Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 22, 2007, Pages 9278-9283

  Sharma, Deepak ^a   Perisic, Ognjen ^b   Peng, Qing ^a   Cao, Yi ^a   Lam, Canaan ^a   Lu, Hui ^b   Li, Hongbin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b University of Illinois at Chicago   (United States)

Author keywords

Atomic force microscopy; Computational design; Mechanical unfolding; Unfolding pathway

Indexed keywords

IMMUNOGLOBULIN; PROTEIN; PROTEIN TOP7; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; ENERGY TRANSFER; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SPECTROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; MECHANICS; METABOLISM; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

COMPUTER SIMULATION; MECHANICS; MODELS, MOLECULAR; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SPECTRUM ANALYSIS;

EID: 34547151186     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700351104     Document Type: Article

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