J.1    Newman, J.2    MacGregor, A.J.3
  • 48
    • 31044445025 scopus 로고    scopus 로고
    • A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope) -restricted immune reactions to autoantigens modified by citrullination
    • Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope) -restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46.
    • (2006) Arthritis Rheum. , vol.54 , pp. 38-46
    • Klareskog, L.1    Stolt, P.2    Lundberg, K.3
  • 49
    • 5644239636 scopus 로고    scopus 로고
    • A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    • Padyukov L, Silva C, Stolt P, et al. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004;50:3085-3092.
    • (2004) Arthritis Rheum. , vol.50 , pp. 3085-3092
    • Padyukov, L.1    Silva, C.2    Stolt, P.3
  • 50
    • 0042667153 scopus 로고    scopus 로고
    • Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
    • Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003;34:395-402.
    • (2003) Nat. Genet. , vol.34 , pp. 395-402
    • Suzuki, A.1    Yamada, R.2    Chang, X.3
  • 51
    • 34548849168 scopus 로고    scopus 로고
    • TRAF1-C5 as a risk locus for rheumatoid arthritis-A genomewide study
    • Plenge RM, Seielstad M, Padyukov L, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis-A genomewide study. N Engl J Med 2007;357:1199-1209.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1199-1209
    • Plenge, R.M.1    Seielstad, M.2    Padyukov, L.3
  • 52
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Burton PR, Clayton DG, Cardon LR, et al. Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-1337.
    • (2007) Nat. Genet. , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3
  • 53
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 54
    • 67649880295 scopus 로고    scopus 로고
    • REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    • Gregersen PK, Amos CI, Lee AT, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 2009;41:820-823.
    • (2009) Nat. Genet. , vol.41 , pp. 820-823
    • Gregersen, P.K.1    Amos, C.I.2    Lee, A.T.3
  • 55
    • 77951561612 scopus 로고    scopus 로고
    • Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    • In press
    • Orozco G, Eyre S, Hinks A, et al. Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Ann Rheum Dis, In press.
    • Ann. Rheum. Dis.
    • Orozco, G.1    Eyre, S.2    Hinks, A.3
  • 56
    • 34548368541 scopus 로고    scopus 로고
    • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    • Lundmark F, Duvefelt K, Iacobaeus E, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007;39:1108-1113.
    • (2007) Nat. Genet. , vol.39 , pp. 1108-1113
    • Lundmark, F.1    Duvefelt, K.2    Iacobaeus, E.3
  • 57
    • 20144388185 scopus 로고    scopus 로고
    • Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis
    • Zhang Z, Duvefelt K, Svensson F, et al. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes & Immunity 2005;6:145-152.
    • (2005) Genes & Immunity , vol.6 , pp. 145-152
    • Zhang, Z.1    Duvefelt, K.2    Svensson, F.3
  • 58
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls
    • The Wellcome Trust Case Control Consortium
    • The Wellcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 2007;447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 59
    • 9644257170 scopus 로고    scopus 로고
    • PTPN22 and autoimmune disease
    • Siminovitch KA. PTPN22 and autoimmune disease. Nat Genet 2004;36:1248-1249.
    • (2004) Nat. Genet. , vol.36 , pp. 1248-1249
    • Siminovitch, K.A.1
  • 60
    • 33745169029 scopus 로고    scopus 로고
    • Role of PTPN22 in type 1 diabetes and other autoimmune diseases
    • Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol 2006;18:207-213.
    • (2006) Semin. Immunol. , vol.18 , pp. 207-213
    • Bottini, N.1    Vang, T.2    Cucca, F.3    Mustelin, T.4
  • 61
    • 28444469783 scopus 로고    scopus 로고
    • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    • Vang T, Congia M, Macis MD, et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005;37:1317-1319.
    • (2005) Nat. Genet. , vol.37 , pp. 1317-1319
    • Vang, T.1    Congia, M.2    Macis, M.D.3
  • 62
    • 40349109578 scopus 로고    scopus 로고
    • Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
    • Rieck M, Arechiga A, Onengut-Gumuscu S, et al. Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J Immunol 2007;179:4704-4710.
    • (2007) J. Immunol. , vol.179 , pp. 4704-4710
    • Rieck, M.1    Arechiga, A.2    Onengut-Gumuscu, S.3
  • 63
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • Swanberg M, Lidman O, Padyukov L, et al. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet 2005;37:486-494.
