메뉴 건너뛰기




Volumn 15, Issue 4, 2010, Pages 360-371

Radioprotectors and mitigators of radiation-induced normal tissue injury

Author keywords

Amifostine; Mitigators; Radioprotector; Tempol

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMIFOSTINE; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BOWMAN BIRK PROTEINASE INHIBITOR; CAPTOPRIL; CBLB 502; DIETHYLDITHIOCARBAMIC ACID; ENALAPRIL; GENISTEIN; GLUTATHIONE; MELATONIN; MELATONIN DERIVATIVE; MISCELLANEOUS DRUGS AND AGENTS; NITROXIDE; OLTIPRAZ; PALIFERMIN; POLYPEPTIDE; PRAVASTATIN; PROTEINASE INHIBITOR; RADIATION MITIGATOR; RADIOPROTECTIVE AGENT; RAMIPRIL; RETINOL; SIMVASTATIN; TEMPOL; THIOCTIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77951724979     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2009-S104     Document Type: Article
Times cited : (395)

References (92)
  • 1
    • 0141815531 scopus 로고    scopus 로고
    • The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001-summary and conclusions
    • Ringborg U, Bergqvist D, Brorsson B et al. The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001-summary and conclusions. Acta Oncol 2003;42:357-365.
    • (2003) Acta Oncol , vol.42 , pp. 357-365
    • Ringborg, U.1    Bergqvist, D.2    Brorsson, B.3
  • 2
    • 9244246263 scopus 로고    scopus 로고
    • Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries
    • Report of an NCI Workshop, December 3-4, 2003
    • Stone HB, Moulder JE, Coleman CN et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res 2004;162: 711-728.
    • (2004) Radiat Res , vol.162 , pp. 711-728
    • Stone, H.B.1    Moulder, J.E.2    Coleman, C.N.3
  • 5
    • 0037078918 scopus 로고    scopus 로고
    • Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage
    • Xavier S, Yamada K, Samuni AM et al. Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage. Biochim Biophys Acta 2002;1573:109-120.
    • (2002) Biochim Biophys Acta , vol.1573 , pp. 109-120
    • Xavier, S.1    Yamada, K.2    Samuni, A.M.3
  • 6
    • 0000416892 scopus 로고
    • Cysteine protection against X irradiation
    • Patt HM, Tyree EB, Straube RL et al. Cysteine protection against X irradiation. Science 1949;110:213-214.
    • (1949) Science , vol.110 , pp. 213-214
    • Patt, H.M.1    Tyree, E.B.2    Straube, R.L.3
  • 7
    • 12744277800 scopus 로고
    • The amines and particularly cysteamine as protectors against roentgen rays
    • Bacq ZM. The amines and particularly cysteamine as protectors against roentgen rays. Acta Radiol 1954;41:47-55.
    • (1954) Acta Radiol , vol.41 , pp. 47-55
    • Bacq, Z.M.1
  • 8
    • 0023754443 scopus 로고
    • Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine
    • Landauer MR, Davis HD, Dominitz JA et al. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine. Pharmacol Ther 1988;39:97-100.
    • (1988) Pharmacol Ther , vol.39 , pp. 97-100
    • Landauer, M.R.1    Davis, H.D.2    Dominitz, J.A.3
  • 9
    • 0021914053 scopus 로고
    • Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721
    • Calabro-Jones PM, Fahey RC, Smoluk GD et al. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med 1985;47:23-27.
    • (1985) Int J Radiat Biol Relat Stud Phys Chem Med , vol.47 , pp. 23-27
    • Calabro-Jones, P.M.1    Fahey, R.C.2    Smoluk, G.D.3
  • 10
    • 0018839016 scopus 로고
    • Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphos-phorothioic acid
    • Yuhas JM. Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphos-phorothioic acid. Cancer Res 1980;40:1519-1524.
    • (1980) Cancer Res , vol.40 , pp. 1519-1524
    • Yuhas, J.M.1
  • 11
    • 0020603425 scopus 로고
    • Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: Implications for mechanisms of radioprotection
    • Purdie JW, Inhaber ER, Schneider H et al. Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: Implications for mechanisms of radioprotection. Int J Radiat Biol Relat Stud Phys Chem Med 1983;43:517-527.
