Dissolution improvement of high drug-loaded solid dispersion

AAPS PharmSciTech

Volumn 7, Issue 2, 2006, Pages

  Okonogi, Siriporn ^a   Puttipipatkhachorn, Satit ^b  

^a CHIANG MAI UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Dissolution; Drug loading; Ofloxacin; Polysorbate 80; Ternary solid dispersion

Indexed keywords

DRUG CARRIER; MACROGOL; NONIONIC SURFACTANT; OFLOXACIN; POLYSORBATE 80; SURFACTANT;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; MOLECULAR WEIGHT; POWDER DIFFRACTION; WETTABILITY; X RAY DIFFRACTION;

ABSORPTION; ANTI-INFECTIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIFFUSION; DRUG CARRIERS; EMULSIONS; OFLOXACIN; POLYETHYLENE GLYCOLS; POLYSORBATES; POWDERS; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 33745080296     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070231     Document Type: Article

References (16)

1. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion system. J Pharm Sci. 1971;60:1281-1302.
2. Craig DQM. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm. 2002;231:131-144.
3. Owusu-Ababio G, Ebube NK, Reams R, Habib M. Comparative dissolution studies for mefenamic acid-polyethylene glycol solid dispersion systems and tablets. Pharm Dev Technol. 1998;3:405-412.
4. Schachter DM, Xiong J. Solid state NMR perspective of drug-polymer solutions: a model system based on poly(ethylene oxide). Int J Pharm. 2004;281:89-101.
5. Sethia S, Squillante E. Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm. 2004;272:1-10.
6. Suzuki H, Sunada H. Influence of water-soluble polymers on the dissolution of nifedipine solid dispersions with combined carriers. Chem Pharm Bull (Tokyo). 1998;46:482-487.
7. Mura P, Faucci MT, Manderioli A, Bramanti G, Parrini P. Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions. Drug Dev Ind Pharm. 1999;25:257-264.
8. Okonogi S, Oguchi T, Yonemochi E, Puttipipatkhachorn S, Yamamoto K. Improved dissolution of ofloxacin via solid dispersion. Int J Pharm. 1997;156:175-180.
9. Craig DQM. Polyethylene glycol and drug release. Drug Dev Ind Pharm. 1990;16:2514-2515.
10. Van den Mooter G, Augustijns P, Blaton N, Kinget R. Physicochemical charaterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. Int J Pharm. 1998;164:67-80.
11. Puttipipatkhachorn S, Nunthanid J, Yamamoto K, Peck GE. Drug physical state and drug-polymer interaction on drug release from chitosan matrix films. J Control Release. 2001;75:143-153.
12. Morris KR, Knipp GT, Serajuddin ATM. Structural properties of polyethylene glycol-polysorbate 80 mixture, a solid dispersion vehicle. J Pharm Sci. 1992;81:1185-1188.
13. Jachowicz R, Nurnberg E, Pieszczek B, Kluczykowska B, Maciejewska A. Solid dispersion of ketoprofen in pellets. Int J Pharm. 2000;206:13-21.
14. Okonogi S, Puttipipatkhachorn S, Yamamoto K. Thermal behavior of ursodeoxycholic acid in urea: identification of anomalous peak in thermal analysis. Drug Dev Ind Pharm. 2001;27:819-823.
15. Corrigan OI, Murphy CA, Timoney RP. Dissolution properties of polyethylene glycols and polyethylene glycol-drug systems. Int J Pharm. 1979;4:67-74.
16. Luner PE, Babu SR, Mehta SC. Wettability of a hydrophobic drug by surfactant solution. Int J Pharm. 1996;128:29-44.