Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage

Biochimica et Biophysica Acta - General Subjects

Volumn 1573, Issue 2, 2002, Pages 109-120

  Xavier, Sandhya ^a   Yamada, Ken Ichi ^a   Samuni, Ayelet M ^a   Samuni, Amram ^b   DeGraff, William ^a   Krishna, Murali C ^a   Mitchell, James B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

DNA damage; Nitroxide; Protection; Radiation

Indexed keywords

1,10 PHENANTHROLINE; COPPER COMPLEX; GENOMIC DNA; HYDROGEN PEROXIDE; HYDROXYLAMINE; NITROXIDE DERIVATIVE; PLASMID DNA; TEMPAMINE; TEMPOL; TEMPONE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA STRAND BREAKAGE; IONIZING RADIATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; COPPER; CYCLIC N-OXIDES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROPHORESIS; HYDROGEN PEROXIDE; HYDROXYLAMINES; NITROGEN OXIDES; OXIDATION-REDUCTION; PHENANTHROLINES; PLASMIDS; RADIATION-PROTECTIVE AGENTS; SPIN LABELS; TRIACETONEAMINE-N-OXYL;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; HABER;

EID: 0037078918     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(02)00339-2     Document Type: Article

References (40)

1. Chapman J.D., Reuvers A.P., Borsa J., Greenstock C.L. Chemical radioprotection and radiosensitization of mammalian cells growing in vitro. Radiat. Res. 64:1973;291-306.
2. Roots R., Okada S. Estimation of lifetimes and diffusion distances of radicals involved in x-ray induced strand breaks or killing of mammalian cells. Radiat. Res. 64:1975;306-320.
3. von Sonntag C. The Chemical Basis of Radiation Biology. 1987;Taylor and Francis, London.
4. Burkitt M.J., Gilbert B.C. Model studies of the iron-catalysed Haber-Weiss cycle and the ascorbate-driven Fenton reaction. Free Radic. Res. Commun. 10:1990;265-280.
5. Ward J.F., Blakely W.F., Joner E.I. Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide. Radiat. Res. 103:1985;383-392.
6. Ward J.F. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiat. Res. 86:1981;185-195.
7. Milligan J.R., Ng J.Y., Wu C.L., Aguilera J.A., Fahey R.C., Ward J.F. DNA repair by thiols in air shows two radicals make a double-strand break. Radiat. Res. 143:1995;273-280.
8. Bacq Z.M. Chemical Protection Against Ionizing Radiation. 1965;C.C. Thomas Publ. Springfield, IL.
9. Fahey R.C. Protection of DNA by thiols. Pharmacol. Ther. 39:1988;101-108.
10. Zheng S., Newton G.L., Gonick G., Fahey R.C., Ward J.F. Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA. Radiat. Res. 114:1988;11-27.
11. Aguilera J.A., Newton G.L., Fahey R.C., Ward J.F. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of net charge on the thiol. Radiat. Res. 130:1992;194-204.
12. Smoluk G.D., Fahey R.C., Calabro-Jones P.M., Aguilera J.A., Ward J.F. Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Res. 48:1988;3641-3647.
13. Mitchell J.B., DeGraff W., Kaufman D., Krishna M.C., Samuni A., Finkelstein E., Ahn M.S., Hahn S.M., Gamson J., Russo A. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol. Arch. Biochem. Biophys. 289:1991;62-70.
14. Hahn S.M., Wilson L., Krishna C.M., Liebmann J., DeGraff W., Gamson J., Samuni A., Venzon D., Mitchell J.B. Identification of nitroxide radioprotectors. Radiat. Res. 132:1992;87-93.
15. Hahn S.M., Tochner Z., Krishna C.M., Glass J., Wilson L., Samuni A., Sprague M., Venzon D., Glatstein E., Mitchell J.B., Russo A. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res. 52:1992;1750-1753.
16. Mitchell J.B., Russo A., Kuppusamy P., Krishna M.C. Radiation, radicals, and images. Ann. N. Y. Acad. Sci. 899:2000;28-43.
17. Mehlhorn R.J., Packer L. Electron paramagnetic resonance spin destruction methods for radical detection. Methods Enzymol. 105:1984;215-220.
18. Belkin S., Mehlhorn R.J., Hideg K., Hankovsky O., Packer L. Reduction and destruction rates of nitroxide spin probes. Arch. Biochem. Biophys. 256:1987;232-243.