    • (1983) Int J Radiat Biol Relat Stud Phys Chem Med , vol.43 , pp. 517-527
    • Purdie, J.W.1    Inhaber, E.R.2    Schneider, H.3
  • 13
    • 8244222299 scopus 로고    scopus 로고
    • Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage
    • Savoye C, Swenberg C, Hugot S et al. Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. Int J Radiat Biol 1997;71:193-202.
    • (1997) Int J Radiat Biol , vol.71 , pp. 193-202
    • Savoye, C.1    Swenberg, C.2    Hugot, S.3
  • 14
    • 34447116285 scopus 로고    scopus 로고
    • Amifostine: The first selective-target and broad-spectrum radioprotector
    • Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: The first selective-target and broad-spectrum radioprotector. The Oncologist 2007;12:738-747.
    • (2007) The Oncologist , vol.12 , pp. 738-747
    • Kouvaris, J.R.1    Kouloulias, V.E.2    Vlahos, L.J.3
  • 15
    • 0037096826 scopus 로고    scopus 로고
    • 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: Clinical practice guidelines of the American Society of Clinical Oncology
    • Schuchter LM, Hensley ML, Meropol NJ et al. 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: Clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2002;20:2895-2903.
    • (2002) J Clin Oncol , vol.20 , pp. 2895-2903
    • Schuchter, L.M.1    Hensley, M.L.2    Meropol, N.J.3
  • 16
    • 58149335531 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2008 clinical practice guideline update: Use of chemotherapy and radiation therapy protectants
    • Hensley ML, Hagerty KL, Kewalramani T et al. American Society of Clinical Oncology 2008 clinical practice guideline update: Use of chemotherapy and radiation therapy protectants. J Clin Oncol 2009;27:127-145.
    • (2009) J Clin Oncol , vol.27 , pp. 127-145
    • Hensley, M.L.1    Hagerty, K.L.2    Kewalramani, T.3
  • 17
    • 0038071449 scopus 로고    scopus 로고
    • Does amifostine have a role in chemoradiation treatment?
    • Brizel DM, Overgaard J. Does amifostine have a role in chemoradiation treatment? Lancet Oncol 2003;4:378-381.
    • (2003) Lancet Oncol , vol.4 , pp. 378-381
    • Brizel, D.M.1    Overgaard, J.2
  • 18
    • 34648816658 scopus 로고    scopus 로고
    • Therapeutic and clinical applications of nitroxide compounds
    • Soule BP, Hyodo F, Matsumoto K et al. Therapeutic and clinical applications of nitroxide compounds. Antioxid Redox Signal 2007;9:1731-1743.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1731-1743
    • Soule, B.P.1    Hyodo, F.2    Matsumoto, K.3
  • 19
    • 0026050304 scopus 로고
    • Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol
    • Mitchell JB, DeGraff W, Kaufman D et al. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. Arch Biochem Biophys 1991;289:62-70.
    • (1991) Arch Biochem Biophys , vol.289 , pp. 62-70
    • Mitchell, J.B.1    Degraff, W.2    Kaufman, D.3
  • 20
    • 0026664064 scopus 로고
    • Tempol, a stable free radical, is a novel murine radiation protector
    • Hahn SM, Tochner Z, Krishna CM et al. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res 1992;52:1750-1753.
    • (1992) Cancer Res , vol.52 , pp. 1750-1753
    • Hahn, S.M.1    Tochner, Z.2    Krishna, C.M.3
  • 21
    • 0001039237 scopus 로고    scopus 로고
    • Protection from radiation-induced alopecia with topical application of nitroxides: Fractionated studies
    • Cuscela D, Coffin D, Lupton GP et al. Protection from radiation-induced alopecia with topical application of nitroxides: Fractionated studies. Cancer J Sci Am 1996;2:273-278.
    • (1996) Cancer J Sci Am , vol.2 , pp. 273-278
    • Cuscela, D.1    Coffin, D.2    Lupton, G.P.3
  • 22
    • 0026548016 scopus 로고
    • Topical application of nitroxide protects radiation-induced alopecia in guinea pigs
    • Goffman T, Cuscela D, Glass J et al. Topical application of nitroxide protects radiation-induced alopecia in guinea pigs. Int J Radiat Oncol Biol Phys 1992;22:803-806.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 803-806
    • Goffman, T.1    Cuscela, D.2    Glass, J.3
  • 23
    • 5144231707 scopus 로고    scopus 로고
    • A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    • Metz JM, Smith D, Mick R et al. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Clin Cancer Res 2004;10:6411-6417.
