Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: An EPR imaging study

Journal of Controlled Release

Volumn 112, Issue 1, 2006, Pages 72-78

  Siepe, Stefanie ^a,c   Herrmann, Werner ^b   Borchert, Hans Hubert ^b   Lueckel, Barbara ^a   Kramer, Andrea ^a   Ries, Angelika ^a   Gurny, Robert ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Controlled release; EPR imaging; HPMC; Microenvironmental pH; Microviscosity

Indexed keywords

CONTROLLED RELEASE; HYDROXYPROPYLMETHYLCELLULOSE (HPMC); MICROENVIRONMENTAL PH; MICROVISCOSITY;

CORRELATION METHODS; DISSOLUTION; HYDRATION; OPTIMIZATION; PARAMAGNETIC RESONANCE; PH EFFECTS; REACTION KINETICS; VISCOSITY;

DRUG PRODUCTS;

CITRIC ACID; FUMARIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; IMIDAZOLE DERIVATIVE; SUCCINIC ACID;

ACIDITY; ARTICLE; CORRELATION ANALYSIS; DIFFUSION; ELECTRON SPIN RESONANCE; HYDRATION; MATRIX TABLET; MICROENVIRONMENT; NON INVASIVE MEASUREMENT; PH; PRIORITY JOURNAL; SPIN LABELING; SUSTAINED RELEASE FORMULATION; VISCOSITY; WATER ABSORPTION;

CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; DELAYED-ACTION PREPARATIONS; DIPYRIDAMOLE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FUMARATES; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; POLYMERS; SOLUBILITY; SUCCINIC ACID; TABLETS; VISCOSITY; WATER;

EID: 33645767703     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.12.021     Document Type: Article

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