메뉴 건너뛰기




Volumn 130, Issue 2, 2010, Pages 166-171

Multi-tasking of helper T cells

Author keywords

Autoimmunity; CD4 helper T cells; Inflammation; Regulatory T cells; T cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; LYMPHOTOXIN; PROTEIN BCL 6; RETINOIC ACID RECEPTOR GAMMA; STAT6 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA;

EID: 77952027489     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03289.x     Document Type: Review
Times cited : (146)

References (65)
  • 2
    • 0032720802 scopus 로고    scopus 로고
    • Kinetics of interferon-γ secretion and its regulatory factors in the early phase of acute graft-versus-host disease
    • Hu HZ, Li GL, Lim YK, Chan SH, Yap EH. Kinetics of interferon-γ secretion and its regulatory factors in the early phase of acute graft-versus-host disease. Immunology 1999 98 : 379 385.
    • (1999) Immunology , vol.98 , pp. 379-385
    • Hu, H.Z.1    Li, G.L.2    Lim, Y.K.3    Chan, S.H.4    Yap, E.H.5
  • 4
    • 0034659770 scopus 로고    scopus 로고
    • Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
    • Leung BP, McInnes IB, Esfandiari E, Wei XQ, Liew FY. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis. J Immunol 2000 164 : 6495 6502. (Pubitemid 30408834)
    • (2000) Journal of Immunology , vol.164 , Issue.12 , pp. 6495-6502
    • Leung, B.P.1    McInnes, I.B.2    Esfandiari, E.3    Wei, X.-Q.4    Liew, F.Y.5
  • 13
    • 0026610142 scopus 로고
    • Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
    • Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992 326 : 298 304.
    • (1992) N Engl J Med , vol.326 , pp. 298-304
    • Robinson, D.S.1    Hamid, Q.2    Ying, S.3
  • 14
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990 145 : 3796 3806.
    • (1990) J Immunol , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 15
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • DOI 10.1084/jem.172.3.921
    • Le GrosG, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 1990 172 : 921 929. (Pubitemid 20301238)
    • (1990) Journal of Experimental Medicine , vol.172 , Issue.3 , pp. 921-929
    • Le Gros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 16
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991 254 : 707 710. (Pubitemid 21917392)
    • (1991) Science , vol.254 , Issue.5032 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 18
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci USA 2004 101 : 1993 1998.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 20
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • DOI 10.1016/S1074-7613(00)80439-2
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996 4 : 313 319. (Pubitemid 26132509)
    • (1996) Immunity , vol.4 , Issue.3 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 23
    • 0033427612 scopus 로고    scopus 로고
    • Ectopic expression of activated Stat6 induces the expression of Th2- specific cytokines and transcription factors in developing Th1 cells
    • Kurata H, Lee HJ, O'Garra A, Arai N. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 1999 11 : 677 688. (Pubitemid 30030707)
    • (1999) Immunity , vol.11 , Issue.6 , pp. 677-688
    • Kurata, H.1    Hyun, J.L.2    O'Garra, A.3    Arai, N.4
  • 25
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006 116 : 1310 1316.
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 26
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-β'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J et al. Transforming growth factor-β'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008 9 : 1341 1346.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3
  • 27
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-β induces development of the T(H)17 lineage
    • Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-β induces development of the T(H)17 lineage. Nature 2006 441 : 231 234.
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 28
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441 : 235 238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 32
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ
    • Yang XO, Pappu BP, Nurieva R et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 2008 28 : 29 39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3
  • 34
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS, Mackay CR. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004 173 : 68 78. (Pubitemid 38797327)
    • (2004) Journal of Immunology , vol.173 , Issue.1 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 35
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008 29 : 138 149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3
  • 37
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008 29 : 127 137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    MacKay, C.R.5    King, C.6
  • 39
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • DOI 10.1146/annurev.immunol.21.120601.141122
    • + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004 22 : 531 562. (Pubitemid 38680433)
    • (2004) Annual Review of Immunology , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 40
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity*
    • Shevach EM. Regulatory T cells in autoimmmunity*. Annu Rev Immunol 2000 18 : 423 449.
    • (2000) Annu Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 41