    • (2004) Clin Cancer Res , vol.10 , pp. 6411-6417
    • Metz, J.M.1    Smith, D.2    Mick, R.3
  • 24
    • 34548068806 scopus 로고    scopus 로고
    • Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging
    • Cotrim AP, Hyodo F, Matsumoto K et al. Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res 2007;13:4928-4933.
    • (2007) Clin Cancer Res , vol.13 , pp. 4928-4933
    • Cotrim, A.P.1    Hyodo, F.2    Matsumoto, K.3
  • 25
    • 33646394317 scopus 로고    scopus 로고
    • High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents
    • Matsumoto K, Hyodo F, Matsumoto A et al. High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents. Clin Cancer Res 2006;12:2455-2462.
    • (2006) Clin Cancer Res , vol.12 , pp. 2455-2462
    • Matsumoto, K.1    Hyodo, F.2    Matsumoto, A.3
  • 26
    • 33750553403 scopus 로고    scopus 로고
    • Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents
    • Hyodo F, Matsumoto K, Matsumoto A et al. Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents. Cancer Res 2006;66:9921-9928.
    • (2006) Cancer Res , vol.66 , pp. 9921-9928
    • Hyodo, F.1    Matsumoto, K.2    Matsumoto, A.3
  • 27
    • 52449117453 scopus 로고    scopus 로고
    • Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer
    • Chitra S, Shyamala Devi CS. Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer. Indian J Dent Res 2008;19:213-218.
    • (2008) Indian J Dent Res , vol.19 , pp. 213-218
    • Chitra, S.1    Shyamala Devi, C.S.2
  • 28
    • 24944500925 scopus 로고    scopus 로고
    • Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients
    • Bairati I, Meyer F, Gélinas M et al. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J Clin Oncol 2005;23:5805-5813.
    • (2005) J Clin Oncol , vol.23 , pp. 5805-5813
    • Bairati, I.1    Meyer, F.2    Gélinas, M.3
  • 29
    • 1842421979 scopus 로고    scopus 로고
    • Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial
    • Ferreira PR, Fleck JF, Diehl A et al. Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial. Head Neck 2004;26:313-321.
    • (2004) Head Neck , vol.26 , pp. 313-321
    • Ferreira, P.R.1    Fleck, J.F.2    Diehl, A.3
  • 30
    • 36248992380 scopus 로고    scopus 로고
    • Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer
    • Misirlioglu CH, Demirkasimoglu T, Kucukplakci B et al. Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer. Med Oncol 2007;24:308-311.
    • (2007) Med Oncol , vol.24 , pp. 308-311
    • Misirlioglu, C.H.1    Demirkasimoglu, T.2    Kucukplakci, B.3
  • 31
    • 0029738838 scopus 로고    scopus 로고
    • Prevention of radioinduced cystitis by orgotein: A randomized study
    • Sanchiz F, Milla A, Artola N et al. Prevention of radioinduced cystitis by orgotein: A randomized study. Anticancer Res 1996;16:2025-2028.
    • (1996) Anticancer Res , vol.16 , pp. 2025-2028
    • Sanchiz, F.1    Milla, A.2    Artola, N.3
  • 32
    • 0027277108 scopus 로고
    • A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium
    • Halperin EC, Gaspar L, George S et al. A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium. Int J Radiat Oncol Biol Phys 1993;26:413-416.
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , pp. 413-416
    • Halperin, E.C.1    Gaspar, L.2    George, S.3
  • 33
    • 24944531781 scopus 로고    scopus 로고
    • Implications for tumor control during protection of normal tissues with antioxidants
    • Camphausen K, Citrin D, Krishna MC et al. Implications for tumor control during protection of normal tissues with antioxidants. J Clin Oncol 2005; 23:5455-5457.
    • (2005) J Clin Oncol , vol.23 , pp. 5455-5457
    • Camphausen, K.1    Citrin, D.2    Krishna, M.C.3
  • 34
    • 39649110870 scopus 로고    scopus 로고
    • Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: A randomized trial among head and neck cancer patients
    • Meyer F, Bairati I, Fortin A et al. Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: A randomized trial among head and neck cancer patients. Int J Cancer 2008;122:1679-1683.