    • (2005) Nat. Genet. , vol.37 , pp. 486-494
    • Swanberg, M.1    Lidman, O.2    Padyukov, L.3
  • 64
    • 0345414139 scopus 로고    scopus 로고
    • Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
    • Sakaguchi N, Takahashi T, Hata H, et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003;426:454-460.
    • (2003) Nature , vol.426 , pp. 454-460
    • Sakaguchi, N.1    Takahashi, T.2    Hata, H.3
  • 65
    • 33846456970 scopus 로고    scopus 로고
    • T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    • Hirota K, Hashimoto M, Yoshitomi H, et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 2007;204:41-47.
    • (2007) J. Exp. Med. , vol.204 , pp. 41-47
    • Hirota, K.1    Hashimoto, M.2    Yoshitomi, H.3
  • 66
    • 34249026701 scopus 로고    scopus 로고
    • Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann S, Gross O, Robinson MJ, et al. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007;8:630-638.
    • (2007) Nat. Immunol. , vol.8 , pp. 630-638
    • LeibundGut-Landmann, S.1    Gross, O.2    Robinson, M.J.3
  • 67
    • 59749087126 scopus 로고    scopus 로고
    • DC activated via dectin-1 convert Treg into IL-17 producers
    • Osorio F, LeibundGut-Landmann S, Lochner M, et al. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008;38:3274-3281.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3274-3281
    • Osorio, F.1    LeibundGut-Landmann, S.2    Lochner, M.3
  • 68
    • 0033564735 scopus 로고    scopus 로고
    • TCR-mediated involvement of CD4+ transgenic T cells in spontaneous inflammatory bowel disease in lymphopenic mice
    • Koh WP, Chan E, Scott K, et al. TCR-mediated involvement of CD4+ transgenic T cells in spontaneous inflammatory bowel disease in lymphopenic mice. J Immunol 1999;162:7208-7216.
    • (1999) J. Immunol. , vol.162 , pp. 7208-7216
    • Koh, W.P.1    Chan, E.2    Scott, K.3
  • 69
    • 0344585521 scopus 로고    scopus 로고
    • Self-peptides drive the peripheral expansion of CD4+CD25 +regulatory T cells
    • Cozzo C, J Larkin, 3rd, Caton AJ. Self-peptides drive the peripheral expansion of CD4+CD25 +regulatory T cells. J Immunol 171:5678-5682, 2003.
    • (2003) J. Immunol. , vol.171 , pp. 5678-5682
    • Cozzo, C.1    Larkin III, J.2    Caton, A.J.3
  • 70
    • 0028267610 scopus 로고
    • Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells
    • Thomas R, Davis LS, Lipsky PE. Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J Immunol 152:2613-2623, 1994.
    • (1994) J. Immunol. , vol.152 , pp. 2613-2623
    • Thomas, R.1    Davis, L.S.2    Lipsky, P.E.3
  • 71
    • 0030475056 scopus 로고    scopus 로고
    • Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
    • Thomas R, Lipsky PE. Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis? Immunol Today 1996;17:559-564.
    • (1996) Immunol. Today , vol.17 , pp. 559-564
    • Thomas, R.1    Lipsky, P.E.2
  • 72
    • 0033168696 scopus 로고    scopus 로고
    • Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis
    • Dittel BN, Visintin I, Merchant RM, CA Janeway, Jr. Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J Immunol 1999;163:32-39.
    • (1999) J. Immunol. , vol.163 , pp. 32-39
    • Dittel, B.N.1    Visintin, I.2    Merchant, R.M.3    Janeway, C.J.4
  • 73
    • 0037114178 scopus 로고    scopus 로고
    • A novel dendritic cell-induced model of erosive inflammatory arthritis: Distinct roles for dendritic cells in T cell activation and induction of local inflammation
    • Leung BP, Conacher M, Hunter D, et al. A novel dendritic cell-induced model of erosive inflammatory arthritis: Distinct roles for dendritic cells in T cell activation and induction of local inflammation. J Immunol 2002;169:7071-7077.
    • (2002) J. Immunol. , vol.169 , pp. 7071-7077
    • Leung, B.P.1    Conacher, M.2    Hunter, D.3
  • 74
    • 0032547818 scopus 로고    scopus 로고
    • Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
    • Ludewig B, Odermatt B, Landmann S, et al. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med 1998;188:1493-1501.
