Down-regulation of the T cell receptor CD3ξ chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness

Clinical and Experimental Immunology

Volumn 120, Issue 1, 2000, Pages 174-182

  Berg, Louise ^a,d   Ronnelid J ^a,c   Klareskog, L ^a   Bucht, A ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CD3 ; Cytokine; Proliferation; Rheumatoid arthritis; Synovial fluid

Indexed keywords

GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR DELTA CHAIN;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; DOWN REGULATION; FEMALE; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; T LYMPHOCYTE;

EID: 0034024239     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01180.x     Document Type: Article

References (44)

1. Kiessling R, Kono K, Petersson M et al. Immunosuppression in human tumor-host interaction. Role of cytokines and alterations in signal-transducing molecules. Springer Semin Immunopathol 1996; 18:227-42.
2. lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 1993; 53:5613-6.
3. Nakagomi H, Petersson M, Magnusson I et al. Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 1993; 53:5610-2.
4. Gunji Y, Hori S, Aoe T et al. High frequency of cancer patients with abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes. Jap J Cancer Res 1994; 85:1189-92.
5. Zea AH, Curti BD, Longo DL et al. Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1995; 1:1327-35.
6. Renner C, Ohnesorge S, Held G et al. T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28. Blood 1996; 88:236-41.
7. Lai P, Rabinowich H, Crowley-Nowick PA et al. Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin Cancer Res 1996; 2:161-73.
8. Maurice MM, Lankester AC, Bezemer AC et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997; 159:2973-8.
9. Healy CG, Simons JW, Carducci MA et al. Impaired expression and function of signal-transducing zeta chains in peripheral T cells and natural killer cells in patients with prostate cancer. Cytometry 1998; 32:109-19.
10. Liossis SN, Hoffman RW, Tsokos GC. Abnormal early TCR/CD3-mediated signaling events of a snRNP-autoreactive lupus T cell clone. Clin Immunol Immunopathol 1998; 88:305-10.
11. Matsuda M, Ulfgren AK, Lenkei R et al. Decreased expression of signal-transducing CD3 zeta chains in T cells from the joints and peripheral blood of rheumatoid arthritis patients. Scand J Immunol 1998; 47:254-62.
12. Trimble LA, Lieberman J. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. Blood 1998; 91:585-94.
13. Tartour E, Latour S, Mathiot C et al. Variable expression of CD3-zeta chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: relationship with TIL phenotype and function. Int J Cancer 1995; 63:205-12.
14. Matsuda M, Petersson M, Lenkei R et al. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int J Cancer 1995; 61:765-72.
15. Aoe T, Okamoto Y, Saito T. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Medicine 1995; 181:1881-6.
16. Kono K, Salazar-Onfray F, Petersson M et al. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell- and natural killer cell-mediated cytotoxicity. Eur J Immunol 1996; 26:1308-13.
17. Otsuji M, Kimura Y, Aoe T et al. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 1996; 93:13119-24.
18. Silverman HA, Johnson JS, Vaughan JH et al. Altered lymphocyte reactivity in rheumatoid arthritis. Arthritis Rheum 1976; 19:509-15.
19. Emery P, Panayi GS, Nouri AM. Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin Exp Immunol 1984; 57:123-9.
20. Lotz M, Tsoukas CD, Robinson CA et al. Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. J Clin Invest 1986; 78:713-21.
21. Seitz M, Napierski I, Kirchner H. Depressed PPD and tetanus toxoid presentation by monocytes to T lymphocytes in patients with rheumatoid arthritis: restoration by interferon gamma. Rheumatol Int 1988; 8:189-96.
22. Hovdenes J, Gaudernack G, Kvien TK et al. A functional study of purified CD4+ and CD8+ cells isolated from synovial fluid of patients with rheumatoid arthritis and other arthritides. Scand J Immunol 1989; 29:641-9.
23. Verwilghen J, Vertessen S, Stevens EA et al. Depressed T-cell reactivity to recall antigens in rheumatoid arthritis. J Clin Immunol 1990; 10:90-98.
24. Mirza NM, Relias V, Yunis EJ et al. Defective signal transduction via T-cell receptor-CD3 structure in T cells from rheumatoid arthritis patients. Human Immunol 1993; 36:91-98.
25. Allen ME, Young SP, Michell RH et al. Altered T lymphocyte signaling in rheumatoid arthritis. Eur J Immunol 1995; 25:1547-54.
26. van den Broek M, Boeije L, Swaak T et al. Functional analysis of synovial fluid and peripheral blood T cells from patients with rheumatoid arthritis. Rheumatol Int 1995; 15:137-43.
27. Carruthers DM, Naylor WG, Allen ME et al. Characterization of altered calcium signalling in T lymphocytes from patients with rheumatoid arthritis (RA). Clin Exp Immunol 1996; 105:291-6.
28. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
29. Franco JL, Ghosh P, Wiltrout RH et al. Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Cancer Res 1995; 55:3840-6.
30. Esin S, Batoni G, Kallenius G et al. Proliferation of distinct human T cell subsets in response to live, killed or soluble extracts of Mycobacterium tuberculosis and Myco. avium. Clin Exp Immunol 1996; 104:419-25.
31. McHugh S, Deighton J, Rifkin I et al. Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol 1996; 26:1260-5.
32. Hessian PA, Highton J, Palmer DG. Quantification of macrophage cell surface molecules in rheumatoid arthritis. Clin Exp Immunol 1989; 77:47-51.
33. Koch AE, Burrows JC, Skoutelis A et al. Monoclonal antibodies detect monocyte/macrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages. Am J Pathol 1991; 138:165-73.
34. Morita Y, Yamamura M, Kawashima M et al. Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheumat 1998; 41:1669-76.
35. Bucht A, Larsson P, Weisbrot L et al. Expression of interferon-gamma (IFN-gamma), IL-10, IL-12 and transforming growth factor-beta (TGF-beta) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 1996; 103:357-67.
36. Ronnelid J, Berg L, Rogberg S et al. Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood. Br J Rheumatol 1998; 37:7-14.
37. Isomaki P, Luukkainen R, Saario R et al. Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 1996; 39:386-95.
38. Lettesjo H, Nordstrom E, Strom H et al. Synovial fluid cytokines in patients with rheumatoid arthritis or other arthritic lesions. Scand J Immunol 1998; 48:286-92.
39. Watson F, Robinson JJ, Phelan M et al. Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis. Ann Rheum Dis 1993; 52:354-9.
40. Felzmann T, Gadd S, Majdic O et al. Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. J Clin Immunol 1991; 11:205-12.
41. Jones J, Laffafian I, Cooper AM et al. Expression of complement regulatory molecules and other surface markers on neutrophils from synovial fluid and blood of patients with rheumatoid arthritis. Br J Rheumatol 1994; 33:707-12.
42. Robertson SE, Young SP, Viner NJ et al. Enhanced co-stimulatory ability of synovial fluid accessory cells in rheumatoid arthritis. Br J Rheumatol 1997; 36:413-9.
43. Torsteinsdottir I, Arvidson NG, Hallgren R et al. Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids. Clin Exp Immunol 1999; 115:554-60.
44. Liote F, Boval-Boizard B, Weill D et al. Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release. Clin Exp Immunol 1996; 106:13-19.