    • (2008) Int J Cancer , vol.122 , pp. 1679-1683
    • Meyer, F.1    Bairati, I.2    Fortin, A.3
  • 35
    • 0037338423 scopus 로고    scopus 로고
    • Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene
    • Guo H, Seixas-Silva JA Jr, Epperly MW et al. Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res 2003;159: 361-370.
    • (2003) Radiat Res , vol.159 , pp. 361-370
    • Guo, H.1    Seixas-Silva Jr., J.A.2    Epperly, M.W.3
  • 36
    • 0032888334 scopus 로고    scopus 로고
    • Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene
    • Stickle RL, Epperly MW, Klein E et al. Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene. Radiat Oncol Investig 1999;7:204-217.
    • (1999) Radiat Oncol Investig , vol.7 , pp. 204-217
    • Stickle, R.L.1    Epperly, M.W.2    Klein, E.3
  • 37
    • 0032897928 scopus 로고    scopus 로고
    • Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis
    • Epperly MW, Bray JA, Krager S et al. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis. Int J Radiat Oncol Biol Phys 1999;43:169-181.
    • (1999) Int J Radiat Oncol Biol Phys , vol.43 , pp. 169-181
    • Epperly, M.W.1    Bray, J.A.2    Krager, S.3
  • 38
    • 0032605109 scopus 로고    scopus 로고
    • Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radio-protective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/ fibrosis
    • Epperly MW, Travis EL, Sikora C et al. Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radio-protective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/ fibrosis. Biol Blood Marrow Transplant 1999;5:204-214.
    • (1999) Biol Blood Marrow Transplant , vol.5 , pp. 204-214
    • Epperly, M.W.1    Travis, E.L.2    Sikora, C.3
  • 39
    • 0034131278 scopus 로고    scopus 로고
    • Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation
    • Epperly MW, Defilippi S, Sikora C et al. Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation. Gene Ther 2000;7:1011-1018.
    • (2000) Gene Ther , vol.7 , pp. 1011-1018
    • Epperly, M.W.1    Defilippi, S.2    Sikora, C.3
  • 40
    • 0028066981 scopus 로고
    • Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial
    • Delanian S, Baillet F, Huart J et al. Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial. Radiother Oncol 1994;32:12-20.
    • (1994) Radiother Oncol , vol.32 , pp. 12-20
    • Delanian, S.1    Baillet, F.2    Huart, J.3
  • 41
    • 0029996626 scopus 로고    scopus 로고
    • Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: An experimental study
    • Lefaix JL, Delanian S, Leplat JJ et al. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: An experimental study. Int J Radiat Oncol Biol Phys 1996;35:305-312.
    • (1996) Int J Radiat Oncol Biol Phys , vol.35 , pp. 305-312
    • Lefaix, J.L.1    Delanian, S.2    Leplat, J.J.3
  • 42
    • 0029030504 scopus 로고
    • Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene-radiotherapy
    • Urano M, Kuroda M, Reynolds R et al. Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene-radiotherapy. Cancer Res 1995;55:2490-2493.
    • (1995) Cancer Res , vol.55 , pp. 2490-2493
    • Urano, M.1    Kuroda, M.2    Reynolds, R.3
  • 43
    • 0037198063 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melatonin
    • Reiter RJ, Tan DX, Burkhardt S. Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melatonin. Mech Ageing Dev 2002;123:1007-1019.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1007-1019
    • Reiter, R.J.1    Tan, D.X.2    Burkhardt, S.3
  • 44
    • 1042279497 scopus 로고    scopus 로고
    • Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants
    • Reiter RJ, Tan DX, Manchester LC et al. Melatonin: Detoxification of oxygen and nitrogen-based toxic reactants. Adv Exp Med Biol 2003;527: 539-548.
    • (2003) Adv Exp Med Biol , vol.527 , pp. 539-548
    • Reiter, R.J.1    Tan, D.X.2    Manchester, L.C.3
  • 45
    • 0037404268 scopus 로고    scopus 로고
    • Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: A study of their individual and synergistic actions
    • Lopez-Burillo S, Tan DX, Mayo JC et al. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: A study of their individual and synergistic actions. J Pineal Res 2003;34:269-277.
    • (2003) J Pineal Res , vol.34 , pp. 269-277
    • Lopez-Burillo, S.1    Tan, D.X.2    Mayo, J.C.3
  • 46
    • 0033002666 scopus 로고    scopus 로고
    • The effect of melatonin on lipid peroxidation during radiotherapy in female rats
    • Kaya H, Delibas N, Serteser M et al. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlenther Onkol 1999;175: 285-288.
