Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 1, 2004, Pages 378-384

  Akagi, Takanori ^a   Ushinohama, Kazami ^a   Ikesue, Shoko ^a   Yukawa, Eiji ^a   Higuchi, Shun ^a   Hamase, Kenji ^a   Zaitsu, Kiyoshi ^a   Ohdo, Shigehiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LUZINDOLE; MELATONIN; MELATONIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL RHYTHM; CHRONOPHARMACOLOGY; CHRONOTHERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE TIME EFFECT RELATION; HORMONE ACTION; LIGHT DARK CYCLE; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; TIME SERIES ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BINDING SITES; CIRCADIAN RHYTHM; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; MALE; MELATONIN; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0347758366     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055657     Document Type: Article

References (40)

1. Akagi T, Ushinohama K, Kage Y, Ishizaki T, Makinosumi T, Yamauchi A, Taguchi Y, Inoue K, Yukawa E, Higuchi S, et al. (2003) Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time. Life Sci 72:1183-1197.
2. Arendt J (1988) Melatonin. Clin Endocrinol 29:205-229.
3. Blask DE (1993) Melatonin in oncology; in Melatonin. Biosynthesis, Physiological Effects and Clinical Applications (Yu H-S and Reiter RJ eds) pp 447-477, CRC Press, Boca Raton, FL.
4. Blask DE (1997) Systemic, cellular and molecular aspects of melatonin action on experimental breast carcinogenesis, in The Melatonin Hypothesis. Breast Cancer and the Use of Electric Power (Stevens RG, Wilson BW, and Anderson LE eds) pp 257-275, Battelle Press, Columbus, OH.
5. Blask DE, Sauer LA, Dauchy RT, Holowachuk EW, Ruhoff MS, and Kopff HS (1999) Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. Cancer Res 59:4693-4701.
6. Calvo JR, Rafii-el-Idrissi M, Pozo D, and Guerrero JM (1995) Immunomodulatory role of melatonin: specific binding sites in human and rodent lymphoid cells. J Pineal Res 18:119-126.
7. Champney TH, Allen GC, Zannelli M, and Beausang LA (1998) Time-dependent effects of melatonin on immune measurements in male Syrian hamsters. J Pineal Res 25:142-146.
8. Cini G, Coronnello M, Mini E, and Neri B (1998) Melatonin's growth-inhibitory effect on hepatoma AH 130 in the rat. Cancer Lett 125:51-59.
9. Conti A and Maestroni GJM (1995) The clinical neuroimmunotherapeutic role of melatonin in oncology. J Pineal Res 19:103-110.
10. Cos S, Blask DE, Lemus-Wilson A, and Hill AB (1991) Effects of melatonin on the cell cycle kinetics and "estrogen-rescue" of MCF-7 human breast cancer cells in culture. J Pineal Res 10:36-42.
11. Dollins AB, Lynch HJ, Wurtman RJ, Deng MH, Kischka KU, Gleason RE, and Lieberman HR (1993) Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacology 112:490-496.
12. Duncan WC (1996) Circadian rhythms and the pharmacology of affective illness. Pharmacol Ther 71:253-312.
13. El-Missiry MA and Abd El-Aziz AF (2000) Influence of melatonin on proliferation and antioxidant system in Ehrlich ascites carcinoma cells. Cancer Lett 151:119-125.
14. Facciola G, Hidestrand M, von Bahr C, and Tybring G (2001) Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes. Eur J Clin Pharmacol 56:881-888.
15. Gauer F, Pevet MM, Skene DJ, Roles BV, and Pevet P (1993) Daily rhythm of melatonin binding sites in the rat pars tuberalis and suprachiasmatic nuclei: evidence for a regulation of melatonin receptors by melatonin itself. Neuroendocrinology 57:120-126.
16. Hori K, Zhang QH, Li HC, Saito S, and Sato Y (1996) Timing of cancer chemotherapy based on circadian variations in tumor tissue blood flow. Int J Cancer 65:360-364.