    • (1998) J. Exp. Med. , vol.188 , pp. 1493-1501
    • Ludewig, B.1    Odermatt, B.2    Landmann, S.3
  • 75
    • 0033526066 scopus 로고    scopus 로고
    • The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL) -12 production by dendritic cells and IL-12 receptor expression on NKT cells
    • Kitamura H, Iwakabe K, Yahata T, et al. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL) -12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med 1999;189:1121-1128.
    • (1999) J. Exp. Med. , vol.189 , pp. 1121-1128
    • Kitamura, H.1    Iwakabe, K.2    Yahata, T.3
  • 76
    • 29144531808 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovium contains plasmacytoid dendritic cells
    • Cavanagh LL, Boyce A, Smith L, et al. Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. Arthritis Res Ther 2005;7: R230-R240.
    • (2005) Arthritis Res. Ther. , vol.7
    • Cavanagh, L.L.1    Boyce, A.2    Smith, L.3
  • 77
    • 0030685745 scopus 로고    scopus 로고
    • Functional CD40-ligand is expressed by T cells in rheumatoid arthritis
    • MacDonald K. P. A., Nishioka N, Lipsky PE, Thomas R. Functional CD40-ligand is expressed by T cells in rheumatoid arthritis. J Clin Invest 1997;100:2404-2414.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2404-2414
    • MacDonald, K.P.A.1    Nishioka, N.2    Lipsky, P.E.3    Thomas, R.4
  • 78
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor kappaB signaling
    • Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev 2006;210:171-186.
    • (2006) Immunol. Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 79
    • 0442307969 scopus 로고    scopus 로고
    • IkappaB kinases: Key regulators of the NF-kappaB pathway
    • Yamamoto Y, Gaynor RB. IkappaB kinases: Key regulators of the NF-kappaB pathway. Trends Biochem Sci 2004;29:72-79.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 72-79
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 80
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
    • Xiao G, Rabson AB, Young W, et al. Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease. Cytokine Growth Factor Rev 2006;17:281-293.
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3
  • 81
    • 34548863106 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2, 3-dioxygenase (IDO) induction and immune regulation
    • Tas SW, Vervoordeldonk MJ, Hajji N, et al. Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2, 3-dioxygenase (IDO) induction and immune regulation. Blood 2007;110:1540-1549.
    • (2007) Blood , vol.110 , pp. 1540-1549
    • Tas, S.W.1    Vervoordeldonk, M.J.2    Hajji, N.3
  • 82
    • 0038771214 scopus 로고    scopus 로고
    • Modulation of NF-kappaB activity by exchange of dimers
    • Saccani S, Pantanoand S, Natoli G. Modulation of NF-kappaB activity by exchange of dimers. Mol Cell 2003;11:1563-1574.
    • (2003) Mol. Cell. , vol.11 , pp. 1563-1574
    • Saccani, S.1    Pantanoand, S.2    Natoli, G.3
  • 83
    • 0033658153 scopus 로고    scopus 로고
    • Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
    • Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev 2000;177:134-140.
    • (2000) Immunol. Rev. , vol.177 , pp. 134-140
    • Sallusto, F.1    Lanzavecchia, A.2
  • 84
    • 0028033310 scopus 로고
    • Activation of human dendritic cells through CD40 cross-linking
    • Caux C, Massacrier C, Vanbervliet B, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994;180:1263-1272.
    • (1994) J. Exp. Med. , vol.180 , pp. 1263-1272
    • Caux, C.1    Massacrier, C.2    Vanbervliet, B.3
  • 85
    • 0036604277 scopus 로고    scopus 로고
    • CD40 Ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB
    • O'Sullivan B. J., Thomas R. CD40 Ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB. J Immunol 2002;168:5491-5498.
    • (2002) J. Immunol. , vol.168 , pp. 5491-5498
    • O'Sullivan, B.J.1    Thomas, R.2
  • 86
    • 58549115247 scopus 로고    scopus 로고
    • Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    • Gringhuis SI, den Dunnen J, Litjens M, et al. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol 2009;10:203-213.
    • (2009) Nat. Immunol. , vol.10 , pp. 203-213
    • Gringhuis, S.I.1    Dunnen, J.D.2    Litjens, M.3
  • 87
    • 0141594607 scopus 로고    scopus 로고
    • Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation
    • Chen LF, Greene WC. Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. J Mol Med 2003;81:549-557.
