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Solution structure of a de novo protein from a designed combinatorial library
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A high-resolution structure was solved for a four-helix-bundle protein from a binary hydrophobic-polar patterned library. This result suggests that sequences that fold into well-packed structures are not extremely rare.
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Wei Y., Kim S., Fela D., Baum J., Hecht M.H. Solution structure of a de novo protein from a designed combinatorial library. Proc. Natl. Acad. Sci. U.S.A. 100:2003;13270-13273 A high-resolution structure was solved for a four-helix-bundle protein from a binary hydrophobic-polar patterned library. This result suggests that sequences that fold into well-packed structures are not extremely rare.
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