    • 44849123303 scopus 로고    scopus 로고
    • Role of Foxp3-positive regulatory T cells during infection
    • Belkaid Y. Role of Foxp3-positive regulatory T cells during infection. Eur J Immunol 2008 38 : 918 921.
    • (2008) Eur J Immunol , vol.38 , pp. 918-921
    • Belkaid, Y.1
  • 42
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T cells
    • DOI 10.1126/science.1155209
    • Lund JM, Hsing L, Pham TT, Rudensky AY. Coordination of early protective immunity to viral infection by regulatory T cells. Science 2008 320 : 1220 1224. (Pubitemid 351929511)
    • (2008) Science , vol.320 , Issue.5880 , pp. 1220-1224
    • Lund, J.M.1    Hsing, L.2    Pham, T.T.3    Rudensky, A.Y.4
  • 43
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • DOI 10.1038/ni1455, PII NI1455
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007 8 : 457 462. (Pubitemid 46605910)
    • (2007) Nature Immunology , vol.8 , Issue.5 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 44
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • DOI 10.1126/science.1078231
    • + T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 1036. (Pubitemid 36222922)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 45
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang XO, Nurieva R, Martinez GJ et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008 29 : 44 56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3
  • 46
    • 34249799285 scopus 로고    scopus 로고
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J Immunol 2007 178 : 6725 6729. (Pubitemid 46847395)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 48
    • 70349334306 scopus 로고    scopus 로고
    • Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells
    • Zeng WP, Chang C, Lai JJ. Immune suppressive activity and lack of T helper differentiation are differentially regulated in natural regulatory T cells. J Immunol 2009 183 : 3583 3590.
    • (2009) J Immunol , vol.183 , pp. 3583-3590
    • Zeng, W.P.1    Chang, C.2    Lai, J.J.3
  • 52
    • 41149158001 scopus 로고    scopus 로고
    • Memory CD4 T cells emerge from effector T-cell progenitors
    • DOI 10.1038/nature06672, PII NATURE06672
    • Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT. Memory CD4 T cells emerge from effector T-cell progenitors. Nature 2008 452 : 356 360. (Pubitemid 351430787)
    • (2008) Nature , vol.452 , Issue.7185 , pp. 356-360
    • Harrington, L.E.1    Janowski, K.M.2    Oliver, J.R.3    Zajac, A.J.4    Weaver, C.T.5
  • 55
    • 58149190437 scopus 로고    scopus 로고
    • Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells
    • Shi G, Cox CA, Vistica BP, Tan C, Wawrousek EF, Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol 2008 181 : 7205 7213.
    • (2008) J Immunol , vol.181 , pp. 7205-7213
    • Shi, G.1    Cox, C.A.2    Vistica, B.P.3    Tan, C.4    Wawrousek, E.F.5    Gery, I.6
  • 56
    • 67650650890 scopus 로고    scopus 로고
    • Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
    • pii: 37865. doi:. [Epub ahead of print]
    • Bending D, De La Pena H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B, Cooke A Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 2009 pii: 37865. doi:. [Epub ahead of print].
    • (2009) J Clin Invest
    • Bending, D.1    De La Pena, H.2    Veldhoen, M.3    Phillips, J.M.4    Uyttenhove, C.5    Stockinger, B.6    Cooke, A.7
  • 57
    • 60549086638 scopus 로고    scopus 로고
    • Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    • Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 2009 39 : 216 224.
    • (2009) Eur J Immunol , vol.39 , pp. 216-224
    • Martin-Orozco, N.1    Chung, Y.2    Chang, S.H.3    Wang, Y.H.4    Dong, C.5
  • 59
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009 10 : 1000 1007.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 61
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007 445 : 766 770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 62
    • 47249134183 scopus 로고    scopus 로고
    • Plasticity of regulatory T cells: Subversion of suppressive function and conversion to enhancement of lung allergic responses
    • Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, Gelfand EW. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. J Immunol 2008 180 : 7117 7124.
    • (2008) J Immunol , vol.180 , pp. 7117-7124
    • Joetham, A.1    Matsubara, S.2    Okamoto, M.3    Takeda, K.4    Miyahara, N.5    Dakhama, A.6    Gelfand, E.W.7
  • 63
    • 70349200850 scopus 로고    scopus 로고
    • Decreased FOXP3 protein expression in patients with asthma
    • Provoost S, Maes T, van Durme YM et al. Decreased FOXP3 protein expression in patients with asthma. Allergy 2009 64 : 1539 1546.
    • (2009) Allergy , vol.64 , pp. 1539-1546
    • Provoost, S.1    Maes, T.2    Van Durme, Y.M.3
  • 64
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • DOI 10.1038/ni0703-616
    • Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol 2003 4 : 616 623. (Pubitemid 36880738)
    • (2003) Nature Immunology , vol.4 , Issue.7 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 65
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T-helper-cell differentiation
    • Wilson CB, Rowell E, Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 2009 9 : 91 105.
    • (2009) Nat Rev Immunol , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.