    • (1999) Strahlenther Onkol , vol.175 , pp. 285-288
    • Kaya, H.1    Delibas, N.2    Serteser, M.3
  • 47
    • 0035046321 scopus 로고    scopus 로고
    • Melatonin stimulates glutathione peroxidase activity in human chorion
    • Okatani Y, Wakatsuki A, Shinohara K et al. Melatonin stimulates glutathione peroxidase activity in human chorion. J Pineal Res 2001;30:199-205.
    • (2001) J Pineal Res , vol.30 , pp. 199-205
    • Okatani, Y.1    Wakatsuki, A.2    Shinohara, K.3
  • 48
    • 0028332850 scopus 로고
    • Potential radioprotective agents. 1. Homologs of melatonin
    • Blickenstaff RT, Brandstadter SM, Reddy S et al. Potential radioprotective agents. 1. Homologs of melatonin. J Pharm Sci 1994;83:216-218.
    • (1994) J Pharm Sci , vol.83 , pp. 216-218
    • Blickenstaff, R.T.1    Brandstadter, S.M.2    Reddy, S.3
  • 49
    • 0033035371 scopus 로고    scopus 로고
    • Melatonin and protection from whole-body irradiation: Survival studies in mice
    • Vijayalaxmi, Meltz ML, Reiter RJ et al. Melatonin and protection from whole-body irradiation: Survival studies in mice. Mutat Res 1999;425: 21-27.
    • (1999) Mutat Res , vol.425 , pp. 21-27
    • Vijayalaxmi1    Meltz, M.L.2    Reiter, R.J.3
  • 50
    • 55349141421 scopus 로고    scopus 로고
    • Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury
    • Topkan E, Tufan H, Yavuz AA et al. Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury. Int J Radiat Biol 2008;84:796-802.
    • (2008) Int J Radiat Biol , vol.84 , pp. 796-802
    • Topkan, E.1    Tufan, H.2    Yavuz, A.A.3
  • 51
    • 57149139038 scopus 로고    scopus 로고
    • Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: Attenuation by melatonin pretreatment
    • Manda K, Ueno M, Anzai K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: Attenuation by melatonin pretreatment. J Pineal Res 2009;46:71-78.
    • (2009) J Pineal Res , vol.46 , pp. 71-78
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 52
    • 54049094703 scopus 로고    scopus 로고
    • Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: An animal model
    • Hussein MR, Abu-Dief EE, Kamel E et al. Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: An animal model. Cell Biol Int 2008;32:1353-1361.
    • (2008) Cell Biol Int , vol.32 , pp. 1353-1361
    • Hussein, M.R.1    Abu-Dief, E.E.2    Kamel, E.3
  • 53
    • 34247346067 scopus 로고    scopus 로고
    • Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice
    • Manda K, Anzai K, Kumari S et al. Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice. Acta Neurobiol Exp (Wars) 2007;67:63-70.
    • (2007) Acta Neurobiol Exp (Wars) , vol.67 , pp. 63-70
    • Manda, K.1    Anzai, K.2    Kumari, S.3
  • 54
    • 0347758366 scopus 로고    scopus 로고
    • Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect
    • Akagi T, Ushinohama K, Ikesue S et al. Chronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect. J Pharmacol Exp Ther 2004;308:378-384.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 378-384
    • Akagi, T.1    Ushinohama, K.2    Ikesue, S.3
  • 55
    • 34249334847 scopus 로고    scopus 로고
    • Melatonin radiosensitizes tumors and radioprotects normal tissues: Time-of day dependency
    • Abstract 338
    • Blask DE, Barthold HJ, Dauchy RT et al. Melatonin radiosensitizes tumors and radioprotects normal tissues: Time-of day dependency. Am Assoc Cancer Res 2000.; Abstract 338.
    • (2000) Am Assoc Cancer Res
    • Blask, D.E.1    Barthold, H.J.2    Dauchy, R.T.3
  • 56
    • 34249326606 scopus 로고    scopus 로고
    • Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119)
    • Berk L, Berkey B, Rich T et al. Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int J Radiat Oncol Biol Phys 2007;68:852-857.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 852-857
    • Berk, L.1    Berkey, B.2    Rich, T.3
  • 57
    • 42049095095 scopus 로고    scopus 로고
    • An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models
    • Burdelya LG, Krivokrysenko VI, Tallant TC et al. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320:226-230.
