-
1
-
-
54449098286
-
Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery
-
Huber T, Menon S, Sakmar TP (2008) Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery. Biochemistry 47:11013-11023.
-
(2008)
Biochemistry
, vol.47
, pp. 11013-11023
-
-
Huber, T.1
Menon, S.2
Sakmar, T.P.3
-
2
-
-
0034464742
-
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
-
Gether U (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113.
-
(2000)
Endocr Rev
, vol.21
, pp. 90-113
-
-
Gether, U.1
-
3
-
-
33748658464
-
Therapeutic potential of monoamine transporter substrates
-
Rothman RB, Baumann MH (2006) Therapeutic potential of monoamine transporter substrates. Curr Top Med Chem 6:1845-1859.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1845-1859
-
-
Rothman, R.B.1
Baumann, M.H.2
-
4
-
-
65649143515
-
Agonist-trafficking and hallucinogens
-
Gonzalez-Maeso J, Sealfon SC (2009) Agonist-trafficking and hallucinogens. Curr Med Chem 16:1017-1027.
-
(2009)
Curr Med Chem
, vol.16
, pp. 1017-1027
-
-
Gonzalez-Maeso, J.1
Sealfon, S.C.2
-
5
-
-
77956783230
-
Mapping the binding-site crevice of the D2 receptor
-
Javitch JA (1998) Mapping the binding-site crevice of the D2 receptor. Adv Pharmacol 42:412-415.
-
(1998)
Adv Pharmacol
, vol.42
, pp. 412-415
-
-
Javitch, J.A.1
-
6
-
-
0032723795
-
Dopamine D4/D2 receptor selectivity is determined by a divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments
-
Simpson MM, et al. (1999) Dopamine D4/D2 receptor selectivity is determined by a divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments. Mol Pharmacol 56:1116-1126.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1116-1126
-
-
Simpson, M.M.1
-
7
-
-
1642410853
-
The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists
-
DOI 10.1073/pnas.0400100101
-
Kalani MY, et al. (2004) The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists. Proc Natl Acad Sci USA 101:3815-3820. (Pubitemid 38381061)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.11
, pp. 3815-3820
-
-
Kalani, M.Y.S.1
Vaidehi, N.2
Hall, S.E.3
Trabanino, R.J.4
Freddolino, P.L.5
Kalani, M.A.6
Floriano, W.B.7
Kam, V.W.T.8
Goddard III, W.A.9
-
8
-
-
30044438605
-
2 dopamine receptors
-
DOI 10.1124/mol.105.017244
-
Lan H, Durand CJ, Teeter MM, Neve KA (2006) Structural determinants of pharmacological specificity between D(1) and D(2) dopamine receptors. Mol Pharmacol 69:185-194. (Pubitemid 43048905)
-
(2006)
Molecular Pharmacology
, vol.69
, Issue.1
, pp. 185-194
-
-
Lan, H.1
Durand, C.J.2
Teeter, M.M.3
Neve, K.A.4
-
9
-
-
36448995359
-
2-adrenergic G protein-coupled receptor
-
DOI 10.1126/science.1150577
-
Cherezov V, et al. (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318:1258-1265. (Pubitemid 350172884)
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Foon, S.T.5
Kobilka, T.S.6
Choi, H.-J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
10
-
-
47949129742
-
Structure of a beta1-adrenergic G-protein-coupled receptor
-
Warne T, et al. (2008) Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 454:486-491.
-
(2008)
Nature
, vol.454
, pp. 486-491
-
-
Warne, T.1
-
11
-
-
56749103466
-
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
-
Jaakola VP, et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322:1211-1217.
