Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid β peptide: A comparative density functional theory study

Journal of Biological Inorganic Chemistry

Volumn 15, Issue 4, 2010, Pages 485-495

  Bora, Ram Prasad ^a   Ozbil, Mehmet ^a   Prabhakar, Rajeev ^a  

^a Department of Biology   (United States)

Author keywords

Amyloid beta peptide; Density functional theory; Insulin degrading enzyme; Metallopeptidase; Peptide hydrolysis

Indexed keywords

AMYLOID BETA PROTEIN; GLYCINE; HISTIDINE; INSULINASE; LYSINE; PHENYLALANINE; WATER;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DENSITY GRADIENT; ENERGY TRANSFER; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROLYSIS; KINETICS; MATHEMATICAL ANALYSIS; METAL BINDING; PRIORITY JOURNAL; PROTEIN BINDING; THERMODYNAMICS;

AMYLOID BETA-PROTEIN; BIOCATALYSIS; CATALYTIC DOMAIN; HUMANS; HYDROLYSIS; INSULYSIN; KINETICS; METALS; MODELS, MOLECULAR; QUANTUM THEORY; SUBSTRATE SPECIFICITY; THERMODYNAMICS; WATER;

EID: 77951926451     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-009-0617-2     Document Type: Article

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