    • (2008) Science , vol.320 , pp. 226-230
    • Burdelya, L.G.1    Krivokrysenko, V.I.2    Tallant, T.C.3
  • 58
    • 33746161021 scopus 로고    scopus 로고
    • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c lamina propria cells
    • Uematsu S, Jang MH, Chevrier N et al. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c lamina propria cells. Nat Immunol 2006;7:868-874.
    • (2006) Nat Immunol , vol.7 , pp. 868-874
    • Uematsu, S.1    Jang, M.H.2    Chevrier, N.3
  • 59
    • 1842423819 scopus 로고    scopus 로고
    • Human intestinal microvascular endothelial cells express Toll-like receptor 5: A binding partner for bacterial flagellin
    • Maaser C, Heidemann J, von Eiff C et al. Human intestinal microvascular endothelial cells express Toll-like receptor 5: A binding partner for bacterial flagellin. J Immunol 2004;172:5056-5062.
    • (2004) J Immunol , vol.172 , pp. 5056-5062
    • Maaser, C.1    Heidemann, J.2    von Eiff, C.3
  • 60
    • 4344669657 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB in vivo selectively protects the murine small intestine against ionizing radiation-induced damage
    • Wang Y, Meng A, Lang H et al. Activation of nuclear factor kappaB in vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res 2004;64:6240-6246.
    • (2004) Cancer Res , vol.64 , pp. 6240-6246
    • Wang, Y.1    Meng, A.2    Lang, H.3
  • 61
    • 33747826874 scopus 로고    scopus 로고
    • Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology
    • Bentzen SM. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nat Rev Cancer 2006;6:702-713.
    • (2006) Nat Rev Cancer , vol.6 , pp. 702-713
    • Bentzen, S.M.1
  • 62
    • 77951748771 scopus 로고    scopus 로고
    • ClinicalTrials.gov, Accessed January 12
    • ClinicalTrials.gov. Vol 2008. Accessed January 12, 2009.
    • (2009) , vol.2008
  • 63
    • 0031829088 scopus 로고    scopus 로고
    • The radioprotective effect of BBI is associated with the activation of DNA repair-relevant genes
    • Dittmann KH, Gueven N, Mayer C et al. The radioprotective effect of BBI is associated with the activation of DNA repair-relevant genes. Int J Radiat Biol 1998;74:225-230.
    • (1998) Int J Radiat Biol , vol.74 , pp. 225-230
    • Dittmann, K.H.1    Gueven, N.2    Mayer, C.3
  • 64
    • 0344553306 scopus 로고    scopus 로고
    • Bowman-Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes
    • Dittmann K, Virsik-Köpp P, Mayer C et al. Bowman-Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes. Int J Radiat Biol 2003;79:801-808.
    • (2003) Int J Radiat Biol , vol.79 , pp. 801-808
    • Dittmann, K.1    Virsik-Köpp, P.2    Mayer, C.3
  • 65
    • 40249091300 scopus 로고    scopus 로고
    • The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport
    • Dittmann K, Mayer C, Kehlbach R et al. The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol 2008;86: 375-382.
    • (2008) Radiother Oncol , vol.86 , pp. 375-382
    • Dittmann, K.1    Mayer, C.2    Kehlbach, R.3
  • 66
    • 44849121345 scopus 로고    scopus 로고
    • Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation
    • Kennedy AR, Davis JG, Carlton W et al. Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation. Radiat Res 2008;169:615-625.
    • (2008) Radiat Res , vol.169 , pp. 615-625
    • Kennedy, A.R.1    Davis, J.G.2    Carlton, W.3
  • 67
    • 17044370493 scopus 로고    scopus 로고
    • Selective radioprotection of normal tissues by Bowman-Birk proteinase inhibitor (BBI) in mice
    • Dittmann K, Toulany M, Classen J et al. Selective radioprotection of normal tissues by Bowman-Birk proteinase inhibitor (BBI) in mice. Strahlenther Onkol 2005;181:191-196.
