Radiation therapy-induced mucositis: Relationships between fractionated radiation, NF-κB, COX-1, and COX-2

Cancer Treatment Reviews

Volumn 32, Issue 8, 2006, Pages 645-651

  Yeoh, Ann ^a,b   Gibson, Rachel ^a,b   Yeoh, Eric ^a,b   Bowen, Joanne ^a,b   Stringer, Andrea ^a,b   Giam, Kar ^b   Logan, Richard ^b,c   Keefe, Dorothy ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Alimentary tract; Cyclooxygenase; Mucositis; NF B; Radiation therapy

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BLEOMYCIN; CISPLATIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 11; INTERLEUKIN 1BETA; INTERLEUKIN 6; IRINOTECAN; MELPHALAN; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PALIFERMIN; PROSTAGLANDIN E2; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ABDOMINAL TUMOR; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CHROMOSOME ABERRATION; COLITIS; EVIDENCE BASED MEDICINE; GENE ACTIVATION; HEAD AND NECK CANCER; HUMAN; LUNG TOXICITY; MUCOSA INFLAMMATION; NONHUMAN; ORAL MUCOSAL DISEASE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; QUALITY OF LIFE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION RESPONSE; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; SYSTEMIC DISEASE;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOSE FRACTIONATION; GASTROINTESTINAL TRACT; HUMANS; MUCOSITIS; NEOPLASMS; NF-KAPPA B; PRACTICE GUIDELINES; RADIOTHERAPY;

EID: 33750432886     PISSN: 03057372     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ctrv.2006.08.005     Document Type: Review

References (67)

