Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9545-9555

  Fong, Desiree H ^a   Lemke, Christopher T ^a,b   Hwang, Jiyoung ^a,c   Xiong, Bing ^a,d   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Research and Development   (Canada)

^c GENENTECH INC   (United States)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2-DEOXYSTREPTAMINE; AMINOGLYCOSIDE RESISTANCE; AMINOGLYCOSIDES; ANTIBIOTIC RESISTANCE; BINARY COMPLEXES; CHOLINE KINASE; CLINICAL SETTINGS; CONFORMATION CHANGE; KINETIC ASSAY; LEGIONELLA PNEUMOPHILA; LIGAND BINDING; METHYLTHIORIBOSE KINASE; PHOSPHORYLATE SUBSTRATES; PHOSPHOTRANSFERASES; PROTEIN KINASE; REGIOSPECIFICITY; SPECTINOMYCIN; SUBSTRATE BINDING; SUBSTRATE SPECIFICITY; TERNARY COMPLEX; THREE-DIMENSIONAL STRUCTURE; UNDERLYING CAUSE;

ANTIBIOTICS; CATALYSTS; ENZYMES;

SUBSTRATES;

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; BACTERIAL ENZYME; CHOLINE KINASE; METHYLTHIORIBOSE KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE; SPECTINOMYCIN; SPECTINOMYCIN PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ISOPROTEIN; LIGAND;

ANTIBIOTIC RESISTANCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; LEGIONELLA PNEUMOPHILA; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYMOLOGY; KINETICS; METABOLISM; METHODOLOGY; PHOSPHORYLATION; PHYLOGENY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

LEGIONELLA PNEUMOPHILA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; KINETICS; LEGIONELLA PNEUMOPHILA; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHYLOGENY; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY;

EID: 77951225260     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038364     Document Type: Article

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