    • (2003) J. Mol. Med. , vol.81 , pp. 549-557
    • Chen, L.F.1    Greene, W.C.2
  • 88
    • 26844572062 scopus 로고    scopus 로고
    • RelA repression of RelB activity induces selective gene activation downstream of TNF receptors
    • Jacque E, Tchenio T, Piton G, et al. RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci U S A 2005;102:14635-14640.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 14635-14640
    • Jacque, E.1    Tchenio, T.2    Piton, G.3
  • 89
    • 34248544993 scopus 로고    scopus 로고
    • C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    • Gringhuis SI, den Dunnen J, Litjens M, et al. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity 2007;26:605-616.
    • (2007) Immunity , vol.26 , pp. 605-616
    • Gringhuis, S.I.1    Dunnen, J.D.2    Litjens, M.3
  • 90
    • 0037240852 scopus 로고    scopus 로고
    • Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10
    • Martin E, O'Sullivan B, Low P, Thomas R. Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity 2003;18:155-167.
    • (2003) Immunity , vol.18 , pp. 155-167
    • Martin, E.1    O'Sullivan, B.2    Low, P.3    Thomas, R.4
  • 91
    • 17444428125 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization
    • Tas SW, de Jong EC, Hajji N, et al. Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur J Immunol 2005;35:1164-1174.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1164-1174
    • Tas, S.W.1    De Jong, E.C.2    Hajji, N.3
  • 92
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
    • Weih F, Carrasco D, Durham SK, et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 1995;80:331-340.
    • (1995) Cell. , vol.80 , pp. 331-340
    • Weih, F.1    Carrasco, D.2    Durham, S.K.3
  • 93
    • 0030292678 scopus 로고    scopus 로고
    • Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent
    • Weih F, Durham SK, Barton DS, et al. Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent. J Immunol 1996;157:3974-3979.
    • (1996) J. Immunol. , vol.157 , pp. 3974-3979
    • Weih, F.1    Durham, S.K.2    Barton, D.S.3
  • 94
    • 0037259791 scopus 로고    scopus 로고
    • CD4 T cell priming in dendritic cell-deficient mice
    • Castiglioni P, Lu C, Lo D, et al. CD4 T cell priming in dendritic cell-deficient mice. Int Immunol 2003;15:127-136.
    • (2003) Int. Immunol. , vol.15 , pp. 127-136
    • Castiglioni, P.1    Lu, C.2    Lo, D.3
  • 95
    • 34249706306 scopus 로고    scopus 로고
    • Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD
    • MacDonald KP, Kuns RD, Rowe V, et al. Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD. Blood 2007;109:5049-5057.
    • (2007) Blood , vol.109 , pp. 5049-5057
    • MacDonald, K.P.1    Kuns, R.D.2    Rowe, V.3
  • 96
    • 20244365648 scopus 로고    scopus 로고
    • Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection
    • Sommers CL, Lee J, Steiner KL, et al. Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med 2005;201:1125-1134.
    • (2005) J. Exp. Med. , vol.201 , pp. 1125-1134
    • Sommers, C.L.1    Lee, J.2    Steiner, K.L.3
  • 97
    • 0037077094 scopus 로고    scopus 로고
    • Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
    • Aguado E, Richelme S, Nunez-Cruz S, et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 2002;296:2036-2040.
    • (2002) Science , vol.296 , pp. 2036-2040
    • Aguado, E.1    Richelme, S.2    Nunez-Cruz, S.3
  • 98
    • 31344480633 scopus 로고    scopus 로고
    • LAT-mediated signaling in CD4+CD25+ regulatory T cell development
    • Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med 2006;203:119-129.
    • (2006) J. Exp. Med. , vol.203 , pp. 119-129
    • Koonpaew, S.1    Shen, S.2    Flowers, L.3    Zhang, W.4
  • 99
    • 37049019860 scopus 로고    scopus 로고
    • Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
    • Siggs OM, Miosge LA, Yates AL, et al. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007;27:912-926.
    • (2007) Immunity , vol.27 , pp. 912-926
    • Siggs, O.M.1    Miosge, L.A.2    Yates, A.L.3
  • 100
    • 49149097651 scopus 로고    scopus 로고
    • Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes
    • Mollah Z. U. A., Pai S, Moore C, et al. Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes. J Immunol 2008;180:3166-3175.
