The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance

Journal of Biological Chemistry

Volumn 274, Issue 43, 1999, Pages 30697-30706

  Thompson, Paul R ^a   Schwartzenhauer, Jeffrey ^a   Hughes, Donald W ^b   Berghuis, Albert M ^a   Wright, Gerard D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE PHOSPHOTRANSFERASE; BUTIROSIN; FRAMYCETIN; KANAMYCIN A; LIVIDOMYCIN; NEAMINE; PHOSPHOTRANSFERASE; RIBOSTAMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOHYDRATE SEQUENCE; CONSERVED SEQUENCE; ELECTROSTATICS; ESCHERICHIA COLI; KANAMYCIN KINASE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENYLALANINE; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE DELETION;

EID: 0032724177     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.43.30697     Document Type: Article

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