-
(2008)
Science
, vol.322
, pp. 1211-1217
-
-
Jaakola, V.P.1
-
12
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
Palczewski K, et al. (2000) Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289:739-745. (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
14
-
-
34447632041
-
Allosteric GPCR modulators: Taking advantage of permissive receptor pharmacology
-
DOI 10.1016/j.tips.2007.06.004, PII S0165614707001496, Allosterism and Collateral Efficacy
-
Leach K, Sexton PM, Christopoulos A (2007) Allosteric GPCR modulators: Taking advantage of permissive receptor pharmacology. Trends Pharmacol Sci 28:382-389. (Pubitemid 47087967)
-
(2007)
Trends in Pharmacological Sciences
, vol.28
, Issue.8
, pp. 382-389
-
-
Leach, K.1
Sexton, P.M.2
Christopoulos, A.3
-
15
-
-
0029913807
-
An evolutionary trace method defines binding surfaces common to protein families
-
DOI 10.1006/jmbi.1996.0167
-
Lichtarge O, Bourne HR, Cohen FE (1996) An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol 257:342-358. (Pubitemid 26114038)
-
(1996)
Journal of Molecular Biology
, vol.257
, Issue.2
, pp. 342-358
-
-
Lichtarge, O.1
Bourne, H.R.2
Cohen, F.E.3
-
16
-
-
1542379652
-
Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions
-
DOI 10.1074/jbc.M312671200
-
Madabushi S, et al. (2004) Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. J Biol Chem 279:8126-8132. (Pubitemid 38294703)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.9
, pp. 8126-8132
-
-
Madabushi, S.1
Gross, A.K.2
Philippi, A.3
Meng, E.C.4
Wensel, T.G.5
Lichtarge, O.6
-
17
-
-
33748460328
-
Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors
-
DOI 10.1002/prot.21074
-
Raviscioni M, He Q, Salicru EM, Smith CL, Lichtarge O (2006) Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors. Proteins 64:1046-1057. (Pubitemid 44420943)
-
(2006)
Proteins: Structure, Function and Genetics
, vol.64
, Issue.4
, pp. 1046-1057
-
-
Raviscioni, M.1
He, Q.2
Salicru, E.M.3
Smith, C.L.4
Lichtarge, O.5
-
18
-
-
77957055780
-
Integrated methods for modeling G-protein coupled receptors
-
Ballesteros J, Weinstein H (1995) Integrated methods for modeling G-protein coupled receptors. Methods Neurosci 25:366-428.
-
(1995)
Methods Neurosci
, vol.25
, pp. 366-428
-
-
Ballesteros, J.1
Weinstein, H.2
-
19
-
-
33947375922
-
Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function
-
DOI 10.1124/jpet.106.116384
-
Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS (2007) Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function. J Pharmacol Exp Ther 321:298-307. (Pubitemid 46456991)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.321
, Issue.1
, pp. 298-307
-
-
Al-Fulaij, M.A.1
Ren, Y.2
Beinborn, M.3
Kopin, A.S.4
-
20
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
Kenakin T (2002) Efficacy at G-protein-coupled receptors. Nat Rev Drug Discov 1:103-110.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 103-110
-
-
Kenakin, T.1
-
21
-
-
0031871997
-
Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: Evidence for multiple, agonist-specific active conformations
-
Wiens BL, Nelson CS, Neve KA (1998) Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: Evidence for multiple, agonist-specific active conformations. Mol Pharmacol 54:435-444.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 435-444
-
-
Wiens, B.L.1
Nelson, C.S.2
Neve, K.A.3
-
22
-
-
0028116711
-
2 dopamine receptor is exposed in the binding-site crevice
-
DOI 10.1073/pnas.91.22.10355
-
Javitch JA, Li X, Kaback J, Karlin A (1994) A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice. Proc Natl Acad Sci USA 91:10355-10359. (Pubitemid 24328995)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.22
, pp. 10355-10359
-
-
Javitch, J.A.1
Li, X.2
Kaback, J.3
Karlin, A.4
-
24
-
-
33644857279
-
Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor
-
Shenoy SK, et al. (2006) beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem 281:1261-1273.
-
(2006)
J Biol Chem
, vol.281
, pp. 1261-1273
-
-
Shenoy, S.K.1
-
25
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
Urban JD, et al. (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320:1-13.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1-13
-
-
Urban, J.D.1
-
26
-
-
34447649922
-
Beta-arrestin-biased ligands at seven-transmembrane receptors
-
Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci 28:416-422.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 416-422
-
-
Violin, J.D.1
Lefkowitz, R.J.2
-
27
-
-
43049109861
-
Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors
-
Kim JH, Cho EY, Min C, Park JH, Kim KM (2008) Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors. Arch Pharm Res 31:474-481.
