Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding

Journal of Biological Chemistry

Volumn 282, Issue 30, 2007, Pages 22195-22206

  Ku, Shao Yang ^a,b   Yip, Patrick ^a   Cornell, Kenneth A ^c   Riscoe, Michael K ^d,e   Behr, Jean Bernard ^f   Guillerm, Georges ^f   Howell, P Lynne ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c BOISE STATE UNIVERSITY   (United States)

^d PORTLAND STATE UNIVERSITY   (United States)

^e PORTLAND VA MEDICAL CENTER   (United States)

^f UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; METHIONINE SALVAGE; RIBOSYL MOIETIES;

ANTIBIOTICS; BACTERIA; BINDING SITES; MAGNESIUM; MAMMALS; NUCLEOTIDES;

ENZYME KINETICS;

5 METHYLTHIORIBOSE KINASE; ADENOSINE DIPHOSPHATE; ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; MAGNESIUM; NUCLEOTIDE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE;

ADENINE NUCLEOTIDES; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; METHIONINE; MODELS, MOLECULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; PROTEIN FOLDING; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS; EUKARYOTA; MAMMALIA;

EID: 34547586984     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611045200     Document Type: Article

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