Strategies to overcome pH-dependent solubility of weakly basic drugs by using different types of alginates

Drug Development and Industrial Pharmacy

Volumn 34, Issue 12, 2008, Pages 1277-1284

  Gutsche, S ^a,b   Krause, M ^a   Kranz, H ^a  

^a BAYER PHARMA AG   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Alginates; Drug delivery; Fumaric acid; pH independent; Weakly basic drug

Indexed keywords

AEROSIL; ALGINIC ACID; CALCIUM PHOSPHATE; FUMARIC ACID; MAGNESIUM STEARATE; POLYMER; PROTANAL LF 120 M; PROTANAL LF 200 M; PROTANAL LF 240 M; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HYDRATION; MICROENVIRONMENT; PH; TABLET COMPRESSION;

ALGINATES; DRUG DELIVERY SYSTEMS; FUMARATES; HARDNESS; HYDROGEN-ION CONCENTRATION; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; VERAPAMIL;

EID: 57349146694     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802032895     Document Type: Article

References (19)

1. Amighi, K., Timmermans, J., Puigdevall, P., Baltes, E., & Moes, A. J. (1998). Peroral sustained-release film coated pellets as a means to overcome physicochemical and biological drug related problems. I. In vitro development and evaluation. Drug Dev. Ind. Pharm., 24, 509-515.
2. Dashevsky, A., Kolter, K., & Bodmeier, R. (2004). pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP. Eur. J. Pharm. Biopharm., 58, 45-49.
3. Efentakis, M., & Buckton, G. (2002). The effect of erosion and swelling on the dissolution of theophylline from low and high viscosity sodium alginate matrices. Pharm. Dev. Technol., 7, 69-77.
4. FMC BioPolymer. (2003). Technical information for Protanal. Philadelphia, USA.
5. Gombotz, W. R., & Wee, S. F. (1998). Protein release from alginate matrices. Adv. Drug Deliv. Rev., 31, 267-285.
6. Guthmann, C., Lipp, R., Wagner, T., & Kranz, H. (2007). Development of a multiple unit pellet formulation for a weakly basic drug. Drug Dev. Ind. Pharm., 33, 341-349.
7. Hodsdon, A. C., Mitchell, J. R., Davies, M. C., & Melia, C. D. (1995). Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices. J. Control Release, 33, 143-152.
8. Hoerter, D., & Dressmann, J. D. (1997). Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. Rev., 25, 3-14.
9. Kranz, H., Guthmann, C., Wagner, T., Lipp, R., & Reinhard, J. (2005). Development of a single unit extended release formulation for ZK 811 752, a weakly basic drug. Eur. J. Pharm. Sci., 26, 47-53.
10. Liew, C. V., Chan, L. W., Ching, A. L., & Heng, P. W. S (2006). Evaluation of sodium alginate as drug release modifier in matrix tablets. Int. J. Pharm., 309, 25-37.
11. Merck & Co. Inc. (2001). Merck index, Vol. XII. NJ: Whitehouse Station.
12. Munday, D. L. (2003). Film coated pellets containing verapamil hydrochloride: Enhanced dissolution into neutral medium. Drug Dev. Ind. Pharm., 29, 575-583.
13. Nie, S., Pan, W., Li, X., & Wu, X. (2004). The effect of citric acid added to hydroxypropyl methylcellulose (HPMC) matrix tablets on the release profile of vinpocetine. Drug Dev. Ind. Pharm., 30, 627-635.
14. Shilpa, A., Agrawal, S. S., & Ray, A. R. (2003). Controlled delivery of drugs from alginate matrix. J. Macromol. Sci. Polym. Rev., C 43, 187-221.
15. Siepe, S., Lueckel, B., Kramer, A., Ries, A., & Gurny, R. (2006). Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH. Int. J. Pharm., 316, 14-20.
16. Sriamornsak, P., Thirawong, N., & Korkerd, K. (2007). Swelling, erosion and release behavior of alginate-based matrix tablers. Eur. J. Pharm. Biopharm., 66, 435-450.
17. Streubel, A., Siepmann, J., Dashevsky, A., & Bodmeier, R. (2000). pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. J. Control Release, 67, 101-110.
18. Takka, S., Rajbhandari, S., & Sakr, A. (2001). Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur. J. Pharm. Biopharm., 52, 75-82.
19. Timmins, P., Delargy, A. M., & Howard, J. R. (1997). Optimization and characterization of a pH-independent extended release hydrophilic matrix tablet. Pharm. Dev. Technol., 2, 25-31.