    • (2008) J. Immunol. , vol.180 , pp. 3166-3175
    • Mollah, Z.U.A.1    Pai, S.2    Moore, C.3
  • 101
    • 0032167379 scopus 로고    scopus 로고
    • Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes
    • Takahashi K, Honeyman MC, Harrison LC. Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes. J Immunol 1998;161:2629-2635.
    • (1998) J. Immunol. , vol.161 , pp. 2629-2635
    • Takahashi, K.1    Honeyman, M.C.2    Harrison, L.C.3
  • 102
    • 39049157857 scopus 로고    scopus 로고
    • Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: Further evidence of a proinflammatory state
    • Devaraj S, Dasu MR, Rockwood J, et al. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: Further evidence of a proinflammatory state. J Clin Endocrinol Metab 93:578-583, 2008.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 578-583
    • Devaraj, S.1    Dasu, M.R.2    Rockwood, J.3
  • 103
    • 40749100302 scopus 로고    scopus 로고
    • Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics
    • Wang X, Jia S, Geoffrey R, et al. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008;180:1929-1937.
    • (2008) J. Immunol. , vol.180 , pp. 1929-1937
    • Wang, X.1    Jia, S.2    Geoffrey, R.3
  • 104
    • 33744921639 scopus 로고    scopus 로고
    • IL-1 breaks tolerance through expansion of CD25 +effector T cells
    • O'Sullivan B, Thomas HE, Pai S, et al. IL-1 breaks tolerance through expansion of CD25 +effector T cells. J Immunol 2006;176:7278-7287.
    • (2006) J. Immunol. , vol.176 , pp. 7278-7287
    • O'Sullivan, B.1    Thomas, H.E.2    Pai, S.3
  • 105
    • 67349212253 scopus 로고    scopus 로고
    • DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes
    • Wolter TR, Wong R, Sarkar SA, Zipris D. DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes. Clin Immunol 2009;132:103-115.
    • (2009) Clin. Immunol. , vol.132 , pp. 103-115
    • Wolter, T.R.1    Wong, R.2    Sarkar, S.A.3    Zipris, D.4
  • 106
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4 (+) CD25 (+) T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, et al. Defective suppressor function in CD4 (+) CD25 (+) T-cells from patients with type 1 diabetes. Diabetes 2005;54:92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3
  • 107
    • 43849096855 scopus 로고    scopus 로고
    • Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study
    • Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study. Lancet 2008;371:1777-1782.
    • (2008) Lancet , vol.371 , pp. 1777-1782
    • Harjutsalo, V.1    Sjoberg, L.2    Tuomilehto, J.3
  • 109
    • 44649160093 scopus 로고    scopus 로고
    • Does social-economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example
    • Jarosz-Chobot P, Polanska J, Polanski A. Does social-economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example. Pediatr Diabetes 2008;9:202-207.
    • (2008) Pediatr. Diabetes , vol.9 , pp. 202-207
    • Jarosz-Chobot, P.1    Polanska, J.2    Polanski, A.3
  • 110
    • 33847654642 scopus 로고    scopus 로고
    • Allergic sensitization and microbial load-A comparison between Finland and Russian Karelia
    • Seiskari T, Kondrashova A, Viskari H, et al. Allergic sensitization and microbial load-A comparison between Finland and Russian Karelia. Clin Exp Immunol 2007;148:47-52.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 47-52
    • Seiskari, T.1    Kondrashova, A.2    Viskari, H.3
  • 111
    • 33846003509 scopus 로고    scopus 로고
    • Signs of beta-cell autoimmunity in nondiabetic schoolchildren: A comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate
    • Kondrashova A, Viskari H, Kulmala P, et al. Signs of beta-cell autoimmunity in nondiabetic schoolchildren: A comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate. Diabetes Care 2007;30:95-100.
    • (2007) Diabetes Care , vol.30 , pp. 95-100
    • Kondrashova, A.1    Viskari, H.2    Kulmala, P.3
  • 112
    • 14844299867 scopus 로고    scopus 로고
    • A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland
    • Kondrashova A, Reunanen A, Romanov A, et al. A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland. Ann Med 2005;37:67-72.
    • (2005) Ann. Med. , vol.37 , pp. 67-72
    • Kondrashova, A.1    Reunanen, A.2    Romanov, A.3
  • 113
    • 0033624114 scopus 로고    scopus 로고
    • Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: The Finnish Diabetes Prediction and Prevention Study
    • Lonnrot M, Korpela K, Knip M, et al. Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: The Finnish Diabetes Prediction and Prevention Study. Diabetes 49:1314-1318, 2000.