1. Avritscher E.B., Cooksley C.D., and Elting L.S. Scope and epidemiology of cancer therapy-induced oral and gastrointestinal mucositis. Semin Oncol Nurs 20 1 (2004) 3-10
2. Naidu M.U., Ramana G.V., Rani P.U., et al. Chemotherapy-induced and/or radiation therapy-induced oral mucositis - complicating the treatment of cancer. Neoplasia 6 5 (2004) 423-431
3. Yeoh E., Horowitz M., Russo A., et al. Effect of pelvic irradiation on gastrointestinal function: a prospective longitudinal study. Am J Med 95 4 (1993) 397-406
4. Yeoh E.K., Russo A., Botten R., et al. Acute effects of therapeutic irradiation for prostatic carcinoma on anorectal function. Gut 43 1 (1998) 123-127
5. Garden A.S. Mucositis: current management and investigations. Semin Radiat Oncol 13 3 (2003) 267-273
6. Gibson RJ. Chemotherapy-induced mucositis: mechanisms of damage, time course of events and possible preventative strategies. Department of Medicine, University of Adelaide, Adelaide; 2004. p. 129.
7. Keefe D.M., Gibson R.J., and Hauer-Jensen M. Gastrointestinal mucositis. Semin Oncol Nurs 20 1 (2004) 38-47
8. Pico J.L., Avila-Garavito A., and Naccache P. Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 3 6 (1998) 446-451
9. McGuire D.B., Rubenstein E.B., and Peterson D.E. Evidence-based guidelines for managing mucositis. Semin Oncol Nurs 20 1 (2004) 59-66
10. Stringer A, Gibson RJ, Logan R, et al. Chemotherapy-induced diarrhoea is associated with changes in the luminal environment in the DA rat. J Exp Biol Med 2006, accepted for publication.
11. Rubenstein E.B., Peterson D.E., Schubert M., et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100 Suppl. 9 (2004) 2026-2046
12. Keefe D.M. Gastrointestinal mucositis: a new biological model. Support Care Cancer 12 1 (2004) 6-9
13. Yeoh A.S., Bowen J.M., Gibson R.J., and Keefe D.M. Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. Int J Radiat Oncol Biol Phys 63 5 (2005) 1295-1303
14. Egan L.J., Eckmann L., Greten F.R., et al. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci USA 101 8 (2004) 2452-2457
15. Kushwaha R.S., Hayne D., Vaizey C.J., et al. Physiologic changes of the anorectum after pelvic radiotherapy for the treatment of prostate and bladder cancer. Dis Colon Rectum 46 9 (2003) 1182-1188
16. Yeoh E.E., Botten R., Russo A., et al. Chronic effects of therapeutic irradiation for localized prostatic carcinoma on anorectal function. Int J Radiat Oncol Biol Phys 47 4 (2000) 915-924
17. Wilkes J.D. Prevention and treatment of oral mucositis following cancer chemotherapy. Semin Oncol 25 5 (1998) 538-551
18. Coleman C.N. Molecular biology in radiation oncology. Radiation oncology perspective of BRCA1 and BRCA2. Acta Oncol 38 Suppl. 13 (1999) 55-59
19. Trenz K., Rothfuss A., Schutz P., and Speit G. Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutat Res 500 1-2 (2002) 89-96
20. Turesson I., Bernefors R., Book M., et al. Normal tissue response to low doses of radiotherapy assessed by molecular markers-a study of skin in patients treated for prostate cancer. Acta Oncol 40 8 (2001) 941-951
21. Hall E.J. Radiobiology for the radiobiologist. 5th ed. (2000), Lippincott Williams & Wilkins, Philadephia
22. Shih A., Miaskowski C., Dodd M.J., Stotts N.A., and MacPhail L. Mechanisms for radiation-induced oral mucositis and the consequences. Cancer Nurs 26 3 (2003) 222-229
23. Fei P., and El-Deiry W.S. P53 and radiation responses. Oncogene 22 37 (2003) 5774-5783
24. Elkind M.M., Sutton-Gilbert H., Moses W.B., Alescio T., and Swain R.W. Radiation response of mammalian cells grown in culture. V. Temperature dependence of the repair of X-ray damage in surviving cells (aerobic and hypoxic). Radiat Res 25 (1965) 359-376
25. Withers H.R. The four R's of radiotherapy. In: Lett J.T., and Adler H. (Eds). Advances in radiation biology (1975), Academic Press, New York 241-247
26. Dorr W., and Kummermehr J. Accelerated repopulation of mouse tongue epithelium during fractionated irradiations or following single doses. Radiother Oncol 17 3 (1990) 249-259
27. Dorr W. Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions. Int J Radiat Biol 72 6 (1997) 635-643
28. van Putten L.M. Current concepts in radiotherapy and chemotherapy of tumors through the study of tumor cell survival. Ned Tijdschr Geneeskd 112 50 (1968) 2267-2271
29. van Putten L.M. Tumour reoxygenation during fractionated radiotherapy; studies with a transplantable mouse osteosarcoma. Eur J Cancer 4 2 (1968) 172-182
30. Van Putten L.M., and Kallman R.F. Oxygenation status of a transplantable tumor during fractionated radiation therapy. J Natl Cancer Inst 40 3 (1968) 441-451
31. Withers H.R., Taylor J.M., and Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27 2 (1988) 131-146
32. Sonis S.T., O'Donnell K.E., Popat R., et al. The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. Oral Oncol 40 2 (2004) 170-176
33. Sonis S.T. Pathobiology of mucositis. Seminars in Oncology Nursing 20 1 (2004) 11-15