    • (2005) Strahlenther Onkol , vol.181 , pp. 191-196
    • Dittmann, K.1    Toulany, M.2    Classen, J.3
  • 68
    • 0032525031 scopus 로고    scopus 로고
    • In vivo radioprotective effects of oltipraz in gamma-irradiated mice
    • Kim SG, Nam SY, Kim CW. In vivo radioprotective effects of oltipraz in gamma-irradiated mice. Biochem Pharmacol 1998;55:1585-1590.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1585-1590
    • Kim, S.G.1    Nam, S.Y.2    Kim, C.W.3
  • 69
    • 33947512453 scopus 로고    scopus 로고
    • Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    • Moulder JE, Cohen EP. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Radiat Oncol 2007; 17:141-148.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 141-148
    • Moulder, J.E.1    Cohen, E.P.2
  • 70
    • 0029902158 scopus 로고    scopus 로고
    • Angiotensin II receptor antagonists in the prevention of radiation nephropathy
    • Moulder JE, Fish BL, Cohen EP et al. Angiotensin II receptor antagonists in the prevention of radiation nephropathy. Radiat Res 1996;146:106-110.
    • (1996) Radiat Res , vol.146 , pp. 106-110
    • Moulder, J.E.1    Fish, B.L.2    Cohen, E.P.3
  • 71
    • 1642580869 scopus 로고    scopus 로고
    • Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    • Kim JH, Brown SL, Kolozsvary A et al. Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat. Radiat Res 2004;161:137-142.
    • (2004) Radiat Res , vol.161 , pp. 137-142
    • Kim, J.H.1    Brown, S.L.2    Kolozsvary, A.3
  • 72
    • 0026554287 scopus 로고
    • Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme
    • Ward WF, Molteni A, Ts'ao CH et al. Radiation pneumotoxicity in rats: Modification by inhibitors of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys 1992;22:623-625.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 623-625
    • Ward, W.F.1    Molteni, A.2    Ts'ao, C.H.3
  • 73
    • 0028000264 scopus 로고
    • Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils
    • Yousefi S, Green DR, Blaser K et al. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci USA 1994;91:10868-10872.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10868-10872
    • Yousefi, S.1    Green, D.R.2    Blaser, K.3
  • 74
    • 0345328280 scopus 로고    scopus 로고
    • Genistein treatment protects mice from ionizing radiation injury
    • Landauer MR, Srinivasan V, Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol 2003;23:379-385.
    • (2003) J Appl Toxicol , vol.23 , pp. 379-385
    • Landauer, M.R.1    Srinivasan, V.2    Seed, T.M.3
  • 75
    • 34848906040 scopus 로고    scopus 로고
    • Pravastatin inhibits the Rho/CCN2/ extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats
    • Haydont V, Bourgier C, Pocard M et al. Pravastatin inhibits the Rho/CCN2/ extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats. Clin Cancer Res 2007;13:5331-5340.
    • (2007) Clin Cancer Res , vol.13 , pp. 5331-5340
    • Haydont, V.1    Bourgier, C.2    Pocard, M.3
  • 76
    • 34547429997 scopus 로고    scopus 로고
    • Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism
    • Wang J, Boerma M, Fu Q et al. Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism. Int J Radiat Oncol Biol Phys 2007;68:1483-1490.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 1483-1490
    • Wang, J.1    Boerma, M.2    Fu, Q.3
  • 77
    • 3042763035 scopus 로고    scopus 로고
    • Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model
    • Williams JP, Hernady E, Johnston CJ et al. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res 2004;161:560-567.
    • (2004) Radiat Res , vol.161 , pp. 560-567
    • Williams, J.P.1    Hernady, E.2    Johnston, C.J.3
  • 78
    • 4344609471 scopus 로고    scopus 로고
    • Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair
    • Finch PW, Rubin JS. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res 2004;91:69-136.
    • (2004) Adv Cancer Res , vol.91 , pp. 69-136
    • Finch, P.W.1    Rubin, J.S.2
  • 79
    • 55049129802 scopus 로고    scopus 로고
    • Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/ progenitor pool
    • Lombaert IM, Brunsting JF, Wierenga PK et al. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/ progenitor pool. STEM CELLS 2008;26:2595-2601.
    • (2008) STEM CELLS , vol.26 , pp. 2595-2601
    • Lombaert, I.M.1    Brunsting, J.F.2    Wierenga, P.K.3
  • 80
    • 33750432886 scopus 로고    scopus 로고
    • Radiation therapy-induced mucositis: Relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2
    • Yeoh A, Gibson R, Yeoh E et al. Radiation therapy-induced mucositis: Relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2. Cancer Treat Rev 2006;32:645-651.