-
(2008)
Arch Pharm Res
, vol.31
, pp. 474-481
-
-
Kim, J.H.1
Cho, E.Y.2
Min, C.3
Park, J.H.4
Kim, K.M.5
-
28
-
-
33947381686
-
The highly conserved DRY motif of class a G protein-coupled receptors: Beyond the ground state
-
DOI 10.1124/mol.106.029470
-
Rovati GE, Capra V, Neubig RR (2007) The highly conserved DRY motif of class A G protein-coupled receptors: Beyond the ground state. Mol Pharmacol 71:959-964. (Pubitemid 46456999)
-
(2007)
Molecular Pharmacology
, vol.71
, Issue.4
, pp. 959-964
-
-
Rovati, G.E.1
Capra, V.2
Neubig, R.R.3
-
29
-
-
44049086134
-
Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-protein-coupled receptor activation
-
Bhattacharya S, Hall SE, Li H, Vaidehi N (2008) Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-protein-coupled receptor activation. Biophys J 94:2027-2042.
-
(2008)
Biophys J
, vol.94
, pp. 2027-2042
-
-
Bhattacharya, S.1
Hall, S.E.2
Li, H.3
Vaidehi, N.4
-
30
-
-
0037174606
-
Beta2 adrenergic receptor activation: Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
-
DOI 10.1074/jbc.M206801200
-
Shi L, et al. (2002) Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem 277:40989-40996. (Pubitemid 35215688)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.43
, pp. 40989-40996
-
-
Shi, L.1
Liapakis, G.2
Xu, R.3
Guarnieri, F.4
Ballesteros, J.A.5
Javitch, J.A.6
-
31
-
-
20444499405
-
2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
-
DOI 10.1074/jbc.M502352200
-
Swaminath G, et al. (2005) Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem 280:22165-22171. (Pubitemid 40827872)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 22165-22171
-
-
Swaminath, G.1
Deupi, X.2
Lee, T.W.3
Zhu, W.4
Thian, F.S.5
Kobilka, T.S.6
Kobilka, B.7
-
32
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
DOI 10.1126/science.274.5288.768
-
Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG (1996) Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274:768-770. (Pubitemid 26398253)
-
(1996)
Science
, vol.274
, Issue.5288
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
33
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
DOI 10.1038/383347a0
-
Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR (1996) Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383:347-350. (Pubitemid 26321766)
-
(1996)
Nature
, vol.383
, Issue.6598
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
34
-
-
8844263762
-
Positive and negative allosteric modulation of metabotropic glutamate receptors: Emerging therapeutic potential
-
Kew JN (2004) Positive and negative allosteric modulation of metabotropic glutamate receptors: Emerging therapeutic potential. Pharmacol Ther 104:233-244.
-
(2004)
Pharmacol Ther
, vol.104
, pp. 233-244
-
-
Kew, J.N.1
-
35
-
-
24044539957
-
1 receptor
-
DOI 10.1124/mol.105.016162
-
Price MR, et al. (2005) Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol 68:1484-1495. (Pubitemid 41540004)
-
(2005)
Molecular Pharmacology
, vol.68
, Issue.5
, pp. 1484-1495
-
-
Price, M.R.1
Baillie, G.L.2
Thomas, A.3
Stevenson, L.A.4
Easson, M.5
Goodwin, R.6
McLean, A.7
McIntosh, L.8
Goodwin, G.9
Walker, G.10
Westwood, P.11
Marrs, J.12
Thomson, F.13
Cowley, P.14
Christopoulos, A.15
Pertwee, R.G.16
Ross, R.A.17
-
36
-
-
1242339659
-
A Family of Evolution-Entropy Hybrid Methods for Ranking Protein Residues by Importance
-
DOI 10.1016/j.jmb.2003.12.078
-
Mihalek I, Res I, Lichtarge O (2004) A family of evolution-entropy hybrid methods for ranking protein residues by importance. J Mol Biol 336:1265-1282. (Pubitemid 38229712)
-
(2004)
Journal of Molecular Biology
, vol.336
, Issue.5
, pp. 1265-1282
-
-
Mihalek, I.1
Res, I.2
Lichtarge, O.3
-
37
-
-
0036300444
-
Structural clusters of evolutionary trace residues are statistically significant and common in proteins
-
DOI 10.1006/jmbi.2001.5327
-