19. Chateauneuf J., Lusztyk J., Ingold K.U. Absolute rate constants for the reactions of some carbon-centered radicals with 2,2,6,6-tetramethylpiperidine-N-oxyl. J. Org. Chem. 53:1988;1629-1632.
20. Nilsson U.A., Olsson L.I., Carlin G., Bylund-Fellenius A.C. Inhibition of lipid peroxidation by spin labels. Relationships between structure and function. J. Biol. Chem. 264:1989;11131-11135.
21. Krishna M.C., DeGraff W., Hankovszky O.H., Sar C.P., Kala i.T., Jeko J., Russo A., Mitchell J.B., Hideg K. Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage. J. Med. Chem. 41:1998;3477-3492.
22. Swartz H.M. Principles of the metabolism of nitroxides and their implications for spin trapping. Free Radic. Res. Commun. 9:1990;399-405.
23. Mitchell J.B., Samuni A., Krishna M.C., DeGraff W.G., Ahn M.S., Samuni U., Russo A. Biologically active metal-independent superoxide dismutase mimics. Biochemistry. 29:1990;2802-2807.
24. Samuni A., Krishna C.M., Riesz P., Finkelstein E., Russo A. A novel metal-free low molecular weight superoxide dismutase mimic. J. Biol. Chem. 263:1988;17921-17924.
25. Krishna M.C., Grahame D.A., Samuni A., Mitchell J.B., Russo A. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc. Natl. Acad. Sci. 89:1992;5537-5541.
26. Krishna M.C., Russo A., Mitchell J.B., Goldstein S., Dafni H., Samuni A. Do nitroxides antioxidants act as scavengers of superoxide or as SOD mimics? J. Biol. Chem. 271:1996;26026-26031.
27. Krishna M.C., Samuni A., Taira J., Goldstein S., Mitchell J.B., Russo A. Stimulation by nitroxides of catalase-like activity of hemeproteins. J. Biol. Chem. 271:1996;26018-26025.
28. Samuni A., Mitchell J.B., DeGraff W., Krishna C.M., Samuni U., Russo A. Nitroxide SOD-mimics: modes of action. Free Radic. Res. Commun. 12-13:1991;187-194.
29. Ohshima H., Gilibert I., Bianchini F. Induction of DNA strand breakage and base oxidation by nitroxyl anion through hydroxyl radical production. Free Radic. Biol. Med. 26:1999;1305-1313.
30. Ayene I.S., Koch C.J., Krisch R.E. Modification of radiation-induced strand breaks by glutathione: comparison of single- and double-strand breaks in SV40 DNA. Radiat. Res. 144:1995;1-8.
31. DeGraff W.G., Krishna M.C., Kaufman D., Mitchell J.B. Nitroxide-mediated protection against x-ray- and neocarzinostatin-induced DNA damage. Free Radic. Biol. Med. 13:1992;479-487.
32. Stamato T.D., Denko N. Asymmetric field inversion gel electrophoresis: a new method for detecting DNA double-strand breaks in mammalian cells. Radiat. Res. 121:1990;196-205.
33. Burkitt M.J., Milne L., Nicotera P., Orrenius S. 1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions. Biochem. J. 313:1996;163-170.
34. Sigman D.S., Graham D.R., D'Aurora V., Stern A.M. Oxygen-dependent cleavage of DNA by the 1,10-phenanthroline cuprous complex. Inhibition of Escherichia coli DNA polymerase I. J. Biol. Chem. 254:1979;12269-12272.
35. 2-induced damage and their protection by nitroxides. Biochim. Biophys. Acta. 1525:2001;70-76.
36. Samuni A., Godinger D., Aronovitch J., Russo A., Mitchell J.B. Nitroxides block DNA scission and protect cells from oxidative damage. Biochemistry. 30:1991;555-561.
37. Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol. 36:1988;95-125.
38. Krisch R.E., Flick M.A., Trumore C.N. Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA. Radiat. Res. 126:1991;251-259.
39. Peak J.G., Ito T., Robb F.T., Peak M.J. DNA damage produced by exposure of supercoiled plasmid DNA to high- and low-LET ionizing radiation: effects of hydroxyl radical quenchers. Int. J. Radiat. Biol. 67:1995;1-6.
40. Shao C., Saito M., Yu Z. Formation of single- and double-strand breaks of pBR322 plasmid irradiated in the presence of scavengers. Radiat. Environ. Biophys. 38:1999;105-109.