The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins

Pharmaceutical Research

Volumn 16, Issue 2, 1999, Pages 241-248

  Shenderova, Anna ^a   Burke, Thomas G ^a   Schwendeman, Steven P ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Camptothecin; Drug stability; Microclimate pH; pH sensitive probe; PLGA

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; DRUG VEHICLE; LACTONE; MICROSPHERE; POLYGLACTIN; TOPOTECAN;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; MICROCLIMATE; PH MEASUREMENT; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL;

EID: 0033043628     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1018876308346     Document Type: Article

References (21)

1. 1. A. Shenderova, T. G. Burke, and S. P. Scwendeman. Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles. Pharm. Res. 14:1406-1414 (1997).
2. 2. J. Heller. Development of poly(orto esters): a historical overview. Biomaterials 11:659-665 (1990).
3. 3. P. K. Gupta, C. T. Hung, and F. C. Lam. In A. Rolland (ed), Pharmaceutical Particulate Carriers: Therapeutic Applications, Marcel Dekker, New York, 1993, pp. 135-165.
4. 4. J. H. Anderson, C. S. McArdle, and T. G. Cooke. In N. Willmott and J. M. Daly (eds), Microspheres and Regional Cancer Therapy; CRC Press, Boca Raton, 1994, pp. 57-70.
5. 5. J. Fassberg and V. J. Stella. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J. Pharm. Sci. 81:676-684 (1992).
6. 6. R. H. Hertzberg, M. J. Caranfa, K. G. Holden, D. J. Jakas, G. Gallagher, M. R. Mattern, S. Mong, J. O. Bartus, R. K. Johnson, and W. D. Kingsbury. Modification of the hydroxy lactone ring of camptothecins: inhibition of mammalian topoisomerase I and biological activity. J. Med. Chem. 32:715-720 (1989).
7. 7. S. M. Li, H. Garreau, and M. Vert. Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media. J. Mater. Sci. Mater. Med. 1:123-130 (1990).
8. 8. S. P. Schwendeman, M. Cardamone, H. R. Bvandon, A. Klibanov, and R. Langer. Stability of proteins and their delivery from biodegradable polymer microspheres. In S. Cohen and H. Bernstein (eds.), Microparticulate Systems for the Delivery of Proteins and Vaccines, Marcel Dekker, New York, 1996, pp. 1-49.
9. 31P NMR spectroscopy. Proceed. Intern. Symp. Control. Rel. of Bioact. Mater. 23:237, (1996).
10. 10. T. G. Park, W. Lu, and G. Grotts. Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly(D,L-lactic acid-co-glycolic acid) microspheres. J. Contr. Rel. 33:211-222 (1995).
11. 11. A. Shenderova, T. G. Burke, and S. P. Schwendeman. Characterization of the microclimate in PLGA microspheres with a camptothecin probe. Pharm. Res. 9:S-254 (1996).
12. 12. D. D. Perrin and B. Dempsey. Buffers for pH and metal ion control, Chapman and Hall, New York, 1987.
13. 13. R. G. Bates, M. Paabo, and R. A. Robinson. Interpretation of pH measurements in alcohol-water solvents. J. Phys. Chem. 67:1833-1838 (1963).
14. 14. R. G. Bates. Determination of pH. Theory and Practice, A Wiley-Interscience Publication, New York, 1973.
15. 15. G. Douheret. Potentiels de jounction liquide et effet de milieu en solvants mixtes eau-solvant aprotique dipolaire. Bull. Soc. Chim. France 8:3122-31 (1968).
16. 16. Y. Zhang, S. Zale, L. Alukonis, and H. Bernstein. Effects of metal salts on PLGA hydrolysis. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22:83-84 (1995).
17. 17. T. G. Park. Degradation of poly(D,L-lactic acid) microspheres: effects of molecular weight. J. Contr. Rel. 30:161-173 (1994).
18. 18. T. French, P. T. C. So, D. J. Weaver Jr., T. Coelho-Sampaio, E. Grattton, E. W. Voss Jr., and J. Carrero. Two-photon fluorescence lifetime imaging microcopy of macrophage-mediated antigen processing. J. Microscopy 185:339-353 (1997).
19. 19. S.-C. Chen, H. Nakamura, and Z. Tamura. Supplemental studies on relationships between structure and spectrum of fluorescein. Chem. Pharm. Bull. 27:475-479 (1979).
20. 20. T. G. Burke, A. K. Mishra, M. C. Wani and M. E. Wall. Lipid bilayer partitioning and stability of camptothecin drugs. Biochemistry 32:5352-5364 (1993).
21. 21. J. T. Carstensen. Drug stability: principles and practices, Dekker, New York, 1995.