17. Horikawa K, Yokota S, Fuji K, Akiyama M, Moriya T, Okamura H, and Shibata S (2000) Nonphotic entrainment by 5-HT1A/7 receptor agonists accompanied by reduced Per1 and Per2 mRNA levels in the suprachiasmatic nuclei. J Neurosci 20:5867-5873.
18. Labrecque G, Belanger PM, Dore F, and Lalande M (1988) 24-Hour variations in the distribution of labeled microspheres to the intestine, liver and kidneys. Annu Rev Chronopharmacol 5:445-448.
19. Lewy AJ, Ahmed S, Jackson JM, and Sack RL (1992) Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 9:380-392.
20. Li JC and Xu F (1997) Influences of light-dark shifting on the immune system, tumor growth and life span of rats, mice and fruit flies as well as on the counteraction of melatonin. Biol Signals 6:77-89.
21. Lissoni P, Barni S, Tancini G, Ardizzoia A, Rovelli F, Cazzaniga M, Brivio F, Piperno A, Aldeghi R, Fossati D, et al. (1993a) Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancer of the digestive tract. Br J Cancer 67:1404-1407.
22. Lissoni P, Barni S, Tancini G, Rovelli F, Ardizzoia A, Conti A, and Maestroni GJM (1993b) A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients. Oncology 50:399-402.
23. 1 melatonin receptors and 2-iodomelatonin binding in the rat and Siberian hamster. Biol Signals Recept 9:188-196.
24. McArthur AJ, Gillette MU, and Prosser RA (1991) Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res 565:158-161.
25. McArthur AJ, Hunt AE, and Gillette MU (1997) Melatonin action and signal transductionin the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. Endocrinology 138:627-634.
26. Neri B, Brocchi A, Carossino AM, Cini-Neri G, Tommasi MS, and Cagnoni M (1995) Effect of melatonin administration on cytokine production in patients with advanced solid tumors. Oncol Rep 2:45-47.
27. Ohdo S, Arata N, Furukubo T, Yukawa E, Higuchi S, Nakano S, and Ogawa N (1998) Chronopharmacology of granulocyte colony-stimulating factor in mice. J Pharmacol Exp Ther 285:242-246.
28. Ohdo S, Grass GM, and Lee VHL (1991) Improving the ocular to systemic ratio of topical timolol by varying the dosing time. Investig Ophthalmol Vis Sci 32:2790-2798.
29. Ohdo S, Koyanagi S, Suyama H, Higuchi S, and Aramaki H (2001) Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Nat Med 7:356-360.
30. Ohdo S, Ogawa N, Nakano S, and Higuchi S (1996) Influence of feeding schedule on the chronopharmacological aspect of sodium valproate in mice. J Pharmacol Exp Ther 278:74-81.
31. Panzer A and Viljoen M (1997) The validity of melatonin as an oncostatic agent. J Pineal Res 22:184-202.
32. Reppert SM and Weaver DR (1995) Melatonin madness. Cell 83:1059-1062.
33. 2 (MEL1B) receptor. J Pineal Res 27:183-192.
34. Starkey SJ (1996) Melatonin and 5-hydroxytryptamine phase-advance the rat circadian clock by activation of nitric oxide synthesis. Neurosci Lett 211:199-202.
35. Starkey SJ, Walker MP, Beresford JM, and Hagan RM (1995) Modulation of the rat suprachiasmatic circadian clock by melatonin in vitro. Neuroreport 6:1947-1951.
36. Sze SF, Ng TB, and Liu WK (1993) Antiproliferative effect of pineal indoles on cultured tumor cell lines. J Pineal Res 14:27-33.
37. Takane H, Ohdo S, Yamada T, Yukawa E, and Higuchi S (2000) Chronopharmacology of antitumor effect induced by interferon-β in tumor-bearing mice. J Pharmacol Exp Ther 294:746-752.
38. Tenn C and Niles LP (1993) Physiological regulation of melatonin receptors in rat suprachiasmatic nuclei: diurnal rhythmicity and effects of stress. Mol Cell Endocrinol 98:43-48.
39. Vacas MI and Cardinali DP (1979) Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin. Neurosci Lett 15:259-263.
40. Watanabe H, Ohdo S, Ishikawa M, and Ogawa N (1992) Effects of social isolation on pentobarbital activity in mice: relationship to racemate levels and enantiomers levels in brain. J Pharmacol Exp Ther 263:1036-1045.