Characterization of the folding energy landscapes of computer generated proteins suggests high folding free energy barriers and cooperativity may be consequences of natural selection

Journal of Molecular Biology

Volumn 338, Issue 3, 2004, Pages 573-583

  Scalley Kim, Michelle ^a   Baker, David ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Folding kinetics; Free energy landscape; Natural selection; Protein design; Protein folding; RMSD, root mean squared deviation; GUNF, free energy of unfolding

Indexed keywords

ARTICLE; COMPUTER AIDED DESIGN; ENERGY; KINETICS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NATURAL SELECTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 1842635571     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.02.055     Document Type: Article

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