    • (2000) Diabetes , vol.49 , pp. 1314-1318
    • Lonnrot, M.1    Korpela, K.2    Knip, M.3
  • 114
    • 0035702136 scopus 로고    scopus 로고
    • No evidence for an association of Coxsackie virus infections during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes
    • Fuchtenbusch M, Irnstetter A, Jager G, Ziegler AG. No evidence for an association of Coxsackie virus infections during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes. J Autoimmun 2001;17:333-340.
    • (2001) J. Autoimmun , vol.17 , pp. 333-340
    • Fuchtenbusch, M.1    Irnstetter, A.2    Jager, G.3    Ziegler, A.G.4
  • 115
    • 34249732096 scopus 로고    scopus 로고
    • Epidemiological and immunological evidence for the hygiene hypothesis
    • Garn H, Renz H. Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology 2007;212:441-452.
    • (2007) Immunobiology , vol.212 , pp. 441-452
    • Garn, H.1    Renz, H.2
  • 116
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • Wen L, Ley RE, Volchkov PY, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008;455:1109-1113.
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1    Ley, R.E.2    Volchkov, P.Y.3
  • 117
    • 59649105735 scopus 로고    scopus 로고
    • Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
    • Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984.
    • (2008) J. Exp. Med. , vol.205 , pp. 2975-2984
    • Oresic, M.1    Simell, S.2    Sysi-Aho, M.3
  • 118
    • 33748492573 scopus 로고    scopus 로고
    • Induction of RelB participates in endotoxin tolerance
    • Yoza BK, Hu JY, Cousart SL, et al. Induction of RelB participates in endotoxin tolerance. J Immunol 2006;177:4080-4085.
    • (2006) J. Immunol. , vol.177 , pp. 4080-4085
    • Yoza, B.K.1    Hu, J.Y.2    Cousart, S.L.3
  • 119
    • 2342551979 scopus 로고    scopus 로고
    • Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
    • Genovese MC, Cohen S, Moreland L, et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 2004;50:1412-1419.
    • (2004) Arthritis Rheum. , vol.50 , pp. 1412-1419
    • Genovese, M.C.1    Cohen, S.2    Moreland, L.3
  • 120
    • 58749090375 scopus 로고    scopus 로고
    • Serious infections during anti-TNFalpha treatment in rheumatoid arthritis patients
    • Favalli EG, Desiati F, Atzeni F, et al. Serious infections during anti-TNFalpha treatment in rheumatoid arthritis patients. Autoimmun Rev 2009;8:266-273.
    • (2009) Autoimmun Rev. , vol.8 , pp. 266-273
    • Favalli, E.G.1    Desiati, F.2    Atzeni, F.3
  • 121
    • 0034024239 scopus 로고    scopus 로고
    • Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness
    • Berg L, Ronnelid J, Klareskog L, Bucht A. Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness. Clin Exp Immunol 2000;120:174-182.
    • (2000) Clin. Exp. Immunol. , vol.120 , pp. 174-182
    • Berg, L.1    Ronnelid, J.2    Klareskog, L.3    Bucht, A.4
  • 122
    • 34248353538 scopus 로고    scopus 로고
    • TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues
    • Zhang Z, Gorman CL, Vermi AC, et al. TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues. Blood 2007;109:4328-4335.
    • (2007) Blood , vol.109 , pp. 4328-4335
    • Zhang, Z.1    Gorman, C.L.2    Vermi, A.C.3
  • 123
    • 0026661062 scopus 로고
    • T-cell receptor a/b chain-CD3 protein complex defect in systemic lupus erythematosus: T-cell function
    • Raziuddin S, Ahmed Al-Janadi M, Alwabel AA. T-cell receptor a/b chain-CD3 protein complex defect in systemic lupus erythematosus: T-cell function. Am J Med 1992;93:461-466.
    • (1992) Am. J. Med. , vol.93 , pp. 461-466
    • Raziuddin, S.1    Al-Janadi, M.A.2    Alwabel, A.A.3
  • 124
    • 54549093790 scopus 로고    scopus 로고
    • Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE)
    • Janko C, Schorn C, Grossmayer GE, et al. Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmun Rev 2008;8:9-12.
    • (2008) Autoimmun Rev. , vol.8 , pp. 9-12
    • Janko, C.1    Schorn, C.2    Grossmayer, G.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.