Madabushi S, et al. (2002) Structural clusters of evolutionary trace residues are statistically significant and common in proteins. J Mol Biol 316:139-154. (Pubitemid 34729272)
-
(2002)
Journal of Molecular Biology
, vol.316
, Issue.1
, pp. 139-154
-
-
Madabushi, S.1
Yao, H.2
Marsh, M.3
Kristensen, D.M.4
Philippi, A.5
Sowa, M.E.6
Lichtarge, O.7
-
38
-
-
0037423759
-
An accurate, sensitive, and scalable method to identify functional sites in protein structures
-
DOI 10.1016/S0022-2836(02)01336-0
-
Yao H, et al. (2003) An accurate, sensitive, and scalable method to identify functional sites in protein structures. J Mol Biol 326:255-261. (Pubitemid 36279373)
-
(2003)
Journal of Molecular Biology
, vol.326
, Issue.1
, pp. 255-261
-
-
Yao, H.1
Kristensen, D.M.2
Mihalek, I.3
Sowa, M.E.4
Shaw, C.5
Kimmel, M.6
Kavraki, L.7
Lichtarge, O.8
-
39
-
-
0035126520
-
Prediction and confirmation of a site critical for effector regulation of RGS domain activity
-
Sowa ME, et al. (2001) Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nat Struct Biol 8:234-237.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 234-237
-
-
Sowa, M.E.1
-
40
-
-
34247194102
-
Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions
-
DOI 10.1038/nsmb1214, PII NSMB1214
-
Ribes-Zamora A, Mihalek I, Lichtarge O, Bertuch AA (2007) Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. Nat Struct Mol Biol 14:301-307. (Pubitemid 46608339)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.4
, pp. 301-307
-
-
Ribes-Zamora, A.1
Mihalek, I.2
Lichtarge, O.3
Bertuch, A.A.4
-
41
-
-
67649951498
-
Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones
-
Kobayashi H, Ogawa K, Yao R, Lichtarge O, Bouvier M (2009) Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones. Traffic 10:1019-1033.
-
(2009)
Traffic
, vol.10
, pp. 1019-1033
-
-
Kobayashi, H.1
Ogawa, K.2
Yao, R.3
Lichtarge, O.4
Bouvier, M.5
-
42
-
-
77149143842
-
Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation
-
Baameur F, et al. (2010) Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol Pharmacol 77:405-415.
-
(2010)
Mol Pharmacol
, vol.77
, pp. 405-415
-
-
Baameur, F.1
-
43
-
-
65649110443
-
Evolutionary Trace Annotation Server: Automated enzyme function prediction in protein structures using 3D templates
-
Ward RM, et al. (2009) Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates. Bioinformatics 25:1426-1427.
-
(2009)
Bioinformatics
, vol.25
, pp. 1426-1427
-
-
Ward, R.M.1
-
44
-
-
47849086673
-
De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features
-
Ward RM, et al. (2008) De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features. PLoS ONE 3:e2136.
-
(2008)
PLoS One
, vol.3
-
-
Ward, R.M.1
-
45
-
-
77649271360
-
Evolutionary trace annotation of protein function in the structural proteome
-
Erdin S, Ward RM, Venner E, Lichtarge O (2010) Evolutionary trace annotation of protein function in the structural proteome. J Mol Biol 396:1451-1473.
-
(2010)
J Mol Biol
, vol.396
, pp. 1451-1473
-
-
Erdin, S.1
Ward, R.M.2
Venner, E.3
Lichtarge, O.4
-
46
-
-
0034633933
-
The fourth transmembrane segment of the dopamine D2 receptor: Accessibility in the binding-site crevice and position in the transmembrane bundle
-
Javitch JA, et al. (2000) The fourth transmembrane segment of the dopamine D2 receptor: Accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry 39:12190-12199.
-
(2000)
Biochemistry
, vol.39
, pp. 12190-12199
-
-
Javitch, J.A.1
-
47
-
-
0037485769
-
Combining inference from evolution and geometric probability in protein structure evaluation
-
DOI 10.1016/S0022-2836(03)00663-6
-
Mihalek I, Res I, Yao H, Lichtarge O (2003) Combining inference from evolution and geometric probability in protein structure evaluation. J Mol Biol 331:263-279. (Pubitemid 36870792)
-
(2003)
Journal of Molecular Biology
, vol.331
, Issue.1
, pp. 263-279
-
-
Mihalek, I.1
Res, I.2
Yao, H.3
Lichtarge, O.4
|