Molecular basis of the structural stability of a Top7-based scaffold at extreme pH and temperature conditions

Journal of Molecular Graphics and Modelling

Volumn 28, Issue 8, 2010, Pages 755-765

  Soares, Thereza A ^a,b   Boschek, Curt B ^a   Apiyo, David ^c   Baird, Cheryl ^a   Straatsma, T P ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Beckman Coulter Inc   (United States)

Author keywords

Affinity reagents; CD4 binding protein; Chemical and thermal denaturation; Experimental interpretation; Protein engineering; Temperature and pH dependent conformations; Thermostable proteins

Indexed keywords

AFFINITY REAGENTS; BINDING PROTEINS; CD4 BINDING PROTEIN; PH-DEPENDENT; PROTEIN ENGINEERING; THERMAL DENATURATIONS; THERMOSTABLE PROTEINS;

BIOCHEMICAL ENGINEERING; CHEMICAL STABILITY; CONFORMATIONS; DENATURATION; DICHROISM; GENETIC ENGINEERING; PH; PYROLYSIS; SCAFFOLDS; SYSTEM STABILITY;

PROTEINS;

ALANINE; ASPARTIC ACID; CD4 ANTIGEN; GLYCINE; MOLECULAR SCAFFOLD; SCAFFOLD PROTEIN; SOLVENT;

ACIDITY; ALPHA HELIX; ARTICLE; BETA SHEET; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DENATURATION; GENETIC CONSERVATION; HIGH TEMPERATURE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; PH; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN STABILITY; TECHNOLOGY; TEMPERATURE; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINS; TEMPERATURE;

BACTERIA (MICROORGANISMS);

EID: 77952102931     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2010.01.013     Document Type: Article

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