    • (2006) Cancer Treat Rev , vol.32 , pp. 645-651
    • Yeoh, A.1    Gibson, R.2    Yeoh, E.3
  • 81
    • 27144462431 scopus 로고    scopus 로고
    • COX-2 inhibitors act as radiosensitizer in tumor treatment
    • Sminia P, Kuipers G, Geldof A et al. COX-2 inhibitors act as radiosensitizer in tumor treatment. Biomed Pharmacother 2005;59(suppl 2):S272-S275.
    • (2005) Biomed Pharmacother , vol.59 , Issue.SUPPL. 2
    • Sminia, P.1    Kuipers, G.2    Geldof, A.3
  • 82
    • 35348956422 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs in cancer prevention and therapy
    • Guadagni F, Ferroni P, Palmirotta R et al. Non-steroidal anti-inflammatory drugs in cancer prevention and therapy. Anticancer Res 2007;27:3147-3162.
    • (2007) Anticancer Res , vol.27 , pp. 3147-3162
    • Guadagni, F.1    Ferroni, P.2    Palmirotta, R.3
  • 83
    • 25844497528 scopus 로고    scopus 로고
    • Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model
    • Bertho JM, Frick J, Prat M et al. Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model. Int J Radiat Oncol Biol Phys 2005;63:911-920.
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 911-920
    • Bertho, J.M.1    Frick, J.2    Prat, M.3
  • 84
    • 0025015087 scopus 로고
    • In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice
    • Uckun FM, Souza L, Waddick KG et al. In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice. Blood 1990;75:638-645.
    • (1990) Blood , vol.75 , pp. 638-645
    • Uckun, F.M.1    Souza, L.2    Waddick, K.G.3
  • 85
    • 0032979426 scopus 로고    scopus 로고
    • Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice
    • Farrell CL, Rex KL, Kaufman SA et al. Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice. Int J Radiat Biol 1999;75:609-620.
    • (1999) Int J Radiat Biol , vol.75 , pp. 609-620
    • Farrell, C.L.1    Rex, K.L.2    Kaufman, S.A.3
  • 86
    • 10344242939 scopus 로고    scopus 로고
    • Palifermin for oral mucositis after intensive therapy for hematologic cancers
    • Spielberger R, Stiff P, Bensinger W et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004;351:2590-2598.
    • (2004) N Engl J Med , vol.351 , pp. 2590-2598
    • Spielberger, R.1    Stiff, P.2    Bensinger, W.3
  • 87
    • 45149120776 scopus 로고    scopus 로고
    • Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma
    • Brizel DM, Murphy BA, Rosenthal DI et al. Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma. J Clin Oncol 2008;26:2489-2496.
    • (2008) J Clin Oncol , vol.26 , pp. 2489-2496
    • Brizel, D.M.1    Murphy, B.A.2    Rosenthal, D.I.3
  • 88
    • 44449179168 scopus 로고    scopus 로고
    • Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury
    • Anscher MS, Thrasher B, Zgonjanin L et al. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2008;71:829-837.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 829-837
    • Anscher, M.S.1    Thrasher, B.2    Zgonjanin, L.3
  • 89
    • 33646919832 scopus 로고    scopus 로고
    • Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation
    • Anscher MS, Thrasher B, Rabbani Z et al. Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int J Radiat Oncol Biol Phys 2006;65:876-881.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 876-881
    • Anscher, M.S.1    Thrasher, B.2    Rabbani, Z.3
  • 90
    • 2442481893 scopus 로고    scopus 로고
    • Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone
    • Xavier S, Piek E, Fujii M et al. Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 2004;279:15167-15176.
    • (2004) J Biol Chem , vol.279 , pp. 15167-15176
    • Xavier, S.1    Piek, E.2    Fujii, M.3
  • 91
    • 47549090432 scopus 로고    scopus 로고
    • TGF in cancer
    • Massagué J. TGF in cancer. Cell 2008;134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 92
    • 33748568793 scopus 로고    scopus 로고
    • Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction
    • Baum BJ, Zheng C, Cotrim AP et al. Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. Biochim Biophys Acta 2006;1758:1071-1077.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1071-1077
    • Baum, B.J.1    Zheng, C.2    Cotrim, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.