34. Dorr W., Hamilton C.S., Boyd T., Reed B., and Denham J.W. Radiation-induced changes in cellularity and proliferation in human oral mucosa. Int J Radiat Oncol Biol Phys 52 4 (2002) 911-917
35. Sonis S.T. The pathobiology of mucositis. Nat Rev Cancer 4 4 (2004) 277-284
36. Sonis S.T. The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Crit Rev Oral Biol Med 13 5 (2002) 380-389
37. Schmid R.M., and Adler G. NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases. Gastroenterology 118 6 (2000) 1208-1228
38. Brach M.A., Hass R., Sherman M.L., et al. Ionizing radiation induces expression and binding activity of the nuclear factor, kappa B. J Clin Invest 88 (1991) 691-695
39. Lee S.J., Dimtchev A., Lavin M.F., Dritschilo A., and Jung M. A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB. Oncogene 17 14 (1998) 1821-1826
40. Sonis S.T. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol 34 1 (1998) 39-43
41. Yeoh ASJ. NFkB and Cox-2 expression in the irradiated colorectum is associated with subsequent histopathologic changes. Department of Physiology, University of Adelaide, Adelaide; 2004. p. 35.
42. Baldwin Jr. A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14 (1996) 649-683
43. Criswell T., Leskov K., Miyamoto S., Luo G., and Boothman D.A. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22 37 (2003) 5813-5827
44. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 49 (1999) 6853-6866
45. Collins T., and Cybulsky M.I. NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?. J Clin Invest 107 3 (2001) 255-264
46. Aota K., Azuma M., Yamashita T., et al. 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun 273 3 (2000) 1168-1174
47. Charalambous M.P., Maihofner C., Bhambra U., Lightfoot T., and Gooderham N.J. Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. Br J Cancer 88 10 (2003) 1598-1604
48. Dubois R.N., Abramson S.B., Crofford L., et al. Cyclooxygenase in biology and disease. Faseb J 12 12 (1998) 1063-1073
49. Cohn S.M., Schloemann S., Tessner T., Seibert K., and Stenson W.F. Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1. J Clin Invest 99 6 (1997) 1367-1379
50. Kuwano T., Nakao S., Yamamoto H., et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. Faseb J 18 2 (2004) 300-310
51. Ben-Av P., Crofford L.J., Wilder R.L., and Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett 372 1 (1995) 83-87
52. Feng D., Nagy J.A., Pyne K., et al. Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators. Microcirculation 6 1 (1999) 23-44
53. Vasile E., Qu H., Dvorak H.F., and Dvorak A.M. Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels. J Histochem Cytochem 47 2 (1999) 159-167
54. Cummins A.G., Munro G.H., Huntley J.F., Miller H.R., and Ferguson A. Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells. Gut 30 3 (1989) 355-360
55. Fraser R., Frisby C., Schirmer M., et al. Divergence of mucosal and motor effects of insulin-like growth factor (IGF)-I and LR3IGF-I on rat isolated ileum following abdominal irradiation. J Gastroenterol Hepatol 15 10 (2000) 1132-1137
56. van den Aardweg G.J., Olofsen-van Acht M.J., van Hooije C.M., and Levendag P.C. Radiation-induced rectal complications are not influenced by age: a dose fractionation study in the rat. Radiat Res 159 5 (2003) 642-650
57. Kang S., Chun M., Jin Y., et al. A rat model for radiation-induced proctitis. J Korean Med Sci 15 (2000) 682-689
58. Chen L., Brizel D.M., Rabbani Z.N., et al. The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 60 5 (2004) 1520-1529
59. Fraser R., Frisby C., Schirmer M., et al. Effects of fractionated abdominal irradiation on small intestinal motility - studies in a novel in vitro animal model. Acta Oncol 36 7 (1997) 705-710
60. Wang J., Zheng H., and Hauer-Jensen M. Influence of short-term octreotide administration on chronic tissue injury, transforming growth factor beta (TGF-beta) overexpression, and collagen accumulation in irradiated rat intestine. J Pharmacol Exp Ther 297 1 (2001) 35-42
61. Dorr W., Reichel S., and Spekl K. Effects of keratinocyte growth factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Radiother Oncol 75 1 (2005) 99-105
62. Dorr W., Brankovic K., and Hartmann B. Repopulation in mouse oral mucosa: changes in the effect of dose fractionation. Int J Radiat Biol 76 3 (2000) 383-390
63. Dorr W., Emmendorfer H., and Weber-Frisch M. Tissue kinetics in mouse tongue mucosa during daily fractionated radiotherapy. Cell Prolif 29 9 (1996) 495-504
64. Gibson R.J., Bowen J.M., Inglis M.R., Cummins A.G., and Keefe D.M. Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer. J Gastroenterol Hepatol 18 9 (2003) 1095-1100
65. Gibson R.J., Keefe D.M., Thompson F.M., et al. Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. Dig Dis Sci 47 12 (2002) 2751-2757
66. Gibson R.J., Bowen J.M., Cummins A.G., and Keefe D.M. Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat. Clin Exp Med 4 4 (2005) 188-195
67. Gibson R.J., Bowen J.M., and Keefe D.M. Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats. Int J Cancer 116 3 (2005) 464-470